LOCUS       NM_016896               4173 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Mus musculus mitogen-activated protein kinase kinase kinase 14
            (Map3k14), mRNA.
ACCESSION   NM_016896
VERSION     NM_016896.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4173)
  AUTHORS   Cao,M., Yi,L., Xu,Y., Tian,Y., Li,Z., Bi,Y., Guo,M., Li,Y., Liu,Y.,
            Xu,X., Sun,J., Li,C. and Duan,W.
  TITLE     Inhibiting NF-kappaB inducing kinase improved the motor performance
            of ALS animal model
  JOURNAL   Brain Res 1843, 149124 (2024)
   PUBMED   39019135
  REMARK    GeneRIF: Inhibiting NF-kappaB inducing kinase improved the motor
            performance of ALS animal model.
REFERENCE   2  (bases 1 to 4173)
  AUTHORS   Morrison,H.A., Eden,K., Trusiano,B., Rothschild,D.E., Qin,Y.,
            Wade,P.A., Rowe,A.J., Mounzer,C., Stephens,M.C., Hanson,K.M.,
            Brown,S.L., Holl,E.K. and Allen,I.C.
  TITLE     NF-kappaB Inducing Kinase Attenuates Colorectal Cancer by
            Regulating Noncanonical NF-kappaB Mediated Colonic Epithelial Cell
            Regeneration
  JOURNAL   Cell Mol Gastroenterol Hepatol 18 (3), 101356 (2024)
   PUBMED   38750899
  REMARK    GeneRIF: NF-kappaB Inducing Kinase Attenuates Colorectal Cancer by
            Regulating Noncanonical NF-kappaB Mediated Colonic Epithelial Cell
            Regeneration.
REFERENCE   3  (bases 1 to 4173)
  AUTHORS   Duan,W., Guo,S., Huang,H.P., Tian,Y., Li,Z., Bi,Y., Yi,L., Cao,M.,
            Guo,M., Li,Y., Liu,Y. and Li,C.
  TITLE     High expression of NF-kappaB inducing kinase in the bulge region of
            hair follicle induces tumor
  JOURNAL   Immunobiology 228 (5), 152705 (2023)
   PUBMED   37459681
  REMARK    GeneRIF: High expression of NF-kappaB inducing kinase in the bulge
            region of hair follicle induces tumor.
REFERENCE   4  (bases 1 to 4173)
  AUTHORS   Bilgic,S.N., Domaniku,A., Toledo,B., Agca,S., Weber,B.Z.C.,
            Arabaci,D.H., Ozornek,Z., Lause,P., Thissen,J.P., Loumaye,A. and
            Kir,S.
  TITLE     EDA2R-NIK signalling promotes muscle atrophy linked to cancer
            cachexia
  JOURNAL   Nature 617 (7962), 827-834 (2023)
   PUBMED   37165186
  REMARK    GeneRIF: EDA2R-NIK signalling promotes muscle atrophy linked to
            cancer cachexia.
REFERENCE   5  (bases 1 to 4173)
  AUTHORS   Aoki,T., Hiura,F., Li,A., Yang,N., Takakura-Hino,N., Mukai,S.,
            Matsuda,M., Nishimura,F. and Jimi,E.
  TITLE     Inhibition of non-canonical NF-kappaB signaling suppresses
            periodontal inflammation and bone loss
  JOURNAL   Front Immunol 14, 1179007 (2023)
   PUBMED   37143646
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4173)
  AUTHORS   Shinkura,R., Matsuda,F., Sakiyama,T., Tsubata,T., Hiai,H.,
            Paumen,M., Miyawaki,S. and Honjo,T.
  TITLE     Defects of somatic hypermutation and class switching in
            alymphoplasia (aly) mutant mice
  JOURNAL   Int Immunol 8 (7), 1067-1075 (1996)
   PUBMED   8757952
REFERENCE   7  (bases 1 to 4173)
  AUTHORS   Koike,R., Nishimura,T., Yasumizu,R., Tanaka,H., Hataba,Y.,
            Hataba,Y., Watanabe,T., Miyawaki,S. and Miyasaka,M.
  TITLE     The splenic marginal zone is absent in alymphoplastic aly mutant
            mice
  JOURNAL   Eur J Immunol 26 (3), 669-675 (1996)
   PUBMED   8605936
REFERENCE   8  (bases 1 to 4173)
  AUTHORS   Nanno,M., Matsumoto,S., Koike,R., Miyasaka,M., Kawaguchi,M.,
            Masuda,T., Miyawaki,S., Cai,Z., Shimamura,T., Fujiura,Y. et al.
