LOCUS       NM_008633               5673 bp    mRNA    linear   ROD 10-MAR-2023
DEFINITION  Mus musculus microtubule-associated protein 4 (Map4), transcript
            variant 2, mRNA.
ACCESSION   NM_008633
VERSION     NM_008633.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5673)
  AUTHORS   Zhang X, Huang S, Niu X, Li S, Wang J and Ran X.
  TITLE     miR-103-3p Regulates the Differentiation and Autophagy of Myoblasts
            by Targeting MAP4
  JOURNAL   Int J Mol Sci 24 (4), 4130 (2023)
   PUBMED   36835542
  REMARK    GeneRIF: miR-103-3p Regulates the Differentiation and Autophagy of
            Myoblasts by Targeting MAP4.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5673)
  AUTHORS   Li L, Feng Y, Zhang J, Zhang Q, Ren J, Sun C, Li S, Lei X, Luo G,
            Hu J and Huang Y.
  TITLE     Microtubule associated protein 4 phosphorylation-induced
            epithelial-to-mesenchymal transition of podocyte leads to
            proteinuria in diabetic nephropathy
  JOURNAL   Cell Commun Signal 20 (1), 115 (2022)
   PUBMED   35902952
  REMARK    GeneRIF: Microtubule associated protein 4 phosphorylation-induced
            epithelial-to-mesenchymal transition of podocyte leads to
            proteinuria in diabetic nephropathy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5673)
  AUTHORS   Argent L, Winter F, Prickett I, Carrasquero-Ordaz M, Olsen AL,
            Kramer H, Lancaster E and Becker EBE.
  TITLE     Caspr2 interacts with type 1 inositol 1,4,5-trisphosphate receptor
            in the developing cerebellum and regulates Purkinje cell morphology
  JOURNAL   J Biol Chem 295 (36), 12716-12726 (2020)
   PUBMED   32675284
REFERENCE   4  (bases 1 to 5673)
  AUTHORS   Li L, Zhang Q, Zhang X, Zhang J, Wang X, Ren J, Jia J, Zhang D,
            Jiang X, Zhang J, Mei H, Chen B, Hu J and Huang Y.
  TITLE     Microtubule associated protein 4 phosphorylation leads to
            pathological cardiac remodeling in mice
  JOURNAL   EBioMedicine 37, 221-235 (2018)
   PUBMED   30327268
  REMARK    GeneRIF: data reveal for the first time that MAP4 drives
            pathological cardiac remodeling through its phosphorylation. These
            findings bear the therapeutic potential to ameliorate pathological
            cardiac remodeling by attenuating MAP4 phosphorylation.
REFERENCE   5  (bases 1 to 5673)
  AUTHORS   Bizet AA, Becker-Heck A, Ryan R, Weber K, Filhol E, Krug P,
            Halbritter J, Delous M, Lasbennes MC, Linghu B, Oakeley EJ,
            Zarhrate M, Nitschke P, Garfa-Traore M, Serluca F, Yang F,
            Bouwmeester T, Pinson L, Cassuto E, Dubot P, Elshakhs NAS, Sahel
            JA, Salomon R, Drummond IA, Gubler MC, Antignac C, Chibout S,
            Szustakowski JD, Hildebrandt F, Lorentzen E, Sailer AW, Benmerah A,
            Saint-Mezard P and Saunier S.
  TITLE     Mutations in TRAF3IP1/IFT54 reveal a new role for IFT proteins in
            microtubule stabilization
  JOURNAL   Nat Commun 6, 8666 (2015)
   PUBMED   26487268
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5673)
  AUTHORS   Voss AK, Thomas T and Gruss P.
  TITLE     Compensation for a gene trap mutation in the murine
            microtubule-associated protein 4 locus by alternative
            polyadenylation and alternative splicing
  JOURNAL   Dev Dyn 212 (2), 258-266 (1998)
   PUBMED   9626500
REFERENCE   7  (bases 1 to 5673)
  AUTHORS   Mangan ME and Olmsted JB.
  TITLE     The gene for microtubule-associated protein 4 (Mtap4) maps to the
            distal region of mouse chromosome 9
  JOURNAL   Mamm Genome 7 (12), 918-919 (1996)
   PUBMED   8995766
REFERENCE   8  (bases 1 to 5673)
  AUTHORS   Mangan ME and Olmsted JB.
