LOCUS       NM_015806               4205 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus mitogen-activated protein kinase 6 (Mapk6), transcript
            variant 1, mRNA.
ACCESSION   NM_015806
VERSION     NM_015806.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4205)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4205)
  AUTHORS   Racedo,S.E., Liu,Y., Shi,L., Zheng,D. and Morrow,B.E.
  TITLE     Dgcr8 functions in the secondary heart field for outflow tract and
            right ventricle development in mammals
  JOURNAL   Dev Biol 506, 72-84 (2024)
   PUBMED   38110169
REFERENCE   3  (bases 1 to 4205)
  AUTHORS   Loza-Valdes,A., El-Merahbi,R., Kassouf,T., Demczuk,A., Reuter,S.,
            Viera,J.T., Karwen,T., Noh,M., Loffler,M.C., Romero-Becerra,R.,
            Torres,J.L., Marcos,M., Sabio,G., Wojda,U. and Sumara,G.
  TITLE     Targeting ERK3/MK5 complex for treatment of obesity and diabetes
  JOURNAL   Biochem Biophys Res Commun 612, 119-125 (2022)
   PUBMED   35523049
REFERENCE   4  (bases 1 to 4205)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4205)
  AUTHORS   Yao,T., Zha,D., Hu,C. and Wu,X.
  TITLE     Circ_0000285 promotes podocyte injury through sponging miR-654-3p
            and activating MAPK6 in diabetic nephropathy
  JOURNAL   Gene 747, 144661 (2020)
   PUBMED   32275999
  REMARK    GeneRIF: circ_0000285 promoted podocyte injury via sponging
            miR-654-3p and activating MAPK6 in diabetic nephropathy.
REFERENCE   6  (bases 1 to 4205)
  AUTHORS   Coulombe,P., Rodier,G., Pelletier,S., Pellerin,J. and Meloche,S.
  TITLE     Rapid turnover of extracellular signal-regulated kinase 3 by the
            ubiquitin-proteasome pathway defines a novel paradigm of
            mitogen-activated protein kinase regulation during cellular
            differentiation
  JOURNAL   Mol Cell Biol 23 (13), 4542-4558 (2003)
   PUBMED   12808096
  REMARK    GeneRIF: ERK3 biological activity is regulated by its cellular
            abundance through the control of protein stability
REFERENCE   7  (bases 1 to 4205)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 4205)
  AUTHORS   Turgeon,B., Lang,B.F. and Meloche,S.
  TITLE     The protein kinase ERK3 is encoded by a single functional gene:
            genomic analysis of the ERK3 gene family
  JOURNAL   Genomics 80 (6), 673-680 (2002)
   PUBMED   12504858
REFERENCE   9  (bases 1 to 4205)
  AUTHORS   Turgeon,B., Saba-El-Leil,M.K. and Meloche,S.
  TITLE     Cloning and characterization of mouse
            extracellular-signal-regulated protein kinase 3 as a unique gene
            product of 100 kDa
  JOURNAL   Biochem J 346 Pt 1 (Pt 1), 169-175 (2000)
   PUBMED   10657254
REFERENCE   10 (bases 1 to 4205)
  AUTHORS   Ershler,M., Nagorskaya,T.V., Visser,J.W. and Belyavsky,A.V.
  TITLE     Novel CDC2-related protein kinases produced in murine hematopoietic
            stem cells
  JOURNAL   Gene 124 (2), 305-306 (1993)
   PUBMED   8444355
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA325060.1, BC100385.1, BC048779.1, AK051508.1 and AC115880.11.
            
            On Nov 8, 2013 this sequence version replaced NM_015806.4.
