LOCUS       NM_011951               3560 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus mitogen-activated protein kinase 14 (Mapk14),
            transcript variant 1, mRNA.
ACCESSION   NM_011951
VERSION     NM_011951.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3560)
  AUTHORS   Valuparampil Varghese,M., James,J., Bharti,D., Rischard,F.,
            Rafikova,O. and Rafikov,R.
  TITLE     Circulating free heme induces cytokine storm and pulmonary
            hypertension through the MKK3/p38 axis
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 327 (4), L574-L586 (2024)
   PUBMED   39197168
  REMARK    GeneRIF: Circulating free heme induces cytokine storm and pulmonary
            hypertension through the MKK3/p38 axis.
REFERENCE   2  (bases 1 to 3560)
  AUTHORS   Tse-Kang,S.Y. and Pukkila-Worley,R.
  TITLE     Lysosome-related organelle integrity suppresses TIR-1 aggregation
            to restrain toxic propagation of p38 innate immunity
  JOURNAL   Cell Rep 43 (9), 114674 (2024)
   PUBMED   39299237
  REMARK    GeneRIF: Lysosome-related organelle integrity suppresses TIR-1
            aggregation to restrain toxic propagation of p38 innate immunity.
REFERENCE   3  (bases 1 to 3560)
  AUTHORS   Ma,H., Jia,H., Zou,W., Ji,F., Wang,W., Zhao,J., Yuan,C. and Jiao,J.
  TITLE     Gasdermin D Mediated Mitochondrial Metabolism Orchestrate
            Neurogenesis Through LDHA During Embryonic Development
  JOURNAL   Adv Sci (Weinh) 11 (35), e2402285 (2024)
   PUBMED   39033542
REFERENCE   4  (bases 1 to 3560)
  AUTHORS   Feng,Y.H., Tang,R.J., Zhang,Y.Y., Lin,J., Liu,Y.J., Li,Y.K.,
            Li,C.J., Zhou,C., Liu,F. and Shen,J.F.
  TITLE     Contribution of inwardly rectifying potassium channel 4.1 in
            orofacial neuropathic pain: Regulation of pannexin 3 via the
            reactive oxygen species-activated P38 MAPK signal pathway
  JOURNAL   Eur J Neurosci 60 (4), 4569-4585 (2024)
   PUBMED   38992988
  REMARK    GeneRIF: Contribution of inwardly rectifying potassium channel 4.1
            in orofacial neuropathic pain: Regulation of pannexin 3 via the
            reactive oxygen species-activated P38 MAPK signal pathway.
REFERENCE   5  (bases 1 to 3560)
  AUTHORS   Waingerten-Kedem,L., Aviram,S., Blau,A., Hayek,T. and Bengal,E.
  TITLE     P38alpha MAPK Coordinates Mitochondrial Adaptation to Caloric
            Surplus in Skeletal Muscle
  JOURNAL   Int J Mol Sci 25 (14), 7789 (2024)
   PUBMED   39063031
  REMARK    GeneRIF: P38alpha MAPK Coordinates Mitochondrial Adaptation to
            Caloric Surplus in Skeletal Muscle.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3560)
  AUTHORS   Derijard,B., Raingeaud,J., Barrett,T., Wu,I.H., Han,J.,
            Ulevitch,R.J. and Davis,R.J.
  TITLE     Independent human MAP-kinase signal transduction pathways defined
            by MEK and MKK isoforms
  JOURNAL   Science 267 (5198), 682-685 (1995)
   PUBMED   7839144
  REMARK    Erratum:[Science 1995 Jul 7;269(5220):17]
REFERENCE   7  (bases 1 to 3560)
  AUTHORS   Han,J., Lee,J.D., Bibbs,L. and Ulevitch,R.J.
  TITLE     A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian
            cells
  JOURNAL   Science 265 (5173), 808-811 (1994)
   PUBMED   7914033
REFERENCE   8  (bases 1 to 3560)
  AUTHORS   Ershler,M., Nagorskaya,T.V., Visser,J.W. and Belyavsky,A.V.
  TITLE     Novel CDC2-related protein kinases produced in murine hematopoietic
            stem cells
  JOURNAL   Gene 124 (2), 305-306 (1993)
   PUBMED   8444355
REFERENCE   9  (bases 1 to 3560)
  AUTHORS   Morris,D.J., Adler,I.D. and Robinson,T.J.
