LOCUS       NM_001205330            5776 bp    mRNA    linear   ROD 10-MAR-2023
DEFINITION  Mus musculus microtubule-associated protein 4 (Map4), transcript
            variant 1, mRNA.
ACCESSION   NM_001205330
VERSION     NM_001205330.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5776)
  AUTHORS   Zhang X, Huang S, Niu X, Li S, Wang J and Ran X.
  TITLE     miR-103-3p Regulates the Differentiation and Autophagy of Myoblasts
            by Targeting MAP4
  JOURNAL   Int J Mol Sci 24 (4), 4130 (2023)
   PUBMED   36835542
  REMARK    GeneRIF: miR-103-3p Regulates the Differentiation and Autophagy of
            Myoblasts by Targeting MAP4.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5776)
  AUTHORS   Li L, Feng Y, Zhang J, Zhang Q, Ren J, Sun C, Li S, Lei X, Luo G,
            Hu J and Huang Y.
  TITLE     Microtubule associated protein 4 phosphorylation-induced
            epithelial-to-mesenchymal transition of podocyte leads to
            proteinuria in diabetic nephropathy
  JOURNAL   Cell Commun Signal 20 (1), 115 (2022)
   PUBMED   35902952
  REMARK    GeneRIF: Microtubule associated protein 4 phosphorylation-induced
            epithelial-to-mesenchymal transition of podocyte leads to
            proteinuria in diabetic nephropathy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5776)
  AUTHORS   Argent L, Winter F, Prickett I, Carrasquero-Ordaz M, Olsen AL,
            Kramer H, Lancaster E and Becker EBE.
  TITLE     Caspr2 interacts with type 1 inositol 1,4,5-trisphosphate receptor
            in the developing cerebellum and regulates Purkinje cell morphology
  JOURNAL   J Biol Chem 295 (36), 12716-12726 (2020)
   PUBMED   32675284
REFERENCE   4  (bases 1 to 5776)
  AUTHORS   Li L, Zhang Q, Zhang X, Zhang J, Wang X, Ren J, Jia J, Zhang D,
            Jiang X, Zhang J, Mei H, Chen B, Hu J and Huang Y.
  TITLE     Microtubule associated protein 4 phosphorylation leads to
            pathological cardiac remodeling in mice
  JOURNAL   EBioMedicine 37, 221-235 (2018)
   PUBMED   30327268
  REMARK    GeneRIF: data reveal for the first time that MAP4 drives
            pathological cardiac remodeling through its phosphorylation. These
            findings bear the therapeutic potential to ameliorate pathological
            cardiac remodeling by attenuating MAP4 phosphorylation.
REFERENCE   5  (bases 1 to 5776)
  AUTHORS   Bizet AA, Becker-Heck A, Ryan R, Weber K, Filhol E, Krug P,
            Halbritter J, Delous M, Lasbennes MC, Linghu B, Oakeley EJ,
            Zarhrate M, Nitschke P, Garfa-Traore M, Serluca F, Yang F,
            Bouwmeester T, Pinson L, Cassuto E, Dubot P, Elshakhs NAS, Sahel
            JA, Salomon R, Drummond IA, Gubler MC, Antignac C, Chibout S,
            Szustakowski JD, Hildebrandt F, Lorentzen E, Sailer AW, Benmerah A,
            Saint-Mezard P and Saunier S.
  TITLE     Mutations in TRAF3IP1/IFT54 reveal a new role for IFT proteins in
            microtubule stabilization
  JOURNAL   Nat Commun 6, 8666 (2015)
   PUBMED   26487268
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5776)
  AUTHORS   Voss AK, Thomas T and Gruss P.
  TITLE     Compensation for a gene trap mutation in the murine
            microtubule-associated protein 4 locus by alternative
            polyadenylation and alternative splicing
  JOURNAL   Dev Dyn 212 (2), 258-266 (1998)
   PUBMED   9626500
REFERENCE   7  (bases 1 to 5776)
  AUTHORS   Mangan ME and Olmsted JB.
