LOCUS       NM_145608               5692 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus mitogen-activated protein kinase kinase kinase 21
            (Map3k21), mRNA.
ACCESSION   NM_145608
VERSION     NM_145608.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5692)
  AUTHORS   Seit-Nebi,A., Cheng,W., Xu,H. and Han,J.
  TITLE     MLK4 has negative effect on TLR4 signaling
  JOURNAL   Cell Mol Immunol 9 (1), 27-33 (2012)
   PUBMED   21602844
  REMARK    GeneRIF: MLK4 is a negative regulator of TLR4 signaling.
REFERENCE   2  (bases 1 to 5692)
  AUTHORS   Bouma,G.J., Hudson,Q.J., Washburn,L.L. and Eicher,E.M.
  TITLE     New candidate genes identified for controlling mouse gonadal sex
            determination and the early stages of granulosa and Sertoli cell
            differentiation
  JOURNAL   Biol Reprod 82 (2), 380-389 (2010)
   PUBMED   19864314
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC105066.12 and AC102420.10.
            
            On Dec 19, 2006 this sequence version replaced NM_145608.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK220424.1, BC021891.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-984               AC105066.12        26135-27118         c
            985-1165            AC105066.12        13370-13550         c
            1166-1314           AC105066.12        11345-11493         c
            1315-1490           AC105066.12        9862-10037          c
            1491-1731           AC105066.12        2399-2639           c
            1732-1854           AC105066.12        240-362             c
            1855-2005           AC102420.10        23109-23259
            2006-2103           AC102420.10        24257-24354
            2104-2862           AC102420.10        25961-26719
            2863-5692           AC102420.10        29018-31847
FEATURES             Location/Qualifiers
     source          1..5692
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 73.65 cM"
     gene            1..5692
                     /gene="Map3k21"
                     /gene_synonym="mKIAA1804; Mlk4"
                     /note="mitogen-activated protein kinase kinase kinase 21"
                     /db_xref="GeneID:234878"
                     /db_xref="MGI:MGI:2385307"
     exon            1..984
                     /gene="Map3k21"
                     /gene_synonym="mKIAA1804; Mlk4"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..3236
                     /gene="Map3k21"
                     /gene_synonym="mKIAA1804; Mlk4"
                     /EC_number="2.7.11.25"
                     /note="mixed lineage kinase 4; mitogen-activated protein
                     kinase kinase kinase MLK4"
                     /codon_start=1
                     /product="mitogen-activated protein kinase kinase kinase
                     21"
                     /protein_id="NP_663583.2"
                     /db_xref="CCDS:CCDS40519.1"
                     /db_xref="GeneID:234878"
                     /db_xref="MGI:MGI:2385307"
                     /translation="MALPVAEGTADTPLSPARDDSGSTSSGMWAALYDYEARGEDELS
                     LRRGQLVEVLSQDAAVSGDEGWWAGQVQRRLGIFPASYVAPCGPVPPPAPPPPRPCSP
                     VHVDFERLELKELIGAGGFGQVYRATWQGQEVAVKAARRDPEQDAAAAAESVRREARL
