LOCUS       NM_011947               4686 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus mitogen-activated protein kinase kinase kinase 3
            (Map3k3), mRNA.
ACCESSION   NM_011947
VERSION     NM_011947.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4686)
  AUTHORS   Ren,J., Huang,Y., Ren,Y., Tu,T., Qiu,B., Ai,D., Bi,Z., Bai,X.,
            Li,F., Li,J.L., Chen,X.J., Feng,Z., Guo,Z., Lei,J., Tian,A.,
            Cui,Z., Lindner,V., Adams,R.H., Wang,Y., Zhao,F., Korbelin,J.,
            Sun,W., Wang,Y., Zhang,H., Hong,T. and Ge,W.P.
  TITLE     Somatic variants of MAP3K3 are sufficient to cause cerebral and
            spinal cord cavernous malformations
  JOURNAL   Brain 146 (9), 3634-3647 (2023)
   PUBMED   36995941
  REMARK    GeneRIF: Somatic variants of MAP3K3 are sufficient to cause
            cerebral and spinal cord cavernous malformations.
REFERENCE   2  (bases 1 to 4686)
  AUTHORS   Tsitsikov,E.N., Phan,K.P., Liu,Y., Tsytsykova,A.V., Kinter,M.,
            Selland,L., Garman,L., Griffin,C. and Dunn,I.F.
  TITLE     TRAF7 is an essential regulator of blood vessel integrity during
            mouse embryonic and neonatal development
  JOURNAL   iScience 26 (8), 107474 (2023)
   PUBMED   37583551
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4686)
  AUTHORS   Huo,R., Yang,Y., Sun,Y., Zhou,Q., Zhao,S., Mo,Z., Xu,H., Wang,J.,
            Weng,J., Jiao,Y., Zhang,J., He,Q., Wang,S., Zhao,J., Wang,J. and
            Cao,Y.
  TITLE     Endothelial hyperactivation of mutant MAP3K3 induces cerebral
            cavernous malformation enhanced by PIK3CA GOF mutation
  JOURNAL   Angiogenesis 26 (2), 295-312 (2023)
   PUBMED   36719480
  REMARK    GeneRIF: Endothelial hyperactivation of mutant MAP3K3 induces
            cerebral cavernous malformation enhanced by PIK3CA GOF mutation.
REFERENCE   4  (bases 1 to 4686)
  AUTHORS   Cai,M., Huang,W., Hu,X., Chen,A. and Zhou,X.
  TITLE     MEKK3 activates IRF7 to trigger a potent type I interferon
            induction in response to TLR7/9 signaling
  JOURNAL   Mol Immunol 134, 183-191 (2021)
   PUBMED   33812250
  REMARK    GeneRIF: MEKK3 activates IRF7 to trigger a potent type I interferon
            induction in response to TLR7/9 signaling.
REFERENCE   5  (bases 1 to 4686)
  AUTHORS   Xu,D., Yao,M., Wang,Y., Yuan,L., Hoeck,J.D., Yu,J., Liu,L.,
            Yeap,Y.Y.C., Zhang,W., Zhang,F., Feng,Y., Ma,T., Wang,Y.,
            Ng,D.C.H., Niu,X., Su,B., Behrens,A. and Xu,Z.
  TITLE     MEKK3 coordinates with FBW7 to regulate WDR62 stability and
            neurogenesis
  JOURNAL   PLoS Biol 16 (12), e2006613 (2018)
   PUBMED   30566428
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4686)
  AUTHORS   Yang,J., Lin,Y., Guo,Z., Cheng,J., Huang,J., Deng,L., Liao,W.,
            Chen,Z., Liu,Z. and Su,B.
  TITLE     The essential role of MEKK3 in TNF-induced NF-kappaB activation
  JOURNAL   Nat Immunol 2 (7), 620-624 (2001)
   PUBMED   11429546
REFERENCE   7  (bases 1 to 4686)
  AUTHORS   Yang,J., Boerm,M., McCarty,M., Bucana,C., Fidler,I.J., Zhuang,Y.
            and Su,B.