            
            Transcript Variant: This variant (1) differs in the 5' UTR,
            compared to variant 2. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100385.1, SRR7974084.14549.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                CA325060.1         1-18
            19-959              BC100385.1         1-941
            960-4083            BC048779.1         462-3585
            4084-4200           AK051508.1         1362-1478
            4201-4205           AC115880.11        69216-69220         c
FEATURES             Location/Qualifiers
     source          1..4205
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 42.3 cM"
     gene            1..4205
                     /gene="Mapk6"
                     /gene_synonym="2610021I23Rik; D130053K17Rik; Erk3; Mapk4;
                     Mapk63; Prkm4; Prkm6"
                     /note="mitogen-activated protein kinase 6"
                     /db_xref="GeneID:50772"
                     /db_xref="MGI:MGI:1354946"
     exon            1..154
                     /gene="Mapk6"
                     /gene_synonym="2610021I23Rik; D130053K17Rik; Erk3; Mapk4;
                     Mapk63; Prkm4; Prkm6"
                     /inference="alignment:Splign:2.1.0"
     exon            155..1327
                     /gene="Mapk6"
                     /gene_synonym="2610021I23Rik; D130053K17Rik; Erk3; Mapk4;
                     Mapk63; Prkm4; Prkm6"
                     /inference="alignment:Splign:2.1.0"
     CDS             773..2935
                     /gene="Mapk6"
                     /gene_synonym="2610021I23Rik; D130053K17Rik; Erk3; Mapk4;
                     Mapk63; Prkm4; Prkm6"
                     /EC_number="2.7.11.24"
                     /note="MAP kinase 6; extracellular signal-regulated kinase
                     3; mitogen activated protein kinase 4; protein kinase,
                     mitogen activated kinase 4; Erk-3 related"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 6"
                     /protein_id="NP_056621.4"
                     /db_xref="CCDS:CCDS23342.1"
                     /db_xref="GeneID:50772"
                     /db_xref="MGI:MGI:1354946"
                     /translation="MAEKFESLMNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDK
                     RVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELN
                     SVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFI
                     NTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAA
                     GCIFAEMLTGKTLFAGAHELEQMQLILDSIPVVHEEDRQELLSVIPVYIRNDMTEPHR
                     PLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYMSIYSFPTDEPISSHPFHI
                     EDEVDDILLMDETHSHIYNWERYHDCQFSEHDWPIHNNFDIDEVQLDPRALSDVTDEE
                     EVQVDPRKYLDGDREKYLEDPAFDTSYSAEPCWQYPDHHENKYCDLECSHTCNYKTRS
                     SPYLDNLVWRESEVNHYYEPKLIIDLSNWKEQSKEKSDKRGKSKCERNGLVKAQIALE
                     EASQQLAERERGQGFDFDSFIAGTIQLSAQHQSADVVDKLNDLNSSVSQLELKSLISK
                     SVSREKQEKGRANLAQLGALYQSSWDSQFVSGGEECFLISQFCCEVRKDEHAEKENTY
                     TSYLDKFFSRKEDSEMLETEPVEEGKRGERGREAGLLSGGGEFLLSKQLESIGTPQFH
                     SPVGSPLKSIQATLTPSAMKSSPQIPHKTYSSILKHLN"
     exon            1328..1472
                     /gene="Mapk6"
                     /gene_synonym="2610021I23Rik; D130053K17Rik; Erk3; Mapk4;
                     Mapk63; Prkm4; Prkm6"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1637
