LOCUS       NM_010837               3447 bp    mRNA    linear   ROD 24-APR-2024
DEFINITION  Mus musculus microtubule-associated protein 6 (Map6), transcript
            variant 1, mRNA.
ACCESSION   NM_010837
VERSION     NM_010837.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3447)
  AUTHORS   de Souza,D.A.R., Mathieu,H., Deloulme,J.C. and Barbier,E.L.
  TITLE     Evaluation of kernel low-rank compressed sensing in preclinical
            diffusion magnetic resonance imaging
  JOURNAL   Front Neurosci 17, 1172830 (2023)
   PUBMED   37332879
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3447)
  AUTHORS   Boulan,B., Ravanello,C., Peyrel,A., Bosc,C., Delphin,C., Appaix,F.,
            Denarier,E., Kraut,A., Jacquier-Sarlin,M., Fournier,A.,
            Andrieux,A., Gory-Faure,S. and Deloulme,J.C.
  TITLE     CRMP4-mediated fornix development involves Semaphorin-3E signaling
            pathway
  JOURNAL   Elife 10, e70361 (2021)
   PUBMED   34860155
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3447)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3447)
  AUTHORS   Gory-Faure,S., Powell,R., Jonckheere,J., Lante,F., Denarier,E.,
            Peris,L., Nguyen,C.H., Buisson,A., Lafanechere,L. and Andrieux,A.
  TITLE     Pyr1-Mediated Pharmacological Inhibition of LIM Kinase Restores
            Synaptic Plasticity and Normal Behavior in a Mouse Model of
            Schizophrenia
  JOURNAL   Front Pharmacol 12, 627995 (2021)
   PUBMED   33790791
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3447)
  AUTHORS   Galiano,M.R., Bosc,C., Schweitzer,A., Andrieux,A., Job,D. and
            Hallak,M.E.
  TITLE     Astrocytes and oligodendrocytes express different STOP protein
            isoforms
  JOURNAL   J Neurosci Res 78 (3), 329-337 (2004)
   PUBMED   15389836
REFERENCE   6  (bases 1 to 3447)
  AUTHORS   Bosc,C., Andrieux,A. and Job,D.
  TITLE     STOP proteins
  JOURNAL   Biochemistry 42 (42), 12125-12132 (2003)
   PUBMED   14567673
REFERENCE   7  (bases 1 to 3447)
  AUTHORS   Andrieux,A., Salin,P.A., Vernet,M., Kujala,P., Baratier,J.,
            Gory-Faure,S., Bosc,C., Pointu,H., Proietto,D., Schweitzer,A.,
            Denarier,E., Klumperman,J. and Job,D.
  TITLE     The suppression of brain cold-stable microtubules in mice induces
            synaptic defects associated with neuroleptic-sensitive behavioral
            disorders
  JOURNAL   Genes Dev 16 (18), 2350-2364 (2002)
   PUBMED   12231625
  REMARK    GeneRIF: STOP-/- mice had no detectable defects in brain anatomy
            but showed synaptic defects, with depleted synaptic vesicle pools
            and impaired synaptic plasticity, associated with severe behavioral
            disorders.
REFERENCE   8  (bases 1 to 3447)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 3447)
  AUTHORS   Denarier,E., Fourest-Lieuvin,A., Bosc,C., Pirollet,F., Chapel,A.,
            Margolis,R.L. and Job,D.
  TITLE     Nonneuronal isoforms of STOP protein are responsible for
            microtubule cold stability in mammalian fibroblasts
  JOURNAL   Proc Natl Acad Sci U S A 95 (11), 6055-6060 (1998)
   PUBMED   9600916
REFERENCE   10 (bases 1 to 3447)
  AUTHORS   Denarier,E., Aguezzoul,M., Jolly,C., Vourc'h,C., Roure,A.,
            Andrieux,A., Bosc,C. and Job,D.
  TITLE     Genomic structure and chromosomal mapping of the mouse STOP gene
            (Mtap6)
  JOURNAL   Biochem Biophys Res Commun 243 (3), 791-796 (1998)
   PUBMED   9501006
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ444318.1, AK018193.2, AK087413.1, BE951502.1 and BE980868.1.
            
            On Aug 25, 2006 this sequence version replaced NM_010837.2.
