LOCUS       NM_013871               1872 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus mitogen-activated protein kinase 12 (Mapk12),
            transcript variant 1, mRNA.
ACCESSION   NM_013871
VERSION     NM_013871.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1872)
  AUTHORS   Escos,A., Diaz-Mora,E., Pattison,M., Fajardo,P.,
            Gonzalez-Romero,D., Risco,A., Martin-Gomez,J., Bonneil,E.,
            Sonenberg,N., Jafarnejad,S.M., Sanz-Ezquerro,J.J., Ley,S.C. and
            Cuenda,A.
  TITLE     p38gamma and p38delta modulate innate immune response by regulating
            MEF2D activation
  JOURNAL   Elife 12, e86200 (2023)
   PUBMED   37458356
  REMARK    GeneRIF: p38gamma and p38delta modulate innate immune response by
            regulating MEF2D activation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1872)
  AUTHORS   Diaz-Mora,E., Gonzalez-Romero,D., Meireles-da-Silva,M.,
            Sanz-Ezquerro,J.J. and Cuenda,A.
  TITLE     p38delta controls Mitogen- and Stress-activated Kinase-1 (MSK1)
            function in response to toll-like receptor activation in
            macrophages
  JOURNAL   Front Cell Dev Biol 11, 1083033 (2023)
   PUBMED   36846591
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1872)
  AUTHORS   Venediktova,N., Solomadin,I. and Starinets,V.
  TITLE     Effect of Thyroxine on the Structural and Dynamic Features of
            Cardiac Mitochondria and Mitophagy in Rats
  JOURNAL   Cells 12 (3), 396 (2023)
   PUBMED   36766738
  REMARK    GeneRIF: Effect of Thyroxine on the Structural and Dynamic Features
            of Cardiac Mitochondria and Mitophagy in Rats.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1872)
  AUTHORS   Romero-Becerra,R., Mora,A., Manieri,E., Nikolic,I., Santamans,A.M.,
            Montalvo-Romeral,V., Cruz,F.M., Rodriguez,E., Leon,M.,
            Leiva-Vega,L., Sanz,L., Bondia,V., Filgueiras-Rama,D.,
            Jimenez-Borreguero,L.J., Jalife,J., Gonzalez-Teran,B. and Sabio,G.
  TITLE     MKK6 deficiency promotes cardiac dysfunction through
            MKK3-p38gamma/delta-mTOR hyperactivation
  JOURNAL   Elife 11, e75250 (2022)
   PUBMED   35971771
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1872)
  AUTHORS   Yin,D.P., Zheng,Y.F., Sun,P., Yao,M.Y., Xie,L.X., Dou,X.W., Tian,Y.
            and Liu,J.S.
  TITLE     The pro-tumorigenic activity of p38gamma overexpression in
            nasopharyngeal carcinoma
  JOURNAL   Cell Death Dis 13 (3), 210 (2022)
   PUBMED   35246508
  REMARK    GeneRIF: The pro-tumorigenic activity of p38gamma overexpression in
            nasopharyngeal carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1872)
  AUTHORS   Papin,J. and Subramaniam,S.
  TITLE     Bioinformatics and cellular signaling
  JOURNAL   Curr Opin Biotechnol 15 (1), 78-81 (2004)
   PUBMED   15102471
  REMARK    Review article
REFERENCE   7  (bases 1 to 1872)
  AUTHORS   Hirai,S., Kawaguchi,A., Hirasawa,R., Baba,M., Ohnishi,T. and
            Ohno,S.
  TITLE     MAPK-upstream protein kinase (MUK) regulates the radial migration
            of immature neurons in telencephalon of mouse embryo
  JOURNAL   Development 129 (19), 4483-4495 (2002)
   PUBMED   12223406
REFERENCE   8  (bases 1 to 1872)
  AUTHORS   Court,N.W., dos Remedios,C.G., Cordell,J. and Bogoyevitch,M.A.
  TITLE     Cardiac expression and subcellular localization of the p38
            mitogen-activated protein kinase member, stress-activated protein
            kinase-3 (SAPK3)
  JOURNAL   J Mol Cell Cardiol 34 (4), 413-426 (2002)
   PUBMED   11991731
  REMARK    GeneRIF: Cardiac expression and subcellular localization
REFERENCE   9  (bases 1 to 1872)
  AUTHORS   Hu,M.C., Wang,Y.P., Mikhail,A., Qiu,W.R. and Tan,T.H.
