LOCUS       NM_011952               1772 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus mitogen-activated protein kinase 3 (Mapk3), mRNA.
ACCESSION   NM_011952 XM_914793
VERSION     NM_011952.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1772)
  AUTHORS   Palacio,V., Pancho,A., Morabito,A., Malkmus,J., He,Z., Soussi,G.,
            Zeller,R., Treutlein,B. and Zuniga,A.
  TITLE     Single-cell profiling of penta- and tetradactyl mouse limb buds
            identifies mesenchymal progenitors controlling digit numbers and
            identities
  JOURNAL   Nat Commun 16 (1), 1226 (2025)
   PUBMED   39890843
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1772)
  AUTHORS   Arriagada,C., Lin,E., Schonning,M. and Astrof,S.
  TITLE     Mesodermal fibronectin controls cell shape, polarity, and
            mechanotransduction in the second heart field during cardiac
            outflow tract development
  JOURNAL   Dev Cell 60 (1), 62-84 (2025)
   PUBMED   39413783
REFERENCE   3  (bases 1 to 1772)
  AUTHORS   Shen,C.L., Tsai,Y.Y., Chou,S.J., Chang,Y.M. and Tarn,W.Y.
  TITLE     RBM4-mediated intron excision of Hsf1 induces BDNF for cerebellar
            foliation
  JOURNAL   Commun Biol 7 (1), 1712 (2024)
   PUBMED   39738787
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1772)
  AUTHORS   Weberling,A., Siriwardena,D., Penfold,C., Christodoulou,N.,
            Boroviak,T.E. and Zernicka-Goetz,M.
  TITLE     Primitive to visceral endoderm maturation is essential for mouse
            epiblast survival beyond implantation
  JOURNAL   iScience 28 (1), 111671 (2024)
   PUBMED   39868030
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1772)
  AUTHORS   Blucher,R.O., Lim,R.S., Ritchie,M.E. and Western,P.S.
  TITLE     VEGF-dependent testicular vascularisation involves MEK1/2
            signalling and the essential angiogenesis factors, SOX7 and SOX17
  JOURNAL   BMC Biol 22 (1), 222 (2024)
   PUBMED   39354506
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1772)
  AUTHORS   Petritsch,C., Woscholski,R., Edelmann,H.M. and Ballou,L.M.
  TITLE     Activation of p70 S6 kinase and erk-encoded mitogen-activated
            protein kinases is resistant to high cyclic nucleotide levels in
            Swiss 3T3 fibroblasts
  JOURNAL   J Biol Chem 270 (44), 26619-26625 (1995)
   PUBMED   7592886
REFERENCE   7  (bases 1 to 1772)
  AUTHORS   Okuda,T., Cleveland,J.L. and Downing,J.R.
  TITLE     PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related
            protein kinase gene family
  JOURNAL   Oncogene 7 (11), 2249-2258 (1992)
   PUBMED   1437147
REFERENCE   8  (bases 1 to 1772)
  AUTHORS   Crews,C.M., Alessandrini,A.A. and Erikson,R.L.
  TITLE     Mouse Erk-1 gene product is a serine/threonine protein kinase that
            has the potential to phosphorylate tyrosine
  JOURNAL   Proc Natl Acad Sci U S A 88 (19), 8845-8849 (1991)
   PUBMED   1717989
REFERENCE   9  (bases 1 to 1772)
  AUTHORS   De Miguel,C., Kligman,D., Patel,J. and Detera-Wadleigh,S.D.
  TITLE     Molecular analysis of microtubule-associated protein-2 kinase cDNA
            from mouse and rat brain
  JOURNAL   DNA Cell Biol 10 (7), 505-514 (1991)
   PUBMED   1716439
REFERENCE   10 (bases 1 to 1772)
  AUTHORS   Owens,W.E. and Berg,R.D.
  TITLE     Bacterial translocation from the gastrointestinal tract of athymic
            (nu/nu) mice
  JOURNAL   Infect Immun 27 (2), 461-467 (1980)
   PUBMED   6966611
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ929318.1 and BC029712.1.
