LOCUS       NM_001163085            4572 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus mitogen-activated protein kinase kinase kinase 15
            (Map3k15), mRNA.
ACCESSION   NM_001163085
VERSION     NM_001163085.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4572)
  AUTHORS   MacDonald,C.J. and Tonegawa,S.
  TITLE     Crucial role for CA2 inputs in the sequential organization of CA1
            time cells supporting memory
  JOURNAL   Proc Natl Acad Sci U S A 118 (3) (2021)
   PUBMED   33431691
REFERENCE   2  (bases 1 to 4572)
  AUTHORS   Imamura,K., Yoshitane,H., Hattori,K., Yamaguchi,M., Yoshida,K.,
            Okubo,T., Naguro,I., Ichijo,H. and Fukada,Y.
  TITLE     ASK family kinases mediate cellular stress and redox signaling to
            circadian clock
  JOURNAL   Proc Natl Acad Sci U S A 115 (14), 3646-3651 (2018)
   PUBMED   29555767
REFERENCE   3  (bases 1 to 4572)
  AUTHORS   Okuyama,T., Kitamura,T., Roy,D.S., Itohara,S. and Tonegawa,S.
  TITLE     Ventral CA1 neurons store social memory
  JOURNAL   Science 353 (6307), 1536-1541 (2016)
   PUBMED   27708103
REFERENCE   4  (bases 1 to 4572)
  AUTHORS   Kohara,K., Pignatelli,M., Rivest,A.J., Jung,H.Y., Kitamura,T.,
            Suh,J., Frank,D., Kajikawa,K., Mise,N., Obata,Y., Wickersham,I.R.
            and Tonegawa,S.
  TITLE     Cell type-specific genetic and optogenetic tools reveal hippocampal
            CA2 circuits
  JOURNAL   Nat Neurosci 17 (2), 269-279 (2014)
   PUBMED   24336151
REFERENCE   5  (bases 1 to 4572)
  AUTHORS   Naguro,I., Umeda,T., Kobayashi,Y., Maruyama,J., Hattori,K.,
            Shimizu,Y., Kataoka,K., Kim-Mitsuyama,S., Uchida,S., Vandewalle,A.,
            Noguchi,T., Nishitoh,H., Matsuzawa,A., Takeda,K. and Ichijo,H.
  TITLE     ASK3 responds to osmotic stress and regulates blood pressure by
            suppressing WNK1-SPAK/OSR1 signaling in the kidney
  JOURNAL   Nat Commun 3, 1285 (2012)
   PUBMED   23250415
REFERENCE   6  (bases 1 to 4572)
  AUTHORS   Craig,E.A., Stevens,M.V., Vaillancourt,R.R. and Camenisch,T.D.
  TITLE     MAP3Ks as central regulators of cell fate during development
  JOURNAL   Dev Dyn 237 (11), 3102-3114 (2008)
   PUBMED   18855897
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929452.9 and AL845167.7.
            
            On Dec 5, 2019 this sequence version replaced NM_001163085.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on alignments, including the human
            paralog NP_005914.1, but the complete splice pattern has not been
            experimentally verified.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131,
                              SAMN01164132 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-602               AL929452.9         192360-192961
            603-742             AL929452.9         206061-206200
            743-766             AL929452.9         208319-208342
            767-960             AL845167.7         23443-23636
            961-1129            AL845167.7         26514-26682
            1130-1236           AL845167.7         29070-29176
            1237-1407           AL845167.7         55291-55461
            1408-1520           AL845167.7         58048-58160
            1521-1680           AL845167.7         58582-58741
            1681-1831           AL845167.7         62367-62517
            1832-1939           AL845167.7         64238-64345
            1940-1989           AL845167.7         66317-66366
            1990-2085           AL845167.7         68771-68866
            2086-2173           AL845167.7         72257-72344
            2174-2307           AL845167.7         74034-74167
            2308-2435           AL845167.7         76749-76876
            2436-2566           AL845167.7         80430-80560
            2567-2672           AL845167.7         80774-80879
            2673-2830           AL845167.7         94859-95016