  TITLE     A muscle-specific variant of microtubule-associated protein 4
            (MAP4) is required in myogenesis
  JOURNAL   Development 122 (3), 771-781 (1996)
   PUBMED   8631255
REFERENCE   9  (bases 1 to 5673)
  AUTHORS   Code RJ and Olmsted JB.
  TITLE     Mouse microtubule-associated protein 4 (MAP4) transcript diversity
            generated by alternative polyadenylation
  JOURNAL   Gene 122 (2), 367-370 (1992)
   PUBMED   1487151
REFERENCE   10 (bases 1 to 5673)
  AUTHORS   West RR, Tenbarge KM and Olmsted JB.
  TITLE     A model for microtubule-associated protein 4 structure. Domains
            defined by comparisons of human, mouse, and bovine sequences
  JOURNAL   J Biol Chem 266 (32), 21886-21896 (1991)
   PUBMED   1718985
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161246.2 and BC044654.1.
            
            [WARNING] On Apr 13, 2023 this sequence was replaced by
            NM_008633.5.
            
            On Apr 15, 2011 this sequence version replaced NM_008633.3.
            
            Transcript Variant: This variant (2) differs in the 3' UTR and has
            multiple coding region differences, compared to variant 1, one of
            which results in a frameshift. The resulting protein (isoform 2)
            has a distinct C-terminus and is the same length as isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC044654.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849374, SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               AC161246.2         179857-180023       c
            168-5666            BC044654.1         78-5576
            5667-5673           AC161246.2         27843-27849         c
FEATURES             Location/Qualifiers
     source          1..5673
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.83 cM"
     gene            1..5673
                     /gene="Map4"
                     /gene_synonym="MAP-4; Mtap-4; Mtap4"
                     /note="microtubule-associated protein 4"
                     /db_xref="GeneID:17758"
                     /db_xref="MGI:MGI:97178"
     exon            1..167
                     /gene="Map4"
                     /gene_synonym="MAP-4; Mtap-4; Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            168..409
                     /gene="Map4"
                     /gene_synonym="MAP-4; Mtap-4; Mtap4"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..3564
                     /gene="Map4"
                     /gene_synonym="MAP-4; Mtap-4; Mtap4"
                     /note="isoform 2 is encoded by transcript variant 2; MAP
                     4"
                     /codon_start=1
                     /product="microtubule-associated protein 4 isoform 2"
                     /protein_id="NP_032659.2"
                     /db_xref="GeneID:17758"
                     /db_xref="MGI:MGI:97178"
                     /translation="MADLSLVDALTEPPPEIEGEIKRDFMAALEAEPYDDIVGETVEK
                     TEFIPLLDGDEKTGNSESKKKPCLDTSQVEGIPSSKPTLLANGDHGMEGNNTAGSPTD
                     FLEERVDYPDYQSSQNWPEDASFCFQPQQVLDTDQAEPFNEHRDDGLADLLFVSSGPT
                     NASAFTERDNPSEDSYGMLPCDSFASTAVVSQEWSVGAPNSPCSESCVSPEVTIETLQ
                     PATELSKAAEVESVKEQLPAKALETMAEQTTDVVHSPSTDTTPGPDTEAALAKDIEEI
                     TKPDVILANVTQPSTESDMFLAQDMELLTGTEAAHANNIILPTEPDESSTKDVAPPME
                     EEIVPGNDTTSPKETETTLPIKMDLAPPEDVLLTKETELAPAKGMVSLSEIEEALAKN
                     DESSAEIPVAQETVVSETEVVLATEVVLPSDPITTLTKDVTLPLEAERPLVTDMTPSL
                     ETEMTLGKETAPPTETNLGMAKDMSPLPESEVTLGKDVVILPETKVAEFNNVTPLSEE