  TITLE     Murine p38-delta mitogen-activated protein kinase, a
            developmentally regulated protein kinase that is activated by
            stress and proinflammatory cytokines
  JOURNAL   J Biol Chem 274 (11), 7095-7102 (1999)
   PUBMED   10066767
REFERENCE   10 (bases 1 to 1872)
  AUTHORS   Mertens,S., Craxton,M. and Goedert,M.
  TITLE     SAP kinase-3, a new member of the family of mammalian
            stress-activated protein kinases
  JOURNAL   FEBS Lett 383 (3), 273-276 (1996)
   PUBMED   8925912
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113069.10.
            
            On Mar 24, 2022 this sequence version replaced NM_013871.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021640.1, Y13439.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-338               AC113069.10        161354-161691       c
            339-468             AC113069.10        161134-161263       c
            469-527             AC113069.10        158407-158465       c
            528-639             AC113069.10        156583-156694       c
            640-669             AC113069.10        156433-156462       c
            670-717             AC113069.10        156129-156176       c
            718-832             AC113069.10        155618-155732       c
            833-904             AC113069.10        154085-154156       c
            905-984             AC113069.10        153907-153986       c
            985-1063            AC113069.10        153759-153837       c
            1064-1237           AC113069.10        153501-153674       c
            1238-1872           AC113069.10        151590-152224       c
FEATURES             Location/Qualifiers
     source          1..1872
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 44.65 cM"
     gene            1..1872
                     /gene="Mapk12"
                     /gene_synonym="Erk6; P38gamma; Prkm12; Sapk3"
                     /note="mitogen-activated protein kinase 12"
                     /db_xref="GeneID:29857"
                     /db_xref="MGI:MGI:1353438"
     exon            1..338
                     /gene="Mapk12"
                     /gene_synonym="Erk6; P38gamma; Prkm12; Sapk3"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..1317
                     /gene="Mapk12"
                     /gene_synonym="Erk6; P38gamma; Prkm12; Sapk3"
                     /EC_number="2.7.11.24"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ERK-6; MAPK 12; MAP kinase 12; MAP kinase p38 gamma;
                     stress-activated protein kinase 3; extracellular
                     signal-regulated kinase 6; mitogen-activated protein
                     kinase p38 gamma"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 12 isoform 1"
                     /protein_id="NP_038899.1"
                     /db_xref="CCDS:CCDS27740.1"
                     /db_xref="GeneID:29857"
                     /db_xref="MGI:MGI:1353438"
                     /translation="MSSPPPARKGFYRQEVTKTAWEVRAVYQDLQPVGSGAYGAVCSA
                     VDSRTGNKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDESLDDF
                     TDFYLVMPFMGTDLGKLMKHETLSEDRIQFLVYQMLKGLKYIHAAGVIHRDLKPGNLA
                     VNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAE
                     MITGKILFKGNDHLDQLKEIMKITGTPPPEFVQKLQSAEAKNYMEGLPELEKKDFASV
                     LTNASPQAVNLLERMLVLDAEQRVTAAEALTHPYFESLRDTEDEPKAQKYDDSFDDVD
                     RTLEEWKRVTYKEVLSFKPPRQLGARVPKETAL"
     exon            339..468
                     /gene="Mapk12"
                     /gene_synonym="Erk6; P38gamma; Prkm12; Sapk3"
                     /inference="alignment:Splign:2.1.0"
     exon            469..527
                     /gene="Mapk12"
                     /gene_synonym="Erk6; P38gamma; Prkm12; Sapk3"
                     /inference="alignment:Splign:2.1.0"
     exon            528..639
                     /gene="Mapk12"
                     /gene_synonym="Erk6; P38gamma; Prkm12; Sapk3"
                     /inference="alignment:Splign:2.1.0"
     exon            640..669
                     /gene="Mapk12"