  TITLE     The gene for microtubule-associated protein 4 (Mtap4) maps to the
            distal region of mouse chromosome 9
  JOURNAL   Mamm Genome 7 (12), 918-919 (1996)
   PUBMED   8995766
REFERENCE   8  (bases 1 to 5776)
  AUTHORS   Mangan ME and Olmsted JB.
  TITLE     A muscle-specific variant of microtubule-associated protein 4
            (MAP4) is required in myogenesis
  JOURNAL   Development 122 (3), 771-781 (1996)
   PUBMED   8631255
REFERENCE   9  (bases 1 to 5776)
  AUTHORS   Code RJ and Olmsted JB.
  TITLE     Mouse microtubule-associated protein 4 (MAP4) transcript diversity
            generated by alternative polyadenylation
  JOURNAL   Gene 122 (2), 367-370 (1992)
   PUBMED   1487151
REFERENCE   10 (bases 1 to 5776)
  AUTHORS   West RR, Tenbarge KM and Olmsted JB.
  TITLE     A model for microtubule-associated protein 4 structure. Domains
            defined by comparisons of human, mouse, and bovine sequences
  JOURNAL   J Biol Chem 266 (32), 21886-21896 (1991)
   PUBMED   1718985
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161246.2.
            
            [WARNING] On Apr 13, 2023 this sequence was replaced by
            NM_001205330.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M72414.1, SRR9219380.23084.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               AC161246.2         179857-180023       c
            168-409             AC161246.2         132706-132947       c
            410-478             AC161246.2         111957-112025       c
            479-601             AC161246.2         85574-85696         c
            602-715             AC161246.2         84005-84118         c
            716-850             AC161246.2         79564-79698         c
            851-1984            AC161246.2         76291-77424         c
            1985-2098           AC161246.2         74942-75055         c
            2099-2205           AC161246.2         48674-48780         c
            2206-2427           AC161246.2         47348-47569         c
            2428-2611           AC161246.2         44129-44312         c
            2612-2671           AC161246.2         43214-43273         c
            2672-2964           AC161246.2         42812-43104         c
            2965-3078           AC161246.2         40658-40771         c
            3079-3171           AC161246.2         39092-39184         c
            3172-3253           AC161246.2         33713-33794         c
            3254-3366           AC161246.2         31904-32016         c
            3367-3556           AC161246.2         30187-30376         c
            3557-5776           AC161246.2         27843-30062         c
FEATURES             Location/Qualifiers
     source          1..5776
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.83 cM"
     gene            1..5776
                     /gene="Map4"
                     /gene_synonym="MAP-4; Mtap-4; Mtap4"
                     /note="microtubule-associated protein 4"
                     /db_xref="GeneID:17758"
                     /db_xref="MGI:MGI:97178"
     exon            1..167
                     /gene="Map4"
                     /gene_synonym="MAP-4; Mtap-4; Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            168..409
                     /gene="Map4"
