LOCUS       NM_172821               6709 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus mitogen-activated protein kinase kinase kinase 13
            (Map3k13), mRNA.
ACCESSION   NM_172821 XM_484537 XM_912405 XM_988258
VERSION     NM_172821.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6709)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6709)
  AUTHORS   Saikia,J.M., Chavez-Martinez,C.L., Kim,N.D., Allibhoy,S., Kim,H.J.,
            Simonyan,L., Smadi,S., Tsai,K.M., Romaus-Sanjurjo,D., Jin,Y. and
            Zheng,B.
  TITLE     A Critical Role for DLK and LZK in Axonal Repair in the Mammalian
            Spinal Cord
  JOURNAL   J Neurosci 42 (18), 3716-3732 (2022)
   PUBMED   35361703
  REMARK    GeneRIF: A Critical Role for DLK and LZK in Axonal Repair in the
            Mammalian Spinal Cord.
REFERENCE   3  (bases 1 to 6709)
  AUTHORS   Li,Y., Ritchie,E.M., Steinke,C.L., Qi,C., Chen,L., Zheng,B. and
            Jin,Y.
  TITLE     Activation of MAP3K DLK and LZK in Purkinje cells causes rapid and
            slow degeneration depending on signaling strength
  JOURNAL   Elife 10, e63509 (2021)
   PUBMED   33475086
  REMARK    GeneRIF: Activation of MAP3K DLK and LZK in Purkinje cells causes
            rapid and slow degeneration depending on signaling strength.
            Erratum:[Elife. 2023 Feb 13;12:e86472. doi: 10.7554/eLife.86472..
            PMID: 36779959]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6709)
  AUTHORS   Chen,M., Geoffroy,C.G., Meves,J.M., Narang,A., Li,Y., Nguyen,M.T.,
            Khai,V.S., Kong,X., Steinke,C.L., Carolino,K.I., Elziere,L.,
            Goldberg,M.P., Jin,Y. and Zheng,B.
  TITLE     Leucine Zipper-Bearing Kinase Is a Critical Regulator of Astrocyte
            Reactivity in the Adult Mammalian CNS
  JOURNAL   Cell Rep 22 (13), 3587-3597 (2018)
   PUBMED   29590625
  REMARK    GeneRIF: LZK overexpression in astrocytes enhanced astrogliosis and
            reduced lesion size. Remarkably, in the absence of injury, LZK
            overexpression alone induced widespread astrogliosis in the CNS and
            upregulated astrogliosis activators pSTAT3 and SOX9.
REFERENCE   5  (bases 1 to 6709)
  AUTHORS   Welsbie,D.S., Mitchell,K.L., Jaskula-Ranga,V., Sluch,V.M., Yang,Z.,
            Kim,J., Buehler,E., Patel,A., Martin,S.E., Zhang,P.W., Ge,Y.,
            Duan,Y., Fuller,J., Kim,B.J., Hamed,E., Chamling,X., Lei,L.,
            Fraser,I.D.C., Ronai,Z.A., Berlinicke,C.A. and Zack,D.J.
  TITLE     Enhanced Functional Genomic Screening Identifies Novel Mediators of
            Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons
  JOURNAL   Neuron 94 (6), 1142-1154 (2017)
   PUBMED   28641113
  REMARK    GeneRIF: LZK cooperates with DLK to promote retinal ganglion cell
            death in response to axon injury.
REFERENCE   6  (bases 1 to 6709)
  AUTHORS   Dickson,H.M., Zurawski,J., Zhang,H., Turner,D.L. and Vojtek,A.B.
  TITLE     POSH is an intracellular signal transducer for the axon outgrowth
            inhibitor Nogo66
  JOURNAL   J Neurosci 30 (40), 13319-13325 (2010)
   PUBMED   20926658
  REMARK    GeneRIF: Scaffold protein POSH, in association with Shroom3 and
            mixed lineage kinase LZK, relays axon outgrowth inhibition
            downstream of NogoA and PirB proteins.
REFERENCE   7  (bases 1 to 6709)
  AUTHORS   Saiga,T., Fukuda,T., Matsumoto,M., Tada,H., Okano,H.J., Okano,H.
            and Nakayama,K.I.
  TITLE     Fbxo45 forms a novel ubiquitin ligase complex and is required for
            neuronal development
  JOURNAL   Mol Cell Biol 29 (13), 3529-3543 (2009)
   PUBMED   19398581
REFERENCE   8  (bases 1 to 6709)
  AUTHORS   Itoh,A., Horiuchi,M., Bannerman,P., Pleasure,D. and Itoh,T.
