LOCUS       NM_001358787            4030 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus microtubule-associated protein 7 (Map7), transcript
            variant 3, mRNA.
ACCESSION   NM_001358787 XM_006512578
VERSION     NM_001358787.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4030)
  AUTHORS   Tymanskyj,S.R. and Ma,L.
  TITLE     MAP7 Prevents Axonal Branch Retraction by Creating a Stable
            Microtubule Boundary to Rescue Polymerization
  JOURNAL   J Neurosci 39 (36), 7118-7131 (2019)
   PUBMED   31391261
  REMARK    GeneRIF: MAP7 binds to the acetylated and stable region of
            individual microtubules and rescues microtubule polymerization in
            developing sensory neurons.
REFERENCE   2  (bases 1 to 4030)
  AUTHORS   Chaudhary,A.R., Lu,H., Krementsova,E.B., Bookwalter,C.S.,
            Trybus,K.M. and Hendricks,A.G.
  TITLE     MAP7 regulates organelle transport by recruiting kinesin-1 to
            microtubules
  JOURNAL   J Biol Chem 294 (26), 10160-10171 (2019)
   PUBMED   31085585
  REMARK    GeneRIF: MAP7 does not alter the force exerted by a single
            kinesin-1 motor, but instead increases its binding rate to the
            microtubule
REFERENCE   3  (bases 1 to 4030)
  AUTHORS   Pan,X., Cao,Y., Stucchi,R., Hooikaas,P.J., Portegies,S., Will,L.,
            Martin,M., Akhmanova,A., Harterink,M. and Hoogenraad,C.C.
  TITLE     MAP7D2 Localizes to the Proximal Axon and Locally Promotes
            Kinesin-1-Mediated Cargo Transport into the Axon
  JOURNAL   Cell Rep 26 (8), 1988-1999 (2019)
   PUBMED   30784582
  REMARK    GeneRIF: MAP7D2 interacts with all three kinesin-1 family members
            and accumulates in the proximal axon through its N-terminal
            microtubule-binding domain.  Depletion of MAP7D2 results in reduced
            axonal cargo entry.
REFERENCE   4  (bases 1 to 4030)
  AUTHORS   Tymanskyj,S.R., Yang,B., Falnikar,A., Lepore,A.C. and Ma,L.
  TITLE     MAP7 Regulates Axon Collateral Branch Development in Dorsal Root
            Ganglion Neurons
  JOURNAL   J Neurosci 37 (6), 1648-1661 (2017)
   PUBMED   28069923
REFERENCE   5  (bases 1 to 4030)
  AUTHORS   He,D., Marie,C., Zhao,C., Kim,B., Wang,J., Deng,Y., Clavairoly,A.,
            Frah,M., Wang,H., He,X., Hmidan,H., Jones,B.V., Witte,D., Zalc,B.,
            Zhou,X., Choo,D.I., Martin,D.M., Parras,C. and Lu,Q.R.
  TITLE     Chd7 cooperates with Sox10 and regulates the onset of CNS
            myelination and remyelination
  JOURNAL   Nat Neurosci 19 (5), 678-689 (2016)
   PUBMED   26928066
REFERENCE   6  (bases 1 to 4030)
  AUTHORS   Hildebrandt,A.L., Cantwell,A.M., Rule,M.C. and King,T.R.
  TITLE     The H-mshi antigen is conserved among standard BALB/cBy, C57BL/6J,
            and wild-derived CAST/Ei and SPRET/Ei inbred strains of mice
  JOURNAL   Immunogenetics 49 (7-8), 666-672 (1999)
   PUBMED   10369925
REFERENCE   7  (bases 1 to 4030)
  AUTHORS   Rule,M.C., Mutcherson,R.J. 2nd, Foss,A.D., Nguyen,T.K., Myrie,K.A.
            and King,T.R.
