LOCUS       NM_016693               4333 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus mitogen-activated protein kinase kinase kinase 6
            (Map3k6), mRNA.
ACCESSION   NM_016693
VERSION     NM_016693.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4333)
  AUTHORS   Tartey,S., Gurung,P., Dasari,T.K., Burton,A. and Kanneganti,T.D.
  TITLE     ASK1/2 signaling promotes inflammation in a mouse model of
            neutrophilic dermatosis
  JOURNAL   J Clin Invest 128 (5), 2042-2047 (2018)
   PUBMED   29629899
  REMARK    GeneRIF: the present study identifies SHP-1 and ASK signaling
            crosstalk as a critical regulator of IL-1alpha-driven inflammation
            and opens future avenues for finding novel drug targets to treat
            neutrophilic dermatosis
REFERENCE   2  (bases 1 to 4333)
  AUTHORS   Imamura,K., Yoshitane,H., Hattori,K., Yamaguchi,M., Yoshida,K.,
            Okubo,T., Naguro,I., Ichijo,H. and Fukada,Y.
  TITLE     ASK family kinases mediate cellular stress and redox signaling to
            circadian clock
  JOURNAL   Proc Natl Acad Sci U S A 115 (14), 3646-3651 (2018)
   PUBMED   29555767
REFERENCE   3  (bases 1 to 4333)
  AUTHORS   Place,D.E., Samir,P., Karki,R., Briard,B., Vogel,P. and
            Kanneganti,T.D.
  TITLE     ASK Family Kinases Are Required for Optimal NLRP3 Inflammasome
            Priming
  JOURNAL   Am J Pathol 188 (4), 1021-1030 (2018)
   PUBMED   29353059
  REMARK    GeneRIF: the ASK1/2 complex is a regulator of NLRP3 activation
REFERENCE   4  (bases 1 to 4333)
  AUTHORS   Gornikiewicz,B., Ronowicz,A., Krzeminski,M. and Sachadyn,P.
  TITLE     Changes in gene methylation patterns in neonatal murine hearts:
            Implications for the regenerative potential
  JOURNAL   BMC Genomics 17, 231 (2016)
   PUBMED   26979619
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4333)
  AUTHORS   Okazaki,T., Higuchi,M., Takeda,K., Iwatsuki-Horimoto,K., Kiso,M.,
            Miyagishi,M., Yanai,H., Kato,A., Yoneyama,M., Fujita,T.,
            Taniguchi,T., Kawaoka,Y., Ichijo,H. and Gotoh,Y.
  TITLE     The ASK family kinases differentially mediate induction of type I
            interferon and apoptosis during the antiviral response
  JOURNAL   Sci Signal 8 (388), ra78 (2015)
   PUBMED   26243192
  REMARK    GeneRIF: Data show that deletion of either MAPKKK5 ASK1 or MAPKKK6
            ASK2 in mice promoted the replication of influenza A virus in the
            lung.
            Erratum:[Sci Signal. 2017 May 30;10(481):eaan8208. doi:
            10.1126/scisignal.aan8208.. PMID: 28559445]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4333)
  AUTHORS   Iriyama,T., Takeda,K., Nakamura,H., Morimoto,Y., Kuroiwa,T.,
            Mizukami,J., Umeda,T., Noguchi,T., Naguro,I., Nishitoh,H.,
            Saegusa,K., Tobiume,K., Homma,T., Shimada,Y., Tsuda,H., Aiko,S.,
            Imoto,I., Inazawa,J., Chida,K., Kamei,Y., Kozuma,S., Taketani,Y.,
            Matsuzawa,A. and Ichijo,H.
  TITLE     ASK1 and ASK2 differentially regulate the counteracting roles of
            apoptosis and inflammation in tumorigenesis
  JOURNAL   EMBO J 28 (7), 843-853 (2009)
   PUBMED   19214184
REFERENCE   7  (bases 1 to 4333)
  AUTHORS   Craig,E.A., Stevens,M.V., Vaillancourt,R.R. and Camenisch,T.D.
  TITLE     MAP3Ks as central regulators of cell fate during development
  JOURNAL   Dev Dyn 237 (11), 3102-3114 (2008)
   PUBMED   18855897
  REMARK    Review article
REFERENCE   8  (bases 1 to 4333)
  AUTHORS   Breitwieser,W., Lyons,S., Flenniken,A.M., Ashton,G., Bruder,G.,
            Willington,M., Lacaud,G., Kouskoff,V. and Jones,N.