  TITLE     Somatic cell hybrid mapping on mouse chromosome 11 (MMU11):
            assignment of markers relative to two breakpoints in band D
  JOURNAL   Genomics 15 (2), 323-331 (1993)
   PUBMED   8449498
REFERENCE   10 (bases 1 to 3560)
  AUTHORS   Ershler,M.A., Nagorskaia,T.V., Fisser,Ia.V. and Beliavskii,A.V.
  TITLE     [Identification of new protein kinase genes, similar to kinases of
            the cdc2 family and expressed in murine hematopoietic stem cells]
  JOURNAL   Dokl Akad Nauk 324 (4), 893-897 (1992)
   PUBMED   1459009
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC170998.2, AK133684.1 and AI132714.1.
            
            On Dec 9, 2009 this sequence version replaced NM_011951.2.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U10871.1, AK133684.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                AC170998.2         74091-74178         c
            89-3545             AK133684.1         2-3458
            3546-3560           AI132714.1         1-15                c
FEATURES             Location/Qualifiers
     source          1..3560
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 14.85 cM"
     gene            1..3560
                     /gene="Mapk14"
                     /gene_synonym="Crk1; Csbp1; CSBP2; Mxi2; p38; p38-alpha;
                     p38a; p38alpha; p38MAPK; PRKM14; PRKM15"
                     /note="mitogen-activated protein kinase 14"
                     /db_xref="GeneID:26416"
                     /db_xref="MGI:MGI:1346865"
     exon            1..514
                     /gene="Mapk14"
                     /gene_synonym="Crk1; Csbp1; CSBP2; Mxi2; p38; p38-alpha;
                     p38a; p38alpha; p38MAPK; PRKM14; PRKM15"
                     /inference="alignment:Splign:2.1.0"
     CDS             399..1481
                     /gene="Mapk14"
                     /gene_synonym="Crk1; Csbp1; CSBP2; Mxi2; p38; p38-alpha;
                     p38a; p38alpha; p38MAPK; PRKM14; PRKM15"
                     /EC_number="2.7.11.24"
                     /note="isoform 1 is encoded by transcript variant 1; MAPK
                     14; MAP kinase 14; MAP kinase p38 alpha; mitogen-activated
                     protein kinase p38 alpha; p38 MAPK; p38 MAP kinase alpha"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 14 isoform 1"
                     /protein_id="NP_036081.1"
                     /db_xref="CCDS:CCDS28583.1"
                     /db_xref="GeneID:26416"
                     /db_xref="MGI:MGI:1346865"
                     /translation="MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDT
                     KTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDV
                     YLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNE
                     DCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT
                     GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIG
                     ANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLI
                     DEWKSLTYDEVISFVPPPLDQEEMES"
     exon            515..644
                     /gene="Mapk14"
                     /gene_synonym="Crk1; Csbp1; CSBP2; Mxi2; p38; p38-alpha;
                     p38a; p38alpha; p38MAPK; PRKM14; PRKM15"
                     /inference="alignment:Splign:2.1.0"
     exon            645..703
                     /gene="Mapk14"
                     /gene_synonym="Crk1; Csbp1; CSBP2; Mxi2; p38; p38-alpha;
                     p38a; p38alpha; p38MAPK; PRKM14; PRKM15"
                     /inference="alignment:Splign:2.1.0"
