LOCUS       NM_008279               2699 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus mitogen-activated protein kinase kinase kinase kinase
            1 (Map4k1), transcript variant 1, mRNA.
ACCESSION   NM_008279
VERSION     NM_008279.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2699)
  AUTHORS   Wang H, Moniruzzaman R, Li L, Ji B, Liu Y, Zuo X, Abbasgholizadeh
            R, Zhao J, Liu G, Wang R, Tang H, Sun R, Su X, Tan TH, Maitra A and
            Wang H.
  TITLE     Hematopoietic progenitor kinase 1 inhibits the development and
            progression of pancreatic intraepithelial neoplasia
  JOURNAL   J Clin Invest 133 (12), e163873 (2023)
   PUBMED   37140994
  REMARK    GeneRIF: Hematopoietic progenitor kinase 1 inhibits the development
            and progression of pancreatic intraepithelial neoplasia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2699)
  AUTHORS   Sawasdikosol S, Zha R, Fisher TS, Alzabin S and Burakoff SJ.
  TITLE     HPK1 Influences Regulatory T Cell Functions
  JOURNAL   Immunohorizons 4 (7), 382-391 (2020)
   PUBMED   32631900
  REMARK    GeneRIF: HPK1 Influences Regulatory T Cell Functions.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2699)
  AUTHORS   Liu J, Curtin J, You D, Hillerman S, Li-Wang B, Eraslan R, Xie J,
            Swanson J, Ho CP, Oppenheimer S, Warrack BM, McNaney CA, Nelson DM,
            Blum J, Kim T, Fereshteh M, Reily M, Shipkova P, Murtaza A, Sanjuan
            M, Hunt JT and Salter-Cid L.
  TITLE     Critical role of kinase activity of hematopoietic progenitor kinase
            1 in anti-tumor immune surveillance
  JOURNAL   PLoS One 14 (3), e0212670 (2019)
   PUBMED   30913212
  REMARK    GeneRIF: data provide novel findings that HKP1 kinase activity is
            critical in conferring suppressive functions of HPK1 in a wide
            range of immune cells including CD4+, CD8+, DC, NK to Tregs, and
            inactivation of kinase domain was sufficient to elicit robust
            anti-tumor immune responses.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2699)
  AUTHORS   Hernandez S, Qing J, Thibodeau RH, Du X, Park S, Lee HM, Xu M, Oh
            S, Navarro A, Roose-Girma M, Newman RJ, Warming S, Nannini M,
            Sampath D, Kim JM, Grogan JL and Mellman I.
  TITLE     The Kinase Activity of Hematopoietic Progenitor Kinase 1 Is
            Essential for the Regulation of T Cell Function
  JOURNAL   Cell Rep 25 (1), 80-94 (2018)
   PUBMED   30282040
  REMARK    GeneRIF: Results identify the importance of HPK1 kinase activity in
            the negative regulation of CD8 effector functions.
REFERENCE   5  (bases 1 to 2699)
  AUTHORS   Jakob SM, Pick R, Brechtefeld D, Nussbaum C, Kiefer F, Sperandio M
            and Walzog B.
  TITLE     Hematopoietic progenitor kinase 1 (HPK1) is required for
            LFA-1-mediated neutrophil recruitment during the acute inflammatory
            response
  JOURNAL   Blood 121 (20), 4184-4194 (2013)
   PUBMED   23460610
REFERENCE   6  (bases 1 to 2699)
  AUTHORS   Brenner D, Golks A, Kiefer F, Krammer PH and Arnold R.
  TITLE     Activation or suppression of NFkappaB by HPK1 determines
            sensitivity to activation-induced cell death
  JOURNAL   EMBO J 24 (24), 4279-4290 (2005)
   PUBMED   16341093
  REMARK    GeneRIF: suppression or activation of NFkappaB by HPK1 determines
            sensitivity to activation-induced cell death
REFERENCE   7  (bases 1 to 2699)
  AUTHORS   Lewitzky M, Harkiolaki M, Domart MC, Jones EY and Feller SM.
  TITLE     Mona/Gads SH3C binding to hematopoietic progenitor kinase 1 (HPK1)
            combines an atypical SH3 binding motif, R/KXXK, with a classical
            PXXP motif embedded in a polyproline type II (PPII) helix
  JOURNAL   J Biol Chem 279 (27), 28724-28732 (2004)
   PUBMED   15100220
  REMARK    GeneRIF: Mona/Gads SH3C binding to hematopoietic progenitor kinase
            1 (HPK1) combines an atypical SH3 binding motif, R/KXXK, with a
            classical PXXP motif embedded in a polyproline type II (PPII) helix
REFERENCE   8  (bases 1 to 2699)
  AUTHORS   Han A, Saijo K, Mecklenbrauker I, Tarakhovsky A and Nussenzweig MC.