  TITLE     Feedback regulation of p38 activity via ATF2 is essential for
            survival of embryonic liver cells
  JOURNAL   Genes Dev 21 (16), 2069-2082 (2007)
   PUBMED   17699753
REFERENCE   9  (bases 1 to 4333)
  AUTHORS   Takeda,K., Shimozono,R., Noguchi,T., Umeda,T., Morimoto,Y.,
            Naguro,I., Tobiume,K., Saitoh,M., Matsuzawa,A. and Ichijo,H.
  TITLE     Apoptosis signal-regulating kinase (ASK) 2 functions as a
            mitogen-activated protein kinase kinase kinase in a heteromeric
            complex with ASK1
  JOURNAL   J Biol Chem 282 (10), 7522-7531 (2007)
   PUBMED   17210579
  REMARK    GeneRIF: Apoptosis signal-regulating kinase (ASK) 2 functions as a
            mitogen-activated protein kinase kinase kinase in a heteromeric
            complex with ASK1.
REFERENCE   10 (bases 1 to 4333)
  AUTHORS   Endo,Y., Liu,Y., Kanno,K., Takahashi,M., Matsushita,M. and
            Fujita,T.
  TITLE     Identification of the mouse H-ficolin gene as a pseudogene and
            orthology between mouse ficolins A/B and human L-/M-ficolins
  JOURNAL   Genomics 84 (4), 737-744 (2004)
   PUBMED   15475251
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL837525.5 and AL671882.6.
            
            On Mar 21, 2009 this sequence version replaced NM_016693.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB021861.4, BC120565.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-614               AL837525.5         9888-10501
            615-754             AL837525.5         11888-12027
            755-778             AL837525.5         12123-12146
            779-969             AL837525.5         12381-12571
            970-1138            AL837525.5         12745-12913
            1139-1245           AL837525.5         14052-14158
            1246-1416           AL837525.5         14576-14746
            1417-1529           AL837525.5         14848-14960
            1530-1689           AL837525.5         15328-15487
            1690-1802           AL837525.5         15700-15812
            1803-1852           AL671882.6         2001-2050
            1853-1960           AL671882.6         2133-2240
            1961-2010           AL671882.6         2338-2387
            2011-2106           AL671882.6         2460-2555
            2107-2194           AL671882.6         2672-2759
            2195-2328           AL671882.6         2839-2972
            2329-2456           AL671882.6         3271-3398
            2457-2593           AL671882.6         3646-3782
            2594-2699           AL671882.6         4050-4155
            2700-2857           AL671882.6         4920-5077
            2858-3050           AL671882.6         5188-5380
            3051-3189           AL671882.6         5466-5604
            3190-3346           AL671882.6         5907-6063
            3347-3523           AL671882.6         6182-6358
            3524-3629           AL671882.6         6600-6705
            3630-3792           AL671882.6         6869-7031
            3793-3905           AL671882.6         7117-7229
            3906-3979           AL671882.6         7313-7386
            3980-4056           AL671882.6         7658-7734
            4057-4333           AL671882.6         7910-8186
FEATURES             Location/Qualifiers
     source          1..4333
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 66.25 cM"
     gene            1..4333
                     /gene="Map3k6"
                     /gene_synonym="Ask2; MAPKKK6; MEKK6"
                     /note="mitogen-activated protein kinase kinase kinase 6"
                     /db_xref="GeneID:53608"
                     /db_xref="MGI:MGI:1855691"
     exon            1..614
                     /gene="Map3k6"
                     /gene_synonym="Ask2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     CDS             272..4147
                     /gene="Map3k6"
                     /gene_synonym="Ask2; MAPKKK6; MEKK6"