                     FAMLRHPNIIQLRGVCLRQPHLCLVLEFARGGALNRALAAAASDPRAPGPRRARRIPP
                     QVLVNWAVQIARGMLYLHEEAVVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGL
                     AREWHRTTRMSAAGTYAWMAPEVIRSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGL
                     AVAYGVAVNKLTLPIPSTCPEPFAKLMKECWEQDPHIRPSFALILQQLTAIEEAVLTN
                     MPQESFHSMQEDWKLEIQQMFSELRTKEKELRSREEELSRAALQQKSQELLLRRREQQ
                     LAEREIDVLERELNVLIFQLSQEAPHVKKRKGRFRRGRLRLKDGHRISLPSDFQHKIT
                     VQASPTLDKRRSSDSGLCSPPGSPLMLPRLRAIQLTSDENNKTRGRNMVFRQEDFEDV
                     KRSFKKKGCTWGPSSVQTKERPEGRERVRPLSDGNSPWSSLLIKSQKTTPLASLFVDQ
                     PGSCEEQKLVPEGLEHRKPKQTKFPGQAHVGLPLCKDSQREDSSEAESREEGSPKGSP
                     VNNVGAPMLRKKTESALCECGMLLASMALGLDVRKLHGAQAPAKPSPKMEKKEEGALQ
                     PASRCQSSPSSLLRQPSAGRAPSGGSTLLLPSAPSHSSKSSLSMKCLLQAGKEESSLG
                     NARDLCGPTTLTPDPGSAAPESGCELIPGLRPKTDYGVLRSMPHAILEQTGERLPGCA
                     IVGDKGCHHMQMGSEETPLWLQSAPEDSGLPHSPSPGPQRDLASQASLVKPEGVLGEC
                     QACPALPQRPHTASVRTTSPPTWVCDKDHQVPALACLLGAQERSRCQTPSLLDASIEG
                     QKKDCAMPLCRVKSVMCQPSIYALEKDFLT"
     exon            985..1165
                     /gene="Map3k21"
                     /gene_synonym="mKIAA1804; Mlk4"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1314
                     /gene="Map3k21"
                     /gene_synonym="mKIAA1804; Mlk4"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1490
                     /gene="Map3k21"
                     /gene_synonym="mKIAA1804; Mlk4"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1731
                     /gene="Map3k21"
                     /gene_synonym="mKIAA1804; Mlk4"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1854
                     /gene="Map3k21"
                     /gene_synonym="mKIAA1804; Mlk4"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..2005
                     /gene="Map3k21"
                     /gene_synonym="mKIAA1804; Mlk4"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2103
                     /gene="Map3k21"
                     /gene_synonym="mKIAA1804; Mlk4"
                     /inference="alignment:Splign:2.1.0"
     exon            2104..2862
                     /gene="Map3k21"
                     /gene_synonym="mKIAA1804; Mlk4"
                     /inference="alignment:Splign:2.1.0"
     exon            2863..5692
                     /gene="Map3k21"
                     /gene_synonym="mKIAA1804; Mlk4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcaccgcca ccggttgtcc gcgctagcgg ctgcggggaa gaactagcca aactggaggc
       61 agagcagagg tcagagcccc cgggcagtgg tcgtaacctc tgtagtcctg ctccagccct
      121 gcacccttcc ctgttagctc ggaccgatga tacgcgtcgc tggagacccg gaaagctgag
      181 gttgtggctg tcgcacttgg tccactagcg acctctcaat cgcccctatg gctctacctg
      241 tagccgaggg cacggctgac acgccgctgt ccccggcccg ggacgactcg gggagtacct
      301 cctccgggat gtgggccgcg ctttatgatt acgaagcgcg cggtgaggac gagctgagcc
      361 tgaggcgcgg tcagctggtc gaggtactgt cgcaggacgc cgcggtgtca ggagacgagg
      421 gctggtgggc cggccaagtg cagcggcgcc tgggcatctt tccggccagc tacgtggcgc
      481 cctgtggccc ggtgccgccg ccggcgccgc ccccgccgag accctgctcg cctgtgcacg
