LOCUS       NM_172688               5682 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus mitogen-activated protein kinase kinase kinase 7
            (Map3k7), transcript variant A, mRNA.
ACCESSION   NM_172688
VERSION     NM_172688.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5682)
  AUTHORS   Yin,K., Zhang,T., Lu,X., Shen,Q., Gu,K., Huang,Y., Li,C., Hou,J.,
            Li,J. and Zhang,G.
  TITLE     Tak1 licenses mitochondrial transfer from astrocytes to POMC
            neurons to maintain glucose and cholesterol homeostasis
  JOURNAL   Cell Rep 43 (12), 114983 (2024)
   PUBMED   39565693
REFERENCE   2  (bases 1 to 5682)
  AUTHORS   Hayakawa-Yano,Y., Furukawa,T., Matsuo,T., Ogasawara,T., Nogami,M.,
            Yokoyama,K., Yugami,M., Shinozaki,M., Nakamoto,C., Sakimura,K.,
            Koyama,A., Ogi,K., Onodera,O., Takebayashi,H., Okano,H. and Yano,M.
  TITLE     Qki5 safeguards spinal motor neuron function by defining the motor
            neuron-specific transcriptome via pre-mRNA processing
  JOURNAL   Proc Natl Acad Sci U S A 121 (37), e2401531121 (2024)
   PUBMED   39226364
REFERENCE   3  (bases 1 to 5682)
  AUTHORS   Sun,Y., Ji,L., Liu,W., Sun,J., Liu,P., Wang,X., Liu,X. and Xu,X.
  TITLE     Influenza virus infection activates TAK1 to suppress
            RIPK3-independent apoptosis and RIPK1-dependent necroptosis
  JOURNAL   Cell Commun Signal 22 (1), 372 (2024)
   PUBMED   39044278
  REMARK    GeneRIF: Influenza virus infection activates TAK1 to suppress
            RIPK3-independent apoptosis and RIPK1-dependent necroptosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5682)
  AUTHORS   Tang,M., Cao,H., Ma,Y., Yao,S., Wei,X., Tan,Y., Liu,F., Peng,Y. and
            Fan,N.
  TITLE     USP13 ameliorates nonalcoholic fatty liver disease through
            inhibiting the activation of TAK1
  JOURNAL   J Transl Med 22 (1), 671 (2024)
   PUBMED   39033101
  REMARK    GeneRIF: USP13 ameliorates nonalcoholic fatty liver disease through
            inhibiting the activation of TAK1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5682)
  AUTHORS   Yang,J., Zhu,L., Pan,H., Ueharu,H., Toda,M., Yang,Q., Hallett,S.A.,
            Olson,L.E. and Mishina,Y.
  TITLE     A BMP-controlled metabolic/epigenetic signaling cascade directs
            midfacial morphogenesis
  JOURNAL   J Clin Invest 134 (8), e165787 (2024)
   PUBMED   38466355
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5682)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 5682)
  AUTHORS   Komatsu,Y., Shibuya,H., Takeda,N., Ninomiya-Tsuji,J., Yasui,T.,
            Miyado,K., Sekimoto,T., Ueno,N., Matsumoto,K. and Yamada,G.
  TITLE     Targeted disruption of the Tab1 gene causes embryonic lethality and
            defects in cardiovascular and lung morphogenesis
  JOURNAL   Mech Dev 119 (2), 239-249 (2002)
   PUBMED   12464436
  REMARK    GeneRIF: TAK1 activation in TGF-beta signaling requires TAB1
REFERENCE   8  (bases 1 to 5682)
  AUTHORS   Alavizadeh,A., Kiernan,A.E., Nolan,P., Lo,C., Steel,K.P. and
            Bucan,M.
  TITLE     The Wheels mutation in the mouse causes vascular, hindbrain, and
            inner ear defects
  JOURNAL   Dev Biol 234 (1), 244-260 (2001)
   PUBMED   11356033
REFERENCE   9  (bases 1 to 5682)
  AUTHORS   Takatsu,Y., Nakamura,M., Stapleton,M., Danos,M.C., Matsumoto,K.,
            O'Connor,M.B., Shibuya,H. and Ueno,N.
