LOCUS       NM_001361989            3135 bp    mRNA    linear   ROD 31-JUL-2024
DEFINITION  Mus musculus mitogen-activated protein kinase 7 (Mapk7), transcript
            variant 7, mRNA.
ACCESSION   NM_001361989 XM_006533281
VERSION     NM_001361989.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3135)
  AUTHORS   You,H., Song,G., Xu,Z., Chen,S., Shen,W., Liu,H., Deng,B., Li,J.
            and Huang,G.
  TITLE     HuR promotes castration-resistant prostate cancer progression by
            altering ERK5 activation via posttranscriptional regulation of
            BCAT1
  JOURNAL   J Transl Med 22 (1), 178 (2024)
   PUBMED   38369471
  REMARK    GeneRIF: HuR promotes castration-resistant prostate cancer
            progression by altering ERK5 activation via posttranscriptional
            regulation of BCAT1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3135)
  AUTHORS   Guo,Y., Xiang,P., Sun,X., Liu,W., Zhou,J., Yin,B., Hou,L.,
            Qiang,B., Li,H., Shu,P. and Peng,X.
  TITLE     Docking protein 6 (DOK6) selectively docks the neurotrophic
            signaling transduction to restrain peripheral neuropathy
  JOURNAL   Signal Transduct Target Ther 9 (1), 32 (2024)
   PUBMED   38351062
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3135)
  AUTHORS   Savage,H., Pareek,S., Lee,J., Ballaro,R., Conterno Minussi,D.,
            Hayek,K., Sadullozoda,M., Lochmann,B.S., McQuade,J.L., LaVoy,E.C.,
            Marmonti,E., Patel,H., Wang,G., Imanishi,M., Kotla,S., Abe,J.I. and
            Schadler,K.
  TITLE     Aerobic Exercise Alters the Melanoma Microenvironment and Modulates
            ERK5 S496 Phosphorylation
  JOURNAL   Cancer Immunol Res 11 (9), 1168-1183 (2023)
   PUBMED   37307577
  REMARK    GeneRIF: Aerobic Exercise Alters the Melanoma Microenvironment and
            Modulates ERK5 S496 Phosphorylation.
REFERENCE   4  (bases 1 to 3135)
  AUTHORS   Tsitsikov,E.N., Phan,K.P., Liu,Y., Tsytsykova,A.V., Kinter,M.,
            Selland,L., Garman,L., Griffin,C. and Dunn,I.F.
  TITLE     TRAF7 is an essential regulator of blood vessel integrity during
            mouse embryonic and neonatal development
  JOURNAL   iScience 26 (8), 107474 (2023)
   PUBMED   37583551
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3135)
  AUTHORS   Abe,J.I., Imanishi,M., Li,S., Zhang,A., Ko,K.A.,
            Samanthapudi,V.S.K., Lee,L.L., Bojorges,A.P., Gi,Y.J., Hobbs,B.P.,
            Deswal,A., Herrmann,J., Lin,S.H., Chini,E.N., Shen,Y.H.,
            Schadler,K.L., Nguyen,T.H., Gupte,A.A., Reyes-Gibby,C., Yeung,S.J.,
            Abe,R.J., Olmsted-Davis,E.A., Krishnan,S., Dantzer,R.,
            Palaskas,N.L., Cooke,J.P., Pownall,H.J., Yoshimoto,M., Fujiwara,K.,
            Hamilton,D.J., Burks,J.K., Wang,G., Le,N.T. and Kotla,S.
  TITLE     An ERK5-NRF2 Axis Mediates Senescence-Associated Stemness and
            Atherosclerosis
  JOURNAL   Circ Res 133 (1), 25-44 (2023)
   PUBMED   37264926
  REMARK    GeneRIF: An ERK5-NRF2 Axis Mediates Senescence-Associated Stemness
            and Atherosclerosis.
REFERENCE   6  (bases 1 to 3135)
  AUTHORS   Regan,C.P., Li,W., Boucher,D.M., Spatz,S., Su,M.S. and Kuida,K.