     exon            704..815
                     /gene="Mapk14"
                     /gene_synonym="Crk1; Csbp1; CSBP2; Mxi2; p38; p38-alpha;
                     p38a; p38alpha; p38MAPK; PRKM14; PRKM15"
                     /inference="alignment:Splign:2.1.0"
     exon            816..845
                     /gene="Mapk14"
                     /gene_synonym="Crk1; Csbp1; CSBP2; Mxi2; p38; p38-alpha;
                     p38a; p38alpha; p38MAPK; PRKM14; PRKM15"
                     /inference="alignment:Splign:2.1.0"
     exon            846..893
                     /gene="Mapk14"
                     /gene_synonym="Crk1; Csbp1; CSBP2; Mxi2; p38; p38-alpha;
                     p38a; p38alpha; p38MAPK; PRKM14; PRKM15"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1008
                     /gene="Mapk14"
                     /gene_synonym="Crk1; Csbp1; CSBP2; Mxi2; p38; p38-alpha;
                     p38a; p38alpha; p38MAPK; PRKM14; PRKM15"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1080
                     /gene="Mapk14"
                     /gene_synonym="Crk1; Csbp1; CSBP2; Mxi2; p38; p38-alpha;
                     p38a; p38alpha; p38MAPK; PRKM14; PRKM15"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1160
                     /gene="Mapk14"
                     /gene_synonym="Crk1; Csbp1; CSBP2; Mxi2; p38; p38-alpha;
                     p38a; p38alpha; p38MAPK; PRKM14; PRKM15"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1239
                     /gene="Mapk14"
                     /gene_synonym="Crk1; Csbp1; CSBP2; Mxi2; p38; p38-alpha;
                     p38a; p38alpha; p38MAPK; PRKM14; PRKM15"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1413
                     /gene="Mapk14"
                     /gene_synonym="Crk1; Csbp1; CSBP2; Mxi2; p38; p38-alpha;
                     p38a; p38alpha; p38MAPK; PRKM14; PRKM15"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..3548
                     /gene="Mapk14"
                     /gene_synonym="Crk1; Csbp1; CSBP2; Mxi2; p38; p38-alpha;
                     p38a; p38alpha; p38MAPK; PRKM14; PRKM15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3525..3530
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mapk14"
                     /gene_synonym="Crk1; Csbp1; CSBP2; Mxi2; p38; p38-alpha;
                     p38a; p38alpha; p38MAPK; PRKM14; PRKM15"
                     /note="hexamer: AATAAA"
     polyA_site      3548
                     /gene="Mapk14"
                     /gene_synonym="Crk1; Csbp1; CSBP2; Mxi2; p38; p38-alpha;
                     p38a; p38alpha; p38MAPK; PRKM14; PRKM15"
                     /note="major polyA site"
ORIGIN      
        1 gatctggatt cagagcgggg cctccttgga gctgttctcg cgagagttcc gcgagaggct
       61 cccggccgct gcctgtggga tcgccgccac tggagcccaa gcggggcgct gaagcgcgag
      121 cgggtgtctt gcggcgtcgg cgtgcgctcc ctccccgggg agcggctgca ggaggaccgc
      181 ggcgggagca gcctcgagcc gtgcagccgg ctccggcacc ttgccgacgc tcgtaggagc
      241 cgccgcggct gacaggggcg gcgggtcgca gcctccacac ctgcgcgggt ggcgggcgcg
      301 gggtccggtc tgccgcgggc gggcgcagag gagagcgtgc ggctgcaggc aggagccccc
      361 gctcggccac ctcctcgccc cgctgctgcc gctggaagat gtcgcaggag aggcccacgt
      421 tctaccggca ggagctgaac aagaccatct gggaggtgcc cgaacgatac cagaacctgt
      481 ccccggtggg ctcgggcgcc tatggctcgg tgtgtgctgc ttttgataca aagacggggc
      541 atcgtgtggc agttaagaag ctgtcgagac cgtttcagtc catcattcac gccaaaagga
      601 cctaccgaga gttgcgtctg ctgaagcaca tgaaacacga aaatgtgatt ggtctgttgg
      661 atgtgttcac acccgcaagg tcactggagg aattcaatga cgtgtacctg gtgacccatc
