LOCUS       NM_172632               4660 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus mitogen-activated protein kinase 4 (Mapk4), transcript
            variant 1, mRNA.
ACCESSION   NM_172632
VERSION     NM_172632.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4660)
  AUTHORS   Huang,H., Kuang,X., Zou,Y., Zeng,J., Du,H., Tang,H., Long,C.,
            Mao,Y., Yu,X., Wen,C., Yan,J. and Shen,H.
  TITLE     MAP4K4 is involved in the neuronal development of retinal
            photoreceptors
  JOURNAL   Exp Eye Res 233, 109524 (2023)
   PUBMED   37290629
REFERENCE   2  (bases 1 to 4660)
  AUTHORS   Zhao,J., Chu,F., Xu,H., Guo,M., Shan,S., Zheng,W., Tao,Y., Zhou,Y.,
            Hu,Y., Chen,C., Ren,T. and Xu,L.
  TITLE     C/EBPalpha/miR-7 Controls CD4+ T-Cell Activation and Function and
            Orchestrates Experimental Autoimmune Hepatitis in Mice
  JOURNAL   Hepatology 74 (1), 379-396 (2021)
   PUBMED   33125780
  REMARK    GeneRIF: C/EBPalpha/miR-7 Controls CD4(+) T-Cell Activation and
            Function and Orchestrates Experimental Autoimmune Hepatitis in
            Mice.
REFERENCE   3  (bases 1 to 4660)
  AUTHORS   El-Merahbi,R., Viera,J.T., Valdes,A.L., Kolczynska,K., Reuter,S.,
            Loffler,M.C., Erk,M., Ade,C.P., Karwen,T., Mayer,A.E., Eilers,M.
            and Sumara,G.
  TITLE     The adrenergic-induced ERK3 pathway drives lipolysis and suppresses
            energy dissipation
  JOURNAL   Genes Dev 34 (7-8), 495-510 (2020)
   PUBMED   32139423
  REMARK    GeneRIF: targeted deletion of ERK3 in mouse adipocytes inhibits
            lipolysis, but elevates energy dissipation, promoting lean
            phenotype and ameliorating diabetes
REFERENCE   4  (bases 1 to 4660)
  AUTHORS   Alvarez-Dominguez,J.R., Zhang,X. and Hu,W.
  TITLE     Widespread and dynamic translational control of red blood cell
            development
  JOURNAL   Blood 129 (5), 619-629 (2017)
   PUBMED   27899360
REFERENCE   5  (bases 1 to 4660)
  AUTHORS   Marquis,M., Daudelin,J.F., Boulet,S., Sirois,J., Crain,K.,
            Mathien,S., Turgeon,B., Rousseau,J., Meloche,S. and Labrecque,N.
  TITLE     The catalytic activity of the mitogen-activated protein kinase
            extracellular signal-regulated kinase 3 is required to sustain CD4+
            CD8+ thymocyte survival
  JOURNAL   Mol Cell Biol 34 (18), 3374-3387 (2014)
   PUBMED   25002529
  REMARK    GeneRIF: Results uncover a unique role for ERK3, dependent on its
            kinase activity, during T cell development and show that this
            atypical MAPK is essential to sustain CD4(+) CD8(+) (DP) thymocytes
            survival during RAG-mediated rearrangements.
REFERENCE   6  (bases 1 to 4660)
  AUTHORS   Kesavan,C., Baylink,D.J., Kapoor,S. and Mohan,S.
  TITLE     Novel loci regulating bone anabolic response to loading: expression
            QTL analysis in C57BL/6JXC3H/HeJ mice cross
  JOURNAL   Bone 41 (2), 223-230 (2007)
   PUBMED   17543594
REFERENCE   7  (bases 1 to 4660)
  AUTHORS   Kant,S., Schumacher,S., Singh,M.K., Kispert,A., Kotlyarov,A. and
            Gaestel,M.
  TITLE     Characterization of the atypical MAPK ERK4 and its activation of
            the MAPK-activated protein kinase MK5
  JOURNAL   J Biol Chem 281 (46), 35511-35519 (2006)
   PUBMED   16973613
  REMARK    GeneRIF: Data show that in contrast to ERK3, ERK4 (MAPK4) is a
            stable protein and binds to MAPKAPK-5. Interaction of ERK4 with
            MAPKAPK-5 leads to translocation of MAPKAPK-5 to the cytoplasm and
            to its activation by phosphorylation. ERK4 can form dimers with
            ERK3.