            
            Transcript Variant: This variant (1) encodes the longest protein
            (isoform 1), also known as N-STOP.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.174310.1, AK018193.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-520               BQ444318.1         2-521
            521-2099            AK018193.2         1-1579
            2100-2101           AK087413.1         2063-2064
            2102-2877           AK018193.2         1582-2357
            2878-2956           BE951502.1         490-568             c
            2957-3424           AK018193.2         2436-2903
            3425-3447           BE980868.1         1-23                c
FEATURES             Location/Qualifiers
     source          1..3447
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.05 cM"
     gene            1..3447
                     /gene="Map6"
                     /gene_synonym="2810411E12Rik; Map-6; Mtap6; STOP"
                     /note="microtubule-associated protein 6"
                     /db_xref="GeneID:17760"
                     /db_xref="MGI:MGI:1201690"
     exon            1..1867
                     /gene="Map6"
                     /gene_synonym="2810411E12Rik; Map-6; Mtap6; STOP"
                     /inference="alignment:Splign:2.1.0"
     CDS             576..3296
                     /gene="Map6"
                     /gene_synonym="2810411E12Rik; Map-6; Mtap6; STOP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     stable tubule-only polypeptide"
                     /codon_start=1
                     /product="microtubule-associated protein 6 isoform 1"
                     /protein_id="NP_034967.2"
                     /db_xref="CCDS:CCDS21479.1"
                     /db_xref="GeneID:17760"
                     /db_xref="MGI:MGI:1201690"
                     /translation="MAWPCITRACCIARFWNQLDKADIAVPLVFTKYSEATEHPGAPP
                     QPPAPLQPALAPPSRAVAIETQPAQGESDAVARATGPAPGPSVDRETVAAPGRSGLGL
                     GAASASTSGSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRA
                     WPLPRRGDHPWIPKPVQIPATSQPSQPVLGVPKRRPQSQERGPMQLSADARDPEGAGG
                     AGVLAAGKASGVDQRDTRRKAGPAWMVTRNEGHEEKPLPPAQSQTQEGGPAAGKASGA
                     DQRDTRRKAGPAWMVTRSEGHEEKPLPPAQSQTQEGGPAAGKASGADQRDTRRKAGPA
                     WMVTRTEGHEETPLPPAQSQTQEGGPAAGKASGADERDTRRKAGPAWMVRRSEGHEQT
                     PAAHAQGTGPEGGKGRAVADALNRQIREEVASTVSSSYRNEFRAWTDIKPVKPIKAKP
                     QYKPPDDKMVHETSYSAQFKGEANKPSAADNKAMDRRRIRSLYSEPFKECPKVEKPSV
                     QSSKPKKTSTSHKPPRKAKDKQVVSGQAAKKKTTEGPSATKPDDKEQSKEMNNKLAEA
                     KESRVKPTSDASKNRGPVTKEPHKDQGSVAPGLPKGQEPLKDQGPVVPGLPKDQVPVV
                     PGSLKGQSPTAPGPTKDQGAVLLGPVKDLGPVAPAPIKVQDHIASELLKNKDSVPLAP
                     AKAQSPLLPEPLKNQSPVVPASTKDQSFPTPAPRKDPGPVIPEPEKDRAPTVPERRKD
                     QHVSIMASLKNEAPMVPESVKNQGLAGPELVKDTGTDTTAPRYLKGHDSVFVAPVKNQ
                     GPVIPEPVKSQDPIIPALAKDQGPMLPEPPKNQSPVVLGPIKNQDPIIPVPLKGQDPL
                     VPAPTKDQGPTAPDPLKTQGPKGTQLPTVSPSPPVMIPTVPHTEYIEGSP"
     exon            1868..2081
                     /gene="Map6"
                     /gene_synonym="2810411E12Rik; Map-6; Mtap6; STOP"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2278
                     /gene="Map6"
                     /gene_synonym="2810411E12Rik; Map-6; Mtap6; STOP"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..3431
                     /gene="Map6"
                     /gene_synonym="2810411E12Rik; Map-6; Mtap6; STOP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3408..3413
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Map6"
                     /gene_synonym="2810411E12Rik; Map-6; Mtap6; STOP"
                     /note="hexamer: AATAAA"
     polyA_site      3431
                     /gene="Map6"
                     /gene_synonym="2810411E12Rik; Map-6; Mtap6; STOP"
                     /note="major polyA site"
ORIGIN      
        1 cttgctgagc cgcaaaaaag ggtggggccg cctctctgca gcagaagacg acagcggcag
       61 cggctgcggc atcaccgggg gtatagatag aggccgtttt gctctctgct ctgtctgggt
