LOCUS       NM_007746               2507 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus mitogen-activated protein kinase kinase kinase 8
            (Map3k8), transcript variant 1, mRNA.
ACCESSION   NM_007746
VERSION     NM_007746.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2507)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2507)
  AUTHORS   Wang,Y., Wu,T., Tsai,M.C., Rezzonico,M.G., Abdel-Haleem,A.M.,
            Xie,L., Gandham,V.D., Ngu,H., Stark,K., Glock,C., Xu,D.,
            Foreman,O., Friedman,B.A., Sheng,M. and Hanson,J.E.
  TITLE     TPL2 kinase activity regulates microglial inflammatory responses
            and promotes neurodegeneration in tauopathy mice
  JOURNAL   Elife 12, e83451 (2023)
   PUBMED   37555828
  REMARK    GeneRIF: TPL2 kinase activity regulates microglial inflammatory
            responses and promotes neurodegeneration in tauopathy mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2507)
  AUTHORS   Latha,K., Patel,Y., Rao,S. and Watford,W.T.
  TITLE     The Influenza-Induced Pulmonary Inflammatory Exudate in Susceptible
            Tpl2-Deficient Mice Is Dictated by Type I IFN Signaling
  JOURNAL   Inflammation 46 (1), 322-341 (2023)
   PUBMED   36227523
REFERENCE   4  (bases 1 to 2507)
  AUTHORS   Latha,K., Rao,S., Sakamoto,K. and Watford,W.T.
  TITLE     Tumor Progression Locus 2 Protects against Acute Respiratory
            Distress Syndrome in Influenza A Virus-Infected Mice
  JOURNAL   Microbiol Spectr 10 (5), e0113622 (2022)
   PUBMED   35980186
  REMARK    GeneRIF: Tumor Progression Locus 2 Protects against Acute
            Respiratory Distress Syndrome in Influenza A Virus-Infected Mice.
REFERENCE   5  (bases 1 to 2507)
  AUTHORS   Kelley,M.B., Geddes,T.J., Ochiai,M., Lampl,N.M., Kothmann,W.W.,
            Fierstein,S.R., Kent,V. and DeCicco-Skinner,K.
  TITLE     Loss of Tpl2 activates compensatory signaling and resistance to
            EGFR/MET dual inhibition in v-RAS transduced keratinocytes
  JOURNAL   PLoS One 17 (3), e0266017 (2022)
   PUBMED   35325006
  REMARK    GeneRIF: Loss of Tpl2 activates compensatory signaling and
            resistance to EGFR/MET dual inhibition in v-RAS transduced
            keratinocytes.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2507)
  AUTHORS   Wang,Y., Macke,J.P., Abella,B.S., Andreasson,K., Worley,P.,
            Gilbert,D.J., Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     A large family of putative transmembrane receptors homologous to
            the product of the Drosophila tissue polarity gene frizzled
  JOURNAL   J Biol Chem 271 (8), 4468-4476 (1996)
   PUBMED   8626800
REFERENCE   7  (bases 1 to 2507)
  AUTHORS   Ohara,R., Hirota,S., Onoue,H., Nomura,S., Kitamura,Y. and
            Toyoshima,K.
  TITLE     Identification of the cells expressing cot proto-oncogene mRNA
  JOURNAL   J Cell Sci 108 (Pt 1), 97-103 (1995)
   PUBMED   7738120
REFERENCE   8  (bases 1 to 2507)
  AUTHORS   Justice,M.J., Morse,H.C. 3rd, Jenkins,N.A. and Copeland,N.G.
  TITLE     Identification of Evi-3, a novel common site of retroviral
            integration in mouse AKXD B-cell lymphomas
  JOURNAL   J Virol 68 (3), 1293-1300 (1994)
   PUBMED   8107195
REFERENCE   9  (bases 1 to 2507)
  AUTHORS   Ohara,R., Miyoshi,J., Aoki,M. and Toyoshima,K.