                     /gene_synonym="MAP-4; Mtap-4; Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            410..478
                     /gene="Map4"
                     /gene_synonym="MAP-4; Mtap-4; Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            479..601
                     /gene="Map4"
                     /gene_synonym="MAP-4; Mtap-4; Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            602..715
                     /gene="Map4"
                     /gene_synonym="MAP-4; Mtap-4; Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            716..850
                     /gene="Map4"
                     /gene_synonym="MAP-4; Mtap-4; Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            851..1984
                     /gene="Map4"
                     /gene_synonym="MAP-4; Mtap-4; Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2098
                     /gene="Map4"
                     /gene_synonym="MAP-4; Mtap-4; Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2205
                     /gene="Map4"
                     /gene_synonym="MAP-4; Mtap-4; Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2427
                     /gene="Map4"
                     /gene_synonym="MAP-4; Mtap-4; Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..2611
                     /gene="Map4"
                     /gene_synonym="MAP-4; Mtap-4; Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            2612..2671
                     /gene="Map4"
                     /gene_synonym="MAP-4; Mtap-4; Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            2672..2964
                     /gene="Map4"
                     /gene_synonym="MAP-4; Mtap-4; Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            2965..3078
                     /gene="Map4"
                     /gene_synonym="MAP-4; Mtap-4; Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            3079..3171
                     /gene="Map4"
                     /gene_synonym="MAP-4; Mtap-4; Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            3172..3253
                     /gene="Map4"
                     /gene_synonym="MAP-4; Mtap-4; Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            3254..3366
                     /gene="Map4"
                     /gene_synonym="MAP-4; Mtap-4; Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            3367..3556
                     /gene="Map4"
                     /gene_synonym="MAP-4; Mtap-4; Mtap4"
                     /inference="alignment:Splign:2.1.0"
     exon            3557..5776
                     /gene="Map4"
                     /gene_synonym="MAP-4; Mtap-4; Mtap4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccttcgtgc cggccttcaa gagggcgacg aggaagcggc cacctccctg tgccccgccc
       61 ctccggctag gtctgtggct tctgcggctc ctcccggctg ctcccggctc ctctctgccc
      121 tctcccggct tcctgcggct ccggcttggg ctcggcggcg gcggcgggca gtcgcagtgg
      181 tacagaatgg ccgacctcag tcttgtggat gcgttgacag aaccacctcc agaaattgag
      241 ggagaaataa agcgagactt catggctgcg ctggaggcag agccctatga tgacatcgtg
      301 ggagaaactg tggagaaaac tgagtttatt cctctcctgg atggtgatga gaaaaccggg
      361 aactcagagt ccaaaaagaa accctgctta gacactagcc aggttgaagg tatcccatct
      421 tctaaaccaa cactcctagc caatggtgat catggaatgg aggggaataa cactgcaggg