  TITLE     TAK1 participates in c-Jun N-terminal kinase signaling during
            Drosophila development
  JOURNAL   Mol Cell Biol 20 (9), 3015-3026 (2000)
   PUBMED   10757786
REFERENCE   10 (bases 1 to 5682)
  AUTHORS   Yamaguchi,K., Shirakabe,K., Shibuya,H., Irie,K., Oishi,I., Ueno,N.,
            Taniguchi,T., Nishida,E. and Matsumoto,K.
  TITLE     Identification of a member of the MAPKKK family as a potential
            mediator of TGF-beta signal transduction
  JOURNAL   Science 270 (5244), 2008-2011 (1995)
   PUBMED   8533096
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK137046.1 and AL833781.5.
            
            On Jul 29, 2009 this sequence version replaced NM_172688.2.
            
            Transcript Variant: This variant (A) lacks an in-frame coding
            segment, compared to variant B. The resulting isoform (A) lacks an
            internal region, as compared to isoform B.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK137046.1, AK053911.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3402              AK137046.1         2-3403
            3403-5682           AL833781.5         61987-64266
FEATURES             Location/Qualifiers
     source          1..5682
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 13.91 cM"
     gene            1..5682
                     /gene="Map3k7"
                     /gene_synonym="B430101B05; Tak1"
                     /note="mitogen-activated protein kinase kinase kinase 7"
                     /db_xref="GeneID:26409"
                     /db_xref="MGI:MGI:1346877"
     exon            1..276
                     /gene="Map3k7"
                     /gene_synonym="B430101B05; Tak1"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..1896
                     /gene="Map3k7"
                     /gene_synonym="B430101B05; Tak1"
                     /EC_number="2.7.11.25"
                     /note="isoform A is encoded by transcript variant A;
                     transforming growth factor-beta-activated kinase 1;
                     TGF-beta-activated kinase 1"
                     /codon_start=1
                     /product="mitogen-activated protein kinase kinase kinase 7
                     isoform A"
                     /protein_id="NP_766276.1"
                     /db_xref="CCDS:CCDS18014.1"
                     /db_xref="GeneID:26409"
                     /db_xref="MGI:MGI:1346877"
                     /translation="MSTASAASSSSSSSASEMIEAPSQVLNFEEIDYKEIEVEEVVGR
                     GAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCL
                     VMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPP
                     NLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGII
                     LWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPS
                     MEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTN
                     MEQVPATNDTIKRLESKLLKNQAKQQSESGRLSLGASRGSSVESLPPTSEGKRMSADM
                     SEIEARIVATAGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPAR
                     SHPWTPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYMK
                     VQTEIALLLQRKQELVAELDQDEKDQQNTSRLVQEHKKLLDENKSLSTYYQQCKKQLE
                     VIRSQQQKRQGTS"
     exon            277..387
                     /gene="Map3k7"
                     /gene_synonym="B430101B05; Tak1"
