LOCUS       NM_001290345            4176 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus mitogen-activated protein kinase kinase kinase kinase
            3 (Map4k3), transcript variant 1, mRNA.
ACCESSION   NM_001290345 XM_006524193
VERSION     NM_001290345.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4176)
  AUTHORS   Chi,J.N., Yang,J.Y., Hsueh,C.H., Tsai,C.Y., Chuang,H.C. and
            Tan,T.H.
  TITLE     MAP4K3/GLK inhibits Treg differentiation by direct phosphorylating
            IKKbeta and inducing IKKbeta-mediated FoxO1 nuclear export and
            Foxp3 downregulation
  JOURNAL   Theranostics 12 (13), 5744-5760 (2022)
   PUBMED   35966593
  REMARK    GeneRIF: MAP4K3/GLK inhibits Treg differentiation by direct
            phosphorylating IKKbeta and inducing IKKbeta-mediated FoxO1 nuclear
            export and Foxp3 downregulation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4176)
  AUTHORS   Chuang,H.C., Tsai,C.Y., Hsueh,C.H. and Tan,T.H.
  TITLE     GLK-IKKbeta signaling induces dimerization and translocation of the
            AhR-RORgammat complex in IL-17A induction and autoimmune disease
  JOURNAL   Sci Adv 4 (9), eaat5401 (2018)
   PUBMED   30214937
  REMARK    GeneRIF: GLK induces IL-17A transcription by activating AhR and
            ROR-gammat.GLK controls IL-17A production and autoimmune responses
            through AhR.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4176)
  AUTHORS   Gineste,C., De Winter,J.M., Kohl,C., Witt,C.C., Giannesini,B.,
            Brohm,K., Le Fur,Y., Gretz,N., Vilmen,C., Pecchi,E., Jubeau,M.,
            Cozzone,P.J., Stienen,G.J., Granzier,H., Labeit,S.,
            Ottenheijm,C.A., Bendahan,D. and Gondin,J.
  TITLE     In vivo and in vitro investigations of heterozygous nebulin
            knock-out mice disclose a mild skeletal muscle phenotype
  JOURNAL   Neuromuscul Disord 23 (4), 357-369 (2013)
   PUBMED   23375831
REFERENCE   4  (bases 1 to 4176)
  AUTHORS   Chuang,H.C., Lan,J.L., Chen,D.Y., Yang,C.Y., Chen,Y.M., Li,J.P.,
            Huang,C.Y., Liu,P.E., Wang,X. and Tan,T.H.
  TITLE     The kinase GLK controls autoimmunity and NF-kappaB signaling by
            activating the kinase PKC-theta; in T cells
  JOURNAL   Nat Immunol 12 (11), 1113-1118 (2011)
   PUBMED   21983831
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4176)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4176)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI430883.1, AK014711.1, BQ442103.1, CF167620.1, CO433380.1,
            CD353921.1, CK618209.1, AK079249.1 and AA289270.1.
            
            On Mar 12, 2014 this sequence version replaced XM_006524193.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The exon combination of this RefSeq is inferred
            because this gene lacks full-length transcript support. This exon
            combination is supported by tiling of partial mouse transcripts and
            by full-length orthologous alignments.
            
            CCDS Note: This CCDS representation has an inferred exon
            combination because this gene lacks full-length transcript support.