                     /gene="Mapk6"
                     /gene_synonym="2610021I23Rik; D130053K17Rik; Erk3; Mapk4;
                     Mapk63; Prkm4; Prkm6"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1839
                     /gene="Mapk6"
                     /gene_synonym="2610021I23Rik; D130053K17Rik; Erk3; Mapk4;
                     Mapk63; Prkm4; Prkm6"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..4205
                     /gene="Mapk6"
                     /gene_synonym="2610021I23Rik; D130053K17Rik; Erk3; Mapk4;
                     Mapk63; Prkm4; Prkm6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4063..4068
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mapk6"
                     /gene_synonym="2610021I23Rik; D130053K17Rik; Erk3; Mapk4;
                     Mapk63; Prkm4; Prkm6"
                     /note="hexamer: AATAAA"
     polyA_site      4083
                     /gene="Mapk6"
                     /gene_synonym="2610021I23Rik; D130053K17Rik; Erk3; Mapk4;
                     Mapk63; Prkm4; Prkm6"
                     /note="major polyA site"
     regulatory      4181..4186
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mapk6"
                     /gene_synonym="2610021I23Rik; D130053K17Rik; Erk3; Mapk4;
                     Mapk63; Prkm4; Prkm6"
                     /note="hexamer: AATAAA"
     polyA_site      4201
                     /gene="Mapk6"
                     /gene_synonym="2610021I23Rik; D130053K17Rik; Erk3; Mapk4;
                     Mapk63; Prkm4; Prkm6"
ORIGIN      
        1 cgcgccctct ctggcgggtc ggggttacat ggcggcgact gcggcaaagc gagagcctcg
       61 gaaacgccgc tgccgccagc acagccggag acctgagccg accttgaggg ctgtccgcgg
      121 gccctgcact ctgtcgatga gtcggagaag tcccgttgta tcagagtaag atggacggta
      181 gctttgactg tgattgtggt gagctggagc cacctgatca ctaagaagag acgtccatca
      241 gccaacgtca ccagggcttc ctgttgaaac acagcgacaa ggaagcgagg aagcagaggg
      301 aactagtgct tcccagcgcc ttaggatgct gctcaggacc agtccaacac tgaatgtatc
      361 tgcactgtga gaggatgtcc acggaggcct gccgggcgca tatttattca cagttttgtc
      421 ccatgttaag tcggttagca tagtaaatct gagtgcatac tatgtcattt cattccgttt
      481 gagtttcttg agtgttttct ttaaatgtct gcagagttgc tgcccttcct tgaactatga
      541 gcactgcaat cttcttaatt ctcagtatga atagagattt ttgagcttta agtctgaggg
      601 gaactcagcg ggcctggttg gcgtctgcaa tgaacatcaa gaaaccatcg tgccgtggga
      661 acgtgattgc ttttctcccg ttttgagaga tctttccttt gatgccagtt ttctcccttg
      721 tttacacaag ttcaacagtt tgaaaggaaa aggcaattgt aagggtttca aaatggcaga
      781 gaaattcgaa agtctcatga acattcatgg ctttgatctg ggctctaggt acatggactt
      841 aaaaccattg ggctgcggag gcaatggctt ggtcttttct gctgtagaca atgactgtga
      901 caaaagagta gccatcaaga aaattgtcct caccgatccc cagagtgtca aacatgctct
      961 ccgtgaaatc aaaattattc gaagacttga ccacgataac attgtgaaag tgtttgaaat
     1021 tcttggtccc agtggaagcc agttaacaga cgatgtgggc tctctcacgg agctgaatag
     1081 cgtctacatt gttcaggagt atatggagac agacttggcg aatgtgctgg agcagggccc
     1141 tttactggaa gagcatgcca ggcttttcat gtatcagctg ctacgtgggc tcaaatatat
     1201 ccattctgca aacgtactgc acagagatct caagccagct aatcttttca ttaacactga
     1261 agacttggtg ctgaagatag gtgactttgg cctggcacgg atcatggatc ctcattattc
     1321 ccataagggt catctttctg aaggattggt taccaaatgg tacagatctc cacggctttt
     1381 actttctcct aataattaca ctaaagccat tgacatgtgg gctgcaggct gcatctttgc
     1441 tgagatgctg actggtaaaa ccctctttgc aggtgcacat gaacttgaac agatgcagct