                     EVTSVKDMSPSAETEAPLAKNADLHSGTELIVDNSMAPASDLALPLETKVATVPIKDK
                     GTVQTEEKPREDSQLASMQHKGQSTVPPCTASPEPVKAAEQMSTLPIDAPSPLENLEQ
                     KETPGSQPSEPCSGVSRQEEAKAAVGVTGNDITTPPNKEPPPSPEKKAKPLATTQPAK
                     TSTSKAKTQPTSLPKQPAPTTSGGLNKKPMSLASGSVPAAPHKRPAAATATARPSTLP
                     ARDVKPKPITEAKVAEKRTSPSKPSSAPALKPGPKTTPTVSKATSPSTLVSTGPSSRS
                     PATTLPKRPTSIKTEGKPADVKRMTAKSASADLSRSKTTSASSVKRNTTPTGAAPPAG
                     MTSTRVKPMSAPSRSSGALSVDKKPTSTKPSSSAPRVSRLATTVSAPDLKSVRSKVGS
                     TENIKHQPGGGRAKVEKKTEAATTAGKPEPNAVTKAAGSIASAQKPPAGKVQIVSKKV
                     SYSHIQSKCGSKDNIKHVPGGGNVQIQNKKVDISKVSSKCGSKANIKHKPGGGDVKIE
                     SQKLNFKEKAQAKVGSLDNVGHLPAGGAVKVTEGGGSEALPCPGPPAGEEPVIPEAAP
                     DAGAPTSASGLSGHTTLSGGGDQREPQTLDSQIQETN"
     exon            410..478
                     /gene="Map4"
                     /gene_synonym="MAP-4; Mtap-4; Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            479..601
                     /gene="Map4"
                     /gene_synonym="MAP-4; Mtap-4; Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            602..715
                     /gene="Map4"
                     /gene_synonym="MAP-4; Mtap-4; Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            716..850
                     /gene="Map4"
                     /gene_synonym="MAP-4; Mtap-4; Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            851..1984
                     /gene="Map4"
                     /gene_synonym="MAP-4; Mtap-4; Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2098
                     /gene="Map4"
                     /gene_synonym="MAP-4; Mtap-4; Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2205
                     /gene="Map4"
                     /gene_synonym="MAP-4; Mtap-4; Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2427
                     /gene="Map4"
                     /gene_synonym="MAP-4; Mtap-4; Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..2611
                     /gene="Map4"
                     /gene_synonym="MAP-4; Mtap-4; Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            2612..2671
                     /gene="Map4"
                     /gene_synonym="MAP-4; Mtap-4; Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            2672..2964
                     /gene="Map4"
                     /gene_synonym="MAP-4; Mtap-4; Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            2965..3078
                     /gene="Map4"
                     /gene_synonym="MAP-4; Mtap-4; Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            3079..3171
                     /gene="Map4"
                     /gene_synonym="MAP-4; Mtap-4; Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            3172..3253
                     /gene="Map4"
                     /gene_synonym="MAP-4; Mtap-4; Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            3254..3369
                     /gene="Map4"
                     /gene_synonym="MAP-4; Mtap-4; Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            3370..3559
                     /gene="Map4"
                     /gene_synonym="MAP-4; Mtap-4; Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            3560..5673
                     /gene="Map4"
                     /gene_synonym="MAP-4; Mtap-4; Mtap4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccttcgtgc cggccttcaa gagggcgacg aggaagcggc cacctccctg tgccccgccc