  TITLE     Mouse male sterility and histoincompatibility (mshi) maps between
            the D10Mit51/168/212 cluster and D10Mit213
  JOURNAL   Mamm Genome 10 (5), 447-450 (1999)
   PUBMED   10337616
REFERENCE   8  (bases 1 to 4030)
  AUTHORS   Fabre-Jonca,N., Allaman,J.M., Radlgruber,G., Meda,P., Kiss,J.Z.,
            French,L.E. and Masson,D.
  TITLE     The distribution of murine 115-kDa epithelial
            microtubule-associated protein (E-MAP-115) during embryogenesis and
            in adult organs suggests a role in epithelial polarization and
            differentiation
  JOURNAL   Differentiation 63 (4), 169-180 (1998)
   PUBMED   9745708
REFERENCE   9  (bases 1 to 4030)
  AUTHORS   Turner,J.P., Carpentino,J.E., Cantwell,A.M., Hildebrandt,A.L.,
            Myrie,K.A. and King,T.R.
  TITLE     Molecular genetic mapping of the mouse male sterility and
            histoincompatibility (mshi) mutation on proximal chromosome 10
  JOURNAL   Genomics 39 (1), 1-7 (1997)
   PUBMED   9027480
REFERENCE   10 (bases 1 to 4030)
  AUTHORS   Ward-Bailey,P.F., Johnson,K.R., Handel,M.A., Harris,B.S. and
            Davisson,M.T.
  TITLE     A new mouse mutation causing male sterility and
            histoincompatibility
  JOURNAL   Mamm Genome 7 (11), 793-797 (1996)
   PUBMED   8875885
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY264190.1, AB098611.1, AK014575.1 and BC052637.1.
            
            On Dec 9, 2017 this sequence version replaced XM_006512578.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219380.37744.1,
                                           SRR1660811.62692.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-336               BY264190.1         3-338
            337-511             AB098611.1         104-278
            512-2345            AK014575.1         290-2123
            2346-4030           BC052637.1         2167-3851
FEATURES             Location/Qualifiers
     source          1..4030
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 9.75 cM"
     gene            1..4030
                     /gene="Map7"
                     /gene_synonym="E-MAP-115; MAP-7; mshi; mste; Mtap7; ste"
                     /note="microtubule-associated protein 7"
                     /db_xref="GeneID:17761"
                     /db_xref="MGI:MGI:1328328"
     exon            1..300
                     /gene="Map7"
                     /gene_synonym="E-MAP-115; MAP-7; mshi; mste; Mtap7; ste"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..2426
                     /gene="Map7"
                     /gene_synonym="E-MAP-115; MAP-7; mshi; mste; Mtap7; ste"
                     /note="isoform 3 is encoded by transcript variant 3;
                     ensconsin; epithelial microtubule-associated protein of
                     115 kDa"
                     /codon_start=1
                     /product="ensconsin isoform 3"
                     /protein_id="NP_001345716.1"
                     /db_xref="GeneID:17761"
                     /db_xref="MGI:MGI:1328328"
                     /translation="MPGSATAIRQERLKKTPARTIPLALFTINEEDELQKSGNARRPK
                     ASDGYKVQEKRTAPSRPTSTVSGQTSNHSGNKPDPPPVLRVDDRQRLARERREEREKQ
                     LAARETVWLEREERARQHYERHLEARKKKLEDQRLKEERRRAAVEEKRRQRLEEDKER
