LOCUS       NM_011949               5099 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript
            variant 1, mRNA.
ACCESSION   NM_011949
VERSION     NM_011949.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5099)
  AUTHORS   Palacio,V., Pancho,A., Morabito,A., Malkmus,J., He,Z., Soussi,G.,
            Zeller,R., Treutlein,B. and Zuniga,A.
  TITLE     Single-cell profiling of penta- and tetradactyl mouse limb buds
            identifies mesenchymal progenitors controlling digit numbers and
            identities
  JOURNAL   Nat Commun 16 (1), 1226 (2025)
   PUBMED   39890843
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5099)
  AUTHORS   Arriagada,C., Lin,E., Schonning,M. and Astrof,S.
  TITLE     Mesodermal fibronectin controls cell shape, polarity, and
            mechanotransduction in the second heart field during cardiac
            outflow tract development
  JOURNAL   Dev Cell 60 (1), 62-84 (2025)
   PUBMED   39413783
REFERENCE   3  (bases 1 to 5099)
  AUTHORS   Shen,C.L., Tsai,Y.Y., Chou,S.J., Chang,Y.M. and Tarn,W.Y.
  TITLE     RBM4-mediated intron excision of Hsf1 induces BDNF for cerebellar
            foliation
  JOURNAL   Commun Biol 7 (1), 1712 (2024)
   PUBMED   39738787
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5099)
  AUTHORS   Weberling,A., Siriwardena,D., Penfold,C., Christodoulou,N.,
            Boroviak,T.E. and Zernicka-Goetz,M.
  TITLE     Primitive to visceral endoderm maturation is essential for mouse
            epiblast survival beyond implantation
  JOURNAL   iScience 28 (1), 111671 (2024)
   PUBMED   39868030
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5099)
  AUTHORS   Blucher,R.O., Lim,R.S., Ritchie,M.E. and Western,P.S.
  TITLE     VEGF-dependent testicular vascularisation involves MEK1/2
            signalling and the essential angiogenesis factors, SOX7 and SOX17
  JOURNAL   BMC Biol 22 (1), 222 (2024)
   PUBMED   39354506
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5099)
  AUTHORS   Winston,B.W., Remigio,L.K. and Riches,D.W.
  TITLE     Preferential involvement of MEK1 in the tumor necrosis
            factor-alpha-induced activation of p42mapk/erk2 in mouse
            macrophages
  JOURNAL   J Biol Chem 270 (46), 27391-27394 (1995)
   PUBMED   7499190
REFERENCE   7  (bases 1 to 5099)
  AUTHORS   Harrouk,W. and Clarke,H.J.
  TITLE     Mitogen-activated protein (MAP) kinase during the acquisition of
            meiotic competence by growing oocytes of the mouse
  JOURNAL   Mol Reprod Dev 41 (1), 29-36 (1995)
   PUBMED   7619503
REFERENCE   8  (bases 1 to 5099)
  AUTHORS   L'Allemain,G., Her,J.H., Del Vecchio,R.L. and Weber,M.J.
  TITLE     Functional expression in mammalian cells of a full-length cDNA
            coding for the pp42/MAP kinase (p42mapk) protein
  JOURNAL   FEBS Lett 292 (1-2), 191-195 (1991)
   PUBMED   1659995
REFERENCE   9  (bases 1 to 5099)
  AUTHORS   Her,J.H., Wu,J., Rall,T.B., Sturgill,T.W. and Weber,M.J.
  TITLE     Sequence of pp42/MAP kinase, a serine/threonine kinase regulated by
            tyrosine phosphorylation
  JOURNAL   Nucleic Acids Res 19 (13), 3743 (1991)
   PUBMED   1649458
REFERENCE   10 (bases 1 to 5099)
  AUTHORS   Payne,D.M., Rossomando,A.J., Martino,P., Erickson,A.K., Her,J.H.,
            Shabanowitz,J., Hunt,D.F., Weber,M.J. and Sturgill,T.W.
  TITLE     Identification of the regulatory phosphorylation sites in
            pp42/mitogen-activated protein kinase (MAP kinase)
  JOURNAL   EMBO J 10 (4), 885-892 (1991)
   PUBMED   1849075
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB648734.1, AK132241.1 and AC154667.2.