      481 tctccaactg acttccttga agagagagtg gactatccgg attatcagag cagccagaac
      541 tggccagaag atgcaagctt ttgtttccag cctcagcaag tgttagatac tgaccaggct
      601 gagcccttta acgagcaccg tgatgatggt ttggcagatc tgctctttgt ctccagtgga
      661 cccacgaacg cttctgcatt tacagagcga gacaatcctt cagaagacag ttacggtatg
      721 cttccctgtg actcatttgc ttccacggct gttgtatctc aggagtggtc tgtgggagcc
      781 ccaaactctc catgttcaga gtcctgtgtc tccccagagg ttactataga aaccctacag
      841 ccagcaacag agctctccaa ggcagcagaa gtggaatcag tgaaagagca gctgccagct
      901 aaagcattgg aaacgatggc agagcagacc actgatgtgg tgcactctcc atccacagac
      961 acaacaccag gcccagacac agaggcagca ctggctaaag acatagaaga gatcaccaag
     1021 ccagatgtga tattggcaaa tgtcacgcag ccatctactg aatcggatat gttcctggcc
     1081 caggacatgg aactactcac aggaacagag gcagcccacg ctaacaatat catattgcct
     1141 acagaaccag acgaatcttc aaccaaggat gtagcaccac ctatggaaga agaaattgtc
     1201 ccaggcaatg atacgacatc ccccaaagaa acagagacaa cacttccaat aaaaatggac
     1261 ttggcaccac ctgaggatgt gttacttacc aaagaaacag aactagcccc agccaagggc
     1321 atggtttcac tctcagaaat agaagaggct ctggcaaaga atgatgagtc ctctgcagaa
     1381 atacctgtgg ctcaggagac agtggtctca gaaacagagg tggtcctggc aacagaagtg
     1441 gtactgccct cagatcccat aacaacattg acaaaggatg tgacactccc cttagaagca
     1501 gagagaccgt tggtgacgga catgactcca tctctggaaa cagaaatgac cctaggcaaa
     1561 gagacagctc cacccacaga aacaaatttg ggcatggcca aagacatgtc tccactccca
     1621 gaatcagaag tgactctggg caaggacgtg gttatacttc cagaaacaaa ggtggctgag
     1681 tttaacaatg tgactccact ttcagaagaa gaggtaacct cagtcaagga catgtctccg
     1741 tctgcagaaa cagaggctcc cctggctaag aatgctgatc tgcactcagg aacagagctg
     1801 attgtggaca acagcatggc tccagcctcc gatcttgcac tgcccttgga aacaaaagta
     1861 gcaacagttc caattaaaga caaaggaact gtacagactg aagaaaaacc acgtgaagac
     1921 tcccagttag catctatgca gcacaaggga cagtcaacag tacctccttg cacggcttca
     1981 ccagaaccag tcaaagctgc agaacaaatg tctaccttac caatagatgc accttctcca
     2041 ttagagaact tagagcagaa ggaaacgcct ggcagccagc cttctgagcc ttgctcagga
     2101 gtatcccggc aagaagaagc aaaggctgct gtaggtgtga ctggaaatga catcactacc
     2161 ccgccaaaca aggagccacc accaagccca gaaaagaaag caaagccttt ggccaccact
     2221 caacctgcaa agacttcaac atcgaaagcc aaaacacagc ccacttctct ccctaagcaa
     2281 ccagctccca ccacctctgg tgggttgaat aaaaaaccca tgagcctcgc ctcaggctca
     2341 gtgccagctg ccccacacaa acgccctgct gctgccactg ctactgccag gccttccacc
     2401 ctacctgcca gagacgtgaa gccaaagcca attacagaag ctaaggttgc cgaaaagcgg
     2461 acctctccat ccaagccttc atctgcccca gccctcaaac ctggacctaa aaccacccca
     2521 accgtttcaa aagccacatc tccctcaact cttgtttcca ctggaccaag tagtagaagt
     2581 ccagctacaa ctctgcctaa gaggccaacc agcatcaaga ctgaggggaa acctgctgat
     2641 gtcaaaagga tgactgctaa gtctgcctca gctgacttga gtcgctcaaa gaccacctct
     2701 gccagttctg tgaagagaaa caccactccc actggggcag cacccccagc agggatgact
     2761 tccactcgag tcaagcccat gtctgcacct agccgctctt ctggggctct ttctgtggac
     2821 aagaagccca cttccactaa gcctagctcc tctgctccca gggtgagccg cctggccaca
     2881 actgtttctg cccctgacct gaagagtgtt cgctccaagg tcggctctac agaaaacatc
     2941 aaacaccagc ctggaggagg ccgggccaaa gtagagaaaa aaacagaggc agctaccaca
     3001 gctgggaagc ctgaacctaa tgcagtcact aaagcagccg gctccattgc gagtgcacag
     3061 aaaccgcctg ctgggaaagt ccagatagta tccaaaaaag tgagctacag ccatattcaa