            This representation is supported by tiling of partial mouse
            transcripts and by full-length orthologous alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164139
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               AI430883.1         1-126
            127-901             AK014711.1         116-890
            902-1287            BQ442103.1         318-703
            1288-1432           CF167620.1         356-500
            1433-2139           CO433380.1         20-726
            2140-2384           CD353921.1         429-673
            2385-2941           CK618209.1         69-625
            2942-4154           AK079249.1         270-1482
            4155-4176           AA289270.1         228-249
FEATURES             Location/Qualifiers
     source          1..4176
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 50.97 cM"
     gene            1..4176
                     /gene="Map4k3"
                     /gene_synonym="4833416M01Rik; 4833416M07Rik;
                     9530052P13Rik; Glk; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1"
                     /note="mitogen-activated protein kinase kinase kinase
                     kinase 3"
                     /db_xref="GeneID:225028"
                     /db_xref="MGI:MGI:2154405"
     exon            1..232
                     /gene="Map4k3"
                     /gene_synonym="4833416M01Rik; 4833416M07Rik;
                     9530052P13Rik; Glk; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..2821
                     /gene="Map4k3"
                     /gene_synonym="4833416M01Rik; 4833416M07Rik;
                     9530052P13Rik; Glk; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1; MEK
                     kinase kinase 3; MAPK/ERK kinase kinase kinase 3; germinal
                     center kinase-related protein kinase"
                     /codon_start=1
                     /product="mitogen-activated protein kinase kinase kinase
                     kinase 3 isoform 1"
                     /protein_id="NP_001277274.1"
                     /db_xref="CCDS:CCDS70847.1"
                     /db_xref="GeneID:225028"
                     /db_xref="MGI:MGI:2154405"
                     /translation="MNPGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAI
                     KVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIY
                     HVTGPLSELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQ
                     ITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLH
                     PMRALFLMTKSNFQPPKLKDKLKWSNSFHHFVKMALTKNPKKRPNAEKLLQHPFVTQP
                     LTRSLAIELLDKVNNPDHSTYHDFDDDDPEPLVAVPHRIPSTSRNVREEKTRSEINFG
                     QVKFDPPLRKETEPHHELPDSDGFFDSSEEIYYTARSNLDLQLEYGQGHQSHCFLGGN
                     KSLLKSVEEELHQRGHVAHLEDDEGDDDDSKHSTMKAKVPPPLPPKPKSIFIPQDTHS
                     AEDGNQGTIKRCPSSGSPAKPSHVPPRPPPPRLPPQKPAVLGNGVNSFQLNGERDGSL
                     YQQQSEQRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNGCPLKIHCATSWI
                     NPDTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSVSGKASQL
                     YSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPRKFAVSAKIPETKWCQKCCVVRNPY
                     TGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIEFPMPCPLRMFEMLVVPEQEYPLVCV
                     GVSRGRDFNQVVRFETVNPNSTSSWFTESDAPQTSVTHVTQLERDTILVCLDCCIKIV
                     NLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQGRSFRSNEVTQEISDNT
                     RIFRLLGSDRVVVLESRPTDNPTANSNLYILAGHENSY"
     exon            233..290
                     /gene="Map4k3"
                     /gene_synonym="4833416M01Rik; 4833416M07Rik;
                     9530052P13Rik; Glk; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            291..381
                     /gene="Map4k3"
                     /gene_synonym="4833416M01Rik; 4833416M07Rik;
                     9530052P13Rik; Glk; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            382..446