  TITLE     Mekk3 is essential for early embryonic cardiovascular development
  JOURNAL   Nat Genet 24 (3), 309-313 (2000)
   PUBMED   10700190
REFERENCE   8  (bases 1 to 4686)
  AUTHORS   Fanger,G.R., Widmann,C., Porter,A.C., Sather,S., Johnson,G.L. and
            Vaillancourt,R.R.
  TITLE     14-3-3 proteins interact with specific MEK kinases
  JOURNAL   J Biol Chem 273 (6), 3476-3483 (1998)
   PUBMED   9452471
REFERENCE   9  (bases 1 to 4686)
  AUTHORS   Fanger,G.R., Johnson,N.L. and Johnson,G.L.
  TITLE     MEK kinases are regulated by EGF and selectively interact with
            Rac/Cdc42
  JOURNAL   EMBO J 16 (16), 4961-4972 (1997)
   PUBMED   9305638
REFERENCE   10 (bases 1 to 4686)
  AUTHORS   Blank,J.L., Gerwins,P., Elliott,E.M., Sather,S. and Johnson,G.L.
  TITLE     Molecular cloning of mitogen-activated protein/ERK kinase kinases
            (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways
            involving mitogen-activated protein kinase and c-Jun kinase
  JOURNAL   J Biol Chem 271 (10), 5361-5368 (1996)
   PUBMED   8621389
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596331.15.
            
            On Dec 6, 2019 this sequence version replaced NM_011947.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK137127.1, BC023781.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-347               AL596331.15        93027-93373
            348-469             AL596331.15        105431-105552
            470-510             AL596331.15        119184-119224
            511-610             AL596331.15        122624-122723
            611-724             AL596331.15        125930-126043
            725-845             AL596331.15        132226-132346
            846-979             AL596331.15        150865-150998
            980-1053            AL596331.15        154126-154199
            1054-1121           AL596331.15        157005-157072
            1122-1214           AL596331.15        157254-157346
            1215-1406           AL596331.15        157922-158113
            1407-1555           AL596331.15        158710-158858
            1556-1687           AL596331.15        159449-159580
            1688-1817           AL596331.15        160058-160187
            1818-1995           AL596331.15        160657-160834
            1996-4686           AL596331.15        162406-165096
FEATURES             Location/Qualifiers
     source          1..4686
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 68.89 cM"
     gene            1..4686
                     /gene="Map3k3"
                     /gene_synonym="MAPKKK3; Mekk3; mKIAA4031"
                     /note="mitogen-activated protein kinase kinase kinase 3"
                     /db_xref="GeneID:26406"
                     /db_xref="MGI:MGI:1346874"
     exon            1..347
                     /gene="Map3k3"
                     /gene_synonym="MAPKKK3; Mekk3; mKIAA4031"
                     /inference="alignment:Splign:2.1.0"
     CDS             344..2224
                     /gene="Map3k3"
                     /gene_synonym="MAPKKK3; Mekk3; mKIAA4031"
                     /EC_number="2.7.11.25"
                     /note="MEKK 3; MAPK/ERK kinase kinase 3; MEK kinase 3"
                     /codon_start=1
                     /product="mitogen-activated protein kinase kinase kinase
                     3"
