LOCUS       NM_011737               6651 bp    mRNA    linear   ROD 04-AUG-2024
DEFINITION  Mus musculus mitogen-activated protein kinase kinase kinase 19
            (Map3k19), mRNA.
ACCESSION   NM_011737 XM_001477564 XM_006529396 XM_914055
VERSION     NM_011737.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6651)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 6651)
  AUTHORS   Osada,S., Izawa,M., Saito,R., Mizuno,K., Suzuki,A., Hirai,S. and
            Ohno,S.
  TITLE     YSK1, a novel mammalian protein kinase structurally related to
            Ste20 and SPS1, but is not involved in the known MAPK pathways
  JOURNAL   Oncogene 14 (17), 2047-2057 (1997)
   PUBMED   9160885
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163690.4 and AC121883.2.
            
            On or before Dec 4, 2019 this sequence version replaced
            XM_006529396.3, NM_011737.1.
            
            CCDS Note: The exon combination of this CCDS representation is
            inferred based on orthologous transcript alignments (e.g., human
            AY574901.1, BC137276.1 and BC137277.1). There are no publicly
            available mouse full-length transcripts supporting this gene; it is
            partially supported by data in PMID:9160885, and by RNA-Seq data
            from the ENCODE project.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131,
                              SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-290               AC163690.4         117270-117559       c
            291-486             AC163690.4         112846-113041       c
            487-675             AC163690.4         109769-109957       c
            676-830             AC163690.4         103563-103717       c
            831-946             AC163690.4         102802-102917       c
            947-1059            AC163690.4         100972-101084       c
            1060-1150           AC163690.4         97068-97158         c
            1151-1223           AC163690.4         95257-95329         c
            1224-1483           AC163690.4         92804-93063         c
            1484-1527           AC163690.4         91589-91632         c
            1528-3948           AC163690.4         84510-86930         c
            3949-4095           AC163690.4         82920-83066         c
            4096-4793           AC121883.2         183663-184360       c
            4794-6651           AC121883.2         179908-181765       c
FEATURES             Location/Qualifiers
     source          1..6651
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 55.8 cM"
     gene            1..6651
                     /gene="Map3k19"
                     /gene_synonym="Ysk4"
                     /note="mitogen-activated protein kinase kinase kinase 19"
                     /db_xref="GeneID:22625"
                     /db_xref="MGI:MGI:1203481"
     exon            1..290
                     /gene="Map3k19"
                     /gene_synonym="Ysk4"
                     /inference="alignment:Splign:2.1.0"
     exon            291..486
                     /gene="Map3k19"
                     /gene_synonym="Ysk4"
                     /inference="alignment:Splign:2.1.0"
     CDS             313..4860
                     /gene="Map3k19"
                     /gene_synonym="Ysk4"
                     /EC_number="2.7.11.1"
                     /note="Yeast Sps1/Ste20-related kinase 4;