                     /inference="alignment:Splign:2.1.0"
     exon            388..453
                     /gene="Map3k7"
                     /gene_synonym="B430101B05; Tak1"
                     /inference="alignment:Splign:2.1.0"
     exon            454..499
                     /gene="Map3k7"
                     /gene_synonym="B430101B05; Tak1"
                     /inference="alignment:Splign:2.1.0"
     exon            500..638
                     /gene="Map3k7"
                     /gene_synonym="B430101B05; Tak1"
                     /inference="alignment:Splign:2.1.0"
     exon            639..763
                     /gene="Map3k7"
                     /gene_synonym="B430101B05; Tak1"
                     /inference="alignment:Splign:2.1.0"
     exon            764..892
                     /gene="Map3k7"
                     /gene_synonym="B430101B05; Tak1"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1023
                     /gene="Map3k7"
                     /gene_synonym="B430101B05; Tak1"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1105
                     /gene="Map3k7"
                     /gene_synonym="B430101B05; Tak1"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1236
                     /gene="Map3k7"
                     /gene_synonym="B430101B05; Tak1"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1366
                     /gene="Map3k7"
                     /gene_synonym="B430101B05; Tak1"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1431
                     /gene="Map3k7"
                     /gene_synonym="B430101B05; Tak1"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1537
                     /gene="Map3k7"
                     /gene_synonym="B430101B05; Tak1"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1599
                     /gene="Map3k7"
                     /gene_synonym="B430101B05; Tak1"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1715
                     /gene="Map3k7"
                     /gene_synonym="B430101B05; Tak1"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..5682
                     /gene="Map3k7"
                     /gene_synonym="B430101B05; Tak1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4593..4598
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Map3k7"
                     /gene_synonym="B430101B05; Tak1"
                     /note="hexamer: AATAAA"
     polyA_site      4616
                     /gene="Map3k7"
                     /gene_synonym="B430101B05; Tak1"
                     /note="major polyA site"
     regulatory      5661..5666
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Map3k7"
                     /gene_synonym="B430101B05; Tak1"
                     /note="hexamer: AATAAA"
     polyA_site      5682
                     /gene="Map3k7"
                     /gene_synonym="B430101B05; Tak1"
                     /note="major polyA site"
ORIGIN      
        1 gacggaaagc gctgaggagc cgaagccggg actcggcggt ggcccgggtc ggtcccgcgc
       61 cacggagcgc cgggcggcgg ggctgcgggg ctccgggctg aagggcgctg cgcgagccgg
      121 agggcgggcg cggccccccg ggcgccgcgg gggatcatgt cgacagcctc cgccgcctcg
      181 tcctcctcct cgtcttctgc cagtgagatg atcgaagcgc cgtcgcaggt cctgaacttc
      241 gaagagatcg actacaagga gatcgaggtg gaagaggttg tcggaagagg agcttttgga
      301 gtagtttgca aagctaagtg gagagcaaaa gatgtcgcta ttaaacagat agaaagtgag