                     /EC_number="2.7.11.25"
                     /note="apoptosis signal-regulating kinase 2"
                     /codon_start=1
                     /product="mitogen-activated protein kinase kinase kinase
                     6"
                     /protein_id="NP_057902.5"
                     /db_xref="CCDS:CCDS18744.1"
                     /db_xref="GeneID:53608"
                     /db_xref="MGI:MGI:1855691"
                     /translation="MAGPCPGAGVLERAGSCWQDPLAEALSRGRSSPAVTGRGCARSR
                     PLSVVYVLTREPGLGVEPGSGTEAEPLPLRCLREACAQLQGTRPPPQLRSLPFATLAL
                     GDTAALDSFYNADVVVLEVSSSLAQPSLFYHLGVRESFSMTNNVLLCSQAELPDLQAL
                     REDVFQKNSDCVGSYTLIPYVVTATGRVLCGDAGLLRGIADGLVQAGAGTEALLTPLV
                     GRLVRLLEATPTDSCGYFRETIRQDIRQARERFSGQQLRQELARLQRRLDSVELLSPD
                     IVMNLLLSYRDVQDYSAIIELVETLQALPTCDVAEQHNVCFHYTFALNRRNRPGDREK
                     ALAVLLPLVKYEGPVAPDLYCMCGRIYKDMFFTSGFQNAGHLEQAYHWYRKAFDVEPS
                     LHSGINAAVLLIAAGQHFEDSEELRLIGMKLACLLARKGCVEKMQYYWDVGFYLGAQI
                     LANDPIQVVLAAEQLYKLNAPIWYLVSVMETFLLYQHFRPTPEPSGGPPLRAHFWLHF
                     LLQSCQPFKMAPPQEDQCLVLVLEINKVLLPARLEIQGTDPVSTVTLSLLDPETQEDP
                     SSWTFPVTSICGISTSKLDQRCCFLYALPPAQDVQLCFPSVERCQRFCGLIQVLVMNP
                     DSSAPTEEAEGAREVLEFDYEYSETGERLVLGRGTYGVVYAGRDRHTRVRIAIKEIPE
                     RDSRFSQPLHEEIALHKRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWG
                     PLKDNESTISFYTRQILQGLSYLHENRIVHRDIKGDNVLINTFSGLLKISDFGTSKRL
                     AGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGRPPFHELGSP
                     QAAMFQVGMYKVHPPVPGSLSAEAQAFLLRTFEPDPRLRASAQELLGDPFLQPGKRSR
                     SPGSPRHTPRPSGAPSGPSSPSADSATQSQTFPRPQAPSQHPPSPPKRCLSYGDTSQL
                     RVPEEPAAEEPASPEESSGLSLLHQESKRRAMLAAVLEQEVPTLAENLLEQEQDSRLS
                     KIHVELLLRCLGAQIHTPNRRQLAQELRTLQAQLRAQSLGPALLKGPLFAFPDAVKQI
                     LRRRQIRPHWMFVLDSLLSRAVRAAMAVLDAESEKKAVLPRSEESSKEESQQKPQESQ
                     ALQSQLPPEQGPPSLMVELGLLRAETDRLRDLLAEKERECQALVQQALHRVHAETRKY
                     APASETPATLPKDQNLVRWLQELSVDPATIQTLLSHSFTLQTLLTCATQDDLVYTRIR
                     GGMVCRIWRAILAQRAGATSVTPVPRDAE"
     exon            615..754
                     /gene="Map3k6"
                     /gene_synonym="Ask2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            755..778
                     /gene="Map3k6"
                     /gene_synonym="Ask2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            779..969
                     /gene="Map3k6"
                     /gene_synonym="Ask2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1138
                     /gene="Map3k6"
                     /gene_synonym="Ask2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1245
                     /gene="Map3k6"
                     /gene_synonym="Ask2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1416
                     /gene="Map3k6"
                     /gene_synonym="Ask2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1529
                     /gene="Map3k6"
                     /gene_synonym="Ask2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1689
                     /gene="Map3k6"
                     /gene_synonym="Ask2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1852
                     /gene="Map3k6"
                     /gene_synonym="Ask2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..1960
                     /gene="Map3k6"
                     /gene_synonym="Ask2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2010
                     /gene="Map3k6"
                     /gene_synonym="Ask2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2106
                     /gene="Map3k6"
                     /gene_synonym="Ask2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2194