  TITLE     Development of intestinal intraepithelial T lymphocytes is
            independent of Peyer's patches and lymph nodes in aly mutant mice
  JOURNAL   J Immunol 153 (5), 2014-2020 (1994)
   PUBMED   8051406
REFERENCE   9  (bases 1 to 4173)
  AUTHORS   Kuramoto,T., Mashimo,T., Koike,R., Miyawaki,S., Yamada,J.,
            Miyasaka,M. and Serikawa,T.
  TITLE     The alymphoplasia (aly) mutation co-segregates with the
            intercellular adhesion molecule-2 (lcam-2) on mouse chromosome 11
  JOURNAL   Int Immunol 6 (7), 991-994 (1994)
   PUBMED   7947467
REFERENCE   10 (bases 1 to 4173)
  AUTHORS   Miyawaki,S., Nakamura,Y., Suzuka,H., Koba,M., Yasumizu,R.,
            Ikehara,S. and Shibata,Y.
  TITLE     A new mutation, aly, that induces a generalized lack of lymph nodes
            accompanied by immunodeficiency in mice
  JOURNAL   Eur J Immunol 24 (2), 429-434 (1994)
   PUBMED   8299692
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK036200.1.
            
            On Apr 6, 2007 this sequence version replaced NM_016896.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036200.1, AK172518.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4173              AK036200.1         2-4174
FEATURES             Location/Qualifiers
     source          1..4173
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 66.8 cM"
     gene            1..4173
                     /gene="Map3k14"
                     /gene_synonym="aly; Nik"
                     /note="mitogen-activated protein kinase kinase kinase 14"
                     /db_xref="GeneID:53859"
                     /db_xref="MGI:MGI:1858204"
     exon            1..64
                     /gene="Map3k14"
                     /gene_synonym="aly; Nik"
                     /inference="alignment:Splign:2.1.0"
     exon            65..339
                     /gene="Map3k14"
                     /gene_synonym="aly; Nik"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..2912
                     /gene="Map3k14"
                     /gene_synonym="aly; Nik"
                     /EC_number="2.7.11.25"
                     /note="NF kappa B-inducing kinase; NF-kappa-beta-inducing
                     kinase; serine/threonine-protein kinase NIK; Nfkb inducing
                     kinase; alymphoplasia"
                     /codon_start=1
                     /product="mitogen-activated protein kinase kinase kinase
                     14"
                     /protein_id="NP_058592.1"
                     /db_xref="CCDS:CCDS25516.1"
                     /db_xref="GeneID:53859"
                     /db_xref="MGI:MGI:1858204"
                     /translation="MAVMEVACPGTPGSAVGQQKELAKAKEKTQSLGKKQSCIFKLEA
                     VEKSPVFCGKWEILNDVITKGTAKDGSEGGPPAISIIAQAECENSQEFSPTFSERIFI
                     AGSQQYSQSESLDQIPNNVAHATEGKMARVCRRGKRHGKARKKRRKKRSKSLAQAGVA
                     LAKPLPRTPEQESCTIPVQEDESPLGNLYARNVSQFTKPLGGPGLGHLCFKKQDEGLR
                     PVLPRPELHKLISPLQCLNHVWKLHHPQATGPRPHPTHPFPYSGMPHPFPFYPLEPWK
                     PYMLDSAVLDKLAGVSGQRPLPGPPHLSQLAHGDSQKPLPGPHLESSCPSRGALEKVP
                     VEEYLVHALQGSVSSGQAHSLASLAKTWSSGSAKLQRLGPETEDNEGVLLTEKLKPVD
                     YEYREEVHWMTHQPRVGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFRVEELVACAGLS
                     SPRIVPLYGAVREGPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYL
                     HTRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMA
                     PEVVMGKPCDAKVDIWSSCCMMLHMLNGCHPWTQYFRGPLCLKIASEPPPIREIPPSC
                     APLTAQAIQEGLRKEPVHRASAMELRRKVGKALQEVGGLKSPWKGEYKEPRPPPQDQA
                     TCHQTLPTPPRENPPAKANTDGAPEPQPPLPPEPPEPSKAPALNLSKEESGTWEPLPL
                     SSLDPATAKGPSFPDRRATLPELELQQLEIELFLNSLSQPFSLEEQEQILSCLSIDSL
                     SLSDDSEKNPSKASQSSRDTLSSGVHSWNSQAEARTCSCSTALARGRPTDIPSYFNGV
