LOCUS       NM_001407572            6165 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus mitogen-activated protein kinase 10 (Mapk10),
            transcript variant 7, mRNA.
ACCESSION   NM_001407572
VERSION     NM_001407572.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6165)
  AUTHORS   Ahmed,M.R., Zheng,C., Dunning,J.L., Ahmed,M.S., Ge,C., Pair,F.S.,
            Gurevich,V.V. and Gurevich,E.V.
  TITLE     Arrestin-3-assisted activation of JNK3 mediates dopaminergic
            behavioral sensitization
  JOURNAL   Cell Rep Med 5 (7), 101623 (2024)
   PUBMED   38936368
  REMARK    GeneRIF: Arrestin-3-assisted activation of JNK3 mediates
            dopaminergic behavioral sensitization.
REFERENCE   2  (bases 1 to 6165)
  AUTHORS   Wang,J., Xiao,B., Kimura,E., Mongan,M., Hsu,W.W., Medvedovic,M.,
            Puga,A. and Xia,Y.
  TITLE     Crosstalk of MAP3K1 and EGFR signaling mediates gene-environment
            interactions that block developmental tissue closure
  JOURNAL   J Biol Chem 300 (7), 107486 (2024)
   PUBMED   38897570
REFERENCE   3  (bases 1 to 6165)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 6165)
  AUTHORS   Priego,M., Noriega,L., Kalinin,S., Hoffman,L.M., Feinstein,D.L. and
            Morfini,G.
  TITLE     Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3) modestly
            increases disease severity in a mouse model of multiple sclerosis
  JOURNAL   J Neuroimmunol 382, 578152 (2023)
   PUBMED   37454525
  REMARK    GeneRIF: Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3)
            modestly increases disease severity in a mouse model of multiple
            sclerosis.
REFERENCE   5  (bases 1 to 6165)
  AUTHORS   Loughran,G., Chou,M.Y., Ivanov,I.P., Jungreis,I., Kellis,M.,
            Kiran,A.M., Baranov,P.V. and Atkins,J.F.
  TITLE     Evidence of efficient stop codon readthrough in four mammalian
            genes
  JOURNAL   Nucleic Acids Res 42 (14), 8928-8938 (2014)
   PUBMED   25013167
REFERENCE   6  (bases 1 to 6165)
  AUTHORS   Beier,H. and Grimm,M.
  TITLE     Misreading of termination codons in eukaryotes by natural nonsense
            suppressor tRNAs
  JOURNAL   Nucleic Acids Res 29 (23), 4767-4782 (2001)
   PUBMED   11726686
  REMARK    Review article
REFERENCE   7  (bases 1 to 6165)
  AUTHORS   Yang,D.D., Kuan,C.Y., Whitmarsh,A.J., Rincon,M., Zheng,T.S.,
            Davis,R.J., Rakic,P. and Flavell,R.A.
  TITLE     Absence of excitotoxicity-induced apoptosis in the hippocampus of
            mice lacking the Jnk3 gene
  JOURNAL   Nature 389 (6653), 865-870 (1997)
   PUBMED   9349820
REFERENCE   8  (bases 1 to 6165)
  AUTHORS   Casanova,E., Garate,C., Ovalle,S., Calvo,P. and Chinchetru,M.A.
  TITLE     Identification of four splice variants of the mouse
            stress-activated protein kinase JNK/SAPK alpha-isoform
  JOURNAL   Neuroreport 7 (7), 1320-1324 (1996)
   PUBMED   8817558
REFERENCE   9  (bases 1 to 6165)
  AUTHORS   Martin,J.H., Mohit,A.A. and Miller,C.A.
  TITLE     Developmental expression in the mouse nervous system of the p493F12
            SAP kinase
  JOURNAL   Brain Res Mol Brain Res 35 (1-2), 47-57 (1996)
   PUBMED   8717339
REFERENCE   10 (bases 1 to 6165)
  AUTHORS   Suzuki,J., Yoshida,S., Chen,Z.L., Momota,Y., Kato,K., Hirata,A. and
            Shiosaka,S.