  TITLE     Erk5 null mice display multiple extraembryonic vascular and
            embryonic cardiovascular defects
  JOURNAL   Proc Natl Acad Sci U S A 99 (14), 9248-9253 (2002)
   PUBMED   12093914
  REMARK    GeneRIF: Erk5 null mice display multiple extraembryonic vascular
            and embryonic cardiovascular defects.
REFERENCE   7  (bases 1 to 3135)
  AUTHORS   Grewal,P.K., Holzfeind,P.J., Bittner,R.E. and Hewitt,J.E.
  TITLE     Mutant glycosyltransferase and altered glycosylation of
            alpha-dystroglycan in the myodystrophy mouse
  JOURNAL   Nat Genet 28 (2), 151-154 (2001)
   PUBMED   11381262
REFERENCE   8  (bases 1 to 3135)
  AUTHORS   Dalmay,T., Horsefield,R., Braunstein,T.H. and Baulcombe,D.C.
  TITLE     SDE3 encodes an RNA helicase required for post-transcriptional gene
            silencing in Arabidopsis
  JOURNAL   EMBO J 20 (8), 2069-2078 (2001)
   PUBMED   11296239
REFERENCE   9  (bases 1 to 3135)
  AUTHORS   Yan,C., Luo,H., Lee,J.D., Abe,J. and Berk,B.C.
  TITLE     Molecular cloning of mouse ERK5/BMK1 splice variants and
            characterization of ERK5 functional domains
  JOURNAL   J Biol Chem 276 (14), 10870-10878 (2001)
   PUBMED   11139578
REFERENCE   10 (bases 1 to 3135)
  AUTHORS   Kamakura,S., Moriguchi,T. and Nishida,E.
  TITLE     Activation of the protein kinase ERK5/BMK1 by receptor tyrosine
            kinases. Identification and characterization of a signaling pathway
            to the nucleus
  JOURNAL   J Biol Chem 274 (37), 26563-26571 (1999)
   PUBMED   10473620
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB868535.1, CA315160.1, BC082315.1 and AY534740.1.
            
            On Mar 31, 2018 this sequence version replaced XM_006533281.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.19098.1,
                                           SRR7652917.614053.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                BB868535.1         2-74
            74-718              CA315160.1         1-645
            719-2571            BC082315.1         770-2622
            2572-3135           AY534740.1         2473-3036
FEATURES             Location/Qualifiers
     source          1..3135
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.96 cM"
     gene            1..3135
                     /gene="Mapk7"
                     /gene_synonym="b2b2346Clo; BMK-1; BMK1; ERK-5; ERK5;
                     Erk5-T; PRKM7"
                     /note="mitogen-activated protein kinase 7"
                     /db_xref="GeneID:23939"
                     /db_xref="MGI:MGI:1346347"
     exon            1..182
                     /gene="Mapk7"
                     /gene_synonym="b2b2346Clo; BMK-1; BMK1; ERK-5; ERK5;
                     Erk5-T; PRKM7"
                     /inference="alignment:Splign:2.1.0"
     exon            183..631
                     /gene="Mapk7"
                     /gene_synonym="b2b2346Clo; BMK-1; BMK1; ERK-5; ERK5;
                     Erk5-T; PRKM7"
                     /inference="alignment:Splign:2.1.0"
     exon            632..797
                     /gene="Mapk7"
                     /gene_synonym="b2b2346Clo; BMK-1; BMK1; ERK-5; ERK5;
                     Erk5-T; PRKM7"
                     /inference="alignment:Splign:2.1.0"
     exon            798..1876
                     /gene="Mapk7"
                     /gene_synonym="b2b2346Clo; BMK-1; BMK1; ERK-5; ERK5;