      541 tagacttcga gcgcctggag ctcaaggagc tgatcggcgc cggcggcttc ggtcaggtgt
      601 accgcgccac ctggcagggc caggaggtgg cggtgaaggc ggcgcgccgg gacccggagc
      661 aggacgcggc ggcggcggcc gagagcgtac ggcgcgaggc gcggctcttc gctatgctgc
      721 ggcaccccaa catcatccag ctgcggggtg tgtgcctgcg gcagccgcac ctctgcctgg
      781 tgctggagtt cgcgcgtggc ggcgcgctca accgcgcgct ggcggcggca gcatcggatc
      841 cgcgagcgcc cggcccccgc cgcgcgcgcc gcatcccccc acaggttctg gtcaactggg
      901 cggtgcagat cgcccgcggc atgctgtacc tgcacgagga ggcggtggtg cccatcctgc
      961 accgtgacct caagtccagc aacattttgc tgctggagaa gatagaacat gatgacattt
     1021 gcaacaagac cctgaagatc acggactttg ggctagcgag ggaatggcac aggaccacca
     1081 ggatgagcgc agcagggacc tacgcctgga tggctcccga ggtcatcagg tcctccctgt
     1141 tctccaaggg cagcgacatc tggagctatg gagtgctgtt gtgggagctg ctcactggtg
     1201 aggtcccgta ccgtggcatc gatggactgg ctgtggcgta cggggtggct gtcaacaagc
     1261 tcacactgcc tattccatcc acctgccctg aaccgtttgc aaaactcatg aaagagtgct
     1321 gggaacaaga ccctcatatc cgcccctcgt ttgccttaat tcttcagcag ctgactgcga
     1381 tcgaagaggc agtgttgacc aacatgcccc aggagtcctt ccattccatg caggaagact
     1441 ggaaactgga gattcagcaa atgttcagtg agctgcgaac caaggagaag gagctgcgtt
     1501 cccgagagga ggagctgagc cgagctgcct tgcaacagaa atcgcaggaa ctgctgctca
     1561 gacgccgcga gcagcagctc gcggagcgtg agatcgacgt gctggagcgc gagctgaacg
     1621 tgctcatctt ccagctgagc caggaggctc cccacgtgaa gaagaggaag ggaaggttca
     1681 ggagaggacg gctgaggctc aaagacggcc accgcatcag cctgccttca gatttccagc
     1741 acaagatcac agtgcaggct tccccgacgc tggacaagcg ccgaagctca gacagcggac
     1801 tgtgcagccc acccggcagc cccttgatgc tcccccgcct ccgggctatt cagttaactt
     1861 cagatgagaa caataaaacc cggggaagga acatggtctt ccgccaagaa gactttgaag
     1921 acgtgaaaag gagtttcaag aaaaaaggat gtacgtgggg accaagctcc gttcaaacaa
     1981 aggaaagacc agaaggcaga gagagggtca gacctctctc agatggcaac agcccttggt
     2041 catctctttt aataaaaagc cagaaaacca cacccttggc ttcactgttt gtggaccagc
     2101 caggttcttg tgaggagcag aaacttgtcc ctgaaggatt agaacataga aaaccaaagc
     2161 aaacgaagtt ccctggccag gcccacgttg gtctacctct ttgcaaagac agccagagag
     2221 aagactcatc agaggctgag agtcgggagg agggatcccc taaggggtcc ccggtgaaca
     2281 acgtgggtgc acccatgctg aggaagaaaa cggagtcagc gctgtgtgag tgtgggatgc
     2341 tgctggcatc gatggctttg ggactggatg tcaggaaact tcacggagcc caggcccccg
     2401 caaaaccatc acccaagatg gaaaagaagg aagagggtgc cctccaacct gcctccaggt
     2461 gccaatcaag tcccagttcc cttctgaggc agccatctgc aggcagggca cccagcggtg
     2521 gctccacgct cctgctgccc agtgccccaa gccattcctc aaagtcttct ctctccatga
     2581 agtgtttgct gcaggctggt aaggaggagt catctttggg gaatgctcgg gacttgtgtg
     2641 gtcctacgac gctcactcca gatcctggct ctgccgcacc agagagcggc tgtgaactca
     2701 tccccggact gagacctaag actgactatg gtgtgttgag aagcatgccg catgccatcc
     2761 tggagcagac aggggagaga ctgccaggct gtgccattgt aggagacaaa ggatgccacc
     2821 acatgcagat gggatctgaa gaaactcctc tctggctcca aagtgcccct gaagactctg
     2881 gattaccaca ctctccctcc cctggacctc aaagggacct ggccagccag gcctctcttg
     2941 tgaaacctga aggtgttctg ggcgagtgcc aggcatgccc ggctctgcca caaaggccac
     3001 acactgcttc ggtgagaaca acatctccac ctacctgggt ttgtgacaag gaccatcagg
     3061 tgccagccct tgcctgcttg cttggtgctc aggagagaag caggtgtcag actccttcct