  TITLE     Ontogeny of neuropsin mRNA expression in the mouse brain
  JOURNAL   Neurosci Res 23 (4), 345-351 (1995)
   PUBMED   8602273
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC123664.15, AC137121.9 and
            AC125252.7.
            
            Summary: The protein encoded by this gene is a member of the MAP
            kinase family. MAP kinases act as integration points for multiple
            biochemical signals, and thus are involved in a wide variety of
            cellular processes, such as proliferation, differentiation,
            transcription regulation and development. This kinase is
            specifically expressed in a subset of neurons in the nervous system
            and is activated by threonine and tyrosine phosphorylation.
            Targeted deletion of this gene in mice suggests that it may have a
            role in stress-induced neuronal apoptosis. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. A recent study provided evidence for translational
            readthrough in this gene, and expression of an additional
            C-terminally extended isoform via the use of an alternative
            in-frame translation termination codon. [provided by RefSeq, Dec
            2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK042368.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               AC123664.15        86197-86322
            127-198             AC123664.15        127887-127958
            199-368             AC123664.15        147591-147760
            369-498             AC137121.9         159442-159571       c
            499-557             AC137121.9         154727-154785       c
            558-696             AC137121.9         153362-153500       c
            697-862             AC137121.9         152478-152643       c
            863-934             AC137121.9         150061-150132       c
            935-1117            AC137121.9         129304-129486       c
            1118-1242           AC137121.9         126325-126449       c
            1243-1306           AC137121.9         91081-91144         c
            1307-1384           AC137121.9         88930-89007         c
            1385-4008           AC137121.9         73562-76185         c
            4009-6165           AC125252.7         1-2157
FEATURES             Location/Qualifiers
     source          1..6165
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 49.61 cM"
     gene            1..6165
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /note="mitogen-activated protein kinase 10"
                     /db_xref="GeneID:26414"
                     /db_xref="MGI:MGI:1346863"
     exon            1..126
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..1527
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /EC_number="2.7.11.24"
                     /note="isoform 7 is encoded by transcript variant 7; JNK3
                     beta1 protein kinase; JNK3 beta2 protein kinase; MAP
                     kinase 10; MAP kinase p49 3F12; c-Jun N-terminal kinase 3;
                     stress-activated protein kinase JNK3; SAPK/Erk/kinase 2"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 10 isoform 7"
                     /protein_id="NP_001394501.1"
                     /db_xref="GeneID:26414"
                     /db_xref="MGI:MGI:1346863"