            2831-3014           AL845167.7         97512-97695
            3015-3180           AL845167.7         98338-98503
            3181-3355           AL845167.7         98972-99146
            3356-3541           AL845167.7         100108-100293
            3542-3647           AL845167.7         100994-101099
            3648-3861           AL845167.7         101963-102176
            3862-3974           AL845167.7         104099-104211
            3975-4075           AL845167.7         104815-104915
            4076-4152           AL845167.7         104987-105063
            4153-4572           AL845167.7         105380-105799
FEATURES             Location/Qualifiers
     source          1..4572
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 73.95 cM"
     gene            1..4572
                     /gene="Map3k15"
                     /gene_synonym="MEKK15"
                     /note="mitogen-activated protein kinase kinase kinase 15"
                     /db_xref="GeneID:270672"
                     /db_xref="MGI:MGI:2448588"
     exon            1..602
                     /gene="Map3k15"
                     /gene_synonym="MEKK15"
                     /inference="alignment:Splign:2.1.0"
     exon            603..742
                     /gene="Map3k15"
                     /gene_synonym="MEKK15"
                     /inference="alignment:Splign:2.1.0"
     exon            743..766
                     /gene="Map3k15"
                     /gene_synonym="MEKK15"
                     /inference="alignment:Splign:2.1.0"
     exon            767..960
                     /gene="Map3k15"
                     /gene_synonym="MEKK15"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1129
                     /gene="Map3k15"
                     /gene_synonym="MEKK15"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1236
                     /gene="Map3k15"
                     /gene_synonym="MEKK15"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1407
                     /gene="Map3k15"
                     /gene_synonym="MEKK15"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1520
                     /gene="Map3k15"
                     /gene_synonym="MEKK15"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1680
                     /gene="Map3k15"
                     /gene_synonym="MEKK15"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1831
                     /gene="Map3k15"
                     /gene_synonym="MEKK15"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..1939
                     /gene="Map3k15"
                     /gene_synonym="MEKK15"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..1989
                     /gene="Map3k15"
                     /gene_synonym="MEKK15"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2085
                     /gene="Map3k15"
                     /gene_synonym="MEKK15"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2173
                     /gene="Map3k15"
                     /gene_synonym="MEKK15"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2307
                     /gene="Map3k15"
                     /gene_synonym="MEKK15"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..2435
                     /gene="Map3k15"
                     /gene_synonym="MEKK15"
                     /inference="alignment:Splign:2.1.0"
     exon            2436..2566
                     /gene="Map3k15"
                     /gene_synonym="MEKK15"
                     /inference="alignment:Splign:2.1.0"
     exon            2567..2672
                     /gene="Map3k15"
                     /gene_synonym="MEKK15"
                     /inference="alignment:Splign:2.1.0"
     exon            2673..2830
                     /gene="Map3k15"
                     /gene_synonym="MEKK15"
                     /inference="alignment:Splign:2.1.0"
