LOCUS       NP_001239129            1288 aa            linear   ROD 04-JUN-2024
DEFINITION  mitogen-activated protein kinase kinase kinase kinase 4 isoform 1
            [Mus musculus].
ACCESSION   NP_001239129
VERSION     NP_001239129.1
DBSOURCE    REFSEQ: accession NM_001252200.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1288)
  AUTHORS   Juin,A., Spence,H.J. and Machesky,L.M.
  TITLE     Dichotomous role of the serine/threonine kinase MAP4K4 in
            pancreatic ductal adenocarcinoma onset and metastasis through
            control of AKT and ERK pathways
  JOURNAL   J Pathol 262 (4), 454-466 (2024)
   PUBMED   38229581
  REMARK    GeneRIF: Dichotomous role of the serine/threonine kinase MAP4K4 in
            pancreatic ductal adenocarcinoma onset and metastasis through
            control of AKT and ERK pathways.
REFERENCE   2  (residues 1 to 1288)
  AUTHORS   Huang,H., Kuang,X., Zou,Y., Zeng,J., Du,H., Tang,H., Long,C.,
            Mao,Y., Yu,X., Wen,C., Yan,J. and Shen,H.
  TITLE     MAP4K4 is involved in the neuronal development of retinal
            photoreceptors
  JOURNAL   Exp Eye Res 233, 109524 (2023)
   PUBMED   37290629
  REMARK    GeneRIF: MAP4K4 is involved in the neuronal development of retinal
            photoreceptors.
REFERENCE   3  (residues 1 to 1288)
  AUTHORS   Molla,M.R., Shimizu,A., Komeno,M., Rahman,N.I.A., Soh,J.E.C.,
            Nguyen,L.K.C., Khan,M.R., Tesega,W.W., Chen,S., Pang,X.,
            Tanaka-Okamoto,M., Takashima,N., Sato,A., Suzuki,T. and Ogita,H.
  TITLE     Vascular smooth muscle RhoA counteracts abdominal aortic aneurysm
            formation by modulating MAP4K4 activity
  JOURNAL   Commun Biol 5 (1), 1071 (2022)
   PUBMED   36207400
  REMARK    GeneRIF: Vascular smooth muscle RhoA counteracts abdominal aortic
            aneurysm formation by modulating MAP4K4 activity.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1288)
  AUTHORS   Lin,Y.C., Lu,Y.H., Lee,Y.C., Hung,C.S. and Lin,J.C.
  TITLE     Altered expressions and splicing profiles of Acin1 transcripts
            differentially modulate brown adipogenesis through an alternative
            splicing mechanism
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1863 (9), 194601 (2020)
   PUBMED   32629174
REFERENCE   5  (residues 1 to 1288)
  AUTHORS   Wu,C., Watts,M.E. and Rubin,L.L.
  TITLE     MAP4K4 Activation Mediates Motor Neuron Degeneration in Amyotrophic
            Lateral Sclerosis
  JOURNAL   Cell Rep 26 (5), 1143-1156 (2019)
   PUBMED   30699345
  REMARK    GeneRIF: These studies highlight a MAP4K4-initiated signaling
            cascade that induces motor neuron degeneration.
REFERENCE   6  (residues 1 to 1288)
  AUTHORS   Poinat,P., De Arcangelis,A., Sookhareea,S., Zhu,X., Hedgecock,E.M.,
            Labouesse,M. and Georges-Labouesse,E.
  TITLE     A conserved interaction between beta1 integrin/PAT-3 and
            Nck-interacting kinase/MIG-15 that mediates commissural axon
            navigation in C. elegans
  JOURNAL   Curr Biol 12 (8), 622-631 (2002)
   PUBMED   11967148
REFERENCE   7  (residues 1 to 1288)
  AUTHORS   Xue,Y., Wang,X., Li,Z., Gotoh,N., Chapman,D. and Skolnik,E.Y.
  TITLE     Mesodermal patterning defect in mice lacking the Ste20 NCK
            interacting kinase (NIK)
  JOURNAL   Development 128 (9), 1559-1572 (2001)
   PUBMED   11290295
REFERENCE   8  (residues 1 to 1288)
  AUTHORS   Becker,E., Huynh-Do,U., Holland,S., Pawson,T., Daniel,T.O. and
            Skolnik,E.Y.