                     Erk5-T; PRKM7"
                     /inference="alignment:Splign:2.1.0"
     CDS             817..2820
                     /gene="Mapk7"
                     /gene_synonym="b2b2346Clo; BMK-1; BMK1; ERK-5; ERK5;
                     Erk5-T; PRKM7"
                     /EC_number="2.7.11.24"
                     /note="isoform c is encoded by transcript variant 7; MAPK
                     7; extracellular signal-regulated kinase 5; big MAP kinase
                     1"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 7 isoform c"
                     /protein_id="NP_001348918.1"
                     /db_xref="GeneID:23939"
                     /db_xref="MGI:MGI:1346347"
                     /translation="MESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDL
                     KPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQ
                     AIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQ
                     SLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEP
                     DCAPPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPVCP
                     DVEMPSPWAPSGDCAMESPPPALPPCSDPAPDTVDLTLQPAPPASELAPPKREGAISD
                     NTKAALKAALLKSLRSRLRDGPSAPLEAPEPRKPVTAQERQREREEKRRRRQERAKER
                     EKRRQERERKERGAGTLGGPSTDPLAGLVLSDNDRSLLERWTRMARPPAPAPAPAPAP
                     APAPSSAQPTSTPTGPVSQSTGPLQPAGSIPGPASQPVCPPPGPVPQPAGPIPAPLQT
                     APSTSLLASQSLVPPSGLPGSGAPEVLPYFPSGPPPPDPGLTPQPSTSESPDVNLVTQ
                     QLSKSQVEDPLPPVFSGTPKGSGAGYGVGFDLEEFLNQSFDMGVADGPQDGQADSASL
                     SASLLADWLEGHGMNPADIESLQREIQMDSPMLLSDLPDLQEP"
     exon            1877..2532
                     /gene="Mapk7"
                     /gene_synonym="b2b2346Clo; BMK-1; BMK1; ERK-5; ERK5;
                     Erk5-T; PRKM7"
                     /inference="alignment:Splign:2.1.0"
     exon            2533..2666
                     /gene="Mapk7"
                     /gene_synonym="b2b2346Clo; BMK-1; BMK1; ERK-5; ERK5;
                     Erk5-T; PRKM7"
                     /inference="alignment:Splign:2.1.0"
     exon            2667..3125
                     /gene="Mapk7"
                     /gene_synonym="b2b2346Clo; BMK-1; BMK1; ERK-5; ERK5;
                     Erk5-T; PRKM7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3102..3107
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mapk7"
                     /gene_synonym="b2b2346Clo; BMK-1; BMK1; ERK-5; ERK5;
                     Erk5-T; PRKM7"
                     /note="hexamer: AATACA"
     polyA_site      3120
                     /gene="Mapk7"
                     /gene_synonym="b2b2346Clo; BMK-1; BMK1; ERK-5; ERK5;
                     Erk5-T; PRKM7"
                     /note="major polyA site"
ORIGIN      
        1 gctggaggag cgtggtcccg gggcggccgg tggggtggtc tgcttcggcg cacgcgaggc
       61 tttggtggtg gccgcggttc ttgttaagtg agcgagcccg ggggaacact catcactggg
      121 ttggcaagac tcaggaatcc caaattcccg aggaggcgtg gcggcggggt gccggccggt
      181 cggtcctgcc tccaaaccca cagaggcgga actgagaggc cctcaggacg atcttctcat
      241 cagcgcttcg tacagaccat ggccgaaccg ctgaaggagg aggacggcga agatggctct
      301 ggggagcccc ctgggagggt gaaggcagaa cccgttcaca ccgctgcctc tgtggtggcc
      361 aagaacctgg ccctgctcaa agcccgctcc ttcgacgtga cctttgacgt gggggacgag
      421 tacgagatca tcgagaccat aggcaatggg gcctacgggg tggtgtcttc ggcgcgccgc