                     SPS1/STE20-related protein kinase YSK4"
                     /codon_start=1
                     /product="mitogen-activated protein kinase kinase kinase
                     19"
                     /protein_id="NP_035867.2"
                     /db_xref="CCDS:CCDS48347.1"
                     /db_xref="GeneID:22625"
                     /db_xref="MGI:MGI:1203481"
                     /translation="MNKNRLIHDFLGVVSRGDVECICGLIPEVHSVLGNLDFQHPQTG
                     NTPLITAAEENLAEVVEILLEGGADITLCNYSNQTALHVANGDIQRQLLAGKGIQAPQ
                     MQLLRSSWLGDLKQLRHLLACEEFLDINFPNSHGLTPLMLAVRDVDLFESLDLLTAYR
                     PDEVLAELLRHHADPKLCDFSGKSAIHYVSQIESWRKQQLLDILMDSMPRPERHAESL
                     LDICHEAGSTPMEMTVSQTENLTLQSISSSEDFDLEDDFSPFILAREGAAPRGENWPR
                     RTEGVEIIVTFPPDPLQEASQEDLKESNQVTSEHQEREQVHPVSPPDDAEMVGLTGRM
                     LTTQPSLLKTDGSSEELCGVDVALSPPRPCLDSSLAASAAGEVAPCVLKEQQRQSDEF
                     PTSDISYSSRRTGLPLPPLSCLPMRSCIFNMEKSPKSPRHRERKVPSLSLSVPKLLEP
                     LSRPLSQSAEFSSSKNHQEVTQEGPVEHTLRGSNCTLWSRNMCSFRKSGKQGVAESWP
                     SQEMEGWDKTKTSGFKEGPSLFSCESVKEDTTPTERERDSGYHVSEMQRGGEDSQYLS
                     SRKKESWTARVVERDSGVEHPILCKLLEVSNSEMTPAEEKEIGNENVPDAKSNSVHKS
                     GAMEPHAASEEVSVPKNGPSVNSDGPAEELEGHRDIEQNRKIPMEEETNPEMNGVVPL
                     THIAFPGEGTSKGPARAEPHLQRRKRPAQNSNSFNLLAHREHDKLQTNTHRTKLDSRT
                     KARNRAPPNLMVSIQASIKPNMHKNSIKTQVFPALELIDHRPHPSSKFQRRAPLTEKK
                     STHQTQKPKKQAFPRIGKHAGIKKPGIPLSAETTDPRLHFLDLKYSDMFKEINSASNG
                     PGIYEMFGTPVYCHIREAERHDHRCYREIRTAPSGRCVVNKCQSSESDRCSNSRARLL
                     QKRQHIKPPKPLHGLRQKHRGFISKDKGCKDMGGHTEDSVSEPDGQMKSPGNDFLSSK
                     DDAQLMHLIPIPELSPEQKAPAPVSDLSIVEEIFTEECADEEGILNDDSLTQSLGDLK
                     EPEGLHPQAPLVPSENSWAVLSEKRSGKRVSPEKHNVEPLDKINAEQMFPGYLEFDSL
                     SEKSKTLVSFSSCSFQENLERAPSPTEQHWARSLEQDSLENNSTTYQTFGKISQEILD
                     PGKNEELTDELLGCLVEELLALDEKDNNSCQIMTNEADAKNLNLVFSRRGNTIEELGR
                     ETTDVKLQRCINGFRIYDEENFLTSNEKKTLSDKSLNHEEAIFWTKGEILGRGAYGTV
                     YCGLTSLGQLIAVKQVALDTSDKLATEKEYRKLQEEVDLLKALKHVNIVAYLGTCLEE
                     NTLSIFMEFVPGGSISSIINRFGPLPEMVFCKYTRQILQGVAYLHDNCVVHRDIKGNN
                     VMLMPTGIIKLIDFGCAKRLAWAGLNGTHSDMLKSMRGTPYWMAPEVINESGYGRKSD
                     IWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPARFSEPAADFVRLCLTR
                     DQHERPSALQLLKHSFLKRSQ"
     exon            487..675
                     /gene="Map3k19"
                     /gene_synonym="Ysk4"
                     /inference="alignment:Splign:2.1.0"
     exon            676..830
                     /gene="Map3k19"
                     /gene_synonym="Ysk4"
                     /inference="alignment:Splign:2.1.0"
     exon            831..946
                     /gene="Map3k19"
                     /gene_synonym="Ysk4"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1059
                     /gene="Map3k19"
                     /gene_synonym="Ysk4"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1150
                     /gene="Map3k19"
                     /gene_synonym="Ysk4"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1223
                     /gene="Map3k19"
                     /gene_synonym="Ysk4"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1483