      721 tcatgggggc ggacctgaac aacatcgtga agtgccagaa gctgaccgac gaccacgttc
      781 agtttctcat ctaccagatc ctccgagggc tgaagtatat acattcggct gacataattc
      841 acagggacct aaagcccagc aacctagctg tgaacgaaga ctgtgagctc aagattctgg
      901 attttgggct ggctcggcac actgatgatg agatgacagg ctacgtggct accaggtggt
      961 accgagcccc agagatcatg ctgaattgga tgcactataa ccagacagtg gatatttggt
     1021 ccgtgggctg catcatggct gagctgttga ccggaagaac gttgtttcct ggtacagacc
     1081 atattgatca gttgaagctc attttaagac tcgttggaac cccaggggct gagcttctga
     1141 agaaaatctc ctcagagtct gcaagaaact acattcagtc tctggcccag atgccgaaga
     1201 tgaacttcgc aaatgtattt attggtgcca atcccctggc tgtcgaccta ctggagaaga
     1261 tgctcgtttt ggactcagat aagaggatca cagcagccca agctcttgcg catgcctact
     1321 ttgctcagta ccacgaccct gatgatgagc ctgttgctga cccttatgac cagtcctttg
     1381 aaagcaggga ccttctcata gatgagtgga agagcctgac ctatgatgaa gtcatcagct
     1441 ttgtgccacc accccttgac caagaagaaa tggagtcctg agcacctggt ttctgttctg
     1501 tctatctcac ttcactgtga ggggaagacc ttctcatggg aactctccaa ataccattca
     1561 agtgcctctt gttgaaagat tccttcatgg tggaaggggg tgcatgtatg tgttagtgtt
     1621 tgtgtgtgtg tgtgtgtctg tctgttcgtc tgtccaccta tctttgtgga agtcactgtg
     1681 atggtagtga ctttatgagt tgtgaatggt ccttggcagt ctgcctgctt tctcagagtc
     1741 tgggcaggcc gatgggaact gtcatctcct tagggatgtg tgtgttcagt gcaaagtaag
     1801 aaatatgaaa atatccctgt tcttagttac cttgccactt tggcttctcc tgtggccctg
     1861 cctttaccat atcagtgaca gagagaggct gcttcaggtc tgaggctatc cctcagccat
     1921 gcataaagtc caagagaacc aactggctcc tggtctctag cctgtgaccg gcttgcttaa
     1981 tgtcctcaga acctgacagg tatgttcaaa actgtcagtc tgtttgtgcc ttaaaagggt
     2041 gagaagggcg cgtagatagt tacagagtct cagctgctga cgttctgagc caggcaagtg
     2101 cacggggctg ttggatggcc agtggggagc tggaaaaaac aaggcagcct ttaggaaggc
     2161 catggtgcat gtgtgtgcat gcgtgtatgt gcagccgccc tccctcactt caggagcaag
     2221 ctgtttgctg tgcttaccct tcacctcagt gcagaggtct ccagtgccga gcacaggcac
     2281 ctgccatcag tagttcctgt gtcatcttca catctagcag agcacggatg tgtttgcatg
     2341 ctgtgctctt ggagcttgtc ctgtcttctg gaagccctgg acaaggcgtg tgaaggcttc
     2401 ccagaagttc ctgtccacat tgcctccgcc caccgacgcc atgggcacac tgctccctcc
     2461 tcctcctcca gctactttgt gttgaacaca attgattctc caggtgctca tggtgcagga
     2521 aaacaggaca gacagagagc acctgaaccc ttgccatctg atgtcaccaa ttcaggaaaa
     2581 cgagtcctct cctaggacta tccccggttc tggaaatcat gttctcctca ctcatggtga
     2641 caagctaaga aagctgaaca aagggagaga cgagagcgcc tgaagccagg agctccttta
     2701 ctatctttct caaaagggtt gttagacaca aaccaagtca tcaaggcccc gctcctctcc
     2761 tcggaagggt cccccacccc ccggcagctt gacactgaat ccagtgtcaa tttggggaga
     2821 aagcagtttt gtcttggaat tttgtatgtt gtaggaatcc ttagagagtg tggttccttc
     2881 tgatggggag aaagggcaaa ttattttaat attttgtatt ttcaccttta taaacatgaa
     2941 tcctcagggg tgaagaactg tttgcataat tttctgaatt ttgagcactt tgtgctatat
     3001 aaggacccat atttaagctt tgtgtgcagt aagaaagtgt aaagccaatt ccagtgttgg
     3061 acgtgacagg tcttgtgttt aggtcaaggt gtctcctctc agtgcaggga catgcctgct
     3121 ctgtggggca ggcgaggacc ctgaatcatt tggagcccag aaggaggcag actggccagg
     3181 tctcaccacc tcagtgtgca gttcaactcc atgccatccc atcaagatgg gttagtagca
     3241 gtgtctgttt ttgaatgcca agtgtgattt ccaacaattc tgctctggtt atttcattga
     3301 agacatcttt gcacatgtga ccatgctgtg ttaggggctg tgttccaggg actggactcg
     3361 aagctagaac tggcagaaga gttctggcat ccacagcgca atgctgccac cacccagttt
     3421 cttcatcaga agacaaggga acgagaaaac tgctgttcgt ttgtatttgt gaacttggct
     3481 gtaatctggt atgccatagg atgtcagata ataccactgg ttaaaataaa gcctagtttt
     3541 caaattcaaa aaaaaaaaaa
//