                     /translation="MGDTGVSGAPMKEMAQVMRIAEVTEDGRVFMSLHFLYYCSEPTL
                     DVKIAFCQGFDKHVDVSSIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGS
                     GAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVF
                     TPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHR
                     DLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDI
                     WSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKY
                     AGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVW
                     YDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAA
                     VNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR"
     exon            127..198
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /inference="alignment:Splign:2.1.0"
     exon            199..368
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /inference="alignment:Splign:2.1.0"
     exon            369..498
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /inference="alignment:Splign:2.1.0"
     exon            499..557
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /inference="alignment:Splign:2.1.0"
     exon            558..696
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /inference="alignment:Splign:2.1.0"
     exon            697..862
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /inference="alignment:Splign:2.1.0"
     exon            863..934
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1117
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1242
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1306
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1384
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..6165
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2323..2328
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /note="hexamer: ATTAAA"
     polyA_site      2345
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /note="major polyA site"
     regulatory      6149..6154
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /note="hexamer: CATAAA"
     polyA_site      6165
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /note="major polyA site"
ORIGIN      
        1 aggtctgttg tacttgtgct gcaatgcagg agagctttgg agatgggaga tacaggggtt
       61 tccggagccc ccatgaagga gatggctcag gtgatgagaa tagctgaagt cactgaggat
      121 ggcagggtat ttatgagcct ccatttctta tactactgca gtgaaccaac cttggatgtg
      181 aaaattgcct tttgtcaggg attcgataaa cacgtggatg tgtcatctat tgccaaacat
      241 tacaacatga gcaaaagcaa ggtggacaac cagttctaca gtgtggaagt gggggactca
      301 accttcaccg ttcttaagcg ctaccagaac ctgaagccaa ttggctctgg ggctcaggga
      361 atagtctgtg ctgcgtacga cgctgtcctt gacagaaatg tggccattaa gaagctcagc
      421 agacccttcc agaaccaaac tcacgccaag agggcttacc gggagctggt cctcatgaag
      481 tgtgtgaacc ataaaaacat tattagctta ttaaatgttt ttacacccca gaaaacactg
      541 gaggagttcc aagatgtcta cttagtgatg gaactgatgg acgccaacct gtgtcaggtg
      601 attcagatgg agctggacca cgagcggatg tcttacttgc tgtaccagat gctgtgtggc
      661 atcaagcacc tccactccgc tgggatcatc cacagggact taaaacccag taacattgta
      721 gtcaagtctg attgcacact gaaaatcctc gacttcggac tggccaggac agcgggtaca
      781 agcttcatga tgactccgta tgtggtgacg cgatattaca gagcccctga ggtcatcctg
      841 ggcatgggct acaaggagaa cgtggacata tggtctgtgg gatgcatcat gggagaaatg