      121 tggaggtgac cgctgccaag cctcgctagg cggccggctg aaccagacgg aaaggagata
      181 aaagcctgct tgcggatcct tccctgcgcc atggcttaag cccacagcct ctttgccaag
      241 catctccttg ctctgccggg gtctgctaga caccgcagtc gcagagaggg cgcgcccaga
      301 cgccctaggc ctggactctg ggacgctgag cctcgctcct attcttcact gcccacagca
      361 gctcctctgc agcaggcgtt tgcagccggc aatcgaggga ctttacggac tttatctcag
      421 cggtaccttg tccccgggtg ctctttgagg gtggaggacg aggcaaaggg cttctaaggg
      481 aaggaagcgg tgggaaccac attggcgggt ctgggttggg gttaaaggga gattggagat
      541 ttgatttagg accacaaaaa ggctttgtgg ctaacatggc gtggccgtgc atcacaaggg
      601 cctgctgcat cgcccgcttc tggaaccagc tggacaaggc ggacattgcg gtgccgctgg
      661 ttttcaccaa gtactcggag gccaccgaac acccaggcgc ccctccgcag ccgccagctc
      721 cgctgcagcc cgcgttagcg cccccctcgc gtgctgtcgc catagagacg cagccagccc
      781 agggagagtc ggatgcagtt gcccgggcaa cagggcctgc gcccgggccc agcgtcgacc
      841 gcgagactgt agccgccccc ggccggagcg ggctgggctt gggcgcggcc tcagcctcca
      901 cttccggctc aggccccgcg gactcggtga tgcgacagga ctaccgcgcc tggaaagtgc
      961 agcggcccga gccaagctgc cggccgcgca gcgagtacca gccgtccgac gcgcccttcg
     1021 agcgcgagac ccagtaccag aaggacttcc gcgcctggcc gctgccccgg cgcggggacc
     1081 atccctggat ccccaagccg gtgcaaatcc ctgcgacttc gcagccttcc caacctgttc
     1141 tcggggtgcc caagcgtcgg cctcagagcc aagagcgcgg gcccatgcaa ctttctgctg
     1201 atgcccggga cccggagggt gctggaggag ccggggtgct ggcggcagga aaggcgtccg
     1261 gtgtagacca gcgcgacaca cgtaggaagg cagggccagc atggatggtg actcgcaacg
     1321 aagggcacga agagaagcct ctgcccccag cccaatccca gacccaggag ggtggtcctg
     1381 cagctggaaa ggcgtccggt gcagatcagc gtgacacacg caggaaggca gggccagcat
     1441 ggatggtgac tcgcagcgaa gggcacgaag agaagcctct gcccccagcc caatcccaga
     1501 cccaggaggg tggtcctgca gctggaaagg cgtccggtgc agatcagcgt gacacacgca
     1561 ggaaggctgg acccgcgtgg atggtgactc gcacggaagg gcacgaggag acgccgctgc
     1621 cacccgccca gtctcagacc caggagggcg gccccgcagc tggaaaggca tctggtgcag
     1681 acgagcgcga cacgaggagg aaggcggggc cggcctggat ggtgcgtcgc tcggaggggc
     1741 acgaacagac acccgctgcc catgcccaag gcacagggcc tgaaggaggc aaggggcgcg
     1801 cggtggcaga tgccctcaac aggcaaatcc gggaggaggt ggcgagtaca gtaagcagct
     1861 cttacaggaa tgaattcaga gcatggactg acatcaagcc tgtgaaaccc atcaaagcca
     1921 agccccagta caagccccca gatgacaaga tggttcatga gaccagctac agcgcccagt
     1981 tcaaagggga ggccaataag cccagtgcag cggacaacaa ggccatggat cgcagaagaa
     2041 tacggagcct ctacagtgag cctttcaagg aatgcccgaa ggtagagaaa cctagtgttc
     2101 agagttccaa accaaaaaag acctcaacga gccataaacc cccaaggaag gccaaagaca
     2161 agcaggtggt gtcgggccag gctgccaaga aaaagaccac agagggcccc agtgctacca
     2221 aacccgacga caaggagcaa agcaaagaga tgaacaataa actggctgag gcgaaagaga
     2281 gccgggtcaa acccaccagt gatgcatcta agaaccgagg tcctgtaacc aaagagccac
     2341 acaaggatca aggctctgtg gccccaggtc ttccaaaagg ccaagagcct ttgaaggatc
     2401 aaggccctgt ggtgccagga ctgccaaaag atcaagttcc tgtagtccca gggtccttaa
     2461 agggtcagag ccctacagcc ccgggcccta caaaggatca aggtgctgtg ctcttagggc
     2521 ccgtgaagga tctaggtcca gtggccccag cacccatcaa ggttcaggac cacatagcat
     2581 ctgagctttt aaagaataaa gattctgtcc ccttagcacc agccaaagcc caaagccctc
     2641 tgttgccaga gcctctgaag aatcagagtc ctgtggttcc agcaagcact aaggatcaaa
     2701 gcttcccaac accagcacct cggaaggacc caggccctgt gatccccgag cccgagaagg
     2761 atcgagctcc cacggtccca gagcgtagga aggaccagca tgtctccatc atggcctctt
     2821 tgaagaacga agctcctatg gtccccgagt ctgtgaagaa tcaaggctta gcaggcccag
     2881 agctagttaa agatacaggt acagatacaa cagcccccag gtatctgaag ggacatgatt
     2941 ctgtgtttgt agcacctgtg aagaaccaag gtccagtgat ccctgagcca gtgaagagcc
     3001 aagaccccat tatcccagca ctagccaagg accaaggtcc catgctccca gagcctccaa
     3061 agaatcaaag ccctgtggtt cttgggccta taaagaatca agaccctata atcccagtac
     3121 ctttgaaggg tcaggatccc ctggtgccag ccccaacaaa ggaccaaggt cctacagccc
     3181 ctgaccctct gaagactcaa ggtcccaaag gcactcaact gcccacagtc tcaccttcac
     3241 ccccagtcat gatcccaaca gttccccata cggaatatat tgagggatcc ccttgattgc
     3301 cctgaaatgc catgaaggag ctggcagtgg aagtgtttcc cttctgggga ggcaaagtca
     3361 tatatttaat ctgcatgaaa ctgtgctgta tagtcttgct ggaatctaat aaaattggtt
     3421 cctctggctc aaaaaaaaaa aaaaaaa
//