      481 cgcctcacgg gtgagctggc ttcctgaggc tcagcatgtg tggactgctt tccagaggcg
      541 gtgaggaacc cgcacggtcc caggaggatc agctgcgccg gggattctgg ttccactcac
      601 gcttacggac taggtgccag ctccccgtta ggccagcagg tggccatcaa gaagatacct
      661 aatgcttttg atgtggtgac caatgccaaa cggaccctca gggagctgaa gatcctcaaa
      721 cacttcaaac acgacaatat catcgccatc aaggacatcc tgaagcctac tgtgccctat
      781 ggagaattca gatctgtcta tgtggtactg gacctcatgg agagcgacct acaccagatc
      841 attcactctt cacagccgct caccctggaa catgtgagat acttcctgta ccagctgctt
      901 cggggcctca aatacatgca ctctgctcag gtcatccacc gtgatcttaa accctctaac
      961 cttctggtca atgagaactg tgagctcaag atcggtgact ttggaatggc ccgtggcctc
     1021 tgtacttccc ctgccgagca ccagtacttc atgactgagt atgtggctac tcgctggtac
     1081 cgtgccccgg agctcatgct ttccctgcac gagtatacgc aggcaatcga cctctggtct
     1141 gtgggctgca tctttggtga gatgctggct cggcgccagc tcttcccagg caaaaactac
     1201 gtgcaccagt tacagctgat catgatggtg ttgggaactc cgtcaccagc tgtgattcag
     1261 gctgtggggg ctgaaagggt gcgagcctat atccagagcc tgccaccaag gcaacctgtg
     1321 ccttgggaga cagtataccc aggtgctgac cgccaggccc tctccctgct gggacgcatg
     1381 ttgcgatttg aacccagtgc ccgaatctca gctgctgctg cccttcgcca ccccttcctg
     1441 gctaagtacc atgaccctga tgatgagcct gattgcgccc caccttttga ctttgctttt
     1501 gaccgtgaag cccttaccag ggagcgcatt aaggaggcca ttgtggctga gattgaggac
     1561 ttccatgcac gacgggaggg catccgccaa caaatccgct tccagccttc tctgcagcct
     1621 gtggctagtg agcctgtgtg tccagatgtt gagatgccca gtccctgggc tccaagtgga
     1681 gactgtgcca tggagtcgcc tcctccagca ctgccaccat gctctgatcc tgcacctgac
     1741 accgttgatc tgactctgca gcctgccccg ccggccagtg agcttgctcc accaaaaaga
     1801 gagggtgcca tctccgacaa taccaaagca gccctcaaag ctgccctgct caagtcccta
     1861 aggagcaggc tcagagatgg gcccagtgca cccttggagg cgcctgagcc tcgaaagccc
     1921 gtgacagctc aggaacgcca gcgagaacga gaagagaagc gcaggaggcg acaagagaga
     1981 gccaaggagc gggagaagcg acgacaagag agagaacgca aggagagggg ggctggtacc
     2041 ttggggggcc cctctactga ccctctggct ggactggtgc tcagtgacaa tgaccgaagc
     2101 ctgctagagc ggtggactcg catggctagg cctcctgccc ctgcccctgc cccagcgcca
     2161 gcaccagcgc cagcaccgtc ctctgcccag cccactagta ctcctactgg ccccgtatct
     2221 cagtctactg gtcctctaca gcctgcaggc tctattccgg gtcctgcctc ccagcctgtt
     2281 tgcccacccc ctggccctgt tccccagcct gctggcccta tccctgctcc gctccagact
     2341 gccccttcca ctagcctttt ggcctcccag tcacttgtgc cacctagtgg gttgcctggt
     2401 tctggtgccc cagaagttct gccttacttc ccatctggcc caccacctcc agatcctggg
     2461 ctcacccctc agccttctac atcagagtca cctgatgtca acctggtgac tcagcagctg
     2521 tccaagtctc aggtggagga ccccctgcct cctgtgttct ctggcactcc aaagggcagt
     2581 ggggctggct acggagttgg ctttgatctg gaggaattct taaatcaatc ttttgatatg
     2641 ggtgtggctg atgggccaca ggatggccag gcagactcag cctcactctc agcctctctc
     2701 cttgctgact ggcttgaggg ccatggcatg aaccctgctg acattgagtc tctgcagcgt
     2761 gagatccaga tggactcccc aatgctgctg tctgacctgc ctgacctcca agagccctga
     2821 aacccacagc ttgtgccttg ctgccaggat agacccagca tcaaggtcca ggggtgcgat
     2881 ccaaagggct gcaccctggg cctggcaggt gaggcttggc ttgagttact ctgcaggttc
     2941 atctcagacc cacctttcag ccttaagcag ccacctgagc caccaccgag ccataacagg
     3001 accaggagac tctactcctc cctgagcagt cttctccagt attgtatttt ttattattgt
     3061 tgtaatatgc atttgttttg ccatcaaaat gaggcctgtg aaatacaagg ttttctttaa
     3121 cctgaaaaaa aaaaa
//