                     /gene="Map3k6"
                     /gene_synonym="Ask2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            2195..2328
                     /gene="Map3k6"
                     /gene_synonym="Ask2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2456
                     /gene="Map3k6"
                     /gene_synonym="Ask2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            2457..2593
                     /gene="Map3k6"
                     /gene_synonym="Ask2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            2594..2699
                     /gene="Map3k6"
                     /gene_synonym="Ask2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            2700..2857
                     /gene="Map3k6"
                     /gene_synonym="Ask2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            2858..3050
                     /gene="Map3k6"
                     /gene_synonym="Ask2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            3051..3189
                     /gene="Map3k6"
                     /gene_synonym="Ask2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            3190..3346
                     /gene="Map3k6"
                     /gene_synonym="Ask2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            3347..3523
                     /gene="Map3k6"
                     /gene_synonym="Ask2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            3524..3629
                     /gene="Map3k6"
                     /gene_synonym="Ask2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            3630..3792
                     /gene="Map3k6"
                     /gene_synonym="Ask2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            3793..3905
                     /gene="Map3k6"
                     /gene_synonym="Ask2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            3906..3979
                     /gene="Map3k6"
                     /gene_synonym="Ask2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            3980..4056
                     /gene="Map3k6"
                     /gene_synonym="Ask2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            4057..4333
                     /gene="Map3k6"
                     /gene_synonym="Ask2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctgggtgta gcacgctgcc ggttgacttc ccaggactct tctgtgacct gtgagccgag
       61 gattactggg taccccagat tcccagaacc cagtcctgga ttgcagatct gtaaggaccg
      121 tgaaagattg agcaaagaag tctttctgga cttaagagtt ccggaacagg acgtccagcc
      181 catctccgga tcccgactgg atccacacct tcagcctcgt gccctgtccc gggttccccg
      241 cgcccggggc cccgcgcttg agcgcccccg catggcgggg ccatgtcctg gggccggggt
      301 tctagaacgg gcgggcagct gctggcagga cccgctggcg gaggcgctga gccggggccg
      361 ctcgtctcct gcggtcacgg gtcggggctg cgcgcggagc cggcctctca gtgtggtcta
      421 cgtgctgacc cgggagccgg ggctcggggt ggagcccggg tcgggaaccg aggcagagcc
      481 gctgccgttg cgatgcctgc gcgaggcctg cgctcagctc cagggcacac ggccaccccc
      541 gcagctacgc agcctaccct ttgcgacgct ggcgctaggc gacaccgctg cgctggactc
      601 cttctacaac gcggatgtag tggtgctgga ggtgagcagc tccctggcac agccttcctt
      661 gttctaccac ctcggcgtgc gtgagagctt cagcatgacc aacaacgtgc tcctctgttc
      721 ccaggcagag ctccctgatc tgcaggccct tcgtgaggat gttttccaga agaactcgga
      781 ttgtgttggc agctacacac tgattcctta tgtggtgaca gccactggcc gggtcttatg
      841 tggcgatgca ggcctcctga ggggcatagc cgatgggcta gtacaggctg gggcgggcac
      901 tgaagccctc ctcactcccc tggtgggccg gcttgtccgt ctgttggagg ctacacccac
      961 agactcttgc ggctatttcc gggagaccat tcgtcaggat atccggcagg ctcgggagcg
     1021 attcagtggg cagcagctga ggcaggagct ggctcgcctg cagcggaggc tggacagcgt
     1081 ggagctgctg agccctgaca ttgtcatgaa tctgctgcta tcgtaccgtg atgtccagga
     1141 ctactcggcc atcattgagc tggtggagac gctgcaggct ttgcccacct gtgatgtggc