                     /gene="Map3k19"
                     /gene_synonym="Ysk4"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1527
                     /gene="Map3k19"
                     /gene_synonym="Ysk4"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..3948
                     /gene="Map3k19"
                     /gene_synonym="Ysk4"
                     /inference="alignment:Splign:2.1.0"
     exon            3949..4095
                     /gene="Map3k19"
                     /gene_synonym="Ysk4"
                     /inference="alignment:Splign:2.1.0"
     exon            4096..4793
                     /gene="Map3k19"
                     /gene_synonym="Ysk4"
                     /inference="alignment:Splign:2.1.0"
     exon            4794..6651
                     /gene="Map3k19"
                     /gene_synonym="Ysk4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5060..5065
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Map3k19"
                     /gene_synonym="Ysk4"
                     /note="hexamer: AAGAAA"
     polyA_site      5081
                     /gene="Map3k19"
                     /gene_synonym="Ysk4"
     regulatory      5314..5319
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Map3k19"
                     /gene_synonym="Ysk4"
                     /note="hexamer: AATAAA"
     polyA_site      5338
                     /gene="Map3k19"
                     /gene_synonym="Ysk4"
                     /note="major polyA site"
     regulatory      6631..6636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Map3k19"
                     /gene_synonym="Ysk4"
                     /note="hexamer: ATTAAA"
     polyA_site      6651
                     /gene="Map3k19"
                     /gene_synonym="Ysk4"
ORIGIN      
        1 gacagcctgc gtcaactaag caagtctcct tgcactgagc caaagggttt gtgcaccctg
       61 aaccagtttt caatacttat ttttaaaata aagtgtttga actgtgcaac actggaacga
      121 aaccaaacaa aaggttctga atctatgctg cttttacatg gaaacggagt tgaagagagc
      181 ggtgatagct ggtccggaaa tcagagccat gaagtaggat gatttgggct gctcctcggc
      241 cgggtgctcc ttcaactggg tcccagctcc ctcagcaaaa ctgactctag gaaattatat
      301 ggaaccagca agatgaacaa aaacagactg attcatgatt tccttggcgt ggtttcaagg
      361 ggtgacgtgg aatgcatttg tggccttatt cctgaagtcc actcagtcct tggaaatctt
      421 gactttcagc acccacagac ggggaacacg cctctcatta ctgctgcgga agaaaatcta
      481 gcagaggttg ttgagattct tctggaaggg ggcgcagata tcaccctttg caattacagc
      541 aatcaaactg cgctccatgt ggctaatggt gacatccaga gacaactctt ggctggcaag
      601 ggaatccagg ctccccaaat gcagctccta cgaagctcgt ggctaggtga tctgaagcag
      661 cttcgacact tgctggcatg tgaagagttc ctggatataa acttccccaa ctcgcatggt
      721 ctgacccctc tgatgctggc tgtgagagat gtggacctat ttgagagtct ggatctatta
      781 acagcttaca gacctgatga agttctagcc gagctcctcc ggcaccatgc agatcctaag
      841 ctttgtgatt tcagtggcaa gtcagcaata cattatgtgt cacaaattga gagttggagg
      901 aagcagcagt tactggacat cctgatggat tctatgccca gaccagaaag acatgccgag
      961 tcactgcttg acatctgtca tgaggcaggc tctactccaa tggagatgac agtttcccaa
     1021 actgaaaacc tcaccttgca gagcatcagc agcagtgagg actttgacct tgaagatgac
     1081 ttcagcccgt tcatattggc tagggaagga gcagctccca ggggtgaaaa ctggccacga
     1141 aggacagaag gtgtggagat tattgtgacg tttccaccgg atcctctcca agaagcaagc
     1201 caagaagact tgaaagaaag caatcaggtg acttcagagc atcaggaacg ggaacaagtg
