LOCUS       NM_177922               1932 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus mitogen-activated protein kinase 15 (Mapk15),
            transcript variant 1, mRNA.
ACCESSION   NM_177922 XM_994652
VERSION     NM_177922.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1932)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1932)
  AUTHORS   Miyatake,K., Kusakabe,M., Takahashi,C. and Nishida,E.
  TITLE     ERK7 regulates ciliogenesis by phosphorylating the actin regulator
            CapZIP in cooperation with Dishevelled
  JOURNAL   Nat Commun 6, 6666 (2015)
   PUBMED   25823377
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1932)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 1932)
  AUTHORS   Yang,S.W., Huang,H., Gao,C., Chen,L., Qi,S.T., Lin,F., Wang,J.X.,
            Hou,Y., Xing,F.Q. and Sun,Q.Y.
  TITLE     The distribution and possible role of ERK8 in mouse oocyte meiotic
            maturation and early embryo cleavage
  JOURNAL   Microsc Microanal 19 (1), 190-200 (2013)
   PUBMED   23351492
  REMARK    GeneRIF: Taken together, our results suggest that ERK8 plays an
            important role in spindle organization during mouse oocyte meiotic
            maturation and early embryo cleavage.
REFERENCE   5  (bases 1 to 1932)
  AUTHORS   Rossi,M., Colecchia,D., Iavarone,C., Strambi,A., Piccioni,F.,
            Verrotti di Pianella,A. and Chiariello,M.
  TITLE     Extracellular signal-regulated kinase 8 (ERK8) controls
            estrogen-related receptor alpha (ERRalpha) cellular localization
            and inhibits its transcriptional activity
  JOURNAL   J Biol Chem 286 (10), 8507-8522 (2011)
   PUBMED   21190936
  REMARK    GeneRIF: a novel function for ERK8 as a bona fide ERRalpha
            corepressor, involved in control of its cellular localization by
            nuclear exclusion, and suggest a key role for this MAP kinase in
            the regulation of the biological activities of this nuclear
            receptor.
REFERENCE   6  (bases 1 to 1932)
  AUTHORS   Xu,Y.M., Zhu,F., Cho,Y.Y., Carper,A., Peng,C., Zheng,D., Yao,K.,
            Lau,A.T., Zykova,T.A., Kim,H.G., Bode,A.M. and Dong,Z.
  TITLE     Extracellular signal-regulated kinase 8-mediated c-Jun
            phosphorylation increases tumorigenesis of human colon cancer
  JOURNAL   Cancer Res 70 (8), 3218-3227 (2010)
   PUBMED   20395206
  REMARK    GeneRIF: Extracellular signal-regulated kinase 8-mediated c-Jun
            phosphorylation increases tumorigenesis of human colon cancer
REFERENCE   7  (bases 1 to 1932)
  AUTHORS   Iavarone,C., Acunzo,M., Carlomagno,F., Catania,A., Melillo,R.M.,
            Carlomagno,S.M., Santoro,M. and Chiariello,M.
  TITLE     Activation of the Erk8 mitogen-activated protein (MAP) kinase by
            RET/PTC3, a constitutively active form of the RET proto-oncogene
  JOURNAL   J Biol Chem 281 (15), 10567-10576 (2006)
   PUBMED   16484222
  REMARK    GeneRIF: Erk8 has a role as a novel effector of RET/PTC3 and,
            therefore, RET biological functions
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116487.14.