     1501 gatcctcgac tccatccctg ttgtgcacga ggaggatcgg caggagcttc tcagcgtgat
     1561 tccagtttac attagaaacg acatgactga gccacacaga ccgctcactc agctgctgcc
     1621 ggggatcagc cgagaagcac tggatttcct ggagcagatt ctgactttca gccccatgga
     1681 ccggctgaca gctgaggaag ccctttccca tccttacatg agcatctact ccttcccgac
     1741 ggatgagccc atctcaagcc accctttcca catagaggac gaagtggacg acattttgct
     1801 tatggatgaa acacacagtc acatttataa ctgggaaagg taccacgatt gtcagttctc
     1861 ggagcatgac tggcctattc ataacaactt tgatatcgat gaggtgcagc ttgacccaag
     1921 agctctgtct gacgtcaccg atgaagaaga agtccaagtt gatcctcgaa aatacttgga
     1981 tggagaccga gagaagtatc tagaggatcc cgccttcgac accagctact ctgctgaacc
     2041 ctgctggcag tacccagatc accacgagaa caagtactgc gatctggagt gtagccacac
     2101 ctgtaactac aaaacaagat catcaccata cttagataac ctggtgtgga gggagagcga
     2161 ggttaaccat tactatgagc ccaagcttat tatagatctt tccaactgga aagagcaaag
     2221 taaagaaaaa tccgataaga gaggcaagtc caagtgtgag aggaacgggt tggtcaaggc
     2281 gcagatcgcg ctagaggaag catcccagca gctggctgag agggagaggg gccaaggctt
     2341 cgactttgac tccttcatcg cggggaccat tcagctcagt gcccagcatc agtctgctga
     2401 cgtagttgac aagttaaacg acttgaatag ctcagtgtcc cagctagaat tgaaaagcct
     2461 gatatccaag tcagtcagcc gagaaaagca agaaaaggga agggctaacc tggcccagct
     2521 gggagccttg taccagtcct cctgggacag ccagtttgtg agtggcgggg aggagtgctt
     2581 cctcatcagt cagttttgtt gtgaggtcag gaaggacgag catgcggaga aggagaacac
     2641 ctacaccagc tatttggaca agttttttag caggaaggag gattccgaaa tgctagaaac
     2701 tgagccagtg gaggaaggga agcgtgggga gagaggccgt gaggcagggc ttctgagcgg
     2761 cggtggggag ttcctcctga gcaagcagct ggagtccata ggcaccccgc agttccacag
     2821 cccagtgggg tccccactca agtccatcca ggccaccttg acaccttccg ctatgaaatc
     2881 ttcccctcaa atccctcaca agacatacag cagcattctg aaacatctga actaaacctc
     2941 agcagacatt tctctttgtt cttcatgaaa tgcgttgtgt ctttttttat cactaatgtt
     3001 ttaagtcttt ttttttttac ttgaatcaga aggtgtcatt aatttgcaag gatttttctt
     3061 ggttctcagt ttgtaaaaca gacttttttt tctacatgtg agttagtttt catttgaact
     3121 ggcatgtcgt ttgcacacac acacatacat acacacacgc acacacacgc aaagaataga
     3181 gcaaaacaat gcagtgcagg aggagacaag atgcgctagg atgattagac attctcatag
     3241 accagtgacc tgctttacgg gaaacaaaac cttgccttga aacttacaca gtgagactgt
     3301 acataattgc atgaaaagat ctattttttt cctgaaacat ttttcattca ttagtatttt
     3361 caagtttttc atactgtaca catttcttaa gacacatgat accagcagca actgaaaacg
     3421 aatgccgaat ttggtacaca tgtgttatct acctcaaggt aacaaaagta tgtggcgaag
     3481 cctaacccac ccatagtgct ccacggcata tgcacttcta tctagccagc gtttatcgta
     3541 gtgaactatt gagactcgtc caccatttat acatgtcctg gtgttcattc tttatagtga
     3601 agtgttaaat acatcacatc ttatttattt ttagcaaatc agtatatttt ctgtatttaa
     3661 ttataaaagt taacttagtt ttaagtttat ttgcaactgc ccttctttcc atttggcact
     3721 atggtttgtt gcctgccgag ctgatccgag acgtcagctc gtcctgaggc tgtccatgta
     3781 cgttaagtaa agtgctcact gtgtatagga atctgtattt tggaggtgct tgatctatct
     3841 acaaagaaaa aattaggaat ttattataaa atgctcctag aagtcttaat ggtgtttatt
     3901 ttttaaaaac ttgtaatgtt agacttgtgt gcatggaagt aattaaggta catcactatt
     3961 gtagtttaaa cattgtacat gataagcctt ccccctcccc accccctgtt tttactgtat
     4021 gtttttattg aatgatctat tccccatccc taggcaagca tgaataaaat taggttaaat
     4081 gtagcatgtc actgctcagt cttttagagt ttgttttgtc tgttttattt tgctgaatcc
     4141 tgtctgtatc tttggttatc ctctttgaag gaaaaagaaa aataaagatg gccagcaggc
     4201 acggc
//