REFERENCE   8  (bases 1 to 4660)
  AUTHORS   Xu,H., Dembski,M., Yang,Q., Yang,D., Moriarty,A., Tayber,O.,
            Chen,H., Kapeller,R. and Tartaglia,L.A.
  TITLE     Dual specificity mitogen-activated protein (MAP) kinase
            phosphatase-4 plays a potential role in insulin resistance
  JOURNAL   J Biol Chem 278 (32), 30187-30192 (2003)
   PUBMED   12777378
REFERENCE   9  (bases 1 to 4660)
  AUTHORS   Turgeon,B., Lang,B.F. and Meloche,S.
  TITLE     The protein kinase ERK3 is encoded by a single functional gene:
            genomic analysis of the ERK3 gene family
  JOURNAL   Genomics 80 (6), 673-680 (2002)
   PUBMED   12504858
REFERENCE   10 (bases 1 to 4660)
  AUTHORS   Garcia,J.I., Zalba,G., Detera-Wadleigh,S.D. and de Miguel,C.
  TITLE     Isolation of a cDNA encoding the rat MAP-kinase homolog of human
            p63mapk
  JOURNAL   Mamm Genome 7 (11), 810-814 (1996)
   PUBMED   8875888
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB526503.1, BC094564.1 and BC058942.1.
            
            On Mar 10, 2006 this sequence version replaced NM_172632.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK079654.1, SRR9219379.50594.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-438               CB526503.1         1-438
            439-1496            BC094564.1         798-1855
            1497-4405           BC058942.1         900-3808
            4406-4660           BC058942.1         3810-4064
FEATURES             Location/Qualifiers
     source          1..4660
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 50.31 cM"
     gene            1..4660
                     /gene="Mapk4"
                     /gene_synonym="A330097D03Rik; Erk3; p63Mapk; Prkm4"
                     /note="mitogen-activated protein kinase 4"
                     /db_xref="GeneID:225724"
                     /db_xref="MGI:MGI:2444559"
     exon            1..110
                     /gene="Mapk4"
                     /gene_synonym="A330097D03Rik; Erk3; p63Mapk; Prkm4"
                     /inference="alignment:Splign:2.1.0"
     exon            111..1496
                     /gene="Mapk4"
                     /gene_synonym="A330097D03Rik; Erk3; p63Mapk; Prkm4"
                     /inference="alignment:Splign:2.1.0"
     CDS             951..2702
                     /gene="Mapk4"
                     /gene_synonym="A330097D03Rik; Erk3; p63Mapk; Prkm4"
                     /EC_number="2.7.11.24"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ERK-4; MAPK 4; MAP kinase 4; extracellular
                     signal-regulated kinase 4; Erk3-related"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 4 isoform 1"
                     /protein_id="NP_766220.2"
                     /db_xref="CCDS:CCDS37856.1"
                     /db_xref="GeneID:225724"
                     /db_xref="MGI:MGI:2444559"
                     /translation="MAEKGDCIASVYGYDLGGRFIDFQPLGFGVNGLVLSATDSRACR
                     KVAVKKIVLSDARSMKHALREIKIIRRLDHDNIVKVYEVLGPKGSDLQGELFKFSVAY
                     IVQEYMETDLACLLEQGTLTEDHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTE
                     DLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCI
                     LAEMLTGKMLFAGAHELEQMQLILDTIPVVREEDKEELLRVMPSFVSSTWEVKRPLRK
                     LLPDVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYMSPYSCPEDEPTSQHPFRIEDEI
                     DDIVLMAASQSQLSNWDRYPVSLSSDLEWRPDRCQDASEVQRDPRAGSTPLAEDVQVD
                     PRKDSQSSSERFLEQSHSSMERAFEADYGRSCDYKVGSPSYLDKLLWRDNKPHHYSEP