       61 ctccggctag gtctgtggct tctgcggctc ctcccggctg ctcccggctc ctctctgccc
      121 tctcccggct tcctgcggct ccggcttggg ctcggcggcg gcggcgggca gtcgcagtgg
      181 tacagaatgg ccgacctcag tcttgtggat gcgttgacag aaccacctcc agaaattgag
      241 ggagaaataa agcgagactt catggctgcg ctggaggcag agccctatga tgacatcgtg
      301 ggagaaactg tggagaaaac tgagtttatt cctctcctgg atggtgatga gaaaaccggg
      361 aactcagagt ccaaaaagaa accctgctta gacactagcc aggttgaagg tatcccatct
      421 tctaaaccaa cactcctagc caatggtgat catggaatgg aggggaataa cactgcaggg
      481 tctccaactg acttccttga agagagagtg gactatccgg attatcagag cagccagaac
      541 tggccagaag atgcaagctt ttgtttccag cctcagcaag tgttagatac tgaccaggct
      601 gagcccttta acgagcaccg tgatgatggt ttggcagatc tgctctttgt ctccagtgga
      661 cccacgaacg cttctgcatt tacagagcga gacaatcctt cagaagacag ttacggtatg
      721 cttccctgtg actcatttgc ttccacggct gttgtatctc aggagtggtc tgtgggagcc
      781 ccaaactctc catgttcaga gtcctgtgtc tccccagagg ttactataga aaccctacag
      841 ccagcaacag agctctccaa ggcagcagaa gtggaatcag tgaaagagca gctgccagct
      901 aaagcattgg aaacgatggc agagcagacc actgatgtgg tgcactctcc atccacagac
      961 acaacaccag gcccagacac agaggcagca ctggctaaag acatagaaga gatcaccaag
     1021 ccagatgtga tattggcaaa tgtcacgcag ccatctactg aatcggatat gttcctggcc
     1081 caggacatgg aactactcac aggaacagag gcagcccacg ctaacaatat catattgcct
     1141 acagaaccag acgaatcttc aaccaaggat gtagcaccac ctatggaaga agaaattgtc
     1201 ccaggcaatg atacgacatc ccccaaagaa acagagacaa cacttccaat aaaaatggac
     1261 ttggcaccac ctgaggatgt gttacttacc aaagaaacag aactagcccc agccaagggc
     1321 atggtttcac tctcagaaat agaagaggct ctggcaaaga atgatgagtc ctctgcagaa
     1381 atacctgtgg ctcaggagac agtggtctca gaaacagagg tggtcctggc aacagaagtg
     1441 gtactgccct cagatcccat aacaacattg acaaaggatg tgacactccc cttagaagca
     1501 gagagaccgt tggtgacgga catgactcca tctctggaaa cagaaatgac cctaggcaaa
     1561 gagacagctc cacccacaga aacaaatttg ggcatggcca aagacatgtc tccactccca
     1621 gaatcagaag tgactctggg caaggacgtg gttatacttc cagaaacaaa ggtggctgag
     1681 tttaacaatg tgactccact ttcagaagaa gaggtaacct cagtcaagga catgtctccg
     1741 tctgcagaaa cagaggctcc cctggctaag aatgctgatc tgcactcagg aacagagctg
     1801 attgtggaca acagcatggc tccagcctcc gatcttgcac tgcccttgga aacaaaagta
     1861 gcaacagttc caattaaaga caaaggaact gtacagactg aagaaaaacc acgtgaagac
     1921 tcccagttag catctatgca gcacaaggga cagtcaacag tacctccttg cacggcttca
     1981 ccagaaccag tcaaagctgc agaacaaatg tctaccttac caatagatgc accttctcca
     2041 ttagagaact tagagcagaa ggaaacgcct ggcagccagc cttctgagcc ttgctcagga
     2101 gtatcccggc aagaagaagc aaaggctgct gtaggtgtga ctggaaatga catcactacc
     2161 ccgccaaaca aggagccacc accaagccca gaaaagaaag caaagccttt ggccaccact
     2221 caacctgcaa agacttcaac atcgaaagcc aaaacacagc ccacttctct ccctaagcaa
     2281 ccagctccca ccacctctgg tgggttgaat aaaaaaccca tgagcctcgc ctcaggctca
     2341 gtgccagctg ccccacacaa acgccctgct gctgccactg ctactgccag gccttccacc
     2401 ctacctgcca gagacgtgaa gccaaagcca attacagaag ctaaggttgc cgaaaagcgg
     2461 acctctccat ccaagccttc atctgcccca gccctcaaac ctggacctaa aaccacccca
     2521 accgtttcaa aagccacatc tccctcaact cttgtttcca ctggaccaag tagtagaagt
     2581 ccagctacaa ctctgcctaa gaggccaacc agcatcaaga ctgaggggaa acctgctgat
     2641 gtcaaaagga tgactgctaa gtctgcctca gctgacttga gtcgctcaaa gaccacctct
     2701 gccagttctg tgaagagaaa caccactccc actggggcag cacccccagc agggatgact
     2761 tccactcgag tcaagcccat gtctgcacct agccgctctt ctggggctct ttctgtggac
     2821 aagaagccca cttccactaa gcctagctcc tctgctccca gggtgagccg cctggccaca