                     HEAVVRRTMERSQKPRQKSNRWSWGSPLHGSSSIHSGDPDRRSVSTMNLSKHVDPVIS
                     KRLSSSSATLLNSPDRARRLQLSPWESSVVSRLLTPTHSFLARSKSTAALSGDTASCS
                     PIIMPFKAAHSRNPVDRPKLFVTPPEGSARRRTIHGLASHKREREREHVPFHVSPGAR
                     RTLSPSNLKARSPAPARLWLPSKSMPHLPGTPRPASSLPPGSVRAASAQAPSSSPGNI
                     RPVKREVKVEPEKKDPLPAVKSRVPLVKVEEVTVEEGTPVKPPEPAAPASAPIATPAP
                     APATDPAPVPAPSSTVTVGVVPKTSAGTTDPEEATRLLAEKRRLAREQREKEERERKE
                     KEELERQKIEELARRVAEERSRREEEARRLEEEQAREKEELALRLAEEERERWEREEV
                     ERVQKQKEEEARAREEAERARQEREKHFQKEEQERLERKKRLEEIMRRTRRTETADKK
                     TTEQRNGDIAKGVLTGEPEVPALPCMASSGNGESAESPHGVALQQSEVTTESSPDLEK
                     QPNENGMSIQNENFEEVINLPVGSKASRLDVTNENPEIPLKPILAFNDEGTLGPLPQV
                     DGVQTQQTAEVI"
     exon            301..399
                     /gene="Map7"
                     /gene_synonym="E-MAP-115; MAP-7; mshi; mste; Mtap7; ste"
                     /inference="alignment:Splign:2.1.0"
     exon            400..477
                     /gene="Map7"
                     /gene_synonym="E-MAP-115; MAP-7; mshi; mste; Mtap7; ste"
                     /inference="alignment:Splign:2.1.0"
     exon            478..641
                     /gene="Map7"
                     /gene_synonym="E-MAP-115; MAP-7; mshi; mste; Mtap7; ste"
                     /inference="alignment:Splign:2.1.0"
     exon            642..759
                     /gene="Map7"
                     /gene_synonym="E-MAP-115; MAP-7; mshi; mste; Mtap7; ste"
                     /inference="alignment:Splign:2.1.0"
     exon            760..870
                     /gene="Map7"
                     /gene_synonym="E-MAP-115; MAP-7; mshi; mste; Mtap7; ste"
                     /inference="alignment:Splign:2.1.0"
     exon            871..984
                     /gene="Map7"
                     /gene_synonym="E-MAP-115; MAP-7; mshi; mste; Mtap7; ste"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1109
                     /gene="Map7"
                     /gene_synonym="E-MAP-115; MAP-7; mshi; mste; Mtap7; ste"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1225
                     /gene="Map7"
                     /gene_synonym="E-MAP-115; MAP-7; mshi; mste; Mtap7; ste"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1479
                     /gene="Map7"
                     /gene_synonym="E-MAP-115; MAP-7; mshi; mste; Mtap7; ste"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1708
                     /gene="Map7"
                     /gene_synonym="E-MAP-115; MAP-7; mshi; mste; Mtap7; ste"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1883
                     /gene="Map7"
                     /gene_synonym="E-MAP-115; MAP-7; mshi; mste; Mtap7; ste"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..1985
                     /gene="Map7"
                     /gene_synonym="E-MAP-115; MAP-7; mshi; mste; Mtap7; ste"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2036
                     /gene="Map7"
                     /gene_synonym="E-MAP-115; MAP-7; mshi; mste; Mtap7; ste"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2094
                     /gene="Map7"