     1201 tgaacagcac aatgtctgct ttcactacac atttgccctc aacaggagga acaggcctgg
     1261 ggaccgggag aaagccctgg ctgtcctgct gccattggtg aagtatgaag gtcccgtggc
     1321 tccggatctg tactgcatgt gtggtcgtat ctacaaggac atgttcttca cttctggctt
     1381 ccaaaatgcc ggccacctgg agcaggccta tcactggtac cgcaaggcgt ttgatgtgga
     1441 gcccagcctg cactcaggca tcaatgcagc tgttctcctc attgcagctg ggcagcattt
     1501 cgaagactct gaggagctcc ggctgattgg catgaagctg gcctgcctgc tagcccgcaa
     1561 aggctgtgtg gagaagatgc agtactactg ggatgtggga ttctacctgg gagcccagat
     1621 tcttgccaac gaccccatcc aggtggtgct ggctgcagag caactgtaca agcttaatgc
     1681 ccccatttgg tacttggtct ccgtgatgga gaccttccta ctgtaccagc atttcagacc
     1741 cacaccagag ccctcaggag gacccccgct gcgagctcac ttctggctcc acttcctgct
     1801 acaatcttgc cagcctttca agatggctcc tcctcaggag gaccagtgcc tggtactggt
     1861 gctggagata aacaaggtcc tgctgcctgc caggcttgag attcagggaa cagaccccgt
     1921 gagcacagtg accctaagct tgctggaccc agagactcag gaggatcctt ccagctggac
     1981 cttcccagtc acctccatct gtgggatcag cacctccaag ctggaccagc gctgctgctt
     2041 cctgtacgca cttcctccgg cccaggacgt ccagctgtgc tttcccagtg tggagcgctg
     2101 ccagcggttc tgtggcctaa ttcaggtctt ggtgatgaat ccggattcct ccgcgcccac
     2161 tgaggaggca gaaggcgcaa gggaggtgct ggagtttgat tatgaatact cggagactgg
     2221 tgagcggctg gtgttgggca gaggcacgta tggggtggtg tatgctggcc gagacaggca
     2281 cacgagggta cgaatcgcca tcaaggagat cccagagaga gatagcagat tctctcagcc
     2341 tctgcatgaa gagatcgctc ttcacaaacg acttcgtcat aagaatattg tgcgttatct
     2401 gggctcagcc agccagggcg gctacctcaa gatcttcatg gaggaagtgc ctggaggcag
     2461 cctgtcctcc ttgcttaggt cagtgtgggg acccctaaag gacaacgaga gcactattag
     2521 cttctataca cgtcagatcc tacaaggact cagctacctc catgagaacc gtatcgttca
     2581 cagagacatc aagggagaca atgttctgat caacaccttc agtgggctgc tcaagatttc
     2641 tgactttggc acctctaagc ggctggcagg catcacaccg tgcacggaga ctttcacagg
     2701 gactctgcag tatatggccc cggaaatcat cgaccagggc ccgcgaggat atgggaaggc
     2761 agctgacatc tggtctctgg gctgcactgt aatcgagatg gcaacaggtc gaccgccctt
     2821 ccatgaacta gggagccctc aggctgcgat gtttcaggtg ggcatgtaca aggtacatcc
     2881 acccgtgccc ggttccctgt cagctgaggc ccaagccttc ctcctccgaa cttttgagcc
     2941 agatccccgc ctccgagcca gtgcccaaga gctgctggga gaccccttcc ttcagccagg
     3001 aaagaggagc cgcagcccgg gctctcctcg gcatactccc cggccctcag gcgccccttc
     3061 cggtccttcc agtccttcag ctgactcagc cacacagtct cagacattcc caaggcccca
     3121 ggcaccctct cagcacccac ccagcccccc aaagcgctgc cttagttatg gggacaccag
     3181 tcagctccgt gtgcccgagg agcccgctgc cgaggaaccc gcgtccccag aagagagttc
     3241 aggcctgagt ctgctgcacc aggagagcaa gcgccgggcc atgctggctg cggtgctgga
     3301 acaggaggtg cccacactag cagagaatct cctggaacag gaacaggact ctcgactcag
     3361 caagattcat gtggaacttc tgcttcggtg ccttggggca caaatccaca ctcctaaccg
     3421 ccggcagctg gcccaggagc tgcggaccct gcaagctcag ctgcgggccc agagcctggg
     3481 ccctgcgctt ttgaaggggc cgctcttcgc ctttccagac gcggtgaagc agatcctccg
     3541 cagacgccag atccgcccac actggatgtt cgtgttggac tcgctgctca gccgtgcagt
     3601 ccgggcggcg atggcggtgc tggacgcgga gtcggagaag aaagcggtct taccgaggtc
     3661 agaagagtcg agtaaagagg agtcccagca gaaacctcag gagagccagg cgctgcagag
     3721 ccagctccca ccagagcagg gacccccatc gttgatggtg gagttgggcc ttttgcgagc
     3781 cgagactgac aggcttcggg accttctggc tgagaaggaa cgtgagtgcc aggcgctggt
     3841 gcaacaggcc ctgcatcggg tgcatgcaga gaccaggaag tatgccccag cttcagagac
     3901 cccagccact ctcccaaagg accagaacct ggtgcggtgg ctacaggaac tgagtgtaga
     3961 tccagccact atccaaacgc tcctgagtca tagcttcacc cttcaaaccc tgctcacctg
     4021 tgccactcaa gatgatctag tgtacaccag aatcagggga gggatggtat gccggatttg
     4081 gagagccatc ttggcacagc gagcaggagc cacatcggtc accccagtac cccgggacgc
     4141 tgagtgatga catcaaagga cacagatacg gatggatgaa cagagaagac acaaacagct
     4201 ttggacacac ctgtcctaga acccaggagc aactacaggg accaggccca accccaatgg
     4261 gtggaactaa ctagggaggc acccaaagga cactacatac aatcataaac tattaaacag
     4321 aacacttgct acc
//