     1261 catcctgtct ctccaccaga tgacgcggag atggtgggcc tcacggggag gatgctaacc
     1321 acacagcctt cacttctgaa gacagacgga agttctgagg agctctgtgg tgtggacgtg
     1381 gctctctcac cacccagacc ttgcttagac tcaagccttg ctgcatctgc agctggggag
     1441 gtggctcctt gtgttctgaa agaacagcaa aggcaatctg atgagtttcc tacctctgac
     1501 ataagctaca gtagccgaag aactgggctt cctctgccac cactatcatg cttgcccatg
     1561 agatcttgta tcttcaatat ggaaaaaagc cccaagtccc caaggcacag ggaaagaaag
     1621 gtccccagcc tcagcctgtc tgtgcctaag ctcctggaac ctcttagccg acctcttagc
     1681 caatctgcag agtttagttc atcaaagaac catcaagaag tcacgcagga aggaccagtg
     1741 gaacacaccc tcaggggttc taactgtacc ctctggtcca gaaacatgtg ttctttccgg
     1801 aagagcggaa aacagggagt agcggagagt tggccatccc aggaaatgga agggtgggac
     1861 aaaactaaaa cctctggctt caaagaaggg ccatctttgt tctcttgtga gagtgtcaaa
     1921 gaagacacta ctcctacaga gagggaaagg gatagtgggt accatgttag tgagatgcaa
     1981 agagggggag aggactccca atatctttca tcaagaaaaa aagagagttg gacagccaga
     2041 gtggttgagc gagattcagg ggttgagcac cccattctct gcaagctcct ggaagtctca
     2101 aattcagaaa tgaccccagc agaggagaaa gagatcggaa atgagaacgt tcctgatgcc
     2161 aaaagcaatt ctgtacacaa atctggagca atggagccac atgcagcgtc agaagaggtt
     2221 agtgttccta agaatggtcc cagtgtgaac tctgacggcc ctgctgaaga gctggaaggt
     2281 catagagaca tagaacagaa cagaaaaata ccaatggagg aagaaacaaa tcccgaaatg
     2341 aatggggtgg tgccgcttac tcacatcgca ttccctggag aagggacatc caagggaccc
     2401 gctagagccg aaccacacct ccaaaggaga aagcgcccgg cgcagaacag caacagcttc
     2461 aacctgcttg ctcaccgaga acacgacaaa ctccagacaa atactcatag aaccaagttg
     2521 gattcaagga ccaaggccag gaacagagca ccccctaatc tcatggtttc catccaagca
     2581 tccattaagc ccaacatgca taaaaacagc ataaaaactc aagttttccc tgctttggaa
     2641 cttatagacc acagacctca tccctcctcc aagtttcaaa ggagagcacc tctgacagaa
     2701 aagaagtcaa cgcatcagac ccagaaacct aaaaagcaag catttcctcg aatcggtaaa
     2761 catgcaggca taaaaaagcc aggcattccc ctctccgctg aaacaacaga tccgagactg
     2821 cacttcctgg atttgaagta cagtgacatg ttcaaagaaa tcaactcagc ctccaacgga
     2881 ccaggcatct atgagatgtt tggaacccct gtttattgtc acattcgcga ggcagaaagg
     2941 cacgaccaca gatgttaccg tgagatacgt acggctccat caggccgatg tgtcgttaat
     3001 aaatgccagt cttccgaaag tgacaggtgc agcaacagca gggcaagact tcttcagaag
     3061 agacaacaca ttaaaccccc aaagccattg catggtctca ggcaaaagca cagagggttc
     3121 atttctaaag acaaaggttg caaggatatg gggggccata cagaggatag cgtttcagaa
     3181 cctgatgggc agatgaaatc tccaggaaat gactttctat cttccaaaga tgacgctcaa
     3241 ctcatgcact tgatccccat ccctgaactg tcccccgaac agaaagcacc cgctccagtc
     3301 tcagatctat ccattgttga ggaaatcttc acagaggagt gtgcagacga agaaggcatt
     3361 ctcaacgatg acagccttac ccaaagcctt ggcgatctga aagagcctga agggttgcac
     3421 ccccaggccc ctctcgttcc ttcagaaaac agctgggctg tgcttagcga gaagcgttcg
     3481 ggcaagcgtg tgtctccaga aaagcacaat gtagaacctc ttgataaaat aaatgctgag
     3541 cagatgttcc cgggttacct ggagtttgat agcctttcag agaagtctaa aacactggtg
     3601 agcttttcca gttgctcttt ccaggagaac ctggaaagag ccccttcccc tacagaacaa
     3661 cactgggcac gttctttgga gcaggacagc ttagaaaata actccaccac ataccagaca
     3721 tttggaaaga tttcccagga aatcttagac ccaggaaaga atgaagagtt gacagacgag
     3781 ttgctgggtt gtctagttga agaactgtta gcactcgatg agaaagataa caactcttgc
     3841 caaataatga caaatgaggc agacgccaaa aacctgaatc ttgtcttcag caggagaggc
     3901 aataccatcg aagaactggg cagagagaca acagatgtca aacttcagag gtgtattaat