  TITLE     Bam32 links the B cell receptor to ERK and JNK and mediates B cell
            proliferation but not survival
  JOURNAL   Immunity 19 (4), 621-632 (2003)
   PUBMED   14563325
REFERENCE   9  (bases 1 to 2699)
  AUTHORS   Schulze-Luehrmann J, Santner-Nanan B, Jha MK, Schimpl A, Avots A
            and Serfling E.
  TITLE     Hematopoietic progenitor kinase 1 supports apoptosis of T
            lymphocytes
  JOURNAL   Blood 100 (3), 954-960 (2002)
   PUBMED   12130508
  REMARK    GeneRIF: Hpk1 supports apoptosis of T lymphocytes by inhibiting the
            antiapoptotic action of NF-kappaB and inducing the proapoptotic
            activity of JNK.
REFERENCE   10 (bases 1 to 2699)
  AUTHORS   Kiefer F, Tibbles LA, Anafi M, Janssen A, Zanke BW, Lassam N,
            Pawson T, Woodgett JR and Iscove NN.
  TITLE     HPK1, a hematopoietic protein kinase activating the SAPK/JNK
            pathway
  JOURNAL   EMBO J 15 (24), 7013-7025 (1996)
   PUBMED   9003777
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166357.3 and AC165142.3.
            
            [WARNING] On Jan 10, 2024 this sequence was replaced by
            NM_008279.3.
            
            On May 25, 2006 this sequence version replaced NM_008279.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y09010.1, AK146273.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-201               AC166357.3         1060-1260           c
            202-259             AC166357.3         842-899             c
            260-350             AC166357.3         634-724             c
            351-381             AC166357.3         1-31                c
            382-415             AC165142.3         90126-90159         c
            416-471             AC165142.3         87570-87625         c
            472-519             AC165142.3         87434-87481         c
            520-562             AC165142.3         87243-87285         c
            563-635             AC165142.3         87086-87158         c
            636-767             AC165142.3         86068-86199         c
            768-830             AC165142.3         85617-85679         c
            831-912             AC165142.3         85437-85518         c
            913-1026            AC165142.3         84824-84937         c
            1027-1105           AC165142.3         84521-84599         c
            1106-1164           AC165142.3         83227-83285         c
            1165-1208           AC165142.3         83082-83125         c
            1209-1253           AC165142.3         82948-82992         c
            1254-1296           AC165142.3         81041-81083         c
            1297-1459           AC165142.3         80143-80305         c
            1460-1542           AC165142.3         79986-80068         c
            1543-1566           AC165142.3         78785-78808         c
            1567-1651           AC165142.3         78100-78184         c
            1652-1728           AC165142.3         75745-75821         c
            1729-1789           AC165142.3         75600-75660         c
            1790-1898           AC165142.3         74392-74500         c
            1899-1957           AC165142.3         74251-74309         c
            1958-2061           AC165142.3         73979-74082         c
            2062-2236           AC165142.3         73164-73338         c
            2237-2299           AC165142.3         72604-72666         c
            2300-2389           AC165142.3         72435-72524         c
            2390-2460           AC165142.3         72283-72353         c
            2461-2516           AC165142.3         71870-71925         c
            2517-2699           AC165142.3         70994-71176         c
FEATURES             Location/Qualifiers
     source          1..2699
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 16.94 cM"
     gene            1..2699
                     /gene="Map4k1"
                     /gene_synonym="Hpk1; mHPK1"
                     /note="mitogen-activated protein kinase kinase kinase
                     kinase 1"
                     /db_xref="GeneID:26411"
                     /db_xref="MGI:MGI:1346882"
     exon            1..201
                     /gene="Map4k1"
                     /gene_synonym="Hpk1; mHPK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..2586
                     /gene="Map4k1"
                     /gene_synonym="Hpk1; mHPK1"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1; HPK;
                     MEKKK 1; MEK kinase kinase 1; MAPK/ERK kinase kinase
                     kinase 1; hematopoietic progenitor kinase 1"
                     /codon_start=1