                     /gene="Map4k3"
                     /gene_synonym="4833416M01Rik; 4833416M07Rik;
                     9530052P13Rik; Glk; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            447..502
                     /gene="Map4k3"
                     /gene_synonym="4833416M01Rik; 4833416M07Rik;
                     9530052P13Rik; Glk; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            503..550
                     /gene="Map4k3"
                     /gene_synonym="4833416M01Rik; 4833416M07Rik;
                     9530052P13Rik; Glk; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            551..593
                     /gene="Map4k3"
                     /gene_synonym="4833416M01Rik; 4833416M07Rik;
                     9530052P13Rik; Glk; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            594..666
                     /gene="Map4k3"
                     /gene_synonym="4833416M01Rik; 4833416M07Rik;
                     9530052P13Rik; Glk; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            667..798
                     /gene="Map4k3"
                     /gene_synonym="4833416M01Rik; 4833416M07Rik;
                     9530052P13Rik; Glk; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            799..861
                     /gene="Map4k3"
                     /gene_synonym="4833416M01Rik; 4833416M07Rik;
                     9530052P13Rik; Glk; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            862..943
                     /gene="Map4k3"
                     /gene_synonym="4833416M01Rik; 4833416M07Rik;
                     9530052P13Rik; Glk; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1054
                     /gene="Map4k3"
                     /gene_synonym="4833416M01Rik; 4833416M07Rik;
                     9530052P13Rik; Glk; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1133
                     /gene="Map4k3"
                     /gene_synonym="4833416M01Rik; 4833416M07Rik;
                     9530052P13Rik; Glk; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1192
                     /gene="Map4k3"
                     /gene_synonym="4833416M01Rik; 4833416M07Rik;
                     9530052P13Rik; Glk; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1255
                     /gene="Map4k3"
                     /gene_synonym="4833416M01Rik; 4833416M07Rik;
                     9530052P13Rik; Glk; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1314
                     /gene="Map4k3"
                     /gene_synonym="4833416M01Rik; 4833416M07Rik;
                     9530052P13Rik; Glk; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1353
                     /gene="Map4k3"
                     /gene_synonym="4833416M01Rik; 4833416M07Rik;
                     9530052P13Rik; Glk; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1407
                     /gene="Map4k3"
                     /gene_synonym="4833416M01Rik; 4833416M07Rik;
                     9530052P13Rik; Glk; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1450
                     /gene="Map4k3"
                     /gene_synonym="4833416M01Rik; 4833416M07Rik;
                     9530052P13Rik; Glk; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1610
                     /gene="Map4k3"
                     /gene_synonym="4833416M01Rik; 4833416M07Rik;
                     9530052P13Rik; Glk; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1723
                     /gene="Map4k3"
                     /gene_synonym="4833416M01Rik; 4833416M07Rik;
                     9530052P13Rik; Glk; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1765
                     /gene="Map4k3"
                     /gene_synonym="4833416M01Rik; 4833416M07Rik;
                     9530052P13Rik; Glk; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1850
                     /gene="Map4k3"
                     /gene_synonym="4833416M01Rik; 4833416M07Rik;
                     9530052P13Rik; Glk; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1930