            
            On Jan 7, 2006 this sequence version replaced NM_011949.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148853.1, SRR1660815.27506.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-679               BB648734.1         2-680
            680-2919            AK132241.1         668-2907
            2920-5099           AC154667.2         14891-17070
FEATURES             Location/Qualifiers
     source          1..5099
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 10.53 cM"
     gene            1..5099
                     /gene="Mapk1"
                     /gene_synonym="9030612K14Rik; ERK; Erk2; MAPK2; p41mapk;
                     p42mapk; Prkm1; PRKM2"
                     /note="mitogen-activated protein kinase 1"
                     /db_xref="GeneID:26413"
                     /db_xref="MGI:MGI:1346858"
     exon            1..358
                     /gene="Mapk1"
                     /gene_synonym="9030612K14Rik; ERK; Erk2; MAPK2; p41mapk;
                     p42mapk; Prkm1; PRKM2"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..1322
                     /gene="Mapk1"
                     /gene_synonym="9030612K14Rik; ERK; Erk2; MAPK2; p41mapk;
                     p42mapk; Prkm1; PRKM2"
                     /EC_number="2.7.11.24"
                     /note="ERT1; ERK-2; MAPK 1; MAPK 2; p42-MAPK; MAP kinase
                     1; MAP kinase 2; mitogen-activated protein kinase 2;
                     extracellular signal-regulated kinase 2"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 1"
                     /protein_id="NP_036079.1"
                     /db_xref="CCDS:CCDS27992.1"
                     /db_xref="GeneID:26413"
                     /db_xref="MGI:MGI:1346858"
                     /translation="MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNL
                     NKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIV
                     QDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCD
                     LKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAE
                     MLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRL
                     FPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELD
                     DLPKEKLKELIFEETARFQPGYRS"
     exon            359..541
                     /gene="Mapk1"
                     /gene_synonym="9030612K14Rik; ERK; Erk2; MAPK2; p41mapk;
                     p42mapk; Prkm1; PRKM2"
                     /inference="alignment:Splign:2.1.0"
     exon            542..731
                     /gene="Mapk1"
                     /gene_synonym="9030612K14Rik; ERK; Erk2; MAPK2; p41mapk;
                     p42mapk; Prkm1; PRKM2"
                     /inference="alignment:Splign:2.1.0"
     exon            732..848
                     /gene="Mapk1"
                     /gene_synonym="9030612K14Rik; ERK; Erk2; MAPK2; p41mapk;
                     p42mapk; Prkm1; PRKM2"
                     /inference="alignment:Splign:2.1.0"
     exon            849..963
                     /gene="Mapk1"
                     /gene_synonym="9030612K14Rik; ERK; Erk2; MAPK2; p41mapk;
                     p42mapk; Prkm1; PRKM2"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1095
                     /gene="Mapk1"
                     /gene_synonym="9030612K14Rik; ERK; Erk2; MAPK2; p41mapk;
                     p42mapk; Prkm1; PRKM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1205
                     /gene="Mapk1"
                     /gene_synonym="9030612K14Rik; ERK; Erk2; MAPK2; p41mapk;
                     p42mapk; Prkm1; PRKM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1331
                     /gene="Mapk1"
                     /gene_synonym="9030612K14Rik; ERK; Erk2; MAPK2; p41mapk;
                     p42mapk; Prkm1; PRKM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..5099