            
            On Feb 1, 2023 this sequence version replaced NM_177922.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048082.1, SRR7345562.2594425.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               AC116487.14        103051-103212       c
            163-261             AC116487.14        102036-102134       c
            262-291             AC116487.14        101878-101907       c
            292-382             AC116487.14        101655-101745       c
            383-513             AC116487.14        101022-101152       c
            514-677             AC116487.14        100775-100938       c
            678-817             AC116487.14        100465-100604       c
            818-875             AC116487.14        99811-99868         c
            876-1013            AC116487.14        99272-99409         c
            1014-1119           AC116487.14        99046-99151         c
            1120-1324           AC116487.14        98716-98920         c
            1325-1428           AC116487.14        98505-98608         c
            1429-1557           AC116487.14        98301-98429         c
            1558-1932           AC116487.14        97826-98200         c
FEATURES             Location/Qualifiers
     source          1..1932
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 35.2 cM"
     gene            1..1932
                     /gene="Mapk15"
                     /gene_synonym="ERK-8"
                     /note="mitogen-activated protein kinase 15"
                     /db_xref="GeneID:332110"
                     /db_xref="MGI:MGI:2652894"
     exon            1..162
                     /gene="Mapk15"
                     /gene_synonym="ERK-8"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1743
                     /gene="Mapk15"
                     /gene_synonym="ERK-8"
                     /EC_number="2.7.11.24"
                     /note="isoform 1 is encoded by transcript variant 1;
                     extracellular signal-regulated kinase 7; ERK-7; MAPK 15;
                     extracellular signal-regulated kinase 8; MAP kinase 15"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 15 isoform 1"
                     /protein_id="NP_808590.1"
                     /db_xref="CCDS:CCDS27558.1"
                     /db_xref="GeneID:332110"
                     /db_xref="MGI:MGI:2652894"
                     /translation="MCAAEVDRHVAQRYLIKRRLGKGAYGIVWKAMDRRTGEVVAIKK
                     IFDAFRDQIDAQRTFREIMLLKEFGGHPNIIRLLDVIPAKNDRDIYLVFESMDTDLNA
                     VIQKGRLLKDIHKRCIFYQLLRATKFIHSGRVIHRDQKPANVLLDSACRVKLCDFGLA
                     RSLGDLPEGPGGQALTEYVATRWYRAPEVLLSSRWYTPGVDMWSLGCILGEMLRGQPL
                     FPGTSTFHQLELILKTIPLPSMEELQDLGSDYSALILQNLGSRPQQTLDALLPPDTPP
                     EALDLLKRLLAFAPDKRLSAEQALQHPYVQRFHCPDREWARESDVRLPVHEGDQLSAP
                     EYRKRLYQIILEQSGNSRSPREEGLGVVASRAELRASPARTQSLKSGVLPQVPAETPA
                     RKRGPKPPRSPGHDPEHVEVRRQSSDPLFQLPPPGRGERPPGATGQPPSAPSGVKTQV
                     RAMAPSLTSQAEAQAANQALIRSDPARGGGPRAVGARRVPSRLPREAPEPRPGRRMFG
                     ISVSQGAQGAARAALGGYSQAYGTVCRSALGRLPLLPGPRA"
     exon            163..261
                     /gene="Mapk15"
                     /gene_synonym="ERK-8"
                     /inference="alignment:Splign:2.1.0"
     exon            262..291
                     /gene="Mapk15"
                     /gene_synonym="ERK-8"
                     /inference="alignment:Splign:2.1.0"
     exon            292..382
                     /gene="Mapk15"
                     /gene_synonym="ERK-8"
                     /inference="alignment:Splign:2.1.0"
     exon            383..513
                     /gene="Mapk15"
                     /gene_synonym="ERK-8"
                     /inference="alignment:Splign:2.1.0"
     exon            514..677
                     /gene="Mapk15"
                     /gene_synonym="ERK-8"
