LOCUS       NM_011161               2452 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus mitogen-activated protein kinase 11 (Mapk11), mRNA.
ACCESSION   NM_011161
VERSION     NM_011161.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2452)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2452)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2452)
  AUTHORS   Yokota,T., Li,J., Huang,J., Xiong,Z., Zhang,Q., Chan,T., Ding,Y.,
            Rau,C., Sung,K., Ren,S., Kulkarni,R., Hsiai,T., Xiao,X., Touma,M.,
            Minamisawa,S. and Wang,Y.
  TITLE     p38 Mitogen-activated protein kinase regulates chamber-specific
            perinatal growth in heart
  JOURNAL   J Clin Invest 130 (10), 5287-5301 (2020)
   PUBMED   32573492
  REMARK    GeneRIF: p38 Mitogen-activated protein kinase regulates
            chamber-specific perinatal growth in heart.
REFERENCE   4  (bases 1 to 2452)
  AUTHORS   Hasan,M.R., Takatalo,M., Ma,H., Rice,R., Mustonen,T. and Rice,D.P.
  TITLE     RAB23 coordinates early osteogenesis by repressing FGF10-pERK1/2
            and GLI1
  JOURNAL   Elife 9, e55829 (2020)
   PUBMED   32662771
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2452)
  AUTHORS   Bang,B.R., Han,K.H., Seo,G.Y., Croft,M. and Kang,Y.J.
  TITLE     The protein tyrosine kinase SYK regulates the alternative p38
            activation in liver during acute liver inflammation
  JOURNAL   Sci Rep 9 (1), 17838 (2019)
   PUBMED   31780731
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2452)
  AUTHORS   Lim,S., Zou,Y. and Friedman,E.
  TITLE     The transcriptional activator Mirk/Dyrk1B is sequestered by
            p38alpha/beta MAP kinase
  JOURNAL   J Biol Chem 277 (51), 49438-49445 (2002)
   PUBMED   12384504
  REMARK    GeneRIF: p38 MAP Kinase suppresses the function of Mirk as a
            transcriptional activator only when cells are proliferating
REFERENCE   7  (bases 1 to 2452)
  AUTHORS   Hu,M.C., Wang,Y.P., Mikhail,A., Qiu,W.R. and Tan,T.H.
  TITLE     Murine p38-delta mitogen-activated protein kinase, a
            developmentally regulated protein kinase that is activated by
            stress and proinflammatory cytokines
  JOURNAL   J Biol Chem 274 (11), 7095-7102 (1999)
   PUBMED   10066767
REFERENCE   8  (bases 1 to 2452)
  AUTHORS   Deak,M., Clifton,A.D., Lucocq,L.M. and Alessi,D.R.
  TITLE     Mitogen- and stress-activated protein kinase-1 (MSK1) is directly
            activated by MAPK and SAPK2/p38, and may mediate activation of CREB
  JOURNAL   EMBO J 17 (15), 4426-4441 (1998)
   PUBMED   9687510
REFERENCE   9  (bases 1 to 2452)
  AUTHORS   Waskiewicz,A.J., Flynn,A., Proud,C.G. and Cooper,J.A.
  TITLE     Mitogen-activated protein kinases activate the serine/threonine
            kinases Mnk1 and Mnk2
  JOURNAL   EMBO J 16 (8), 1909-1920 (1997)
   PUBMED   9155017
REFERENCE   10 (bases 1 to 2452)
  AUTHORS   Jiang,Y., Chen,C., Li,Z., Guo,W., Gegner,J.A., Lin,S. and Han,J.
  TITLE     Characterization of the structure and function of a new
            mitogen-activated protein kinase (p38beta)
  JOURNAL   J Biol Chem 271 (30), 17920-17926 (1996)
   PUBMED   8663524
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC092526.1 and AI480540.1.