                     /protein_id="NP_036077.1"
                     /db_xref="CCDS:CCDS25548.1"
                     /db_xref="GeneID:26406"
                     /db_xref="MGI:MGI:1346874"
                     /translation="MDEQEALDSIMKDLVALQMSRRTRLSGYETMKNKDTGHPNRQSD
                     VRIKFEHNGERRIIAFSRPVRYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDK
                     AIDILDRSSSMKSLRILLLSQDRNHTSSSPHSGVSRQVRIKPSQSAGDINTIYQAPEP
                     RSRHLSVSSQNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETSEQCMLDPLS
                     SAENSLSGSCQSLDRSADSPSFRKSQMSRARSFPDNRKECSDRETQLYDKGVKGGTYP
                     RRYHVSVHHKDYNDGRRTFPRIRRHQGNLFTLVPSSRSLSTNGENMGVAVQYLDPRGR
                     LRSADSENALTVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQ
                     VQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKILTIFMEYMPGGS
                     VKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDF
                     GASKRLQTICMSGTGIRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPP
                     WAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIFVEARQRPSAEELLTHHFAQL
                     VY"
     exon            348..469
                     /gene="Map3k3"
                     /gene_synonym="MAPKKK3; Mekk3; mKIAA4031"
                     /inference="alignment:Splign:2.1.0"
     exon            470..510
                     /gene="Map3k3"
                     /gene_synonym="MAPKKK3; Mekk3; mKIAA4031"
                     /inference="alignment:Splign:2.1.0"
     exon            511..610
                     /gene="Map3k3"
                     /gene_synonym="MAPKKK3; Mekk3; mKIAA4031"
                     /inference="alignment:Splign:2.1.0"
     exon            611..724
                     /gene="Map3k3"
                     /gene_synonym="MAPKKK3; Mekk3; mKIAA4031"
                     /inference="alignment:Splign:2.1.0"
     exon            725..845
                     /gene="Map3k3"
                     /gene_synonym="MAPKKK3; Mekk3; mKIAA4031"
                     /inference="alignment:Splign:2.1.0"
     exon            846..979
                     /gene="Map3k3"
                     /gene_synonym="MAPKKK3; Mekk3; mKIAA4031"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1053
                     /gene="Map3k3"
                     /gene_synonym="MAPKKK3; Mekk3; mKIAA4031"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1121
                     /gene="Map3k3"
                     /gene_synonym="MAPKKK3; Mekk3; mKIAA4031"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1214
                     /gene="Map3k3"
                     /gene_synonym="MAPKKK3; Mekk3; mKIAA4031"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1406
                     /gene="Map3k3"
                     /gene_synonym="MAPKKK3; Mekk3; mKIAA4031"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1555
                     /gene="Map3k3"
                     /gene_synonym="MAPKKK3; Mekk3; mKIAA4031"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1687
                     /gene="Map3k3"
                     /gene_synonym="MAPKKK3; Mekk3; mKIAA4031"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1817
                     /gene="Map3k3"
                     /gene_synonym="MAPKKK3; Mekk3; mKIAA4031"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1995