      361 tctgagagga aggctttcat tgtggagctc cggcagttgt cacgtgtgaa ccatcctaac
      421 attgtcaagt tgtatggagc ctgcctgaat ccagtatgtc ttgtgatgga atatgcagag
      481 gggggctcat tgtataatgt gctgcatggt gctgaaccat tgccttacta cactgctgct
      541 catgccatga gctggtgttt acagtgttcc caaggagtgg cttacctgca cagcatgcag
      601 cccaaagcgc tgattcacag ggacctcaag cctccaaact tgctgctggt tgcaggaggg
      661 acagttctaa aaatctgcga ttttggtaca gcttgtgaca tccaaacaca catgaccaat
      721 aataaaggga gtgctgcttg gatggcgcct gaagtatttg aaggtagcaa ttacagtgaa
      781 aagtgtgatg tcttcagctg gggtattatc ctctgggaag tgataacacg ccggaaaccc
      841 ttcgatgaga tcggtggccc agctttcaga atcatgtggg ctgttcataa tggcactcga
      901 ccaccactga tcaaaaattt acctaagccc attgagagct tgatgacacg ctgttggtct
      961 aaggacccat ctcagcgccc ttcaatggag gaaattgtga aaataatgac tcacttgatg
     1021 cggtacttcc caggagcgga tgagccgtta cagtatcctt gtcagtactc tgatgaaggg
     1081 cagagcaact cagccaccag cacaggctca ttcatggaca ttgcttctac aaataccagt
     1141 aataaaagtg acacaaatat ggaacaggtt cctgccacaa acgacactat taaacgcttg
     1201 gagtcaaaac ttttgaaaaa ccaggcaaag caacagagtg aatctggacg cctgagcttg
     1261 ggagcctctc gtgggagcag tgtggagagc ttgcccccca cttccgaggg caagaggatg
     1321 agtgctgaca tgtctgaaat agaagccagg atcgtggcga ctgcaggtaa cgggcaacca
     1381 aggcgtagat ccatccaaga cttgactgtt actgggacag aacctggtca ggtgagcagc
     1441 cggtcatcca gccctagtgt cagaatgatc actacctcag gaccaacctc agagaagcca
     1501 gctcgcagtc acccgtggac ccctgatgat tccacagata ccaatggctc agataactcc
     1561 atcccaatgg cgtatcttac actggatcac cagctacagc ctctagcgcc gtgcccaaac
     1621 tccaaagaat ccatggcagt gttcgaacaa cattgtaaaa tggcacagga gtatatgaaa
     1681 gttcaaaccg aaatcgcatt gttactacag agaaagcaag aactagttgc agaattggac
     1741 caggatgaaa aggaccagca aaatacatct cgtctggtac aggaacataa aaagctttta
     1801 gatgaaaaca aaagcctttc tacttattac cagcaatgca aaaaacaact agaggtcatc
     1861 agaagccaac agcagaaacg acaaggcact tcatgattct ctgggaccgt tacgttttaa
     1921 aatatgcaaa gacctttttt taagagaaga caaaccatta taacagttca tgagtgttag
     1981 ctttttggcg tgttctgaat gccaaatgcc tctctttgct gcatttgtta tgtcagttac
     2041 ctttcttctt atggtggata taaaatccac tgtcgtgttg cagcagatga tggcacctgt
     2101 ggcttgggaa ggcgagcgtg ctcagcttca gagcacatga agtgaacctg gctgtatgtg
     2161 catgctcctg gagtgagcta cctaacagga gggggtagca cactggctac tgtgtgcagg
     2221 catcatcctt tctctgtagt aaaaggtggg acctcaagaa ttttcttcaa agtgctcatc
     2281 tcaaaaatct gatttttttc ccagtagatg gtatgctcca atgtaaagac agggtattaa
     2341 aataacttgt ggtacattac agagggacag aatgttgagg ctgagttcaa agacagggtt
     2401 tgtgccaaca catcctggat caatactaac tgtagtccca cctgttacta ttaaaggtga
     2461 gtggtggcag ctgtgcttaa ggagagcaag tttactgact ttcgtgaggt tgagcatcgt
     2521 ctgtgaaata tgaatgacat gctcttttta caccctatgg attttcaatt ctgtgtgaaa
     2581 acagaagcct ttctgacttt taatattagt agcagatgaa attgaaagat gatgatgtag
     2641 cttaaatgat ccttcttgta accattactg agttgtttta tgatatattt gaagaaaatt
     2701 gaaaaataat agagacacaa atcattggcc cagctaaagg aggcttgagc tgagctatcg
     2761 gtctgttata ccaaataagg aacacagcag gctaatcagg aggcccgagt aaggaaggca
     2821 aaggaggaaa attaaaccca ctttcgtagc tactcagagg acttgattcc tctgaagtcc
     2881 tttcctgagt ctgttgcctt cccatgcttt taagagaatt tgaacactta caaagagaat
     2941 atttatattg ttaacaataa gtttactacc aaccttcaaa ataacttaaa ggtaataata