                     /gene="Mapk1"
                     /gene_synonym="9030612K14Rik; ERK; Erk2; MAPK2; p41mapk;
                     p42mapk; Prkm1; PRKM2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2897..2902
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mapk1"
                     /gene_synonym="9030612K14Rik; ERK; Erk2; MAPK2; p41mapk;
                     p42mapk; Prkm1; PRKM2"
                     /note="hexamer: AATAAA"
     polyA_site      2927
                     /gene="Mapk1"
                     /gene_synonym="9030612K14Rik; ERK; Erk2; MAPK2; p41mapk;
                     p42mapk; Prkm1; PRKM2"
                     /note="major polyA site"
     polyA_site      5066
                     /gene="Mapk1"
                     /gene_synonym="9030612K14Rik; ERK; Erk2; MAPK2; p41mapk;
                     p42mapk; Prkm1; PRKM2"
     regulatory      5069..5074
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mapk1"
                     /gene_synonym="9030612K14Rik; ERK; Erk2; MAPK2; p41mapk;
                     p42mapk; Prkm1; PRKM2"
                     /note="hexamer: ATTACA"
     polyA_site      5099
                     /gene="Mapk1"
                     /gene_synonym="9030612K14Rik; ERK; Erk2; MAPK2; p41mapk;
                     p42mapk; Prkm1; PRKM2"
ORIGIN      
        1 gacgcgaacc cttccctcct cccactcgta gcccgcccgt caggcaggaa ggctggcagt
       61 ggttctaccg gcggttaatt ctctcctctg tgttgtcctc cttcctcgtt cccgatcgcc
      121 ggcgggggcg gctacacggg cggcagcgcg gttcctgcgg gaagcgcagc ataagtcgag
      181 cggcagccgc gaagcgtcga accgaacgcg gcggcggcgg cggcggcggc ggctgtgcag
      241 ccaacatggc ggcggcggcg gcggcgggcc cggagatggt ccgcgggcag gtgttcgacg
      301 tagggccgcg ctacaccaac ctctcgtaca tcggagaagg cgcctacggc atggtttgct
      361 ctgcttatga taatctcaac aaagttcgag ttgctatcaa gaaaatcagt ccttttgagc
      421 accagaccta ctgtcaaaga accctaagag agataaaaat cttactgcgc ttcagacatg
      481 agaacatcat tggcatcaat gacatcatcc gggcaccaac cattgagcaa atgaaagatg
      541 tatatatagt acaggacctc atggagacgg acctttacaa gctcttgaag acacagcacc
      601 tcagcaatga ccacatctgc tattttcttt atcagatcct gagagggcta aagtatatcc
      661 attcagctaa cgttctgcac cgtgacctca agccttccaa cctcctgctg aacaccactt
      721 gtgatctcaa gatctgtgac tttggccttg cccgtgttgc agatccagat catgatcaca
      781 cagggttctt gacagagtac gtagccacac gttggtacag agctccagaa attatgttga
      841 attccaaggg ttataccaag tccattgata tttggtctgt gggctgcatc ctggcagaga
      901 tgctatccaa caggcctatc ttcccaggaa agcattacct tgaccagctg aatcacatcc
      961 tgggtattct tggatctcca tcacaggaag atctgaattg tataataaat ttaaaagcta
     1021 gaaactattt gctttctctc ccgcacaaaa ataaggtgcc atggaacagg ttgttcccaa
     1081 atgctgactc caaagctctg gatttactgg ataaaatgtt gacatttaac cctcacaaga
     1141 ggattgaagt tgaacaggct ctggcccacc catacctgga gcagtattat gacccaagtg
     1201 atgagcccat tgctgaagcg ccattcaagt ttgacatgga gttggacgac ttacctaagg
     1261 agaagctcaa agaactcatt tttgaagaga ctgctagatt ccagccagga tacagatctt
     1321 aaattggtca ggacaagggc tcagaggact ggacgagttc agatgtcggt gtccccccag
     1381 ttctttaccc tggtcctgtc ttcagcccgt ctcagcttac ccactcttga ctcctttgag
     1441 cctttcagag gggcagtttc tggtagtagc agcttttata ctttcacgga attccttcag
     1501 tccagagagt tctggcagca ggccgtgcag cagtgtgcac tttcaatgca cttaactgct
     1561 tactgttgtt tagtcacgaa ctgctttctg gtttgaaaga tgcagtggtt cctccctgtt
     1621 ctgaatcctt tctccatatc atgtgctgaa ccatcagcct catcagaggg agagtctttc
     1681 cagacttgtt ccagttactg gcacctcact tcacagtagg gaggctagga cataaggcac
     1741 cttaagtcag tgacagctcc aaatttgcac ttcatctgtt ggctagtaac tgtctaccta
     1801 gacagtagga gcttgtgggt atccctggat ggtattacag gctacagggg caggggcttc
     1861 tgttgcagga gtcctttggg gctattttcc tgtgtatcat gttagtccta aatttaaggt
     1921 atgtactatt tgcccagctt tttaaaaatt tgatcattgt ttaaatgaaa taggaaggaa
     1981 gcattgcacc agcagtatct gttgttctgc agattttata tggttacttg tatcgtaatg