     3121 tgctggatgc cagcatagaa ggtcagaaga aggactgtgc catgcccttg tgtagagtga
     3181 agagcgtgat gtgtcagccg tccatctacg ccctggagaa agactttctg acctgatgac
     3241 ttctgccttc ccgccatgat catttgatgg gggcacacgg aggcaccatg tgtcttgtgc
     3301 tgattctgag gagcactagt gactgctatt agctgctgta tcacggccac ttcatgctag
     3361 ttacccagtg acttgaagta cacagaagtt caaatgagtg tcagcggagg tggggccttc
     3421 ctagccagtt cctgtgcttc agtcttacgt atgtcctgcc catgaggaca caattggcga
     3481 aactgcaatg gccgattctc gtagcttcct gccttcatcc ttttctctct tttaaaaagt
     3541 ccttttgggg ttttatttgt ttgtttttat acaacaaaaa agccaagaaa taattattcc
     3601 cttcttgcca ataataatgt gatgttaaaa gtaaacatat ttatttatgg agcagggaaa
     3661 aggtcctact gtgtggagtt aattcagggt cctatttaaa cttcccagag aaagcagtag
     3721 ccttgtaatg tggaagtgtg tccattgact cctgagttac acaaagatag ccctcttcca
     3781 ggaggtttta ctggacgtag cctatgaaag ctttattgag gcctgaagag atggctaaac
     3841 agttaagcat gcatatcaca catttgcagg gcccaagttc agttccaggc acccatatca
     3901 gagagctcac acctatctat gactacagtt ccagggcatc caatggcctc ttctggcttc
     3961 cactggcacc tcctttcata tgcatgtacc accacacaga tgtacacaga cacatactta
     4021 aaagttaaag tattttgaaa gtttgatcga atatattata ttgttgtctc atgtaaccaa
     4081 aatgccctag aacaacttaa agggaggcac tagttactcg gctcatggtt ttggagggat
     4141 cagtgcaaca gtgggaaggg ctgagtgggc tgtcttcaca tcacagagga cagaaagcag
     4201 aagagggggg agacaggaag aaaacagggc aaggtttttt ttagcagtaa ctgccgagca
     4261 tcactgagac caggcattca tatttggcac cctgcacaag gccactctgt aggtttccct
     4321 gaagaaacgg ctcatcatta gtagccagag gtgggaaatt ccttcatgct cttgtagtct
     4381 ttaaaaatta aaagacccat ggctggttat gtgcgaagaa cccgtgtgct gtggacatgc
     4441 atgttgtgtg gttttaagtc tccctgagcc tgcagttttg ccaacgctaa caacactgct
     4501 gtgcaggaga tggcaggaca ggtttccagt cagcttttca tgctccactg aactccgagt
     4561 caacatgtgc atctgtgagg gtgagcaggc atggcgggaa gacacagatg acttctggaa
     4621 gtgactttgg ggagcagatg tgattggaaa caacttaaag ctattcacga gtcacctgcg
     4681 taacttcaca gagagagcgg tgcatcatcg gggctgggcg actgactctt caggagctca
     4741 gtgcccttgt ctgggtttct tgagtactgt gatccccttc tgtctgtcac cagaacatag
     4801 ttatttgaga ggcagatagt aaatacttaa attctgacac agtaggaagc taaattatcc
     4861 gtagccctta cgtcttattt aacattgtat ctcgacttac cgataatagc aggaatttaa
     4921 aggggattaa ataggtgcga tgacagatct gagtcccata caggcttgtc agcaggtgac
     4981 cttcggggaa gatctcgctg cctgctctac gcaggtttca ggtgctcaga gcaaaacttt
     5041 aggttttcac cagacttcct gtgttgtttc cactctccga ctttgcttca cctcagtgtt
     5101 tattaaatgg tctaacaggg gcgcagttgg ctcgacattt gtcacattgg gtagaccatt
     5161 tggcctcttc tcttcacgag acgctaaaag taaaagacgt gcccccaaat acccagtgca
     5221 cggaaggaaa atactgaaac agatggtgtg ctcagctttg cttctgcccc agccttcctc
     5281 agagtgtgtg tatgacggag atggtgaaat cagacctgtc tatgtgtcac gtcctctcta
     5341 gctctgtgtt ccagcctccc ttctcttcat tttgctccac tgtgatgaat ttagaaagga
     5401 agccatgcta aaacataagg agccaatccg actcactgct gctggggttt tcactgacat
     5461 cccagatttt cggtgcatgc tacacaccta gcaggacctg gactttcatt ttctgtggac
     5521 cttggtgacc caatagatca tttaatctgg ttcctactga cccatactct gctttttcct
     5581 ctcacagcag actaacatct ggggtccgga cacgctatga tcagaagcct gtggctgaca
     5641 aaaatgttta catatgttgt ctagtttttt aataaacctt tttttaaagc tt
//