                     /gene="Map3k3"
                     /gene_synonym="MAPKKK3; Mekk3; mKIAA4031"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..4686
                     /gene="Map3k3"
                     /gene_synonym="MAPKKK3; Mekk3; mKIAA4031"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3779
                     /gene="Map3k3"
                     /gene_synonym="MAPKKK3; Mekk3; mKIAA4031"
     regulatory      4661..4666
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Map3k3"
                     /gene_synonym="MAPKKK3; Mekk3; mKIAA4031"
                     /note="hexamer: AATAAA"
     polyA_site      4686
                     /gene="Map3k3"
                     /gene_synonym="MAPKKK3; Mekk3; mKIAA4031"
                     /note="major polyA site"
ORIGIN      
        1 gtttttcgga gcgttcctga ggtggagaac agtggccggt cggagcgtct tctggacttc
       61 aggactcgca ggcggcccgg tcgagtggcg ccgccgaggc cgggttgggc cgagcctggg
      121 agcgccgggg atgtagcggg ccaacctgct catgccacag cgcccggccg cggccggagc
      181 cggagcctgg ggaggcggcg ggggccccga gcgcagccca cggcccccgc gcggagccag
      241 gcccgctgcc gtccccgccg cccgctcccc cggcatgcag ccccggctgc ggaggtgaca
      301 cttctgggct gtagtcgcca ccgccgcctc cgccatcgcc accatggatg aacaagaggc
      361 attagactcg atcatgaagg acctggtggc cctccagatg agccgacgaa cccggttgtc
      421 tggatatgag accatgaaga ataaggacac aggtcaccca aacaggcaga gtgacgtcag
      481 aatcaagttt gaacacaatg gggagagacg aattatagca ttcagccggc ctgtgagata
      541 cgaagatgtg gagcacaagg tgacaacagt ctttgggcag cctcttgatt tgcattatat
      601 gaataatgag ctctccatcc tgttgaaaaa ccaagatgat ctcgataaag ccattgacat
      661 tttggataga agctcaagta tgaaaagcct taggatacta ctgttatccc aagacagaaa
      721 ccatactagt tcctctcccc actctggagt gtccaggcag gttcggatca agccttccca
      781 gtctgcaggg gatataaata ccatctacca agctcctgag cccagaagca ggcacctgtc
      841 tgtcagctcc cagaaccctg gccgaagctc tcctcccccg ggatatgtac ctgagcgaca
      901 acagcacatt gcccggcaag gatcctatac gagcatcaac agcgaaggtg aattcatccc
      961 agagaccagc gaacagtgta tgctagatcc cctcagcagt gccgaaaatt ccttgtcagg
     1021 aagctgccaa tccttggaca ggtcagcaga cagcccatcc ttcaggaaat cacaaatgtc
     1081 ccgagcccgg agcttcccag acaacagaaa ggaatgctca gatcgggaga cccagctcta
     1141 tgataaaggt gtcaaaggtg gaacctatcc caggcgctac catgtgtctg tgcatcacaa
     1201 agactacaat gatggcagaa gaacatttcc ccgaatacga cggcatcaag gcaacctatt
     1261 cactctggtg ccctcaagtc gctccttgag cacaaatggc gagaacatgg gtgtagctgt
     1321 gcaatacctg gacccccgtg ggcgcctacg gagtgcagac agtgagaatg ccctcactgt
     1381 gcaggaaagg aatgtgccaa ccaaatctcc tagtgctccc atcaattggc gtcgggggaa
     1441 gctcctgggt caaggtgcct tcggcagggt ctacttgtgc tatgatgtgg acacaggacg
     1501 tgaacttgct tctaagcagg tccagtttga cccagatagt cctgagacaa gcaaggaggt
     1561 gagtgctctg gagtgtgaga tccagttgct gaagaacctg cagcatgagc gcattgtgca
     1621 gtactacggc tgcctgcggg accgtgctga gaagatcctc accatcttta tggagtatat
     1681 gccagggggc tctgtaaaag accagttgaa ggcctacgga gctctgacag agagtgtgac
     1741 ccgcaagtac acccggcaga ttctggaggg catgtcatac ctgcacagca acatgattgt
     1801 gcatcgggac atcaagggag ccaatatcct ccgagactca gctgggaatg tgaagcttgg
     1861 ggattttggg gccagcaaac gcctacagac catctgcatg tcagggacag gcattcgctc
     1921 tgtcactggc acaccctact ggatgagtcc tgaagtcatc agtggcgagg gctatggaag
     1981 aaaggcagac gtgtggagcc tgggctgtac tgtggtggaa atgctgacag agaaaccacc