            
            On Apr 21, 2006 this sequence version replaced NM_011952.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029712.1, Z14249.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 BQ929318.1         1-6
            7-1772              BC029712.1         1-1766
FEATURES             Location/Qualifiers
     source          1..1772
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.25 cM"
     gene            1..1772
                     /gene="Mapk3"
                     /gene_synonym="Erk-1; Erk1; Ert2; Esrk1; Mnk1; Mtap2k;
                     p44; p44erk1; p44mapk; Prkm3"
                     /note="mitogen-activated protein kinase 3"
                     /db_xref="GeneID:26417"
                     /db_xref="MGI:MGI:1346859"
     exon            1..193
                     /gene="Mapk3"
                     /gene_synonym="Erk-1; Erk1; Ert2; Esrk1; Mnk1; Mtap2k;
                     p44; p44erk1; p44mapk; Prkm3"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..1163
                     /gene="Mapk3"
                     /gene_synonym="Erk-1; Erk1; Ert2; Esrk1; Mnk1; Mtap2k;
                     p44; p44erk1; p44mapk; Prkm3"
                     /EC_number="2.7.11.24"
                     /note="MAP kinase 3; insulin-stimulated MAP2 kinase;
                     extracellular signal-regulated kinase 1; pp42/MAP kinase;
                     microtubule-associated protein 2 kinase; p44 MAP kinase"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 3"
                     /protein_id="NP_036082.1"
                     /db_xref="CCDS:CCDS21841.1"
                     /db_xref="GeneID:26417"
                     /db_xref="MGI:MGI:1346859"
                     /translation="MAAAAAAPGGGGGEPRGTAGVVPVVPGEVEVVKGQPFDVGPRYT
                     QLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVI
                     GIRDILRAPTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHS
                     ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML
                     NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM
                     KARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQY
                     YDPTDEPVAEEPFTFDMELDDLPKERLKELIFQETARFQPGAPEGP"
     exon            194..376
                     /gene="Mapk3"
                     /gene_synonym="Erk-1; Erk1; Ert2; Esrk1; Mnk1; Mtap2k;
                     p44; p44erk1; p44mapk; Prkm3"
                     /inference="alignment:Splign:2.1.0"
     exon            377..566
                     /gene="Mapk3"
                     /gene_synonym="Erk-1; Erk1; Ert2; Esrk1; Mnk1; Mtap2k;
                     p44; p44erk1; p44mapk; Prkm3"
                     /inference="alignment:Splign:2.1.0"
     exon            567..683
                     /gene="Mapk3"
                     /gene_synonym="Erk-1; Erk1; Ert2; Esrk1; Mnk1; Mtap2k;
                     p44; p44erk1; p44mapk; Prkm3"
                     /inference="alignment:Splign:2.1.0"
     exon            684..798
                     /gene="Mapk3"
                     /gene_synonym="Erk-1; Erk1; Ert2; Esrk1; Mnk1; Mtap2k;
                     p44; p44erk1; p44mapk; Prkm3"
                     /inference="alignment:Splign:2.1.0"
     exon            799..930
                     /gene="Mapk3"
                     /gene_synonym="Erk-1; Erk1; Ert2; Esrk1; Mnk1; Mtap2k;
                     p44; p44erk1; p44mapk; Prkm3"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1040