                     /gene_synonym="Erk6; P38gamma; Prkm12; Sapk3"
                     /inference="alignment:Splign:2.1.0"
     exon            670..717
                     /gene="Mapk12"
                     /gene_synonym="Erk6; P38gamma; Prkm12; Sapk3"
                     /inference="alignment:Splign:2.1.0"
     exon            718..832
                     /gene="Mapk12"
                     /gene_synonym="Erk6; P38gamma; Prkm12; Sapk3"
                     /inference="alignment:Splign:2.1.0"
     exon            833..904
                     /gene="Mapk12"
                     /gene_synonym="Erk6; P38gamma; Prkm12; Sapk3"
                     /inference="alignment:Splign:2.1.0"
     exon            905..984
                     /gene="Mapk12"
                     /gene_synonym="Erk6; P38gamma; Prkm12; Sapk3"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1063
                     /gene="Mapk12"
                     /gene_synonym="Erk6; P38gamma; Prkm12; Sapk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1237
                     /gene="Mapk12"
                     /gene_synonym="Erk6; P38gamma; Prkm12; Sapk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1872
                     /gene="Mapk12"
                     /gene_synonym="Erk6; P38gamma; Prkm12; Sapk3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1848..1853
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mapk12"
                     /gene_synonym="Erk6; P38gamma; Prkm12; Sapk3"
                     /note="hexamer: AATAAA"
     polyA_site      1872
                     /gene="Mapk12"
                     /gene_synonym="Erk6; P38gamma; Prkm12; Sapk3"
                     /note="major polyA site"
ORIGIN      
        1 actttgcggg ccagagacaa gggtcgggtg ggagttggcg gttatagaga gttcagggtg
       61 gcgaccccga gagaagagcc cgcaaaggaa aatctcagag gcgggcaggc gggtagccgg
      121 cgcggagtac gccctgccac gcagtgaccc ggggcgcgcg ggcggagccc ctgatcccgg
      181 gtccggtcct ggggcgcggt gctccggctg gggatgagct ccccgccacc cgcccgcaag
      241 ggcttttacc gccaggaggt gaccaaaacg gcctgggagg tgcgcgccgt gtaccaagac
      301 ctgcagcccg ttggctctgg tgcctatggt gcagtgtgct ctgcagtaga cagccgcact
      361 ggcaacaagg tggccatcaa gaagttgtac cggcccttcc agtcggagct gtttgccaag
      421 cgcgcctaca gagagttgcg cctcctcaaa cacatgcgcc acgagaacgt cattgggcta
      481 ctggatgtgt tcacacctga tgagtctctg gacgacttca cagacttcta cctggtgatg
      541 ccattcatgg gcactgatct gggcaaactc atgaagcatg agaccctgag tgaagacaga
      601 atccagtttc ttgtgtatca gatgttgaag gggctgaagt atatccatgc ggctggtgtc
      661 atccacagag acttgaagcc tggcaacctg gctgtgaatg aggactgtga gctgaagatc
      721 ctagactttg gccttgccag gcaggcagac agtgagatga caggatatgt ggtaacccgg
      781 tggtatcggg caccagaggt catcttgaat tggatgcgct acacgcagac agtggacatt
      841 tggtccgttg gctgcatcat ggcggagatg attactggga agatcctgtt caaaggcaat
      901 gaccacctgg accagctgaa ggagatcatg aagatcacag ggacgccccc tcctgagttt
      961 gttcagaagc tacagagtgc agaggccaag aactacatgg aaggcctccc tgagttagaa
     1021 aagaaggatt ttgcctctgt cctgaccaac gcaagccctc aggctgtgaa tctcctggaa
     1081 aggatgctgg tgctggatgc ggaacagcgg gtgacagcag ctgaggcgtt aacccatcca
     1141 tactttgagt cccttcggga cactgaggat gaacccaagg cccagaaata tgacgactcc
     1201 tttgatgatg tagaccgcac ccttgaggaa tggaagcgtg tgacttacaa ggaagttctc
     1261 agcttcaagc ctcctaggca gctaggagcc agagttccaa aggagacggc tctgtgacga
     1321 cctctgggtg gtttgggggg tatccaaagg aggttggctc ggagcttcac ggcaccttgg
     1381 cttcccttct ctggaaaagg aatcctggtt aacaccccga cagtgcctgg agcttgtatc
     1441 ccaagtcttc cacctggaca tgctgtgtag acccttgaat catgaaccct ccatctccaa
     1501 acctgttctt cggctttcga gtgccccaga tgaccctgga agaacatcta agctttctgt
     1561 ccaagacccc tacccaacat gggactagcc tttgaattct ggagttgtac atgaaatcag
     1621 tattcgtgaa aaagcttcag agtgagcaga gcttaggaga caagtgccag acctgagctc
     1681 tgctcgctct ggacaatgcc aaggccaact cctgagacgg aatgagacag aggttttggg
     1741 gacactgact cagggacatc atctcttctg gaagtgggtg gattctctta cacccttagc
     1801 ctggaattcg aaccagccat ttggtgttgc ctaagtggct gggggcaaat aaaccctttt
     1861 gtagatctcc ca
//
