LOCUS       NM_011950               1406 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus mitogen-activated protein kinase 13 (Mapk13), mRNA.
ACCESSION   NM_011950 XM_973530
VERSION     NM_011950.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1406)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1406)
  AUTHORS   Escos,A., Diaz-Mora,E., Pattison,M., Fajardo,P.,
            Gonzalez-Romero,D., Risco,A., Martin-Gomez,J., Bonneil,E.,
            Sonenberg,N., Jafarnejad,S.M., Sanz-Ezquerro,J.J., Ley,S.C. and
            Cuenda,A.
  TITLE     p38gamma and p38delta modulate innate immune response by regulating
            MEF2D activation
  JOURNAL   Elife 12, e86200 (2023)
   PUBMED   37458356
  REMARK    GeneRIF: p38gamma and p38delta modulate innate immune response by
            regulating MEF2D activation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1406)
  AUTHORS   Diaz-Mora,E., Gonzalez-Romero,D., Meireles-da-Silva,M.,
            Sanz-Ezquerro,J.J. and Cuenda,A.
  TITLE     p38delta controls Mitogen- and Stress-activated Kinase-1 (MSK1)
            function in response to toll-like receptor activation in
            macrophages
  JOURNAL   Front Cell Dev Biol 11, 1083033 (2023)
   PUBMED   36846591
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1406)
  AUTHORS   Romero-Becerra,R., Mora,A., Manieri,E., Nikolic,I., Santamans,A.M.,
            Montalvo-Romeral,V., Cruz,F.M., Rodriguez,E., Leon,M.,
            Leiva-Vega,L., Sanz,L., Bondia,V., Filgueiras-Rama,D.,
            Jimenez-Borreguero,L.J., Jalife,J., Gonzalez-Teran,B. and Sabio,G.
  TITLE     MKK6 deficiency promotes cardiac dysfunction through
            MKK3-p38gamma/delta-mTOR hyperactivation
  JOURNAL   Elife 11, e75250 (2022)
   PUBMED   35971771
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1406)
  AUTHORS   Kim,W.K., Olson,A.W., Mi,J., Wang,J., Lee,D.H., Le,V., Hiroto,A.,
            Aldahl,J., Nenninger,C.H., Buckley,A.J., Cardiff,R., You,S. and
            Sun,Z.
  TITLE     Aberrant androgen action in prostatic progenitor cells induces
            oncogenesis and tumor development through IGF1 and Wnt axes
  JOURNAL   Nat Commun 13 (1), 4364 (2022)
   PUBMED   35902588
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1406)
  AUTHORS   Goldberg,H.J., Huszar,T., Mozes,M.M., Rosivall,L. and Mucsi,I.
  TITLE     Overexpression of the type II transforming growth factor-beta
            receptor inhibits fibroblasts proliferation and activates
            extracellular signal regulated kinase and c-Jun N-terminal kinase
  JOURNAL   Cell Biol Int 26 (2), 165-174 (2002)
   PUBMED   11846446
  REMARK    GeneRIF: Overexpression of the type II transforming growth
            factor-beta receptor inhibits fibroblasts proliferation and
            activates extracellular signal regulated kinase and c-Jun
            N-terminal kinase
REFERENCE   7  (bases 1 to 1406)
  AUTHORS   Hu,M.C., Wang,Y.P., Mikhail,A., Qiu,W.R. and Tan,T.H.
  TITLE     Murine p38-delta mitogen-activated protein kinase, a
            developmentally regulated protein kinase that is activated by
            stress and proinflammatory cytokines
  JOURNAL   J Biol Chem 274 (11), 7095-7102 (1999)
   PUBMED   10066767
REFERENCE   8  (bases 1 to 1406)
  AUTHORS   Maucher,C., Weissinger,E.M., Kremmer,E., Baccarini,M., Procyk,K.,
            Henderson,D.W., Wolff,L., Kolch,W., Kaspers,B., Mushinski,J.F. and
            Mischak,H.
  TITLE     Activation of bcl-2 suppressible 40 and 44 kDa p38-like kinases
            during apoptosis of early and late B lymphocytic cell lines
  JOURNAL   FEBS Lett 427 (1), 29-35 (1998)
   PUBMED   9613594
REFERENCE   9  (bases 1 to 1406)
  AUTHORS   Jiang,Y., Gram,H., Zhao,M., New,L., Gu,J., Feng,L., Di Padova,F.,
            Ulevitch,R.J. and Han,J.
  TITLE     Characterization of the structure and function of the fourth member
            of p38 group mitogen-activated protein kinases, p38delta
  JOURNAL   J Biol Chem 272 (48), 30122-30128 (1997)
   PUBMED   9374491
REFERENCE   10 (bases 1 to 1406)
  AUTHORS   Foltz,I.N., Lee,J.C., Young,P.R. and Schrader,J.W.
  TITLE     Hemopoietic growth factors with the exception of interleukin-4
            activate the p38 mitogen-activated protein kinase pathway
  JOURNAL   J Biol Chem 272 (6), 3296-3301 (1997)
   PUBMED   9013568
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ182359.1, AK146993.1 and U81823.1.