                     /gene_synonym="E-MAP-115; MAP-7; mshi; mste; Mtap7; ste"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2194
                     /gene="Map7"
                     /gene_synonym="E-MAP-115; MAP-7; mshi; mste; Mtap7; ste"
                     /inference="alignment:Splign:2.1.0"
     exon            2195..2415
                     /gene="Map7"
                     /gene_synonym="E-MAP-115; MAP-7; mshi; mste; Mtap7; ste"
                     /inference="alignment:Splign:2.1.0"
     exon            2416..4010
                     /gene="Map7"
                     /gene_synonym="E-MAP-115; MAP-7; mshi; mste; Mtap7; ste"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3919..3924
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Map7"
                     /gene_synonym="E-MAP-115; MAP-7; mshi; mste; Mtap7; ste"
                     /note="hexamer: ATTAAA"
     polyA_site      3942
                     /gene="Map7"
                     /gene_synonym="E-MAP-115; MAP-7; mshi; mste; Mtap7; ste"
                     /note="major polyA site"
     regulatory      3982..3987
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Map7"
                     /gene_synonym="E-MAP-115; MAP-7; mshi; mste; Mtap7; ste"
                     /note="hexamer: AATAAA"
     polyA_site      4010
                     /gene="Map7"
                     /gene_synonym="E-MAP-115; MAP-7; mshi; mste; Mtap7; ste"
ORIGIN      
        1 agttgccaag tagctggtag tatctgtcag ctgttctcac tgtttaccca taggggatct
       61 attacaagtg ctcaaatgaa caggcagctt aggagctagc agcttctggg agctgcaatt
      121 acataagcat atatatttaa tataattgcc gaacaagtag cagcgttatg cctgggtcag
      181 ctacagcgat ccgacaagag agactgaaga agactcctgc aaggacaatt ccccttgctc
      241 tattcaccat taatgaggaa gatgagctgc agaagagtgg aaatgccaga agacccaaag
      301 cgtctgatgg ctataaagta caagagaaga gaactgcccc cagccgcccc acttctacag
      361 tttcaggaca aactagcaac cactcaggaa acaaaccaga tcccccacct gtgctacggg
      421 ttgatgaccg gcagcggcta gccagagaac gccgagagga acgagaaaaa cagctagctg
      481 cacgagaaac cgtctggcta gagagagaag aacgagcccg gcagcactat gagagacatc
      541 tggaggcgag gaagaagaag ctggaggacc aacggctgaa ggaggagcgg aggagggctg
      601 cggtggagga gaagcggagg cagaggctgg aggaggacaa ggagcgccat gaagctgttg
      661 tccgacggac gatggaaagg agccagaagc caaggcagaa gtctaaccgc tggtcctggg
      721 gaagccctct ccatgggagc tcgagcatcc acagtggaga tccagacagg cgctcagttt
      781 ccaccatgaa tctttcgaaa catgttgatc ctgtcattag caagcggctc tcctcctcgt
      841 ctgcaacttt gctaaactct ccagatagag ctcgccgcct gcagctcagc ccctgggaga
      901 gcagcgttgt tagcagactt ctgacgccca cacattcgtt cctggccaga agcaaaagca
      961 cggccgcctt gtctggagac acagcatctt gcagccccat catcatgccc ttcaaagctg
     1021 cacactctag aaacccagtg gaccgaccaa aactctttgt aacaccgcct gagggctctg
     1081 cacgaaggag gaccattcat ggactagcga gccataaaag agagcgagaa agagaacacg
     1141 ttcccttcca cgtttccccg ggcgcccgca ggactctgtc tccatctaat ctcaaagcga
     1201 ggtcaccggc tccagcccgc ctttggctcc catccaagtc catgcctcat ctgcctggta
     1261 ctccccggcc tgcatcctcc ttgcctcccg gctcagtcag agctgcttcc gctcaggccc
     1321 cctcctcctc tcctggcaac atccggcctg tcaagagaga agtgaaagtg gagcctgaga
     1381 agaaagaccc tttacccgca gtaaagagca gggtgccatt agtgaaggta gaggaggtca