  TITLE     Impaired regenerative response of primary sensory neurons in
            ZPK/DLK gene-trap mice
  JOURNAL   Biochem Biophys Res Commun 383 (2), 258-262 (2009)
   PUBMED   19358824
REFERENCE   9  (bases 1 to 6709)
  AUTHORS   Craig,E.A., Stevens,M.V., Vaillancourt,R.R. and Camenisch,T.D.
  TITLE     MAP3Ks as central regulators of cell fate during development
  JOURNAL   Dev Dyn 237 (11), 3102-3114 (2008)
   PUBMED   18855897
  REMARK    Review article
REFERENCE   10 (bases 1 to 6709)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DQ480427.1, AK047986.1, AK054039.1, BB455895.2, BB549158.2,
            BP761466.1 and CX240141.1.
            
            On Oct 5, 2007 this sequence version replaced NM_172821.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ480427.1, SRR9219382.104303.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2880              DQ480427.1         1-2880
            2881-4328           AK047986.1         955-2402
            4329-5613           AK054039.1         1165-2449
            5614-5687           BB455895.2         105-178
            5688-5956           BB549158.2         389-657
            5957-6564           BP761466.1         86-693
            6565-6709           CX240141.1         37-181
FEATURES             Location/Qualifiers
     source          1..6709
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 12.92 cM"
     gene            1..6709
                     /gene="Map3k13"
                     /gene_synonym="C130026N12Rik; LZK"
                     /note="mitogen-activated protein kinase kinase kinase 13"
                     /db_xref="GeneID:71751"
                     /db_xref="MGI:MGI:2444243"
     CDS             1..2880
                     /gene="Map3k13"
                     /gene_synonym="C130026N12Rik; LZK"
                     /EC_number="2.7.11.25"
                     /codon_start=1
                     /product="mitogen-activated protein kinase kinase kinase
                     13"
                     /protein_id="NP_766409.2"
                     /db_xref="CCDS:CCDS37294.1"
                     /db_xref="GeneID:71751"
                     /db_xref="MGI:MGI:2444243"
                     /translation="MANPQEHLSCSSLPHLPLTENKTSGGRNELAAMGNHPSPKLPED
                     PQERGAIQSELMEITGSPISTTVLTSVSEDSRGQFENSVLQLREQDESEMTLSLGNSN
                     TVDGENTNGPEDIKIQFSRSGSGSGGFLEGLFGCLRPVWNIIGKAYSTDYKLQQQDTW
                     EVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNETDIKHLRKLKHPNIIAF
                     KGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIH
                     RDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVD
                     IWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSK
                     PRNRPSFRQTLMHLDIASADVLATPQETYFKSQAEWREEVKKHFEKIKSEGTCIHRLD
                     EELIRRRREELRHALDIREHYERKLERANNLYMELSAIMLQLEMREKELLKREQAVEK
                     KYPGTYKRHPVRPIIHPNAMEKLMKRKGVPHKAGVQTKRPDLLRSEGIPSTEAVPTAS
                     PLSGSPKMSTASSRSRYRSKPRHRRGNSRGSHSDFAAILKTQPAQENSPHPTYMHHTQ
                     AQCASVHQHNPLQQQYQQIPPAQPQSRHPRLNAHGQDIATCANNLRYFGPAAALRSPL
                     SNHAQRQMPGSSPDLISTAMAADWRNSELDQDQVGPWGCCQAEPYDPCFQCRPEHSGS
                     LDVPTTEPVGRSPDLSSSPAHNPLSGNAQGSERTGANGFSGCQSGISHQFTPPMLPQK
                     TRPLQKSGDDSSEEEGEVDSEVEFPRRQRPHRCISSYQSYSTFSSENFSVSDGEEGNT
                     SDHSNSPDESANRRQDRLAETLDDLLSQTPEAPIEISSHSDGLSDKECAVRRVKTQMS
                     LGKLCAEERGYENPVQFGDSDCDSSEGECSDATVRTSKNYSSATW"
     exon            1..472
                     /gene="Map3k13"
                     /gene_synonym="C130026N12Rik; LZK"
                     /inference="alignment:Splign:2.1.0"
     exon            473..656
                     /gene="Map3k13"
                     /gene_synonym="C130026N12Rik; LZK"
                     /inference="alignment:Splign:2.1.0"