      901 gttcgccaca aaatcctctt tcccggaagg gactatattg accagtggaa caaagtcatc
      961 gagcagctag gaactccgtg tccagagttc atgaagaaat tgcagcccac agtcagaaac
     1021 tacgtggaga atcggcccaa gtacgcagga ctcaccttcc ccaagctctt tccagattcc
     1081 ctcttcccag cggattctga gcacaataaa cttaaagcca gccaagccag ggatttgttg
     1141 tctaagatgt tagtgattga cccagcgaag aggatatcgg tggacgacgc actgcagcat
     1201 ccgtacatca acgtttggta cgacccggct gaagtggagg cgcctccgcc tcagatatat
     1261 gataagcagc tggatgaaag ggagcacacc atcgaagaat ggaaagaact tatctacaag
     1321 gaggtaatga actcagaaga gaagactaag aatggcgtag tcaaaggcca gccctcgcct
     1381 tcaggtgcag cagtgaacag cagtgagagt ctccctccat cctcgtctgt caacgacatc
     1441 tcctccatgt ccaccgacca gaccctcgca tctgacactg acagcagcct ggaggcctcg
     1501 gcgggaccgt tgggttgttg caggtgacta gccgcctgcc tgcgaaaccc agcgttcttc
     1561 aggagatgac gcgatagaac acagcacaca tgcacacaca cagcttgctc tcacacacac
     1621 tcagcttgct cacacacaca cacacacata cacacaaaca cacactgtct ctctctcaca
     1681 cacacacact gtcacaacgc actcacgaaa ggtcaagaaa aaaataacaa tagagagatc
     1741 caacataaaa ttaagttaaa tttttctgcg tgcttctcca aagttctgta tcacagctga
     1801 gctgaaatgt atacttaact tctagttgcg ctcgctttgg tttccctcca gcagtgctta
     1861 ctacacaaga caaatcagac acaattagag aaacctttcc ctaaagtgta acttaagtgg
     1921 ctgcagaacc agcaacctgt aactgccctt caaatggcat gaggaggtgg gcacgggtcc
     1981 cgcccagcat gtgtgtgtct ctatctcgcg tctacctgct cttccggcct agtcagatgg
     2041 atgtagatac agatcccgca tgtgtctgta ttcaaacagc acttagagat gctcctgtca
     2101 gtgtcctcca ggctccacca agacacacac cggggtacca catggtccat ttcatgtgat
     2161 ctattactct gacataaatc catctgtaat atattgccag tatataagct gtttagtttg
     2221 ttaattgatt aagctgtatg tcttataaga gactatgtaa agggggaaaa tggaggcgtg
     2281 aactctcaga cccttgaaga tgtagcttcc gaatttgaac cgattaaatg gcacctgtat
     2341 accaatttgt agaaagaaca tatgtgatgc ttaaatccag ggtgggggga gggagggagc
     2401 aatagctttc aggttctaaa tagggttgtc ctttagatgg aagatgtgag tcaaagccaa
     2461 gggcgctctc tctggaagtc agtgagtagc agggaccaga gcgtattgct gcagtataga
     2521 ctgaacggaa ggaaaccact gcccaggggc cgggggatgg cgcatctgtg ttctaaacat
     2581 tggacactat tgtttatttt taaaattacg gtcaaaagag caagttgctg aaggaaggga
     2641 caggcgtcaa gacaggatca ttgtgcacaa atcccgggtg gtaaaagccc tttcccgaga
     2701 cacagtggag agaccttcat gtgactgact ttagagaaga ttgatggaga ttatagggca
     2761 tgtttcccat gtgtgagctg cttcccagag tcctcccctg ctgatatttt attccctctt
     2821 ctggaattgg ataacataat taaaataaaa tccccaaagc acacagagag atcttcagga
     2881 tagcatctcc aagcatcttc atgggctgtg ttttccctca gagggatttc ccaggcccct
     2941 tggtatgact ggtgtttcat acttattgat gtattttcat agatgtgtgt aatctgagaa
     3001 gggctgataa cctgactttt gtactgcagt agatacacga gagcaataac gccgtgccaa
     3061 cgtagctcct actagctagc attagcagcg actttgtcct aaagccatga aacgtttgtg
     3121 tgtttagtga aatcatctga atttagctca aatccccgag agatcctatc tgagcactca
     3181 gagaggcact gtgaaacatc gtggttatat acaaggcaat gcctgtgtgg cttctgagca
     3241 ataacaggcc aggcctggct tcccttcttc ctcccttggg tgaagcatcc actacagtta
     3301 tttgcactct ggccactttg gtgctcaccc ctgtggtgat atttcacctg aggaaaagtg
     3361 gaacgtgtga gcagatgaag gtaatgggcc tggcagatgg gaaagccttg actacagagg
     3421 aaacagcaat gccggggctc tgcaaactgc cttaaaccca acagcgtgga agatcttctc
     3481 tcttcaagca atagtcagtc agaagcctca gacccatccc caactcctgc caccaccaca