  TITLE     The murine cot proto-oncogene: genome structure and tissue-specific
            expression
  JOURNAL   Jpn J Cancer Res 84 (5), 518-525 (1993)
   PUBMED   8320169
REFERENCE   10 (bases 1 to 2507)
  AUTHORS   Justice,M.J., Gilbert,D.J., Kinzler,K.W., Vogelstein,B.,
            Buchberg,A.M., Ceci,J.D., Matsuda,Y., Chapman,V.M., Patriotis,C.,
            Makris,A. et al.
  TITLE     A molecular genetic linkage map of mouse chromosome 18 reveals
            extensive linkage conservation with human chromosomes 5 and 18
  JOURNAL   Genomics 13 (4), 1281-1288 (1992)
   PUBMED   1354644
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138768.3.
            
            On Nov 17, 2006 this sequence version replaced NM_007746.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK140334.1, AK149846.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               AC138768.3         91132-91233         c
            103-460             AC138768.3         87261-87618         c
            461-628             AC138768.3         81302-81469         c
            629-890             AC138768.3         78827-79088         c
            891-997             AC138768.3         77777-77883         c
            998-1150            AC138768.3         72897-73049         c
            1151-1397           AC138768.3         72098-72344         c
            1398-2507           AC138768.3         69607-70716         c
FEATURES             Location/Qualifiers
     source          1..2507
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 2.73 cM"
     gene            1..2507
                     /gene="Map3k8"
                     /gene_synonym="c-COT; Cot; Cot/Tpl2; Est; Estf; Tpl-2;
                     Tpl2"
                     /note="mitogen-activated protein kinase kinase kinase 8"
                     /db_xref="GeneID:26410"
                     /db_xref="MGI:MGI:1346878"
     exon            1..102
                     /gene="Map3k8"
                     /gene_synonym="c-COT; Cot; Cot/Tpl2; Est; Estf; Tpl-2;
                     Tpl2"
                     /inference="alignment:Splign:2.1.0"
     exon            103..460
                     /gene="Map3k8"
                     /gene_synonym="c-COT; Cot; Cot/Tpl2; Est; Estf; Tpl-2;
                     Tpl2"
                     /inference="alignment:Splign:2.1.0"
     exon            461..628
                     /gene="Map3k8"
                     /gene_synonym="c-COT; Cot; Cot/Tpl2; Est; Estf; Tpl-2;
                     Tpl2"
                     /inference="alignment:Splign:2.1.0"
     exon            629..890
                     /gene="Map3k8"
                     /gene_synonym="c-COT; Cot; Cot/Tpl2; Est; Estf; Tpl-2;
                     Tpl2"
                     /inference="alignment:Splign:2.1.0"
     exon            891..997
                     /gene="Map3k8"
                     /gene_synonym="c-COT; Cot; Cot/Tpl2; Est; Estf; Tpl-2;
                     Tpl2"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1150
                     /gene="Map3k8"
                     /gene_synonym="c-COT; Cot; Cot/Tpl2; Est; Estf; Tpl-2;
                     Tpl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1397
                     /gene="Map3k8"
                     /gene_synonym="c-COT; Cot; Cot/Tpl2; Est; Estf; Tpl-2;
                     Tpl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..2507
                     /gene="Map3k8"
                     /gene_synonym="c-COT; Cot; Cot/Tpl2; Est; Estf; Tpl-2;
                     Tpl2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2477..2482