  TITLE     Nck-interacting Ste20 kinase couples Eph receptors to c-Jun
            N-terminal kinase and integrin activation
  JOURNAL   Mol Cell Biol 20 (5), 1537-1545 (2000)
   PUBMED   10669731
REFERENCE   9  (residues 1 to 1288)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (residues 1 to 1288)
  AUTHORS   Su,Y.C., Han,J., Xu,S., Cobb,M. and Skolnik,E.Y.
  TITLE     NIK is a new Ste20-related kinase that binds NCK and MEKK1 and
            activates the SAPK/JNK cascade via a conserved regulatory domain
  JOURNAL   EMBO J 16 (6), 1279-1290 (1997)
   PUBMED   9135144
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ142598.1, BB651050.1, BC145390.1, U88984.1, AV445090.1,
            BQ571658.1, AK159799.1 and BF721981.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC145390.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1288
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 18.53 cM"
     Protein         1..1288
                     /product="mitogen-activated protein kinase kinase kinase
                     kinase 4 isoform 1"
                     /EC_number="2.7.11.1"
                     /note="MEKKK 4; MEK kinase kinase 4; nck-interacting
                     kinase; HPK/GCK-like kinase HGK; MAPK/ERK kinase kinase
                     kinase 4; NCK interacting kinase"
                     /calculated_mol_wt=146585
     Region          8..289
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(31..34,37,39,52,54,83,105..108,153,157..158,160,
                     170..171)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270806"
     Region          970..1268
                     /region_name="CNH"
                     /note="Domain found in NIK1-like kinases, mouse citron and
                     yeast ROM1, ROM2; smart00036"
                     /db_xref="CDD:214481"
     CDS             1..1288
                     /gene="Map4k4"
                     /gene_synonym="9430080K19Rik; HGK; Nik"
                     /coded_by="NM_001252200.1:318..4184"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS78573.1"
                     /db_xref="GeneID:26921"
                     /db_xref="MGI:MGI:1349394"
ORIGIN      
        1 mandspaksl vdidlsslrd pagifelvev vgngtygqvy kgrhvktgql aaikvmdvte
       61 deeeeiklei nmlkkyshhr niatyygafi kksppghddq lwlvmefcga gsitdlvknt
      121 kgntlkedwi ayisreilrg lahlhihhvi hrdikgqnvl ltenaevklv dfgvsaqldr
      181 tvgrrntfig tpywmapevi acdenpdaty dyrsdlwscg itaiemaega pplcdmhpmr
      241 alfliprnpp prlkskkwsk kffsfiegcl vknymqrpst eqllkhpfir dqpnerqvri
      301 qlkdhidrtr kkrgekdete yeysgseeee eevpeqegep ssivnvpges tlrrdflrlq
      361 qenkerseal rrqqllqeqq lreqeeykrq llaerqkrie qqkeqrrrle eqqrrerear
      421 rqqereqrrr eqeekrrlee lerrrkeeee rrraeeekrr vereqeyirr qleeeqrhle
      481 ilqqqllqeq amllhdhrrp haqqqppppq qqdrskpsfh apepkphydp adrarevedr
      541 frktnhsspe aqakqtgrgl eppvpsrses fsngnsesvh palqrpaepq vqwshlaslk
      601 nnvspvsrsh sfsdpspkfa hhhlrsqdpc ppsrseglsq ssdsksevpe ptqkawsrsd
      661 sdevpprvpv rttsrspvls rrdsplqggg qqnsqagqrn stssieprll werveklvpr
      721 pgsgsssgss nsgsqpgshp gsqsgsgerf rvrssskseg spsprqesaa kkpddkkevf
      781 rplkpagevd ltalakelra vedvrpphkv tdyssssees gttdeeeedv eqegaddsts
      841 gpedtraass pnlsngetes vktmivhddv esepamtpsk egtlivrqtq sasstlqkhk
      901 ssssftpfid prllqispss gttvtsvvgf scdglrpeai rqdptrkgsv vnvnptntrp
      961 qsdtpeirky kkrfnseilc aalwgvnllv gtesglmlld rsgqgkvypl isrrrfqqmd
     1021 vleglnvlvt isgkkdklrv yylswlrnki lhndpevekk qgwttvgdle gcvhykvvky
     1081 erikflvial kssvevyawa pkpyhkfmaf ksfgellhkp llvdltveeg qrlkviygsc
     1141 agfhavdvds gsvydiylpt hiqcsikpha iiilpntdgm ellvcyedeg vyvntygrit
     1201 kdvvlqwgem ptsvayirsn qtmgwgekai eirsvetghl dgvfmhkraq rlkflcernd
     1261 kvffasvrsg gssqvyfmtl grtsllsw
//