            
            On Feb 23, 2008 this sequence version replaced NM_011161.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092526.1, AK144846.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2195              BC092526.1         1-2195
            2196-2439           BC092526.1         2197-2440
            2440-2452           AI480540.1         1-13                c
FEATURES             Location/Qualifiers
     source          1..2452
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 44.66 cM"
     gene            1..2452
                     /gene="Mapk11"
                     /gene_synonym="p38-2; P38b; p38beta; p38beta2; Prkm11;
                     Sapk2; Sapk2b"
                     /note="mitogen-activated protein kinase 11"
                     /db_xref="GeneID:19094"
                     /db_xref="MGI:MGI:1338024"
     exon            1..209
                     /gene="Mapk11"
                     /gene_synonym="p38-2; P38b; p38beta; p38beta2; Prkm11;
                     Sapk2; Sapk2b"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1188
                     /gene="Mapk11"
                     /gene_synonym="p38-2; P38b; p38beta; p38beta2; Prkm11;
                     Sapk2; Sapk2b"
                     /EC_number="2.7.11.24"
                     /note="MAPK 11; MAP kinase 11; MAP kinase p38 beta;
                     mitogen-activated protein kinase p38 beta; protein kinase,
                     mitogen activated kinase, 11, p38beta"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 11"
                     /protein_id="NP_035291.4"
                     /db_xref="CCDS:CCDS27741.1"
                     /db_xref="GeneID:19094"
                     /db_xref="MGI:MGI:1338024"
                     /translation="MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDA
                     RLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEV
                     YLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNE
                     DCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ
                     GKALFPGNDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSVFHG
                     ANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPDDEPEAEPYDESVEAKERTL
                     EEWKELTYQEVLSFKPLEPSQLPGTHEIEQ"
     exon            210..339
                     /gene="Mapk11"
                     /gene_synonym="p38-2; P38b; p38beta; p38beta2; Prkm11;
                     Sapk2; Sapk2b"
                     /inference="alignment:Splign:2.1.0"
     exon            340..398
                     /gene="Mapk11"
                     /gene_synonym="p38-2; P38b; p38beta; p38beta2; Prkm11;
                     Sapk2; Sapk2b"
                     /inference="alignment:Splign:2.1.0"
     exon            399..510
                     /gene="Mapk11"
                     /gene_synonym="p38-2; P38b; p38beta; p38beta2; Prkm11;
                     Sapk2; Sapk2b"
                     /inference="alignment:Splign:2.1.0"
     exon            511..540
                     /gene="Mapk11"
                     /gene_synonym="p38-2; P38b; p38beta; p38beta2; Prkm11;
                     Sapk2; Sapk2b"
                     /inference="alignment:Splign:2.1.0"
     exon            541..588
                     /gene="Mapk11"
                     /gene_synonym="p38-2; P38b; p38beta; p38beta2; Prkm11;
                     Sapk2; Sapk2b"
                     /inference="alignment:Splign:2.1.0"
     exon            589..703
                     /gene="Mapk11"
                     /gene_synonym="p38-2; P38b; p38beta; p38beta2; Prkm11;
                     Sapk2; Sapk2b"
                     /inference="alignment:Splign:2.1.0"
     exon            704..775
                     /gene="Mapk11"
                     /gene_synonym="p38-2; P38b; p38beta; p38beta2; Prkm11;
                     Sapk2; Sapk2b"
                     /inference="alignment:Splign:2.1.0"
     exon            776..855
                     /gene="Mapk11"
                     /gene_synonym="p38-2; P38b; p38beta; p38beta2; Prkm11;
                     Sapk2; Sapk2b"
                     /inference="alignment:Splign:2.1.0"