                     /product="mitogen-activated protein kinase kinase kinase
                     kinase 1 isoform 1"
                     /protein_id="NP_032305.2"
                     /db_xref="CCDS:CCDS39865.1"
                     /db_xref="GeneID:26411"
                     /db_xref="MGI:MGI:1346882"
                     /translation="MALVDPDIFNKDPREHYDLLQRLGGGTYGEVFKARDKVSKDLVA
                     LKMVKMEPDDDVATLQKEILMLKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDI
                     YQVTGSLSELQISYVCREVLQGLAYLHSEKKIHRDIKGANILINDCGEVKLADFGISA
                     QIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDV
                     HPLRVLFLMTKSGYQPPRLKEKSRWSSSFHNFVKVTLTKNSKKRPSATKMLSHQLVSQ
                     PGLNRGLILDLLDKMKNPGKGLPVDIEDEEPEPPPAIPRRIRSTYRASSLGIPDADCC
                     RRQMEFQRPRCVDCRPQAETVRLYPPAHFGSTSPRSQLSDSDDDYDDVDIPAPSENIP
                     PPLPPKPKFRSPSDDGSGGIRDDGQLSPGVLVRCASGPPPRTPRPGPPPATCSPHLTA
                     RSDPSLWNPAAPEPGQPPLVPPRKEKMRGKMENEKRREKYPLLVKLFNGCPLQIHSTA
                     AWTHPSTKDQNLLLGAEEGIFILNRNDQEATLEMIFPGRTTWLYCINNLLMSLSGKTP
                     YLYSHSILGLLERKDGRTGSPIAHISPHRLLARKNMVSSKIQDTKGCRACCVAESASS
                     GGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLPVFTLLTTPGSELPAVCIG
                     VSPGQAAKSVLFHTVRFGALSCWLDDSSTEHKGPVQVIQVKEDMVMVLMDGSLKLVTP
                     EGAPAPGLRTPEIPMTEAVEAVAMVEDRLEAFWKHGVQVWAPGLKQPLQELRDPTLTF
                     RLLCSPRPVVVETRPTDDPTAPSNLYIQE"
     exon            202..259
                     /gene="Map4k1"
                     /gene_synonym="Hpk1; mHPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            260..350
                     /gene="Map4k1"
                     /gene_synonym="Hpk1; mHPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            351..415
                     /gene="Map4k1"
                     /gene_synonym="Hpk1; mHPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            416..471
                     /gene="Map4k1"
                     /gene_synonym="Hpk1; mHPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            472..519
                     /gene="Map4k1"
                     /gene_synonym="Hpk1; mHPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            520..562
                     /gene="Map4k1"
                     /gene_synonym="Hpk1; mHPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            563..635
                     /gene="Map4k1"
                     /gene_synonym="Hpk1; mHPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            636..767
                     /gene="Map4k1"
                     /gene_synonym="Hpk1; mHPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            768..830
                     /gene="Map4k1"
                     /gene_synonym="Hpk1; mHPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            831..912
                     /gene="Map4k1"
                     /gene_synonym="Hpk1; mHPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1026
                     /gene="Map4k1"
                     /gene_synonym="Hpk1; mHPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1105
                     /gene="Map4k1"
                     /gene_synonym="Hpk1; mHPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1164
                     /gene="Map4k1"
                     /gene_synonym="Hpk1; mHPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1208
                     /gene="Map4k1"
                     /gene_synonym="Hpk1; mHPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1253
                     /gene="Map4k1"
                     /gene_synonym="Hpk1; mHPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1296
                     /gene="Map4k1"
                     /gene_synonym="Hpk1; mHPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1459
                     /gene="Map4k1"
                     /gene_synonym="Hpk1; mHPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1542
                     /gene="Map4k1"
                     /gene_synonym="Hpk1; mHPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1566
                     /gene="Map4k1"
                     /gene_synonym="Hpk1; mHPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1651
                     /gene="Map4k1"
                     /gene_synonym="Hpk1; mHPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1728
                     /gene="Map4k1"
                     /gene_synonym="Hpk1; mHPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1789
                     /gene="Map4k1"
                     /gene_synonym="Hpk1; mHPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1898