     exon            657..848
                     /gene="Map3k13"
                     /gene_synonym="C130026N12Rik; LZK"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1007
                     /gene="Map3k13"
                     /gene_synonym="C130026N12Rik; LZK"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1166
                     /gene="Map3k13"
                     /gene_synonym="C130026N12Rik; LZK"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1275
                     /gene="Map3k13"
                     /gene_synonym="C130026N12Rik; LZK"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1385
                     /gene="Map3k13"
                     /gene_synonym="C130026N12Rik; LZK"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1502
                     /gene="Map3k13"
                     /gene_synonym="C130026N12Rik; LZK"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1640
                     /gene="Map3k13"
                     /gene_synonym="C130026N12Rik; LZK"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..2412
                     /gene="Map3k13"
                     /gene_synonym="C130026N12Rik; LZK"
                     /inference="alignment:Splign:2.1.0"
     exon            2413..2480
                     /gene="Map3k13"
                     /gene_synonym="C130026N12Rik; LZK"
                     /inference="alignment:Splign:2.1.0"
     exon            2481..2778
                     /gene="Map3k13"
                     /gene_synonym="C130026N12Rik; LZK"
                     /inference="alignment:Splign:2.1.0"
     exon            2779..6709
                     /gene="Map3k13"
                     /gene_synonym="C130026N12Rik; LZK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6159..6164
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Map3k13"
                     /gene_synonym="C130026N12Rik; LZK"
                     /note="hexamer: ATTAAA"
     polyA_site      6178
                     /gene="Map3k13"
                     /gene_synonym="C130026N12Rik; LZK"
                     /note="major polyA site"
ORIGIN      
        1 atggccaacc ctcaggagca cctgagctgc tcctctttgc cacacttgcc cttgactgag
       61 aacaaaacct ctggtggacg aaatgagctt gcagctatgg ggaaccaccc ttcacccaag
      121 ctccctgagg accctcagga gaggggggct atacagtcag agctgatgga gatcacaggc
      181 agcccgatct ccacaacagt gttgaccagt gtaagcgagg attctagggg ccagtttgag
      241 aacagtgttc ttcagctaag ggaacaggat gagtcagaga tgaccctgtc tctggggaac
      301 agcaacactg tggatggaga gaacacgaac ggaccagaag acatcaagat tcagttcagc
      361 aggtcaggca gcggcagcgg cgggtttctc gaaggactgt ttggatgtct caggcccgtg
      421 tggaatatca ttgggaaggc atattccact gattacaagc tgcagcagca agatacttgg
      481 gaagtgccat ttgaggaaat ctcagagctg caatggctgg gtagtggagc ccaaggagct
      541 gtcttcctgg gcaaattccg agcagaggag gtggccatca agaaggtgag agaacaaaat
      601 gagacggaca tcaagcatct gaggaagctg aagcacccta acatcatcgc cttcaagggt
      661 gtttgcactc aggccccgtg ctactgcatc atcatggagt actgtgccca cggacagctg
      721 tacgaggtcc tgagagctgg ccggaagatc acgccccggc tgcttgtgga ctggtccacg
      781 ggaatcgcca gtggaatgaa ttatctccat ctccacaaga ttatacaccg tgacctcaag
      841 tcgcccaatg ttttagtgac tcacacagat gcagtgaaaa tttcagactt tggcacatct
      901 aaggaactca gtgataaaag caccaagatg tccttcgctg gcaccgtcgc gtggatggca
      961 ccagaggtga tccggaatga gcctgtctcg gagaaggtgg acatatggtc atttggtgtg
     1021 gtactttggg agctgctgac aggggagatt ccctacaagg atgtggactc ttccgccatc
     1081 atttggggtg tcggcagcaa cagcttgcat ctcccagttc cttccacttg cccggatgga
     1141 ttcaaaatcc ttatgaaaca gacatggcag agtaagcctc gcaaccgacc ttctttcagg
     1201 cagacgctca tgcatctgga tatcgcgtct gcagatgtgc tcgccacccc tcaagaaact
     1261 tacttcaagt ctcaggctga atggagagaa gaagtgaaga aacattttga gaaaatcaaa
     1321 agtgaaggga cctgtataca ccgattagat gaagaactga ttcgccggcg cagggaggag