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Map3k8"
                     /gene_synonym="c-COT; Cot; Cot/Tpl2; Est; Estf; Tpl-2;
                     Tpl2"
                     /note="hexamer: AATAAA"
     polyA_site      2496
                     /gene="Map3k8"
                     /gene_synonym="c-COT; Cot; Cot/Tpl2; Est; Estf; Tpl-2;
                     Tpl2"
                     /note="major polyA site"
ORIGIN      
        1 agtgcaggcc tgggctgtgg cgcgggacgc gagcactggc gctcaccgcg cctcctgcgg
       61 gggacactgc ctggactgct gaactctgtt tgctgagcct ggactcccag caggcactac
      121 agtgatggag tacatgagca ctggaagtga cgagaaagaa gaaattgatt tattaattaa
      181 gcatttaaac gtgtcagaag tcatagacat aatggagaac ctttatgcaa gtgaagagcc
      241 aggagtgtat gagcccagtc tgatgaccat gtatccagac agcaatcaaa atgaggaacg
      301 ttcggagtca ctgcttcgga gtggccagga ggttccctgg ctgtcatctg tcagatatgg
      361 gaccgtggag gatctgcttg catttgcaaa ccatgtctcc aatatgacaa agcattttta
      421 tggacgtcga ccacaagaat gtggaatttt attaaatatg gtaatcagtc cccagaatgg
      481 ccgctaccaa atcgattcgg atgttctcct tgttccttgg aagctgacat acaggaacat
      541 cggctctggt ttcgttcctc ggggggcctt tggaaaagta tacttagccc aagacatgaa
      601 gacaaagaaa agaatggcgt gcaaactgat ccctatagat cagtttaagc catcggatgt
      661 ggaaatccag gcctgtttcc ggcatgagaa cattgctgag ttatatggtg ccgtcctatg
      721 gggcgatact gtccatctct ttatggaagc cggcgaggga gggtctgttc tggagaaact
      781 ggagagttgt gggcccatga gagaatttga aattatttgg gtgacgaagc acattctcaa
      841 gggacttgat tttctgcact ccaagaaagt gatccaccat gatattaaac ctagcaacat
      901 tgtattcatg tctacaaaag ctgttttggt agattttggc ctgagtgtta agatgactga
      961 agatgtctat cttcccaagg acctccgggg aacagagata tacatgagcc cagaggtgat
     1021 cctatgtcgg ggccattcca caaaagccga catctacagc cttggagcca cactcatcca
     1081 catgcagaca ggcaccccac cctgggtgaa gcgctaccct cgatcagcct atccctccta
     1141 cctatacatt atccacaagc aggcacctcc cctggaagac atcgctggtg actgcagtcc
     1201 aggcatgagg gagctgatag aagctgccct ggagaggaac cccaaccacc gccccaaagc
     1261 agcagaccta ctgaaacatg aagccctgaa tcccccaaga gaggaccagc cacgatgtca
     1321 gagtctggac tctgccctct ttgaacggaa gaggctgctg agcaggaagg aactacaact
     1381 tcctgagaac attgctgatt catcatgcac aggcagcacc gaagagtctg aagtgctcag
     1441 gagacagcgt tccctctaca ttgacctcgg agctctggct ggctacttca atattgttcg
     1501 tgggccacca accctggaat acggctgatg gatggctttg ttggcaacaa aacaggatat
     1561 ttctctcctg aatgttggtt ttgcagaccc tacacagcgg ccctggatag tgaattttac
     1621 ccaggttttt aggggtcaag gaggcctcta gtgacacagg aacagctgtg gccctttttt
     1681 gaagctactc tgacatgtcc cagagcccaa ggttctcatt tctcaggtgg tgggactaga
     1741 cagagggagt ggcaagctca gggaaggatc atttctggtg ataattccat tcactttgca
     1801 ctttgatggg cattaaaaaa aatagccctc acaagatagt aacctcaaat tcctgttctt
     1861 ggttcttatt taagcatggg tcttcattca actcagaagg cctgatctgt gtatattctg
     1921 gtgtgtattg tatggtagct ctttgagcct tggttggtcg actctagtgt aagtttaatt
     1981 aattgtatat tgtgtgaata gaacaactta aatattacag caatacactg ggctagtgtc
     2041 tcacaaataa ctgatttact cagagccacc tgacagcagg ccactagtga cagtttctgt
     2101 tatgttccta tggaaacact gtactgtaca tactatgctt aaaacattta aaacacaatg
     2161 ttttaaatgt ggacagaact gtgtaaacca cataatttct gtacatccca aaggatgaga
     2221 agtgtgacct tcaagaaaat ggaaatattt gtaaattctt ggtaatgcct ccgttgtaat
     2281 taatgaaact attttcttta aagtgtttct atgttaaaat agcatactgt gtatgtttta
     2341 tccaaattca ttcatgaatc tttcatatat atatgcatat atatacatat attgtagagt
     2401 gtgaatattc ttatttaaag tatattttta cattatgcaa atgaacttta acattttagt
     2461 ccaatgtgac tagtcaaata aaccaaataa actgagtatt ttgtctt
//