                     KLILDLSHWKQAASAPPRAAVAADPVSREDEPASLFLEIAQWVKSTQSGSERASPPPD
                     APEPRLSASPPGHPTPIDGGASPQFDLDVFISRALKLCTKPEDLPENKLGDLNGACIS
                     EHPGDLVQTEAFSKERW"
     exon            1497..1641
                     /gene="Mapk4"
                     /gene_synonym="A330097D03Rik; Erk3; p63Mapk; Prkm4"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1803
                     /gene="Mapk4"
                     /gene_synonym="A330097D03Rik; Erk3; p63Mapk; Prkm4"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..2005
                     /gene="Mapk4"
                     /gene_synonym="A330097D03Rik; Erk3; p63Mapk; Prkm4"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..4614
                     /gene="Mapk4"
                     /gene_synonym="A330097D03Rik; Erk3; p63Mapk; Prkm4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4591..4596
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mapk4"
                     /gene_synonym="A330097D03Rik; Erk3; p63Mapk; Prkm4"
                     /note="hexamer: AATAAA"
     polyA_site      4614
                     /gene="Mapk4"
                     /gene_synonym="A330097D03Rik; Erk3; p63Mapk; Prkm4"
                     /note="major polyA site"
ORIGIN      
        1 gactgtcggg gagccggcgg gagctcggcc gcgccagggc tggtgcaacc gggcggagag
       61 cgccggcgcc gcggccgcag acaaagggcc gccgcgctcc gtctgcctcg ggaaggggac
      121 tttgtccgaa tgacgctaca ttcctgcagc ccaaaggcat cctgccgagc atcctctgtc
      181 aaggtgctgc agataagtgg gtgaaagagg atgtcctctc gtctgaagcc tctgaagggt
      241 cctggcctgg cagctgagtt ctttttgtac ttgggacagc agatgtaact gcagagctcg
      301 tgcgagagtg tgactttgcc caactcctga ctcaccagac tggttggggt tttggaatca
      361 aaacggaact tgtagaaaga taaactggca gaaagaaaaa gaagccccta gaatcgtcta
      421 gaatccatta actgagtctg ctcttgctgc tcagagcaca gagggaggct gtgatccgat
      481 taagctctgg gcccacttaa gtaaagcaac aagcgcgcgc gcagcaagca gctcctgcac
      541 ttgagccaca cagaaggatt caaagttgcc ggatactttt tatactctga gatccatgga
      601 gatagaagat aacgatacag gcttttattt ctaataatgc cggatctaga agatgtgcga
      661 accattttaa gcatccagga gggttcttga atcgcaggag ttggtggcaa accctccaag
      721 tgcaggtaac aacaacctta gcagcatccg gctaagcagg tcgggatgca aggacttgca
      781 gcccttcctg tcccctgaca gctggcagca gcgacctcac caggagccaa agcatccctc
      841 agttgtgaga tttgacagaa tgaggtgtgc tggggaagcc actagctgga acctggcctt
      901 tcctgactgc ccctgcattt tccagccggc cccggaccac tgaggcaaca atggctgaga
      961 aaggtgactg catcgccagc gtctacgggt atgaccttgg tgggcgcttc attgacttcc
     1021 aaccccttgg ctttggggtc aacgggctgg tgctgtcagc tacggacagc agggcttgcc
     1081 ggaaggtggc cgtgaagaag atcgttctga gtgacgcccg cagcatgaag cacgcgctcc
     1141 gagagatcaa aatcatccgg cgcctggacc acgacaacat tgtcaaggtg tacgaggtgc
     1201 tgggacccaa ggggagcgat ctgcagggcg agctcttcaa gtttagcgtg gcctatatcg
     1261 tccaagagta catggagact gacctggcgt gcctgctgga gcagggcacg ctgactgagg
     1321 accacgccaa gctgttcatg tatcagctgc tccgtgggct caagtacatc cactctgcga
     1381 acgtgctgca cagagacctg aagcccgcca acatcttcat cagcacggag gaccttgtgc
     1441 tcaagattgg ggatttcggg ttggcaagga tcgtggatca acattactca cacaagggtt
     1501 atctgtcaga agggttggtg acaaagtggt accggtctcc gagactgctc ctgtccccaa
     1561 ataactacac aaaagccatc gatatgtggg cagctggctg catcctggca gagatgctca
     1621 cggggaaaat gctcttcgct ggggctcacg agctggagca gatgcagctc atcctagaca
     1681 ccatccctgt ggtccgggag gaagacaagg aggagctgct cagggtgatg ccgtccttcg
     1741 tcagcagcac ctgggaggtg aagaggccac tgcgcaagct gctcccggac gtcaacagtg
     1801 aagccattga ctttctggag aagatcctga cctttaaccc catggaccgc ttaacagctg