                     KVQIQSLNGEHLHIREFHRVKVGDIATGISSQIPATAFSLVTKDGQPVCYDMEVPDSG
                     IDLQCTLAPDGSFAWTWRVKHGQLENRP"
     exon            340..409
                     /gene="Map3k14"
                     /gene_synonym="aly; Nik"
                     /inference="alignment:Splign:2.1.0"
     exon            410..620
                     /gene="Map3k14"
                     /gene_synonym="aly; Nik"
                     /inference="alignment:Splign:2.1.0"
     exon            621..1241
                     /gene="Map3k14"
                     /gene_synonym="aly; Nik"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1379
                     /gene="Map3k14"
                     /gene_synonym="aly; Nik"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1509
                     /gene="Map3k14"
                     /gene_synonym="aly; Nik"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1641
                     /gene="Map3k14"
                     /gene_synonym="aly; Nik"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1746
                     /gene="Map3k14"
                     /gene_synonym="aly; Nik"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1910
                     /gene="Map3k14"
                     /gene_synonym="aly; Nik"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2061
                     /gene="Map3k14"
                     /gene_synonym="aly; Nik"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2394
                     /gene="Map3k14"
                     /gene_synonym="aly; Nik"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..2501
                     /gene="Map3k14"
                     /gene_synonym="aly; Nik"
                     /inference="alignment:Splign:2.1.0"
     exon            2502..2646
                     /gene="Map3k14"
                     /gene_synonym="aly; Nik"
                     /inference="alignment:Splign:2.1.0"
     exon            2647..2747
                     /gene="Map3k14"
                     /gene_synonym="aly; Nik"
                     /inference="alignment:Splign:2.1.0"
     exon            2748..4173
                     /gene="Map3k14"
                     /gene_synonym="aly; Nik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4173
                     /gene="Map3k14"
                     /gene_synonym="aly; Nik"
                     /note="putative"
ORIGIN      
        1 ccggagcgat cgctggccag cgaagcgcca cactcgcttg tttgaggaca acggcgctcc
       61 gccggtgagc acgagcctgg gagatggccg tgatggaagt ggcctgcccg ggcactcctg
      121 ggtcagcagt cgggcagcag aaggagcttg ccaaagccaa ggagaagaca cagtcactgg
      181 ggaagaagca gagctgcatc ttcaagcttg aggccgtgga gaagagcccc gtgttctgtg
      241 ggaagtggga gatcctaaac gacgtgatca ccaaaggcac agccaaggac ggctctgagg
      301 gaggaccacc ggccatctcc atcatcgccc aggctgaatg tgagaatagc caagagttca
      361 gccccacctt ctcagagcgc attttcatcg cggggtcaca gcagtacagc cagtctgaga
      421 gtctcgatca aatccccaac aatgtggccc atgcaactga aggcaaaatg gcccgtgtgt
      481 gccggagggg aaaacgtcac ggcaaagccc gaaaaaaacg taggaagaag aggtcgaagt
      541 cactggccca ggcaggagtg gccttagcca agcccctgcc cagaacccct gagcaagaga
      601 gctgtaccat cccagtacag gaagatgagt ctccactagg caacctctat gccagaaatg
      661 tctcccagtt caccaagcct ctggggggac caggccttgg ccacctgtgc tttaagaaac
      721 aagatgaagg cctgcgaccg gtactgcctc gaccagaact ccacaaactg atcagcccct
      781 tgcaatgtct aaaccacgtg tggaaactcc accaccccca ggccacaggc ccccggcccc
      841 acccgactca ccccttcccc tacagcggaa tgccccatcc tttcccattc taccccctgg
      901 agccctggaa accctatatg ctggactctg ccgtcctgga caaactagcc ggtgtcagcg
      961 gccagcggcc tctgcctggc ccaccgcatc taagccaact ggcccatgga gacagtcaga
     1021 agccgctgcc tggcccacac ctggagtcca gctgcccgtc tcggggtgcc ctagaaaagg
     1081 ttcccgtgga ggaatacctg gtgcatgcgc tccaaggaag tgtgagctca ggccaggccc