                     /inference="alignment:Splign:2.1.0"
     exon            678..817
                     /gene="Mapk15"
                     /gene_synonym="ERK-8"
                     /inference="alignment:Splign:2.1.0"
     exon            818..875
                     /gene="Mapk15"
                     /gene_synonym="ERK-8"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1013
                     /gene="Mapk15"
                     /gene_synonym="ERK-8"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1119
                     /gene="Mapk15"
                     /gene_synonym="ERK-8"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1324
                     /gene="Mapk15"
                     /gene_synonym="ERK-8"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1428
                     /gene="Mapk15"
                     /gene_synonym="ERK-8"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1557
                     /gene="Mapk15"
                     /gene_synonym="ERK-8"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1932
                     /gene="Mapk15"
                     /gene_synonym="ERK-8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1912..1917
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mapk15"
                     /gene_synonym="ERK-8"
                     /note="hexamer: AATAAA"
     polyA_site      1932
                     /gene="Mapk15"
                     /gene_synonym="ERK-8"
                     /note="major polyA site"
ORIGIN      
        1 atcgcggctg ctggttccca agccaacgga tcaacaggtc cagctccaga gaaagaatcg
       61 gtggacccct agagccagcg cctgcctctc gccatgtgtg ctgccgaggt ggaccgtcat
      121 gtagcccaga gatacctgat caagcggagg cttgggaagg gggcctatgg cattgtgtgg
      181 aaggccatgg accggaggac tggcgaggtt gtggccatca agaaaatctt tgatgccttt
      241 agggaccaga tagatgctca gaggaccttc cgtgagatta tgcttctcaa ggagtttgga
      301 ggccatccca acatcatccg cctgcttgat gtaatcccag cgaagaatga cagggatatt
      361 tacctggtgt ttgagtccat ggacaccgac ctgaatgcag tcatccagaa gggcagacta
      421 ctgaaggaca tccacaagcg gtgcatcttt taccagctcc tgagagccac caagtttatc
      481 cattcagggc gcgtcatcca tcgggatcag aagccagcca atgttctact ggattctgct
      541 tgccgggtga aactctgtga ctttggcctg gcacgctccc tcggtgacct ccctgagggg
      601 cctgggggtc aggccctgac agagtatgtg gccacacgct ggtaccgagc tccagaggtg
      661 cttctgtctt cccgatggta tacccctggg gtggacatgt ggagcctggg ctgcatatta
      721 ggagagatgc ttcgagggca gccactgttt cccgggacat ctactttcca ccagctggag
      781 ctgatcctga agaccatccc attgccttcc atggaggagc tccaggacct tggctcagac
      841 tacagtgctt tgattctgca gaatcttggg tccaggccac agcagacgct ggacgccctc
      901 ctgccgccag acaccccccc agaagccctg gacctcctca agcgactctt ggcgtttgct
      961 ccggacaagc gccttagtgc agagcaggcg ctgcaacacc cctacgtgca gagattccat
     1021 tgccccgacc gcgagtgggc acgggagtcc gacgtgcggc tcccggtgca cgaaggagac
     1081 cagctctctg caccagagta tcgcaaacgc ctgtaccaga ttatcctgga gcaaagtggg
     1141 aacagccgca gccctcgaga ggaaggcctg ggggttgtgg cctcgcgggc tgagctcagg
     1201 gcttccccgg cccggacgca atcgctcaag tcgggagtcc tcccccaggt cccggcggag
     1261 acgccagcgc gaaaacgcgg acccaaacct ccgcgtagcc ctggtcatga tcctgagcat
     1321 gtggaagttc gcaggcagag ctcagacccc ctgttccaac ttccgccgcc aggaaggggg
     1381 gaaaggcccc caggggccac agggcagcca ccctcggcac cctcaggggt gaagactcaa
     1441 gtgagggcga tggcgccgtc cctgacttca caggcagagg ctcaggcggc caatcaggct
     1501 ctgatccgca gtgatccggc ccggggcggt gggccgaggg cggtcggcgc gcgacgggtc
     1561 ccttcccgcc tgccccggga ggccccggaa ccccgacccg gccgaaggat gtttggcatc
     1621 tcggtctcgc agggggccca gggcgcagcc agagctgcgc ttggcggcta ctcccaggcc
     1681 tacgggaccg tgtgccgctc ggcgctgggc cgcctgcccc tgctccccgg accgcgtgcg
     1741 tgagccaccc acccacctcc ttgaggcaac ccggcgccgt cccccagacc ccaatgcatc
     1801 ttctccctcc tctgcctccc tgccttcgag ttcccggagg gttctttgag cctctctccc
     1861 ctaagaaaga gtagatggaa gtctccactc caccccccaa tactttcttc caataaagtt
     1921 ttatctttcc ta
//