     1861 agatggggct tcagcatcct tacatgagcc cgtactcgtg ccccgaggat gagcccacct
     1921 cacaacaccc tttccgcatt gaggacgaga tcgacgacat cgtgctgatg gctgccagtc
     1981 agagccagct ctccaactgg gacaggtatc ctgtgagcct gtcctcagat ctggaatggc
     2041 ggcctgaccg gtgccaggac gccagcgagg tgcagcgcga tccacgtgca ggctctacac
     2101 cgctggcgga ggatgttcag gtggacccac gcaaggactc acagagcagc tccgagcgct
     2161 tcctggagca gtcacactcg tccatggagc gcgccttcga ggccgactat ggacggtcct
     2221 gcgactacaa agtggggtct ccatcctacc tggacaagct actgtggcgc gacaacaagc
     2281 cccaccacta ctcggaaccc aagctcatcc tggacctgtc gcactggaag caggcggcca
     2341 gcgctccccc cagggctgca gtagcagcag accctgtgtc acgtgaggat gagccagcaa
     2401 gcctctttct ggagattgca cagtgggtca agagcacaca aagtggctct gagcgtgcca
     2461 gtcctccccc tgatgcccca gagccccgtc tctctgcctc acccccggga cacccaacac
     2521 ccatcgatgg gggtgccagt ccccagttcg acttagacgt gttcatctcg cgtgccctaa
     2581 agctctgcac caaacctgag gacctcccgg aaaacaaact gggcgacctg aatggcgcgt
     2641 gcatctctga gcaccctggc gacctcgtgc agacagaggc cttctccaaa gaaaggtggt
     2701 gagcacagaa ggggtgcggg aaaactcccg gagcaggatc cccatccaga aagctggacc
     2761 acttccgtgc tccctcgcac tccttcatcc cctctctgct gcgttggggt tagcagaaca
     2821 cacgcggatc cggggagaaa gaagaatgtc catttcttaa actgccttaa taactagcct
     2881 ttaacctctg ggagcgggtt tgaaccgagc ctggctggga gccgtcagtt tcccatcgaa
     2941 gggaaggtct gttgagattg tgtgcaaggg aagaaaggga tctagggcag cagtctacgc
     3001 cctgcaagag tagaggggtc agaaacagct tgcagacagt ttccaagcca cgtgacccac
     3061 ttagtctcaa atggacattt gggcccagag aagccgttag gaccaccagc ctaatggtgt
     3121 cagaagcctg tgtcccaagc ccctgcccct ggaccagtgt ctgaccacag tataatgtct
     3181 tcctctgctg gggtcactct gggtttttgg tcagaaaact tggtcccgag tgcttctcac
     3241 tgtcccttgc catctgtccc ctctgtccct ttaatttagg acaatggttc ctgttttctg
     3301 aaactggaaa cagaactagt ttctttctcc tagtcaccag acatagttct atgactctcc
     3361 aagtgcttaa ttgccctcac ctgccacctc cctgtattta accgacccag ctcagtctga
     3421 agttattgct tcataacttc agagcagtct gggggctgtg ggtaaattga ggtaaacatc
     3481 tcccaggcct gtgcctacag cctccacctg catgccctat gcactttcct gactcgttcc
     3541 ccaatagata ttgtacatgg gtgagtttga agacagcaat cacaagaatc cctcttgtcc
     3601 agaccccagc ctcccaccca ccccgcccac acacacatac acacagctcc tctccaagcc
     3661 tatttcggga ccaaatgttc ttggcacaaa ttgctcattt gtagagaaag caataaggtg
     3721 ccttccataa aaacaaatga gctaggaggg aagattccac agaagaccca tcatccttca
     3781 gtagtgtcgc ccatgatcag aggcatccat tcggtcctag ccaagagtag accctaaagg
     3841 aatggcctga gagctagcaa ccctggaaca agaaacccag aaagataaac taggagctta
     3901 aaaaggggtc ccaacctcaa gtgtcccaaa gagtcagcta tggagatgga aaacccaaga
     3961 caaagaaagg gattcaaagt agtcccaccc tggtagctta agttaagaca gacttggagt
     4021 cagtccaaag ccctctgcgg aaaaaacatg gggaaggggg cttgggggaa tacaaacagt
     4081 ccccggtctg tccctgaaca ctctgccact ggaatctctc ctccccctct ccctgccaac
     4141 atcccaaaga tacccacaag aggtctagct ggtctgttga gagatctcct tgggctgtgt
     4201 tcattctcac atcgcagcac cttaaatctt agctaactat gatttgtata ttgggacgta
     4261 caatgcatca gaaacgtata ttttaaaaca attaatcatg cggactggtt tttaagtggg
     4321 aaaatatgta aatataaagt ggtttaggtt ttattctgtt ctttttttct ttcttttctt
     4381 ttcttttttc tttttttttt tttttaattt tctttaagac aatgcaatgc acaccactcc
     4441 ttatgtgcca tttgtcctcc gagggaagct ttacttttta agtaaaggga catgctgctg
     4501 actgaccacc agttcacgga gaactgctac aattattcat gttcttaaaa gaatctgtta
     4561 aatattatta aacttgatca ggatgagcca aataaagttt tattggaaca taaaaaaaaa
     4621 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