     1141 acagcctggc cagcctggct aagacatggt cctcgggaag cgccaagctg cagaggctcg
     1201 gccccgaaac tgaggacaac gagggggtcc tgcttactga gaaactcaag ccagtggatt
     1261 atgagtatcg agaagaggtc cactggatga cacaccagcc tcgggtgggc agaggctcct
     1321 tcggcgaggt ccacagaatg aaggacaagc agacaggctt ccagtgtgct gtcaaaaagg
     1381 tacgactcga ggtgtttcgg gtagaggaac tagtggcctg tgctggtctg agctcgccca
     1441 gaatcgtccc tctctatgga gctgtgagag aaggcccgtg ggtgaacatc ttcatggaac
     1501 tgctagaagg tggctcgctg ggtcagctca taaagcaaat gggctgtctg ccagaagacc
     1561 gagcccttta ctacctgggc caggccctgg aggggctgga gtacctccac acacgcagga
     1621 ttctgcatgg cgatgtcaaa gctgacaacg tgctcctgtc cagtgatgga agccgagcgg
     1681 ccctctgcga ctttggccac gccttgtgcc tgcaacctga cggcctaggg aaatccttgc
     1741 tcacagggga ctacattcct ggcacggaga cccacatggc accagaagtg gtgatgggaa
     1801 agccctgcga tgccaaggtg gacatctgga gcagctgctg catgatgctc cacatgctca
     1861 acggctgcca cccctggact cagtacttcc gaggcccgct ttgtctcaag attgccagcg
     1921 agcctccacc gatcagggag atcccacctt cctgcgcacc cctcacagcc caggccatcc
     1981 aagaggggct gaggaaagag cccgtccacc gagcatctgc catggagctt cggaggaaag
     2041 tgggcaaggc actacaggaa gtgggaggtc tgaaaagccc ttggaaagga gaatataaag
     2101 aaccaagacc tccaccccaa gaccaagcca cctgccacca gaccctacct actccgccga
     2161 gagagaaccc accagccaag gccaacacag acggggctcc tgagcctcag cctcctctac
     2221 cgccagaacc accagaaccg agcaaagcgc cagccctgaa cctgagcaag gaggagtctg
     2281 gcacatggga acccctgcct ctgtcctccc tggacccagc cactgccaaa ggccccagct
     2341 tcccagaccg gagggcaacc ttgccagagc tggagctaca gcaactggag atagaactgt
     2401 ttctcaacag cctgtcccag ccgttctctc tggaggaaca ggaacaaatc ctctcctgcc
     2461 tcagcatcga cagcctctcg ctgtcagatg acagtgaaaa gaatccatcg aaggcctctc
     2521 agagctcacg ggacaccctg agttctggcg tgcactcttg gaacagccaa gctgaggcaa
     2581 gaacctgcag ctgcagcacg gcgctggccc gggggcggcc tactgacatc ccgagctact
     2641 tcaacggggt caaggtccag atccagtctc tcaatggcga acacctgcat atccgggaat
     2701 tccaccgcgt caaggtggga gacattgcca ccggcatcag cagccagatc ccagccacag
     2761 ctttcagcct ggtgaccaaa gatggacagc ctgtttgcta tgacatggag gtgccagact
     2821 cgggcatcga cctgcagtgc accctggccc ctgatggcag ctttgcttgg acctggaggg
     2881 tcaagcatgg tcagctggag aaccgaccct agtcctgtct tccaccacca gctccactct
     2941 ggccacggca ggcttccttt gatctcagtg ctcgctggtg ctctgagatg ctggatgagt
     3001 ctgcacaggg acctgccagt ccctggttca gcatgtagac cagggcttgt gagcagagca
     3061 gcgaagggaa cagagtaaag cacctcccag gacttgcctc ctggcaggag aaactcttcc
     3121 ctcatgagga gacaaggagg aaggaaaaca ggggtctctg tgactctcca aacaaggtag
     3181 ccagacccac atgggtcagt cagcacttgc cagcagttgg ggagcagctt ctagcctggg
     3241 tcacgaagag caggtacccc taggaaggca ggagagtgtc taggggttcc tgcccagctc
     3301 ctacagggca aggcagtagg tgtgccggcc caggggctgt ggagttcttg gccccgtgtc
     3361 tagcctccct ggccttgact agtgtgagac agaaggagca ggaagggcac tagaatgcac
     3421 tgagccttca ggtcattgca gcccacatcc tggattgagc tccttgatca accagggacc
     3481 acagaagaga catgattctc gggcctcacg tttgtggcta tgggcagcac tcctcagcgt
     3541 cagccccact ggctccctgg cactctagtc cctcatctgt ggcaatgaag gatgacacgt
     3601 gagacccacc tgacaggaac ggtctgcaaa tgataaactc aagaaagcca cagaaacagg
     3661 gcttgccacc ctctgggggc acactgtcag catccagcat ggtgtggcaa ggcattgcca
     3721 gcagcagcac tttgcactca ggtgacctca aagcactttc ctggctgcct tccagcagag
     3781 cattggctct gcatgagcag gggcaggcca ggggatgggg aagaagggac tgtcttgacc
     3841 catcatccac acaggcttga ccccccctca agcttctttc agacttaaga tgagcatcgt
     3901 cgcccccact gccctagctg ggacttctcc tggtgggact tggaaacagc tgcttaggac
     3961 tcattgtagc attaagttca ctgtgaatca tttgttggga ggggcacaga gacttctcta
     4021 gggaaactca tccccccacc tcaaccagcc aggatagctc tgtccagctc tttgcaagga
     4081 tctaggctgc tcctggcccc agcacatgaa cggcagccac ggtgctgcat ctggggtgta
     4141 ttgagttcta taagcaataa aatttggaat gac
//