     1441 cagtcgaaga ggggacaccc gtgaagccac ctgagcctgc tgctccagcc tcggccccca
     1501 ttgcaacccc agcccctgct ccagctacgg acccggcccc agtccctgca ccatcatcca
     1561 ctgtgactgt cggtgtagtt cctaagactt ctgcaggcac caccgaccca gaggaggcta
     1621 cgaggttgct ggctgagaag aggcgtctag ccagagagca gagggagaag gaggaacggg
     1681 agaggaagga aaaggaagag ctggagagac aaaagataga ggaattggcc cgtagggtgg
     1741 ctgaagagcg aagtcgcagg gaagaagaag cccgcaggct ggaagaggag caggctcgag
     1801 agaaagagga gctggcgctg cgtctggctg aggaggagcg ggagcggtgg gagagggagg
     1861 aggtggagcg cgtgcagaag cagaaagaag aagaagcccg agcccgggag gaggcagaga
     1921 gggctcggca ggaacgagag aagcatttcc agaaagaaga gcaggaacgg ctggagagga
     1981 agaagcgact tgaagagatt atgagaagaa ccaggaggac agagaccgct gataagaaaa
     2041 ccactgagca aagaaatggt gacatagcca aaggagttct cactggagag ccagaagtac
     2101 ctgcactgcc gtgtatggcc tcttcaggaa acggagagtc tgcagagagc ccacatggag
     2161 tcgctttaca gcaatcagaa gtgaccacag agagttctcc agatttggaa aaacagccaa
     2221 atgaaaacgg aatgtccata caaaatgaaa attttgaaga agttataaac ttacctgttg
     2281 gatcaaaagc gtccagatta gatgtcacca atgagaaccc agaaattcct ttgaaaccaa
     2341 ttttggcctt taatgatgaa gggacacttg ggcccctacc tcaggtggat ggtgtgcaga
     2401 cacaacagac cgcagaagtt atatgagtgt ctcctccaaa gaaccaaagc aaacgttttc
     2461 tacaatgaat ggaacttcag gctccgctcg aagcagctcc tccctctggt tttctaaaga
     2521 gttcctgacc atcgttttta aaagacgtat taaagccagc taaagacagc agactcagta
     2581 gctttcctga tcgttttcgc caacagaaag agatggctcc ttaatctgat accctgagat
     2641 ggcattttcc agtgtgtttc ttcttagtaa atcaattttt tttctttgtt ctttaaaaac
     2701 acaaaagagc attttattat aaaaagaaat ggactggcaa ggcgtgatta tcacacagat
     2761 cttttttcat ttttaaactt cagtatataa gattagcaaa aataaaatac cttttactat
     2821 gtaacacttg acagtgggta tctctttgcc ctccaggcag agtgagcgga aggtatttaa
     2881 acaaattgga ttgtttaaat attactacct ggctctcgta aacacagctc gtcgcgggca
     2941 tcctgcagac cctgctgcca cagccttctg agactcctct tacagaacta cactggcaag
     3001 tttgaaaatg tgtaaacatt tttttacagc aagaaaataa tttgctgtcc tttttgtttt
     3061 ctgtttttgt ttttgttttc ctactttttg gagaatgggt ttctctgtgt agccctggct
     3121 gttctagaac tggctctgca gaccagactg acctcggact cagtctctgc ttcctgagtg
     3181 ccgagatcga aggcgtgcgc caaccccgcc tggctcagcc gtcctcttaa gtgatatgtt
     3241 tataaaagct ttttttcagc tagataaatt aaaacaaggc agggtgcaga catgctctag
     3301 cagacgtctc cgcatgccgc cgtgggagcg tgaatgtccc tgtgaggcgc tctgaagttg
     3361 tatgctgctg ccacccacag tgagggtagg acttctctcc ctttgcctta cgtgatcaca
     3421 aatgatgtgg gggaaataaa tatttaatat tcctttagat caaagaattt ggttctgctc
     3481 gtttcagagc aatgaaaaat aagtgatgtc acgttgacgt tgggggacaa ggactgacat
     3541 agatgtcctt ggtgtagagg gactgtcagc ctctcctgtc ttatcattct tcactcctgc
     3601 tgctcagccc tgctgtataa acttgcactt tcatttgcta atataaattc aattttattt
     3661 tcccacttac gagacgacca atgagagatg gagacaggag cgccaagggc aatggtgtat
     3721 ccctcccact atgatgtatt ggttttatac taagagcaat tggttaatct acaagattta
     3781 atgtgagact atttattcat ctattggggt tcttttaaat ccaagcatac aatctttatc
     3841 aacagtttgt aaaacattgt taaaacatca gtttgtgggg tttccctatt tggttgtcct
     3901 tatacatcta gatattgtat taaaaaaaat ctgttcagca aacttgttct atttatttaa
     3961 atctaccaaa cataaaatac aaataaaatg tttgacatag ttttaccgta aaaaaaaaaa
     4021 aaaaaaaaaa
//