                     /gene="Mapk3"
                     /gene_synonym="Erk-1; Erk1; Ert2; Esrk1; Mnk1; Mtap2k;
                     p44; p44erk1; p44mapk; Prkm3"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1195
                     /gene="Mapk3"
                     /gene_synonym="Erk-1; Erk1; Ert2; Esrk1; Mnk1; Mtap2k;
                     p44; p44erk1; p44mapk; Prkm3"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1772
                     /gene="Mapk3"
                     /gene_synonym="Erk-1; Erk1; Ert2; Esrk1; Mnk1; Mtap2k;
                     p44; p44erk1; p44mapk; Prkm3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1751..1756
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mapk3"
                     /gene_synonym="Erk-1; Erk1; Ert2; Esrk1; Mnk1; Mtap2k;
                     p44; p44erk1; p44mapk; Prkm3"
                     /note="hexamer: AATATA"
     polyA_site      1772
                     /gene="Mapk3"
                     /gene_synonym="Erk-1; Erk1; Ert2; Esrk1; Mnk1; Mtap2k;
                     p44; p44erk1; p44mapk; Prkm3"
                     /note="major polyA site"
ORIGIN      
        1 gggaggcggg aggagtggag atggcggcgg cggcggcggc tccggggggc gggggcgggg
       61 agcccagggg aactgctggg gtcgtcccgg tggtccccgg ggaggtggag gtggtgaagg
      121 ggcagccatt cgatgtgggc ccacgctaca cgcagctgca gtacatcggc gagggcgcgt
      181 acggcatggt cagctcagct tatgaccacg tgcgcaagac cagagtggcc atcaagaaga
      241 tcagcccctt tgagcatcaa acctactgtc agcgcacgct gagggagatc cagatcttgc
      301 tgcgattccg ccatgagaat gttataggca tccgagacat cctcagagcg cccaccctgg
      361 aagccatgag agatgtttac attgttcagg acctcatgga gacagacctg tacaagctgc
      421 ttaaaagcca gcagctgagc aatgaccaca tctgctactt cctctaccag atcctccggg
      481 gcctcaagta tatacactca gccaatgtgc tgcaccggga cctgaagcct tccaatctgc
      541 ttatcaacac cacctgcgac cttaagatct gtgattttgg cctggcccgg attgctgacc
      601 ctgagcacga ccacactggc tttctgacgg agtatgtggc cacacgctgg taccgagccc
      661 cagagatcat gcttaattcc aagggctaca ccaaatccat cgacatctgg tctgtgggct
      721 gcattctggc tgagatgctc tccaaccggc ccatcttccc cggcaagcac tacctggacc
      781 agctcaacca cattctaggt atcttgggtt ccccatccca ggaggacctt aattgcatca
      841 ttaacatgaa ggcccgaaac tacctgcagt ctctgccctc gaaaaccaag gtggcttggg
      901 ccaagctctt tcctaaatct gactccaaag ctcttgacct gctggaccgg atgttaacct
      961 tcaacccaaa caagcgcatc acagtagagg aagcgctggc tcacccttac ctggaacagt
     1021 actacgatcc gacagatgag ccagtggccg aggagccatt caccttcgac atggagctgg
     1081 atgacctccc caaggagcgg ctgaaggagt tgatcttcca ggagacagcc cgcttccagc
     1141 caggggcgcc agagggcccc taacaagaac agacacccct gtccttttgg atctggtcct
     1201 gctcctacct gctccttctc tgcagattgt tagaaagtga actttgctca acccagaccc
     1261 cggcagccca ggctggacca agggtgggcc tggccacctt ctctcacttt gctggggtct
     1321 cctgcttcaa gcaggcttct cccactccaa tcccctgccc catctcccca tagcctgagt
     1381 gatgaggtgg ccccagagct gatctctgct gctgtgtctt tatctaccct tgctagcccc
     1441 ggctctggta gaccgttctg gaatggaggg gctatgatcg tcctaggacc tgtgctacgg
     1501 aggggtggag ggcactgagt agggctctgc cctattcatc ttgttggaac cccaccccat
     1561 tttccctgac agaacattcc taagtctcaa gggctagttt ccctgaggag cccaggccta
     1621 accctctctc tctcaagctg ccacatgtaa cgcccttgct gcttctgtgt gtgggtgatt
     1681 ggatgtgggg gtggggcccg tggagagccg gtgcccctcc ccatctcccc gtgcctgtat
     1741 ctaatatata aatatagaga tgtgtatatg ga
//