     exon            2831..3014
                     /gene="Map3k15"
                     /gene_synonym="MEKK15"
                     /inference="alignment:Splign:2.1.0"
     exon            3015..3180
                     /gene="Map3k15"
                     /gene_synonym="MEKK15"
                     /inference="alignment:Splign:2.1.0"
     exon            3181..3355
                     /gene="Map3k15"
                     /gene_synonym="MEKK15"
                     /inference="alignment:Splign:2.1.0"
     exon            3356..3541
                     /gene="Map3k15"
                     /gene_synonym="MEKK15"
                     /inference="alignment:Splign:2.1.0"
     exon            3542..3647
                     /gene="Map3k15"
                     /gene_synonym="MEKK15"
                     /inference="alignment:Splign:2.1.0"
     exon            3648..3861
                     /gene="Map3k15"
                     /gene_synonym="MEKK15"
                     /inference="alignment:Splign:2.1.0"
     exon            3862..3974
                     /gene="Map3k15"
                     /gene_synonym="MEKK15"
                     /inference="alignment:Splign:2.1.0"
     exon            3975..4075
                     /gene="Map3k15"
                     /gene_synonym="MEKK15"
                     /inference="alignment:Splign:2.1.0"
     exon            4076..4152
                     /gene="Map3k15"
                     /gene_synonym="MEKK15"
                     /inference="alignment:Splign:2.1.0"
     exon            4153..4572
                     /gene="Map3k15"
                     /gene_synonym="MEKK15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4552..4557
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Map3k15"
                     /gene_synonym="MEKK15"
                     /note="hexamer: ATTAAA"
     polyA_site      4572
                     /gene="Map3k15"
                     /gene_synonym="MEKK15"
                     /note="major polyA site"
ORIGIN      
        1 gcgggctttc aaagggcgct cggggcaagc cggccctgag ctccgctccg ccggccgccg
       61 gagaacccgt ggtcacctgc ccgccccggc ctctgcgccc gccccctgct ccggctccct
      121 gcggccgccg tccgtcctcc ggtccgcccg tccgtcatcc gcctgtgcag caggtgtctc
      181 ggggaagagc acctgggctt cgaagccgcc agccccgcgg gccagtcaca tggagggcgg
      241 cggcggcagc ggcggcggcg gcgggccagt ccctgccgag gctccggagg aagccggcga
      301 gccgccccag ggcaggctgc ccccggggcc cgagggcgcg gcggggctgg cggagcccga
      361 gagcacgggg gacgcggcgg gcggcgaggc cgagggcggg cgcgggccac gccgggctct
      421 gcgggctgtc tacgtgcgca gcgaaagttc gcagggggca gccgccggcg gcggccccga
      481 ggccggggcg ctcaagtgcc tgcttcgggc ttgcgaagcc gagggcgccc acctcacctc
      541 cgtccccttc ggggagctcg acttcgggga gacggccgtg ctcgatgcct tctacgatgc
      601 agatgttgcc attgtggaca tgagtgatat ctccagacag ccttcccttt tctaccatct
      661 tggagtccga gagagttttg acatggctaa caatgtaatt ctctactatg atactgatgc
      721 tgacactgct ctgtcattga aggatatggt cactcaaaaa aacacagcat ccagtggaaa
      781 ttattatttt atcccctaca ctgtgacacc atgtgctgac tatttttgct gtgagagtga
      841 tgcccaaagg agagcctcag agtacatgca gcctaactgg gacaccatac tgggcccgct
      901 gtgtatgccc ctggtcgaca ggttcactag cctccttaag gacatccgtg tgacttcatg
      961 tgcttattat aaagaaacat tgttaaatga catccggaaa gccagagaga aataccaagg
     1021 tgatgaactg gcgaaagagt tgactcggat caaattccgt atggataaca ttgaggttct
     1081 gacatcggac atcatcatta acttacttct gtcctaccgt gatatccagg actacgatgc
     1141 aatggtcaag ctggtagaga cactgaagat gctgccaacg tgtgatttgg ctgatcagca
     1201 caacattaaa tttcactatg catttgcact gaataggaga aacagcacag gtgaccgtga
     1261 aaaggctctt caggttatgc tccaagttct gcaaagctgt gaccacccag ctcctgacat
     1321 gttttgcctg tgtgggcgga tatacaagga catcttcctg gattcaggtt gtgaagagga
     1381 tgcaagcaga gacagtgcca ttgagtggta tcgcaaaggg tttgaactcc agtcatccct
     1441 ttattcagga attaaccttg cagttttgct gatagtttct ggacaacagt ttgaaacttc