     3541 tccctccatt cccaacaaat acacacacac acacacacac acacacacac tacatacaga
     3601 caacacactg ctgtgtggcc attcctggga ttgcttccca cagcacggtt cattgcaaga
     3661 cgtgatattg aaaagggaga gaagagaagt ggtgggcggg agctagctag ctaccttcag
     3721 atcttagagg gtgcagctca ttcccctgga taaagatatc cgtctgtagc tggatctttt
     3781 ggttaatgtt gtggacaaag tgatctttat aaacactgat tcattttcat gatctctctc
     3841 cctttcccat ctaccttcgt tctttttttt tttctatttc ttaacttacc tgtattctct
     3901 tctttttctg tagtttgctt ttatgagtgt gatctctgca ctccctcacc ctatatcaca
     3961 ccagattaat gcccagacaa ctgcttgata gaaacaagtt tcaaggggga attccataat
     4021 aatcaagatg gtgacagaca ggcagggctc tcagcggaat ggcggatgtg cttaacagtc
     4081 aggatcctac tgacaagtgc tgaccatttc tactgggtag atgaaagcag gcaaatcaga
     4141 ttacctcgtc ttcccctcct tcaggttagc ctgggtacca gtagcacgtc tcctagtggc
     4201 cggcaccctt ggacagagat cccccatgga caagaaaata ggaagcaaat ctcttgggtt
     4261 ttaaatagca cattgaggga aagatgaaca tttagctcct ggatctcatg aaggattggt
     4321 ttttagctaa gccagggatg gatggaggag aaacaaccct gagggtcaat gtcaaaacat
     4381 tcccattgag acccccaatg ctctgagaat gttcacagta tacattatgc cctctagtgg
     4441 gtcttgctag gaaaaaaaaa aacccagtat ttattttatg taatatcggt tacacacaag
     4501 agtgttcttg ttttgggggc agagaactgt tctgagacct ggactgtgtt tgtggaagat
     4561 tcaaaggagc ttcatgtatt cattttgcaa cagaaggttg gcatagtgag gacttacaaa
     4621 tctgtccctt cagtaggcaa ccttggtcct taatatgttc catggtgttc tgtagaaagg
     4681 gagagggtgt atttttttgc tggttaggga gtgtttggtg ggtcagtgtg atcatttttt
     4741 ccaatgggat acattgacct tatagcccaa tttttttctt gtgcaataaa gatggaaact
     4801 aatacttcat ctctcagaat ccatcattag agcttcatag gtctttatcc cagggctgga
     4861 ctaggatgta gccaagtctt agcagttgga ggaaacatgc tcacttgatg gctcagtggt
     4921 agcgtggctg gcttctctca gtcagttatc actaccagaa cgagtatcat ataaaggcac
     4981 cgataacagc tgaccagtag atgagagaga cttggtcatg gagcatagaa caaactgaat
     5041 gcatgaacaa gacatcattc tgtgatctgt tagggcaaag actaactggt ctcattctac
     5101 agctcttaag tatttaccac agaggccagg ttatacaaaa tctactgctg ttccgttttc
     5161 ttagcaaata agaacgtact gtgttctgta aagaattttg ttaattaact ttgctgggaa
     5221 agataatgtt tatgatccag agagagcaga gaagtctttg gggggtgtgg attttgatcc
     5281 cagcttcttt gggtctgaag agcaatcctc tcaccactcc aacactcctg ccctcatgga
     5341 tacgtgcaca tgttaacttc aagagtccac tgtcttccac gtgtagcctt agaaatggca
     5401 ctaactaaac aaactaaaaa tggagaatgt aaacaaccaa atcagtcatt ttccttgcga
     5461 ctaaaatata aacggtatct cctctttggg cacccagaga gatctttgtt aattcacttt
     5521 ggtcagtcaa agcgaagtgg tagaattttt ttttttttac atgtgaactg ttcattttat
     5581 tcttgctcat gtgggaccaa cggccagtat atcccagtag agatgaattt cccagccctc
     5641 atttgccacc atttgtcctc cgtgtcatag gacaatagca gggtgcctac ctttgcctgc
     5701 tattctgcat gactggaccc ccccccaaaa aaaactactg atgaagagaa ttgtcctatg
     5761 tcagtgttta tgagatgtgt ctacagcacc ccccccccac acacacacat gttcacattt
     5821 gcccatatag ttctctcaac ctggaagcca aaatcatgta tgtccaatct cgttgcaaag
     5881 tcgtggaggt gagacaggct gtcactagcc tgataggttt gttgtgctct caatggtgtc
     5941 aaatatggga tcaaactcat tcaatccatg tctgtgttct ttctcacgtt cttttccatt
     6001 tttctctcat tttaaatatg tctgtggaaa agagcatgaa ttgaagaatt tgaattcttt
     6061 agactcttca cagttggaac caagtcaacg tattgtaatt tgtatgtctt atgaatcatt
     6121 aaagctgaag gaaatacgct tcccttctca taaaaccaaa caaaa
//