     3961 ggattccgga tatatgatga ggaaaacttt cttacctcaa atgaaaagaa gacactttct
     4021 gacaagagct taaaccacga agaggctatc ttctggacca agggtgagat ccttgggaga
     4081 ggagcctatg gcacagtata ctgtgggctc accagcctag ggcagctaat agctgtaaaa
     4141 caggtggcct tggatacttc tgataaactg gctaccgaga aggaataccg gaaactgcag
     4201 gaggaagtgg atttgctgaa ggcactgaag catgtcaaca tagtagctta tctagggacg
     4261 tgcttggagg agaacactct gagcatcttc atggaatttg tccctggtgg ttccatctct
     4321 agtataataa accgctttgg gccactgcct gagatggtgt tctgtaaata cacaagacag
     4381 atcctgcaag gtgttgccta tctccatgac aactgtgtgg tacatcgaga tatcaaaggg
     4441 aacaacgtca tgctcatgcc aacgggaata ataaagttga ttgacttcgg ctgtgccaag
     4501 cgtttggcct gggcaggctt aaatggtacc cacagtgaca tgctcaagtc catgcgtggg
     4561 actccatact ggatggcccc ggaggtcatc aatgagtctg gctatggaag gaaatcagat
     4621 atatggagca ttggctgcac cgtgttcgag atggccacag ggaagcctcc tttggcttcc
     4681 atggatagga tggcagccat gttctacatt ggagcccaca gaggcctaat gcctcctcta
     4741 cctgcccgat tctcagaacc tgctgcggac ttcgtgcgtt tgtgcctgac cagggaccag
     4801 catgagagac cttctgctct ccagctcttg aagcactcct tcctgaagag aagccagtga
     4861 gcacacatcg acttcccact ttaaaccccc aaccattgct ttgctgtggg gaatgatggt
     4921 taagggactt gttttcctat tgtaaatcca acccagccct atttaaccag atcctgcagc
     4981 attagtggaa agttttagtt atgtactgac cttaaatttc aggcacatct gcctatatgc
     5041 atgtgaacaa tttcatacta agaaaactac caaaaacccc attccagtgt tacaattttg
     5101 actgctcaaa aactatctct actgattcat attcttcttt tttttttttt ttttttttga
     5161 gacaggatct cacaacatag ccttggctgt cctggaactt gctatgtaga ccaggttagc
     5221 cttgaactca cagagatcta cctgcctcta cctcagagtg ctgaaattaa aggcatgagc
     5281 caccacagcc agctaagttc cttttaggtt taaaataaat gacacacatt ttgcctgata
     5341 ctctgtgtgt gtgtgtctgt gtgtgcacat atgtaaatcg aaggttggct ttggtgtctt
     5401 cctctgttgt ctattttatt ttttgagact ggacctggag ctcacccact ggataggctg
     5461 gatagcaagc ttggggtgat cctaggctcc tggctctact ttcctagtaa tttttatttt
     5521 taatttttta aaatttattt atatgagtaa actgtagttg tcttcataca caccagaaga
     5581 gggcatcaga tcccattaca gatagttgtg agccaccatg tggttgctgg gaattgaact
     5641 caggaccttt ggaagagcag tcggtgctct taactgctga gccatctccc cccagtaatt
     5701 taaaaaaaaa cattttttta aatgtgtacc tgagtgtatg tacaccgtgt gaatgcaggt
     5761 gtcctcagag gtcagatgat gtcagatgcc ctgaaactgg agttcccagg agttgtgagc
     5821 cccctgatgt atgtgccagg aaccttgtaa gagcagtaca tgccattaac tctgcagagc
     5881 catccctcca gctccagtcc aacatggttg tggggatggg ggtgggtgga gggagtgact
     5941 gaatttaggc ctcaagcttg ttcagcaagc attttaacca ctgagttatc ccttcagcca
     6001 cccatgactt aactctggca aaagaagtct ggaggaagtt gggaaggtag ggtgagtcta
     6061 gggaatgcag actgtgatgg tgtagccaac ctgtcagaaa tgtgtgtgtg tgtgtgtatg
     6121 tgtgtgtatg tgtgtacaca catgacactt ttgagatcag gctttggagc aatgaagccc
     6181 aagaagctgg aatttcccgt tatctcatga taaccttgga gttcaggaac cttaggacat
     6241 ttaagaggag ctaaggtgct ccttgaattc tttgtgaaca cagaagtctt caggaagcgg
     6301 ggcagctgct tacagatctt cactgctaag cctgcttgct tttctgaatt ttagttttaa
     6361 aaaatgtaac ttttgggctg gagaaatggc tcagaactaa agagtacttc tacataggtt
     6421 aaaaaaaaat cagtatttaa gaaaaaaaac ccaactcatt actttttctt ttgcttctct
     6481 gtattttcct ttcattttgt ttggttttcg gggttttgag atagggtttc tctgtgtagc
     6541 cttggctgta ctacctagaa cttgctctat agatagacca agctggcctc aaactcaaga
     6601 ggtttaccta cctctgcctc cccagtactt attaaaggct gtgccactgc t
//