                     /gene="Map4k3"
                     /gene_synonym="4833416M01Rik; 4833416M07Rik;
                     9530052P13Rik; Glk; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..1991
                     /gene="Map4k3"
                     /gene_synonym="4833416M01Rik; 4833416M07Rik;
                     9530052P13Rik; Glk; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2109
                     /gene="Map4k3"
                     /gene_synonym="4833416M01Rik; 4833416M07Rik;
                     9530052P13Rik; Glk; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2168
                     /gene="Map4k3"
                     /gene_synonym="4833416M01Rik; 4833416M07Rik;
                     9530052P13Rik; Glk; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..2272
                     /gene="Map4k3"
                     /gene_synonym="4833416M01Rik; 4833416M07Rik;
                     9530052P13Rik; Glk; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2444
                     /gene="Map4k3"
                     /gene_synonym="4833416M01Rik; 4833416M07Rik;
                     9530052P13Rik; Glk; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2445..2513
                     /gene="Map4k3"
                     /gene_synonym="4833416M01Rik; 4833416M07Rik;
                     9530052P13Rik; Glk; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2514..2606
                     /gene="Map4k3"
                     /gene_synonym="4833416M01Rik; 4833416M07Rik;
                     9530052P13Rik; Glk; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2607..2677
                     /gene="Map4k3"
                     /gene_synonym="4833416M01Rik; 4833416M07Rik;
                     9530052P13Rik; Glk; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2678..2733
                     /gene="Map4k3"
                     /gene_synonym="4833416M01Rik; 4833416M07Rik;
                     9530052P13Rik; Glk; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2734..4156
                     /gene="Map4k3"
                     /gene_synonym="4833416M01Rik; 4833416M07Rik;
                     9530052P13Rik; Glk; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4133..4138
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Map4k3"
                     /gene_synonym="4833416M01Rik; 4833416M07Rik;
                     9530052P13Rik; Glk; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1"
                     /note="hexamer: AATAAA"
     polyA_site      4155
                     /gene="Map4k3"
                     /gene_synonym="4833416M01Rik; 4833416M07Rik;
                     9530052P13Rik; Glk; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1"
                     /note="major polyA site"
ORIGIN      
        1 gcggccgcgg cgtgcagccg ggcgattgtg accggcggcg gagccgggcc ggccgcgggc
       61 gctccctccg tgcggccccc gtgagcgccc cccctccccg ggccgggagg gaggtggggg
      121 gcacccgggg cccgccatga acccgggctt cgatctgtcc cgccggaacc cgcaggagga
      181 cttcgagctg atccagcgca tcggcagcgg cacctacggc gacgtctaca aggcacggaa
      241 tgtcaacact ggagaattag cagcaattaa agtgataaaa ttggaaccag gagaagactt
      301 tgcggttgta cagcaagaaa tcattatgat gaaagactgc aaacacccaa acattgttgc
      361 ttattttgga agctatctca ggcgagataa actttggatt tgcatggaat tctgtggagg
      421 tggctcttta caggacatat atcatgtaac tggacccctt tcagaactgc agattgcata
      481 tgttagcaga gaaactctac agggattgta ttaccttcac agtaaaggaa aaatgcaccg
      541 agatataaag ggcgctaaca ttctcctaac ggataatggt cacgtgaaac tagctgattt
      601 tggagtttct gcacagataa cagctacaat tgccaaacgg aagtccttca ttggaacgcc
      661 atattggatg gccccagaag tcgcggctgt tgagaggaaa ggcgggtaca atcaactgtg
      721 tgacctctgg gcggtgggca tcactgccat cgagctggcg gagctccagc cacccatgtt
      781 tgaccttcac ccgatgaggg cattgtttct aatgacaaaa agcaatttcc agcctcctaa
      841 actaaaagat aagttgaagt ggtcaaatag tttccatcat tttgtgaaga tggctcttac
      901 caaaaatcca aagaaaagac ccaatgcaga aaagctgtta cagcatccct ttgtcacaca