     3001 aaatgccatt aaaaaaataa atccctaaga tctatttttt cagtccatgt taacacattt
     3061 tgataccagt gcatgaatgt cttttaaatt agatgccatc agcttcgctt ttatagtgtt
     3121 catgtttgta aagagaacat ttggaatgga aagatgatcg ctgtggtact tagatgtaca
     3181 tctcgcatgt tcctgctctg ttccagatga gcacgagaag ctagcgaagg tgttctttaa
     3241 ggctaagaca gataaccttt ttcctgttat ttttttcctc tctgagtttt ataatgaatc
     3301 ccttctgtat acagtgaagg taagggagag tttatagcaa gatgtgcctt cctcaaaacc
     3361 tgttagtaga aagctcctgg gagctaaatg tcttctttca cttaaataaa aaagattata
     3421 gatagcctca aactctatta ggtgacatga gtgccgagct cagcgttagt agtgacataa
     3481 aactgacaca gaagatagct gtagtctgag tccaagacca acaccgcctg ccactgctgc
     3541 ctgtgcagac atctggcact ccacaggaga gccatggtct ctgctgtgca gcatgctgaa
     3601 agcatcttga cttcccagga gattccacat tacatggatg caagctcatt tctagccagt
     3661 tgttttgcaa ggtctgcatc ctacaactaa aaggaaattt tgttgtcctg gtcacttgaa
     3721 agtattcaaa caagcaaatg gaagaaaaca ctggatttgc tcatggtacc agtgttgaaa
     3781 gattgttact cggttgcttg tgtatgctca gctccttggg gtttccgaca ctgtggtcct
     3841 ggacagcctt aagtaggtgc actggcacac tcacatgcat ttttaaagct ccactatcgc
     3901 tgaacgtgag cacaccatcc atacttgaaa tccataccag tttgctcaat gtctcaacct
     3961 gtaaaacctt caaataacaa cataccaagg agccagatgg tcactaattc ctgttctaca
     4021 atttattcaa gcctcacttc ttgggtgaag tagaaaacag gcagacaggt ttatacattg
     4081 atgtccaaga accagacagt cctgcacaga cactagtggc attttgtttc catttccagg
     4141 aaaggaagca aggttgtgca atgtggagtg aagtcctcct cagcagtaaa gccatgctct
     4201 aggttgagta agtcagttaa gagcaccata ctgccatact gaaaacatct gcttagagtt
     4261 atttacaagt ggttggctat tttttgttga agtatttttt gaatagcgaa tgtctttttc
     4321 cttcaaattt ctgtcattct cccaaggccc cctcctcctg cagccagaga ttacaggtgg
     4381 ttttgtttct ccctccttcc ctgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     4441 gtgtgtgtgt gtagtcaact cctctattca caagctagta aagctatcta cttttattcc
     4501 tgtccaggta tttcttgtaa gatgatataa tgcagaaatt cttgtgcata ctctgtaact
     4561 gaaggaggct tttttgattt atttttgtct ttaataaaat tcagattgtt atttcaggct
     4621 ggtatgtagg aatggtagct ggcttctcta cacgacgact gagctgtggg tttgcccagt
     4681 ggtatttacc tcatgcagac caatagctga atcaccagtt tcctagcata ctcagtacag
     4741 tgtaccatag tcatgccaga gactgaatca tcggactgag agtcggctta gcagttaaga
     4801 gcactcatgt ggaggactag ggttctgttc ccagcacccg catggagact cccaactctc
     4861 tgcaactcca gttccggggt ggtctgactc cttatgttcc tgatggttct tgtaagcaca
     4921 tggtgcatat atactcagac gagcgtgcgc gcgcgcacac acacacacac acacacacac
     4981 acacgtgaga aaaaaaaagt cctctttatt ttttcatggg ccttcatttt tatggagtac
     5041 agcataaaag tgactgactt atcattgcaa acttcttaat gttttttcta agctacagta
     5101 accattttgc ttttatatca agtaaccccc ccccccgctt atagataacc acatattttt
     5161 actatctatc cattagtttc ctcgttgctt cagtattgat aagctactgt tactaatgac
     5221 aagttcatgt cagccccacc atagaagccc ctgtaagatg ctgaaggcgg gggttgctaa
     5281 gcattggccc ctgaatctgc tcttctacca gctccatctg tgtaggtgga gtcacttgtg
     5341 tgagaactgc ccactcatca gcagaggaaa catttctaca cctcctcaac ccagatatct
     5401 gctcggaatg actgcgatgt tgtgaaggcc ccctgtgaat tggagggctt cagtgttggc
     5461 actcactcac ttggaattcc ttcttccatc tgagagacaa aatgcccaaa atgaagtaca
     5521 agtactgggc caactgacag aagatccacc cggcacacag gaagtgagct ctggtctgaa
     5581 cttttgtcat ctttgtggtg gtggtatttt tgtttctgtc tactaggaag tcatatttaa
     5641 ttaaggcgta atttatgtac aataaacttc attcatttca aa
//