     1501 gatggaacta aggaaaatag gtgtccggct gaacagttta ttgggaagaa aagggagcct
     1561 ggagaaaatg aacaattact gggatgtagg tcagttcttc accgtcagca tgctggcaag
     1621 tgatattggg aaagctgtcc aggcagcaga gaggttgttc aaactgaaac ccccagtctg
     1681 gtacctgcgg tcattagttc agaacttgct gttaattcaa cgcttcaaga aacccattac
     1741 agaacattca cccaggcagg aacggcttaa cttctggtta gatatcattt ttgaagcaac
     1801 gaatgaagtt actaatggac tcagatttcc agttctggta atagagccaa ccaaagtcta
     1861 ccagccttct tatgtttcta tcaacaatga agctgaagaa agaactgttt ctttatggca
     1921 tgtctcaccc acagaaatga aacaaatcca tgagtggaat tttacagcct cttctattaa
     1981 aggaataagc ctatccaagt ttgatgaacg gtgctgtttt ctttatgtcc atgataattc
     2041 tgatgacttt caaatctact tttccaccga agaccagtgt aatagatttt gttctttggt
     2101 caaagagatg ctaaacaatg gagtgggcag tacagtggag ttggagggag aggctgatgg
     2161 agacacctta gagtatgagt atgaccatga tgcgaatggg gagagagttg tcttggggaa
     2221 aggctcctat gggattgtgt atgccggccg tgatctcagt aatcaagtac ggatagccat
     2281 caaggaaatc ccagagagag atatcaggta ctctcagcct ctgcatgaag aaatagctct
     2341 gcacaagtat ctcaaacatc gcaacatcgt ccagtaccta ggctctgttt cagagaatgg
     2401 ctacattaag atatttatgg agcaggtgcc tggaggaagc ctttctgctc tcttacgatc
     2461 taaatgggga cctatgaagg aacccactat caagttttat accaaacaga tcctggaagg
     2521 cctgaagtat ctccatgaaa accagatagt gcacagagac ataaagggag ataatgttct
     2581 ggtgaacacc tatagtggag tggtaaaaat ctctgatttt ggaacctcta aacgcctcgc
     2641 aggaattaac ccatgcaccg agacctttac aggaactctg cagtacatgg cacctgagat
     2701 tattgatcaa ggacctcggg gatatggtgc tccagctgat atctggtcct tgggctgcac
     2761 catcattgag atggcaacca gcaggcctcc attccatgag cttggtgagc cccaagcagc
     2821 catgtttaag gtagggatgt ttaagatcca ccctgaaatt ccagaggccc tttcagctga
     2881 agccagagcc ttcatcttgt cttgttttga gcctgaccct cagaaacgtg tcactgctgc
     2941 tgaccttctc caagaagggt tcttaaggca ggtgaacaaa ggcaaaaaga accgaattgc
     3001 tttcaagcct tcagagggtg ttcggagtgg cactggtact ctggctctgc cttcatcagg
     3061 agagcttgtg ggcagcagca gcagcgagca tggctcaatc tccccagact cggatgccca
     3121 gcctgatgca ttctttgaga aagtccaggt gcccaaacat cagctcagcc accttctcag
     3181 tgtcccagat gaaagcccag ccttagatga ccgaagcaca gccttacccc cagaggagag
     3241 ggaccctggt ctctttctgc tgcgcaagga cagtgagcgc agagccatcc tttacagaat
     3301 cctttgggag gaacagaacc aagtggcttc caacttgcaa gagtgtgtgg tccagagttc
     3361 agaagagttg cttctctcag ttagccacat caaacagata attggaatcc tgagggactt
     3421 catccgctcc ccagagcaca gggtgatggc agccacaata tcaaaactaa aggtggacct
     3481 ggactttgac agctcatcca tcaaccagat tcacctgatt ctgtttgggt tccaagatgc
     3541 tgtcaataga attttgagaa accacttaat taggccccac tggatgtttg caatggacaa
     3601 catcattcgc agagctgtgc aggctgcagt caccattctc attccagagc tccaagccca
     3661 ctttgagcct gcttctgaga ctgaaggggt agacaaggac acagaagtag aaggggacta
     3721 tcccctagta gacctcctca gccaagaagt gcatgtgaca cctagaggca ccagacctgg
     3781 ctcagtggct atccaggagg gccagcccca ccagcaagac ccaagtctcc aactgagcaa
     3841 gctcaggcaa gagaccaaca gactttggga acacctagtt caaaaagaga gggagtacca
     3901 gaatcttctt cgcctaattc tagaccagaa aactcaagaa ttgtatcacc ttcagttaca
     3961 gtacaaatcc aatggtggta cagagaaccc tccaccccct gatggactgg gaaccgacag
     4021 agagcttata gactggttgc aactacaagg agtggatgcc aatacaatag aaaagattgt
     4081 tgaagaggac tatacacttt ctgatattct caatgatatc actaaggaag acctaaggtg
     4141 cctccgacta cggggtggtg tcctctgtag gctctggcat gcagtctccc agcacagaag
     4201 acaaatgcag gagtcttcac agtgagccaa gcctggggag aatgggcaaa aagtccccta
     4261 cacctgctca tgattaaagc ttctgttggt gtactcacaa actccgagtt tccacagaaa
     4321 gacccttgtc catttaattc aagcacgtgt gattgtagag catccttgtt tataaacaag
     4381 attgtaagta atgtcagccc tgacctaata tttaaaaagt cagcatatcg ctggaaagat
     4441 aaagcatacg tattttataa actagtgtaa ttacttaaat gtgaaaggtt aaaaagtgtg
     4501 ccttgcaatg ggagtacagt ttcatgtatg ttaaatgtct aaatggaaaa aattaaacta
     4561 ttttaccttt ga
//