     exon            856..934
                     /gene="Mapk11"
                     /gene_synonym="p38-2; P38b; p38beta; p38beta2; Prkm11;
                     Sapk2; Sapk2b"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1108
                     /gene="Mapk11"
                     /gene_synonym="p38-2; P38b; p38beta; p38beta2; Prkm11;
                     Sapk2; Sapk2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..2444
                     /gene="Mapk11"
                     /gene_synonym="p38-2; P38b; p38beta; p38beta2; Prkm11;
                     Sapk2; Sapk2b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2407..2412
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mapk11"
                     /gene_synonym="p38-2; P38b; p38beta; p38beta2; Prkm11;
                     Sapk2; Sapk2b"
                     /note="hexamer: AATAAA"
     polyA_site      2444
                     /gene="Mapk11"
                     /gene_synonym="p38-2; P38b; p38beta; p38beta2; Prkm11;
                     Sapk2; Sapk2b"
                     /note="major polyA site"
ORIGIN      
        1 caccccgctt tgctcagcgg tgctgggcgt ggggcgcggg ccgggtgctg cgcgcgggga
       61 tccggggcgc tcgctccagc tgcttctgtg gatatgtcgg gtccgcgcgc gggattctac
      121 cggcaagagc tgaacaaaac agtatgggag gtgccgcagc ggctgcaggg cctacgcccg
      181 gtgggctccg gcgcctacgg ctcagtctgc tcggcctacg acgcgcggct gcgccagaag
      241 gtggctgtaa agaagctgtc tcgccctttc caatcgctga tccacgcgag gaggacatac
      301 cgtgagctgc gcctactcaa gcacctgaag cacgagaacg tcataggact tttggacgtc
      361 ttcacgccgg ccacatccat cgaggatttc agcgaagtgt acctcgtgac gaccctgatg
      421 ggcgccgacc tgaataacat cgtcaagtgt caggccctga gcgatgagca tgttcaattc
      481 cttgtctacc agctgctgcg tgggctgaag tatatccact cggcgggcat catccaccgg
      541 gacctgaagc ccagcaatgt agcggtgaac gaggactgcg agctgaggat cctggacttt
      601 gggctagcac gccaggctga tgaggagatg accggatatg tggccacacg gtggtaccgg
      661 gcgccagaga tcatgctaaa ctggatgcac tacaaccaga cagtggacat ctggtctgtg
      721 ggctgcatca tggctgaact gctgcaagga aaggccctct ttcctggaaa cgactacatc
      781 gaccagctga agcgaatcat ggaggtggtg ggcacgccca gtcctgaggt tctggcaaag
      841 atatcctcgg agcatgcccg gacatacatc cagtctctgc ctcccatgcc ccagaaggac
      901 ctcagcagtg tcttccatgg agccaacccc ctggccatag acctccttgg aagaatgctg
      961 gtactagaca gcgaccagag ggtcagtgcg gccgaagcct tggcccacgc atacttcagc
     1021 cagtaccatg accctgacga tgagccagag gcagagccct atgatgaaag tgttgaggcc
     1081 aaggagcgca cgctggagga gtggaaggag cttacttacc aagaagtcct tagcttcaag
     1141 cccctggaac cctcacagct ccctggcacc catgaaattg agcagtgagg cattgcctga
     1201 agtgggagac ctgagcctgt cccctctact cagctttccg gctttcctca agaggcgcct
     1261 ctcaggcagc cctgacactt aacctgggac cgaccccctt gccttgagaa actctacaca
     1321 cacacacaca cacacacaca cacacacaca cacacagagg aatgcacgga tgtgtacata
     1381 tgcctccctc ccattatgtg ctggagtctg ggcagtagtg tttctggacc taccttggtc
     1441 cacccaggtt ctccttggga cctccgtgtg tgggatctga gtgtgtccct gtccttgtcc
     1501 aggtctcttc tgctcttgag gactatctgg attgggagga aggctaatgg gccatggtcc
     1561 ctggagactc tgagggaggg ggagtcacag tggttggaga tgctcaacca ggaagtgagt
     1621 ggctgaaagc agaggcaagc ccagtgtccc tcctaactga gtggcgtttc ctctggggat
     1681 gggaaagctg agaccaccat cagattatct atctagtcag aaaagcctgc tgaagatttg
     1741 tggttgcctg tggtatgtgg gcacatgggc atgagtatgc accctgggat acacatcaga
     1801 acaaatgcag gcatgtgctg gtgtgtatga atctctgagc acccaagagg cagcagccat
     1861 ttctggtctg gtgcctaagt tggagataac tcttgcctcc tctcccccca agttcctgtt
     1921 ttctaatggg tcttgaatcc cagctgtgaa ctagaccaaa ggctctgaga ggtgccaaga
     1981 tccattagtt taagcaaatg taagggtata ggagcagcag caggatcctg agtcacaagg
     2041 gcacaatgcc agctggagag ctgatgaagt tgggggtcta atctcaagga tgctaggtgg
     2101 ccagcaccca cggatgtgag catggacatt cttgccccgg gaccttgatt caaagttgac
     2161 aaacgtctgt ccacgttcta cctccaccaa cccttgaggt tctgcagctg gtctggggtg
     2221 ctatggtttg caagtcaccc ctcatctccc catcccccag agaggagctg accaagtaac
     2281 ttttgaggta gggccctgtt tgaaaacgcg ttgggggtgt aacgcctccc tgaagagaca
     2341 atgatctctt gcttatcagg gaccaagggg ctctggatgt caagtgcctg caccaagagt
     2401 gtgcacaata aaggggcatc cctcttgctc ttgtctgtgc aaaaaaaaaa aa
//