     2041 gaggtggagc tcttgccaaa atgttacatg ctatccttag ccagagagtg aaagtaacag
     2101 ctgtgcttgt catttactga aaggtggaca cacacaaagc tgtggaagtt tccagaacag
     2161 tagagagcaa gctgacctag atgttcaggg cagagctcca tataaccttg aacagccaca
     2221 cagaaggctg tttgcgtaac cacattcact acctagggat ttagctaaaa ggaacactgc
     2281 atctttaaat gagaaagtgt acagttcttc tcctgcagca tgtcagcatc tcgagctcac
     2341 ttttcagcag tgtaatgact tgtatgtaat aaagccttga tgggctctcc tcatgaagct
     2401 ctgctctgtt gccaagttag agatgtttct ggtactgctg agttaatgtc ataaaaggct
     2461 agcagtaact gttcgagctc tcttttattt ccttctctcc tatattttgt tcctgcactg
     2521 tgtgctgtgg agttgatggt gttatcccag tgcggtgcct ccagaccccc tcactgctct
     2581 ctgatgagaa atatgccttg ttcaatactt actgtgctct tgcatgactg ttaaggtttc
     2641 tgtgcagaga ccaatgtcca agtgtcacat cctttgattg aacgaaatct gttgtgacct
     2701 ctgagttgta ttccatgaag agaatgctac ccagaagata atgtagaaaa gataattata
     2761 ttgttaactt ttcatttctc agctgtcctt ttgttttctt ggtttttatt ttttattttg
     2821 acatcaatgg aaaatgggtt ctataaagac tgcctgctag tatgaacagc aatgcaatgc
     2881 acttgtaact catggaaata aatgtacatc tttatcttta cacccatgat aagattcagt
     2941 gttgattttc tctggattgg tgtgtcctaa gtaggcactc ataatcaatt tatggcttgt
     3001 gcttcagaca aaaatgttca tgggccttac tctacttctc cccactccac cctacccccc
     3061 atgcactgcc cctcacagca gtttacgtat atggctggga aaggtccttt tcagctgcac
     3121 atggtgccat gcatcgttaa tcccagcatt cagaagtcag aggcaggtgg atctctgaat
     3181 ggaagcaggc ctgatttgca tagggaggtc caagacagct ggaactctat aggtcctgtc
     3241 tcaaaaaaaa cagagtcctc cccgtctgcc tctcagcagc aaatgaatct gacatgatcc
     3301 tctctaaaac aggtctcaag tagtcagatg ttgatgatgg cacccaaaca tgcccaagtt
     3361 aggatctggt tccctctgaa aagggccttc ttgcctctgt atcctagagc tgtaggaagg
     3421 gctgttcaag atctcatgta cctgctacca agttcaaggt agcacatacc tcacctggct
     3481 aaagaatggc tgactcatcc cagaaaccag atctcagttc ttggcctaaa tccctgcttt
     3541 tcacttccac acatgaagcc cactggcatt gaaggaatag aggttcagct ttcattgata
     3601 cagtagtggt cagttttcct ttttcttttt gtcttttttt ttaaagcact gactgttctc
     3661 ctacttgttt ctttttcata tttttaatcc catgagatta atttgcattc ttgtgaataa
     3721 ggaaaccata gcctcatctt ctcgaggtct gagctttctg cccttcctgg cactgtggag
     3781 aggggttggt gtgagatcac tcacttcatc ctagtcactg tatcacaagt gtggctttca
     3841 tgtagccatt gtaaatgaca gctcagagct gtcaggtata gaaacgctca ttattttggt
     3901 tctcatgttt ctaaaaatgt ttggataacg tcatctgcat actggtgtca ttgggtgcct
     3961 ctactattca tacacataga taagctgtct ggtggatggg ctttttgtcc aagtcttaat
     4021 atgtgaggga aaaaaaccca aaaacatgaa aacatttagc atgaagaaga tagctatcca
     4081 acaatcccag agcgcttgat gataccggca ttcagagctg acactgacct actctgtggt
     4141 gcatttattc tgcccccacc ctcatccctc tcatttgagg acaggcaaca cttgggctgg
     4201 gcatgactgt tagttttggg aagctgtgaa ttaacagcag ctatctctga ggaatcacaa
     4261 aggtagacac ctacactgca tgccacatag tattcagacc acttagggag acttccattt
     4321 gcttaggata atatttacat taatattagt agttaggttt gaacttttgg tgacttctat
     4381 actacggtaa cacattcata tatgcatatg ctttgggtcc ttcatactac ttttatattt
     4441 gtaaatcagt gttttggagc aattccaagt ttaagggaaa tatttttgta aatgtgatgg
     4501 ttttgaaaat ctgagcaatt cttttgctta caagtttttt taaagcattt gtgctttaaa
     4561 attgtgctag tgtttggaat atgataccct ataacccaga taagaaacat aagaatggag
     4621 taaacgctgt cgcttgtcgt gctatgccca gcttggcgtg ctggatcagc agtgggactc
     4681 cggagtccct agggtcacac cagctcacct gcagcttgtt gcctttctgt gccgtccgcc
     4741 cgcccttcag agcactccag aaagttctga catggctctg tatctgctct gtactgtgga
     4801 tgcctttttg gtgttgtatc ccaaactgca tagattattt aggataatga taagtttaaa
     4861 aaattaatgt tgaagaaaga ttttattaag aatttaaatg ttttttcatt atattgttaa
     4921 acttgaacat ttatctgtgg cttatgtgat ttggttaata tgtataaaaa ttgtaagagg
     4981 tttatatttc atcttaattc ttttgatgtt gtaaacgtgc ttttcaattc attatttgaa
     5041 tgtttatggc acctgacttg taaaaagaat tacaaaaaaa aaaatcctta gaatcatta
//