     2041 ttgggcagag tatgaagcta tggctgccat tttcaagatt gccacccagc ctaccaatcc
     2101 tcagctgccc tctcacatct cagaacacgg cagggacttc ctgaggcgca tatttgtgga
     2161 agctcgtcag agaccctcag ctgaggagct gctcacacac cactttgcac agctagtgta
     2221 ctgagctctc aaggctatgc agctgccagc tgccacctgc tgagcaggca aggggctgct
     2281 gtcaggctca gtgaagttgc tgcttcttcc aggcaaggct atgaccagtg gagcatcggt
     2341 ccagccattg tttgtctgtg ccccatctgc cactgggact caaagccagg atgggatagc
     2401 tctggcatca agactgggag ctccagcctg taagacccaa gagctttagc accttaagct
     2461 cagtatggcg ggaagggctg gaaacagtat gcaagactgc catgggtcct gcctaccctc
     2521 agatgtgtcc taacactgca gacagcactg aagtcaagag ggactggggc acaggaggtc
     2581 ctcaagggta tgaatagtgt tacttcattc agagtgttac tttgtttctc tcccaatgtt
     2641 tggagaccac cagcctgtct ctgggctgca agcctgaggt aaagcccagc atcccccagc
     2701 caacagaagg tagaggtttg ggctacccca ctatagcttc caggtattcg gtgtcagtcc
     2761 tgtcttacca aagatgaatg aagcaaatgt tacactgcct tattctggga aggaggagct
     2821 actcggataa gcagggcctg agagatggag ctgcctccag aaactgggga gacccagtct
     2881 tgtcaatgca attgtctctg ttttacaagt tggagtcact cttatgctgt tcccagtttt
     2941 aaaactggag actttgccct ctgagctctg gagacccatg tgggcttagg ccttggactg
     3001 gatggaagag ctgatggcct ctgccccctg gcctgccctc tgttccctca ctggagcaga
     3061 gaaagtagac aacacaagtc agggcacctg gttctgggca gctcagcaga gtgcaggggg
     3121 ttgtctcagg ctgtctgcat ctcaaatctg tcaggcctga gcccactcca tgggaaagtc
     3181 cttgagctgc cacaaccgtg tccaaagcca ccagctgtgt tcctcagccc gacctgtcca
     3241 cttgtcatca acctcattcc cttcttgttc ctcccacaaa ggaggatgcc agtaggggct
     3301 agggaaagag ttatctccaa gcagcttaga gttggccata tttacctcag cctgggtgct
     3361 ggtcctttct tccagcccct ttcttcccct ccaaatgtgc ctatttctag agctcctccc
     3421 tcctaactcc caaatttttg ggagttatca ttaaaggaaa ggaaaaaaaa aaaaaagaag
     3481 ccagtgccca gggatgggca tctccaggga gctggggatt agtgccaggc agctctttgc
     3541 cagccatgcc cacttcccca tgggcacaga acaagccaaa gccttcgttg tatgttgacg
     3601 atgcactttt atgaatgtag tttctatcgc tgtttttagc cttttcacat catgtaatgt
     3661 gaggccttgt acttgttaat ttatatctca gatccatatt tgatggtttt atatatatat
     3721 atcaattcta gactgttacc ggtgatggac tcctgaagag agaacagaaa ttgaaagcag
     3781 ctggttttgc agatatgtgt gttgcacggt gccaattggg cctgggcccc tctgttttat
     3841 ttcctttccc ttgggggtct gtcaggccac tctctaactg ctctgaagcc agtgagcaaa
     3901 gtcctgcttc cacctcagcc tttgcccaaa gtagggactg gcccctcttc tagaccaaag
     3961 ctgccaaaag gcagctgggc ctctccatga ccccatcctg atggctatat agcacccttt
     4021 agcctatccc tatccacacc ccgaacccaa aggagataga gattggtggg gtgacaagat
     4081 gttagatgag acaactctgc ttgtcacagg ttcaggctct cacggagctc cccccatatc
     4141 cccatggggg ggggggggga gtgtattacc tcataggcaa tgtttctaaa atgaacttaa
     4201 aagtaaacca acaaattctg cactccaaag ggggggtggg ggggagacac ctttttttgt
     4261 gccaaaaact gtggacatgc tggttcagca gcctcaggac caagctgtta atttattttt
     4321 ttcttattaa caaatccaaa tgacaagttg tgggcctcca gggtggcctg ggcccaaagg
     4381 ttatgaagga aggtttccta gcagcccttg gcctgctgtg caaagatgct acaccacctt
     4441 catttgttct tcattccatg gggtttatct gccttcacca accccacatg gaagggccaa
     4501 gcctgggtca ggtgcacgct gccaccctcc ttcccctccc tcccacttgc ccagctctgt
     4561 gtctgaattg tggaatgtgc agaagaacct gcagccatag ttattgacta tatcttgact
     4621 gagggcttgc agtgcaaagc caggccagtg cattacttac aataaaaggg atcatttata
     4681 tcagaa
//