            
            On Apr 2, 2009 this sequence version replaced NM_011950.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U81823.1, BC001992.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                CJ182359.1         3-14
            13-1382             AK146993.1         1-1370
            1383-1406           U81823.1           1340-1363
FEATURES             Location/Qualifiers
     source          1..1406
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 15.0 cM"
     gene            1..1406
                     /gene="Mapk13"
                     /gene_synonym="SAPK4; Serk4"
                     /note="mitogen-activated protein kinase 13"
                     /db_xref="GeneID:26415"
                     /db_xref="MGI:MGI:1346864"
     exon            1..212
                     /gene="Mapk13"
                     /gene_synonym="SAPK4; Serk4"
                     /inference="alignment:Splign:2.1.0"
     exon            213..342
                     /gene="Mapk13"
                     /gene_synonym="SAPK4; Serk4"
                     /inference="alignment:Splign:2.1.0"
     exon            343..401
                     /gene="Mapk13"
                     /gene_synonym="SAPK4; Serk4"
                     /inference="alignment:Splign:2.1.0"
     exon            402..510
                     /gene="Mapk13"
                     /gene_synonym="SAPK4; Serk4"
                     /inference="alignment:Splign:2.1.0"
     exon            511..540
                     /gene="Mapk13"
                     /gene_synonym="SAPK4; Serk4"
                     /inference="alignment:Splign:2.1.0"
     exon            541..588
                     /gene="Mapk13"
                     /gene_synonym="SAPK4; Serk4"
                     /inference="alignment:Splign:2.1.0"
     exon            589..703
                     /gene="Mapk13"
                     /gene_synonym="SAPK4; Serk4"
                     /inference="alignment:Splign:2.1.0"
     exon            704..775
                     /gene="Mapk13"
                     /gene_synonym="SAPK4; Serk4"
                     /inference="alignment:Splign:2.1.0"
     exon            776..855
                     /gene="Mapk13"
                     /gene_synonym="SAPK4; Serk4"
                     /inference="alignment:Splign:2.1.0"
     exon            856..934
                     /gene="Mapk13"
                     /gene_synonym="SAPK4; Serk4"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1111
                     /gene="Mapk13"
                     /gene_synonym="SAPK4; Serk4"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1388
                     /gene="Mapk13"
                     /gene_synonym="SAPK4; Serk4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1362..1367
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mapk13"
                     /gene_synonym="SAPK4; Serk4"
                     /note="hexamer: ATTAAA"
     polyA_site      1387
                     /gene="Mapk13"
                     /gene_synonym="SAPK4; Serk4"
                     /note="major polyA site"
ORIGIN      
        1 ggggcgggag gggaccgcgg cgggacaccc gggccgggag cccgcgggca gccaccgcaa
       61 cctcctcgca ggaccgccac cacggggtcc gggatgagcc tcactcggaa aaggggcttc
      121 tacaagcagg acatcaacaa gactgcctgg gagctaccca agacctacct ggcgcccgcg
      181 cacgtcggca gcggggccta tggagcggtg tgctcggcca tcgacaagcg gacaggggag
      241 aaggtggcca tcaagaagct gagccggccc ttccagtcgg agatctttgc caagcgcgct
      301 taccgcgagc ttctgctctt gaagcacatg caccatgaga acgtcattgg gcttctggat
      361 gtcttcaccc ctgcgtcttc ccttcggagc ttccatgatt tctacctggt gatgcccttc
      421 atgcagacag acctacagaa gatcatgggg atggaattca gcgaggataa ggtccagtac
      481 ttggtgtacc agatgctcaa aggtctaaag tacatccact ccgctggcat cgtccacagg
      541 gacctgaaac cgggcaacct ggctgtgaat gaagactgtg agctgaagat cctggacttt
      601 gggctggccc gccacacaga cactgagatg acgggctatg tggtgacccg ctggtaccgg
      661 gcccccgagg tgatcctcag ctggatgcat tacaaccaga cagtcgacat ctggtctgtt
      721 ggttgcatca tggcagaaat gctgactgga aagacactct tcaagggcaa ggactacctg
      781 gaccagctga cccagatcct gaaagtgact ggggtgccag gtgccgagtt cgtgcagaag
      841 ctgaaagaca aggcggccaa atcctatatt cagtccctgc cccagagccc caagaaggat
      901 ttcacacagc tcttcccacg cgccagtccg caagctgcag acctgctcga caagatgctg
      961 gagctggatg tggacaagcg tctgaccgct gctcaggcac tggctcaccc cttctttgaa
     1021 cccttccggg accctgagga ggagacagag gcccagcagc cttttgatga tgccttagaa
     1081 catgagaaac tcagcgtgga cgaatggaaa caacacatct acaaagagat ctcaaacttc
     1141 agtcccatag cccggaagga ctcacggcga cgaagtggca tgaagctgca gtgattgatg
     1201 gctggcctcc atgtagccca ggttggcctc catgtagccc aggctggcct tgagtcttcc
     1261 tcctctcctt ttttgagaca ggatcttact gtgtagccct ggagccctgg ctagacctgc
     1321 aactcaagag atccacccac ctctgttacc tgggtggtgg gattaaaggc atgcaccact
     1381 gcgcccagaa aaaaaaaaaa aaaaaa
//