      961 gcctctgaca cggtctttgg caatcgagtt gctggacaaa gtgaataatc cagaccattc
     1021 cacataccac gattttgatg atgatgaccc agagcctctt gttgccgtac cacatagaat
     1081 tccttcaacg agtagaaatg tgagagaaga aaaaacacgc tcagagataa actttggcca
     1141 ggtaaaattt gatccgccct taaggaagga gacagagcca catcacgaac ttcccgacag
     1201 tgatggtttt ttcgacagtt cagaagaaat atactacact gcaagatcta atctggatct
     1261 gcaactagag tacggacaag gacaccaaag ccattgcttc ttaggtggca acaagagtct
     1321 tctgaagtct gttgaagagg aattacatca gcgaggacat gtggcacact tagaagatga
     1381 cgaaggcgac gatgacgact ctaagcattc aaccatgaaa gcaaaagtcc cgcctcctct
     1441 gccaccaaag cctaaatcca tcttcatacc acaggataca cattctgctg aggacggtaa
     1501 tcaaggaaca atcaagagat gtccctcatc agggagcccg gcaaagccat cccacgttcc
     1561 acctagacca cctccgccca ggttaccgcc acagaagcct gctgttttag gaaatggagt
     1621 gaactccttc cagctaaatg gtgagcgaga cggatcatta tatcagcagc agagtgagca
     1681 aagaggcaca aacctttcaa gaaaggagaa gaaggacgtc ccgaaaccaa ttagtaatgg
     1741 tcttccccca acacctaaag tgcatatggg agcgtgtttt tcaaaggttt ttaatggatg
     1801 tcccttgaaa atccactgtg ccacatcctg gataaaccca gacacgagag accagtactt
     1861 gatatttggc gctgaagagg gcatttatac ccttaatctc aatgaacttc atgaaacatc
     1921 aatggaacag ctgttccccc gcaggtgtac gtggctgtat gtgatgaaca attgcctgct
     1981 gtcagtctcg ggcaaagcct ctcagcttta ctcccacaac ttaccggggc ttttcgatta
     2041 tgcaagacag atgcagaagc ttccagtagc catcccagca cacaagctcc ccgaccgaat
     2101 actgcccagg aaatttgctg tatcagcaaa gattcctgaa accaaatggt gccagaagtg
     2161 ctgcgtggtg agaaatcctt acacgggcca taagtacctg tgcggggcgc ttcagaccag
     2221 cattgttcta ttagaatggg ttgagccaat gcagaaattt atgttaatta agcacataga
     2281 gtttcctatg ccgtgtccac tccggatgtt tgagatgctg gtggtccctg agcaggagta
     2341 ccctctggtc tgtgttggcg tcagcagagg gcgagacttc aaccaagtgg ttcggtttga
     2401 gacggtcaat cccaattcta cctcgtcgtg gtttacagag tcagatgccc cgcagacaag
     2461 cgtcactcat gtgacccagc tggagagaga caccatcctt gtgtgcttgg attgttgtat
     2521 aaaaatagtc aatctccaag gaaggttgaa atccagcagg aaattgtcat cagaactcac
     2581 cttcgatttc cagatagagt ccatagtttg tctacaagac agtgtgctag cgttctggaa
     2641 acacgggatg caaggtagaa gctttagatc taatgaggta acacaagaaa tttcagataa
     2701 cacaagaatc ttcagactcc ttggatctga cagggttgtg gttttggaaa gtcggccaac
     2761 tgataaccca acagcaaata gcaatttata catcttggcg ggtcacgaaa acagctactg
     2821 agacacggtg ttcttgacag tgacctgtgg agacagtgac cacagctgct gcaacgttag
     2881 tggaggagtg aagctatgca gaccctgcag gaacctagat tctgtttctt ataatttatt
     2941 gtggcatgag acagatggga gaacattttg ttttaagtgg tatggatata tttagcatat
     3001 tgaaccacac aagtgcttaa ttcattgtta tgtaatcttt gtacatataa gcagtatttt
     3061 tctgtgaaac ttcatattgc tgaaggcata cactaagaat ttatgtagat aatgtacttt
     3121 tatgagatgt aaaagtgtct tatctgtaca gatgtaaatg ttgatgaaaa tgcaactggg
     3181 gttaatattt taagaattct ttagtatatt cttgggtgtg gtcatattac aaaatgggat
     3241 gctggcaatg aaccaagaca ttaacactat tgtattttta ttatatataa tttagtaata
     3301 tggacataaa tcctgtaact tttaaaatgg taacgagctg taatcatttt ataatcttgt
     3361 ttttaatttt aatgcacgtg cactggtgtt tctcctgcac agagtattga catgtgatgt
     3421 gttgtcacag agagcctgtg acacccaccg tgaatacaac atctttttta catgtatttg
     3481 gattgttttc tatgtgaaac aaaccagtta accacctgtt gtagtaactg atctttttat
     3541 atttaaggag aattgtgtaa gataagcttg tctgtgctta ggatacacct tcgcaaaaac
     3601 ttaaatcatg gaatggcggt accacggtag aacactgcag ctgtcgccag ggttacagtg
     3661 cgcataagag caactcgcat tgctgaggag tccgcactag acatttcaca gtcacactga
     3721 agagctgtca cattccagag tgagctgatc aggtttctcg tgggctttta cttctgttgg
     3781 cattagttta tcacttccat atttctttag attttgagta ttaatacatg gccaaaataa
     3841 tttagttact acctcataca aacattataa tggttactac agatcacaag aagttagttt
     3901 ggttaaaatc attgttgatt ggttttttcc aatggagtgt atctgtctta tcaagataga
     3961 taccaagttg tagcaaagtg cacacctctg actctctttg gtatatgttc atatgttctt
     4021 tatattttga tgtgagtata tatacactaa gaacaagcta aattgtgatt tatgcttcat
     4081 ttattttaac tgataatggt tttaaatacg ttcctgattg tacatactgt aaaataaaca
     4141 tgttttttaa catgctaaaa aaaaaaaaaa aaaaaa
//