                     /gene="Map4k1"
                     /gene_synonym="Hpk1; mHPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..1957
                     /gene="Map4k1"
                     /gene_synonym="Hpk1; mHPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2061
                     /gene="Map4k1"
                     /gene_synonym="Hpk1; mHPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2236
                     /gene="Map4k1"
                     /gene_synonym="Hpk1; mHPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2299
                     /gene="Map4k1"
                     /gene_synonym="Hpk1; mHPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2389
                     /gene="Map4k1"
                     /gene_synonym="Hpk1; mHPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2460
                     /gene="Map4k1"
                     /gene_synonym="Hpk1; mHPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2461..2516
                     /gene="Map4k1"
                     /gene_synonym="Hpk1; mHPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2517..2699
                     /gene="Map4k1"
                     /gene_synonym="Hpk1; mHPK1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcgggccc aggacttgtg tggagacaga aggtaatacc aaagcttgaa ccctgaggcc
       61 ctgttggccc cctgggcact ggcccagccc cggcctccag gaatggccct tgtggacccc
      121 gacattttta ataaggaccc tcgagaacac tatgatctac tgcaacgact gggtggtgga
      181 acttatggag aagtattcaa ggctcgcgac aaggtgtcta aggacctggt ggctttgaag
      241 atggtgaaga tggagcctga tgatgacgtc gccacccttc agaaggagat tctcatgctg
      301 aaaacttgcc ggcacgccaa catcgtggct taccatggca gttacctctg gctgcagaag
      361 ctgtggatct gcatggaatt ctgtggagct ggttctctcc aggacatcta ccaagtgact
      421 ggctctctgt ccgagctcca gatcagctat gtgtgccggg aagtgcttca gggactggcc
      481 tacctgcatt cagagaagaa gatacatcga gacatcaagg gagccaacat cctcatcaac
      541 gactgcgggg aggttaagct ggctgacttt gggatctcag cccagattgg ggcgacactg
      601 gcccggcgcc tttctttcat tgggacaccg tactggatgg ctccagaggt ggcagcggtg
      661 gccctgaagg gtggatacaa tgagctgtgc gacatctggt ctcttggcat cacagccatc
      721 gagctggctg agcttcagcc ccctctcttt gatgtgcacc ctctcagggt tctcttcctc
      781 atgaccaaga gcgggtacca gcctcctcgg ctgaaggaaa agagcagatg gtcatcttcc
      841 ttccacaact ttgtcaaagt caccctcact aagaactcca agaaacgccc cagtgccacc
      901 aagatgctca gtcatcagct ggtgtcccag ccagggctga acagaggcct gatcttggat
      961 cttcttgaca aaatgaagaa tcctgggaag gggctgcctg ttgatattga agatgaggag
     1021 cctgagccac cccctgccat ccctcggcgg atcagatcta cctaccgggc cagctcacta
     1081 gggatcccag atgcagactg ctgccggagg caaatggagt tccagaggcc cagatgcgtg
     1141 gactgcagac ctcaggctga aactgttcgc ttatatcccc ctgcacactt cgggagcacc
     1201 agtcccagga gtcagctgtc agattctgat gacgactatg atgatgtgga catccctgcc
     1261 ccttcagaga acatacctcc tccactgccc cccaagccca agtttcggtc tccatcagat
     1321 gatggttctg gaggaattag ggacgatggg caattgagcc caggggttct ggttcgatgt
     1381 gcaagtgggc cccctccacg tactccccga cctggacctc ccccagcgac ctgcagccct
     1441 cacctcacag ctcgctcaga tccctcattg tggaacccag ctgctccgga gccaggccag
     1501 cccccactcg tacccccaag gaaggaaaag atgaggggaa agatggagaa cgagaagcgc
     1561 agagagaaat atccccttct tgtgaaatta ttcaatggct gtccccttca gatccacagc
     1621 acagctgcct ggacacatcc ctctacaaaa gatcagaacc tgctcctggg ggcagaggaa
     1681 ggcattttca tactgaaccg gaatgatcag gaggccacgc tggaaatgat cttccctggc
     1741 cgcacaacct ggctctattg catcaacaac ctcctcatgt ctctctcagg gaagacaccc
     1801 tacctgtatt ctcatagcat cctgggcctg cttgaaagga aagacggcag aacgggaagc
     1861 cccattgctc acattagccc tcaccggtta ctggcaagaa agaacatggt ctccagtaag
     1921 atccaggaca ccaaaggctg ccgggcttgc tgtgtggctg agagtgctag ctctgggggc
     1981 ccattcttat gtggggcatt ggagacgtct gtggttttgc tccagtggta ccaaccaatg
     2041 aacaaattct tgcttgtccg gcaggtgctg ttcccgctgc ccacgccgct gccggtgttc
     2101 acgctgctga caacgccggg ctccgagctg ccagctgtgt gcatcggcgt gagcccgggg
     2161 caggcggcaa agtcggtgct cttccacacc gtgcgcttcg gtgcgctgtc ctgctggctg
     2221 gacgactcca gcacggagca caagggacca gtgcaggtga tccaagtaaa ggaagacatg
     2281 gtgatggtgt tgatggatgg ctctctaaag ctagtgaccc cagagggggc accagctcct
     2341 gggctccgca cccctgagat ccccatgaca gaagcggtcg aggctgtggc tatggttgaa
     2401 gatcgactcg aggccttctg gaagcatgga gttcaggtgt gggctccagg cttgaaacag
     2461 ccgctgcagg agctgagaga ccccaccctc accttccgtc tgctctgctc ccccaggccg
     2521 gtagtggtgg agacaaggcc cacggatgac cctacggccc ccagcaacct ctacatccag
     2581 gaatgagcca ttgagagggc atgggaaacg gatgcctgca gactcctaac agacgcacta
     2641 gtggtcatga catgacctta tctcccaata aacttgactt tagtcttgtc atcttgaaa
//