     2881 actgtttctg cccctgacct gaagagtgtt cgctccaagg tcggctctac agaaaacatc
     2941 aaacaccagc ctggaggagg ccgggccaaa gtagagaaaa aaacagaggc agctaccaca
     3001 gctgggaagc ctgaacctaa tgcagtcact aaagcagccg gctccattgc gagtgcacag
     3061 aaaccgcctg ctgggaaagt ccagatagta tccaaaaaag tgagctacag ccatattcaa
     3121 tccaagtgtg gttccaagga caatattaag catgtccctg gaggtggcaa tgttcagatt
     3181 cagaacaaga aagtggacat atccaaggtc tcctccaagt gtgggtccaa agctaatatc
     3241 aagcacaagc ctggtggagg agatgtcaag attgaaagtc agaagttgaa cttcaaggag
     3301 aaggcccaag ccaaagtggg atcccttgat aacgtgggcc acttgcctgc aggaggtgcc
     3361 gtgaaggtaa ctgagggcgg tggcagtgag gcccttccgt gtccaggccc ccccgctggg
     3421 gaggagccag tcatccctga ggctgcgcct gacgctggcg cccctacttc agccagtggc
     3481 ctcagtggcc acaccaccct gtcagggggt ggtgaccaaa gggagcccca gaccttggac
     3541 agccagatcc aggagacaaa ttgagaccta caggctgacg ttccgggcaa atgccagggc
     3601 ccgcaccgac catggggctg acattgtctc ccggcctccc cacttccctg gtggcccaag
     3661 cttggggtct cgagccctgg gctccttttc ccgggctgtc tactagactt gtaagctctt
     3721 gggtgctggg cagccccttt aggcctccct ccctcctgcc tcgcttgctc aaggcagcag
     3781 cagccccact cgctgccatt acacctcctt ccaccccttt ctgggccaac tccaacttca
     3841 ctatctcacc acttcaccac tgcaccacgg agaaagttgg gcggggacgg gagtccagtg
     3901 ggatctctgt gggatctagg ggtgaggagc tggattccag ccttggctgt ttggtttttt
     3961 tggaccaaac ccaaaagaaa ctgacaaacc tctcttccct ggctcaacct ggagggactg
     4021 gtaaaggtga actccacgtg gagaccagca ccgactgaat ccctggaacc taaaccactc
     4081 cttgacccca cggggtggaa gccaccattt ggtggtacca ggcccttttg ctgcctcacc
     4141 tcaagttagt caaggatcag tcctccttgt ccccacgact tatcgtacct gagtagctgc
     4201 tgtctcactt ttttattctt tcctctccca ataacctatg aactggtggt gtagtttgca
     4261 ggctgaagcc atgtctaaat gagagttctt ggtaggtggt gagggaagtg gggaaggaga
     4321 tcccgagtct ccactgagga ggctgtcaga tattggcggg ggttgcccta ctctgggcag
     4381 cttgggccct gcaggaagaa gtgaagtcag acagctaggg tgggtcagtg tggctgattg
     4441 tgttggtatt gtgtgtatgc tgcttttcta accaagaggc tggttttggc atctatctca
     4501 ttccctggga atgcggtggt taaatgtgtg atacaaaatc agggctggag aaacagaaat
     4561 gaaggtcaaa atcgctggcc tgtacctaca ggccatagca cccaaatcct catatctagg
     4621 ggagcctgaa atgtccagaa cgcttgtgaa cagtggggaa tcaggtgtga aaatttaaaa
     4681 ctaaaatgca tgagactgag gccatccagt cttctggtgt ggcgggagag gtggagccat
     4741 ggtggtgcag ccatcccagc gtggtctgct catggatggg atggttgcaa tgttgagaaa
     4801 atcccgggaa ttttatcaac acaagattct tattgcactt gtattttttg tattaaagtt
     4861 tgcatggttt ctaataaagg attcaaacct aagtttgtat tgaaatggcc tgggagtgtc
     4921 taagggctcc tctgataggg cattttctgc tgggcagatt tgcctctcag gaggctggcc
     4981 cagacttggt ccccttggcc ctcctccgaa cagactctgc ctttgcttgg gtacagtttg
     5041 aggaggtaga ggtctttact ctctctctgc caagggaagg tatccctggg cttgaaggtc
     5101 ttctccattt atgaggtagc agttactttg tgataatctt gacactgaat ccctagctct
     5161 ctaagcacac acaaagaatt gctgggacct gtggaaaaaa gactgcctga gctggggagt
     5221 ggctttcttc ccaagctgtc agaactaagc ttggagcctg cattgtctgt attttgcagc
     5281 aataggggcc cacggagctg ggaaggacac agtggggacc agggtagtga tgactgagcg
     5341 tatacaggta cttgctaccc tccttgatgt tgatcttagg gccttgaaga tgctaaggaa
     5401 attgacaaga aacaagtcca ttggccaagg attagagaaa ggaaggtaac ccaagctctg
     5461 taggtagctc cctggaagga tcccacgagc cagagaacct gagaaggctg gtctagcagc
     5521 ttgggaccac aggccatgtg atgtgcatac ttcaaaatgt ttgggaataa ggtccttctg
     5581 tattttatag tttgctcatg gcttagccat tacccatgtc tgtaattgtt gtactgattt
     5641 aaacaataaa gctgcctgac atcccaccat gtt
//