     3121 tccaagtgtg gttccaagga caatattaag catgtccctg gaggtggcaa tgttcagatt
     3181 cagaacaaga aagtggacat atccaaggtc tcctccaagt gtgggtccaa agctaatatc
     3241 aagcacaagc ctggtggagg agatgtcaag attgaaagtc agaagttgaa cttcaaggag
     3301 aaggcccaag ccaaagtggg atcccttgat aacgtgggcc acttgcctgc aggaggtgcc
     3361 gtgaagactg agggcggtgg cagtgaggcc cttccgtgtc caggcccccc cgctggggag
     3421 gagccagtca tccctgaggc tgcgcctgac gctggcgccc ctacttcagc cagtggcctc
     3481 agtggccaca ccaccctgtc agggggtggt gaccaaaggg agccccagac cttggacagc
     3541 cagatccagg agacaagcat ctaatgatga cattctggtc tcgtcttcca tctcccctgt
     3601 gttccctctc ttgtctcccc cccttgttac cctctcccat ccctcctcac gtgtcactgc
     3661 agattgagac ctacaggctg acgttccggg caaatgccag ggcccgcacc gaccatgggg
     3721 ctgacattgt ctcccggcct ccccacttcc ctggtggccc aagcttgggg tctcgagccc
     3781 tgggctcctt ttcccgggct gtctactaga cttgtaagct cttgggtgct gggcagcccc
     3841 tttaggcctc cctccctcct gcctcgcttg ctcaaggcag cagcagcccc actcgctgcc
     3901 attacacctc cttccacccc tttctgggcc aactccaact tcactatctc accacttcac
     3961 cactgcacca cggagaaagt tgggcgggga cgggagtcca gtgggatctc tgtgggatct
     4021 aggggtgagg agctggattc cagccttggc tgtttggttt ttttggacca aacccaaaag
     4081 aaactgacaa acctctcttc cctggctcaa cctggaggga ctggtaaagg tgaactccac
     4141 gtggagacca gcaccgactg aatccctgga acctaaacca ctccttgacc ccacggggtg
     4201 gaagccacca tttggtggta ccaggccctt ttgctgcctc acctcaagtt agtcaaggat
     4261 cagtcctcct tgtccccacg acttatcgta cctgagtagc tgctgtctca cttttttatt
     4321 ctttcctctc ccaataacct atgaactggt ggtgtagttt gcaggctgaa gccatgtcta
     4381 aatgagagtt cttggtaggt ggtgagggaa gtggggaagg agatcccgag tctccactga
     4441 ggaggctgtc agatattggc gggggttgcc ctactctggg cagcttgggc cctgcaggaa
     4501 gaagtgaagt cagacagcta gggtgggtca gtgtggctga ttgtgttggt attgtgtgta
     4561 tgctgctttt ctaaccaaga ggctggtttt ggcatctatc tcattccctg ggaatgcggt
     4621 ggttaaatgt gtgatacaaa atcagggctg gagaaacaga aatgaaggtc aaaatcgctg
     4681 gcctgtacct acaggccata gcacccaaat cctcatatct aggggagcct gaaatgtcca
     4741 gaacgcttgt gaacagtggg gaatcaggtg tgaaaattta aaactaaaat gcatgagact
     4801 gaggccatcc agtcttctgg tgtggcggga gaggtggagc catggtggtg cagccatccc
     4861 agcgtggtct gctcatggat gggatggttg caatgttgag aaaatcccgg gaattttatc
     4921 aacacaagat tcttattgca cttgtatttt ttgtattaaa gtttgcatgg tttctaataa
     4981 aggattcaaa cctaagtttg tattgaaatg gcctgggagt gtctaagggc tcctctgata
     5041 gggcattttc tgctgggcag atttgcctct caggaggctg gcccagactt ggtccccttg
     5101 gccctcctcc gaacagactc tgcctttgct tgggtacagt ttgaggaggt agaggtcttt
     5161 actctctctc tgccaaggga aggtatccct gggcttgaag gtcttctcca tttatgaggt
     5221 agcagttact ttgtgataat cttgacactg aatccctagc tctctaagca cacacaaaga
     5281 attgctggga cctgtggaaa aaagactgcc tgagctgggg agtggctttc ttcccaagct
     5341 gtcagaacta agcttggagc ctgcattgtc tgtattttgc agcaataggg gcccacggag
     5401 ctgggaagga cacagtgggg accagggtag tgatgactga gcgtatacag gtacttgcta
     5461 ccctccttga tgttgatctt agggccttga agatgctaag gaaattgaca agaaacaagt
     5521 ccattggcca aggattagag aaaggaaggt aacccaagct ctgtaggtag ctccctggaa
     5581 ggatcccacg agccagagaa cctgagaagg ctggtctagc agcttgggac cacaggccat
     5641 gtgatgtgca tacttcaaaa tgtttgggaa taaggtcctt ctgtatttta tagtttgctc
     5701 atggcttagc cattacccat gtctgtaatt gttgtactga tttaaacaat aaagctgcct
     5761 gacatcccac catgtt
//