     1381 ctcaggcatg ctctggatat tcgggagcac tacgagagaa agctcgaacg ggctaacaat
     1441 ctgtacatgg agctgagcgc catcatgctg cagctggaga tgcgcgagaa ggagctcctt
     1501 aagcgagagc aagcagtgga aaagaagtac cctggaacct acaaacgaca ccctgtccgt
     1561 ccaatcatcc acccgaatgc catggagaaa ctcatgaaaa ggaagggtgt gcctcacaag
     1621 gctggggtgc agactaagcg gccagacctg ttgcgatccg aaggcattcc tagtacagaa
     1681 gcggttccca ctgcatcccc cctgtctgga agtcccaaaa tgtccaccgc aagcagcaga
     1741 agccggtacc gaagcaaacc acgtcaccgc cgagggaaca gtagaggcag ccatagcgac
     1801 ttcgcagcaa tcttgaaaac ccagcccgcc caggaaaatt caccccaccc cacctacatg
     1861 caccacactc aggctcagtg cgcttcagtc catcaacata accctctcca gcagcaatac
     1921 cagcaaattc ctcctgccca gcctcagagc cggcatccca gactcaatgc gcatgggcag
     1981 gacattgcaa cctgcgccaa taacctgagg tactttggcc ccgcagcggc cctgcggagt
     2041 ccactcagca accatgcaca aagacagatg cctggctcaa gccccgacct catctccaca
     2101 gccatggctg cagattggag aaattctgaa cttgatcaag accaagttgg accctggggc
     2161 tgttgtcagg ctgaacccta tgatccctgt ttccagtgca ggccagaaca ttctgggtct
     2221 ttagatgttc ccactactga gccagtgggg aggagcccag acctttccag ttcaccagca
     2281 cacaatcctc tttcaggaaa tgcccaaggc tctgagagaa caggggcaaa tggattcagt
     2341 ggctgtcagt ctggtatttc tcatcaattc acacccccaa tgctacctca gaagacacgg
     2401 ccccttcaga agagtggcga tgactcctca gaagaggaag gggaagtgga cagtgaagta
     2461 gaatttcctc gacgacagag gcctcaccgc tgcattagca gttaccagtc atactcaacc
     2521 tttagctccg agaacttctc tgtgtctgat ggagaggagg gcaacactag tgaccactcg
     2581 aacagtcccg atgaatccgc caacagacgg caggaccgcc tggcagagac gctggacgac
     2641 ctgctgtctc agacacccga ggcccccatc gagatctcct cccactcaga tgggctgtct
     2701 gacaaggagt gtgctgttcg gcgcgtgaag acacagatgt ccctaggcaa gctgtgtgcc
     2761 gaggagcgcg gctacgagaa ccctgtgcag tttggagact cggactgtga ctcttcagag
     2821 ggagagtgtt ccgatgccac agttaggacc agcaagaact acagctctgc cacctggtga
     2881 caagggctct gactcctctc cagcaataga ctcctcccac cttcatctgt ctgggaggag
     2941 tggccctgtc ccagaaacaa gccacagtga caggaacatg agacttgtca aatctctggg
     3001 aaatacccaa atgaaactac gtctcactga gcatttcaat caagaatggc agggatctat
     3061 tgtactgaat actccggcta ctgtaacatt gattttattt atttttgttg gacattttaa
     3121 cactttatat tgtaaagagt gaactatata tgatgcagac acaataattt ctttacaaaa
     3181 aaatttaagg aaatgttgct ctttaggaac aacatttgga atttgtgggg ccaggtgtca
     3241 ctgtcacttg aacacaggac tggatctttc gtccatgctt gaagagtttg taaggagaca
     3301 tgttgaacat tgaaaacaca agccaaagga agcgcagcca cattaaggtc gactggctcg
     3361 tccatgtgaa ggatggagac gacctggaag ttgagtgatc tcatagcacc aatgccttgg
     3421 aagggcatgt gcttcctcta ggaggaagag ccacacagag ctgtcactgc acatctggaa
     3481 gccatttcgt ttcgtgaacg ttaagcagaa cctggtggtc agagctttag cagcatcagg
     3541 tcccgccctc agcacatgct tcccattcag tgccgccatt tccccacccc tgaccagcgt
     3601 gctcttctag acgcagtgcc atttcttcca agtagcttcc tttctttccg cctgttggcc
     3661 actgcttcta ggaaggagaa agggtccgga aggagacaaa gggggaagat ggaaagagca
     3721 tctgtgacac aagcctgtaa aacttccttc tcaaggtggc tctgttcagc tatctaagca
     3781 agacggtgtg accctctctg accaggttgt ctacctcctg gaaccacact gattcacaca
     3841 gaaggcagct aggatgtgcg cacccagtgt ccatcccaaa ccatctttat tttgttcatg
     3901 atctcattct agctcggaag ctttggtggc tgtctgtcaa tcactgtagc ataaaaggct
     3961 aagttagcag ctcgtaaaag gtgaccccac caccaccaca tttttgctaa atgctatctg
     4021 taaaatacgg taggtttttt tgtttgtttg tttctttgtt ttctgttttt tgttttcatt
     4081 ctgagtcact gcagttttgt ctagttgggt caggaaacgt gtagaaggaa cagctgatgc
     4141 taagcaggaa ttagaattac tttagtttcc ccaaagcatg cgactcttcc tgtgtctaga
     4201 gttctgggct gtgaaaggta ccctgaggtg ctttgtagag ccttggttcg aagcaggaaa
     4261 tgtctcacag tcccctgagg gctgggtcac aggtgggcac caccatgcct ggcttaaaga
     4321 tgtttcatct agactttatg tatacgcacg ttggcccgat tcctgtctct ggtgcaggct
     4381 tctgccaagc attgacctgc actggctgta ttctgatgtt gcatcctgtg aggatgttag
     4441 gtattaagac attccaaccc cagtggaaat agtgtccatg ggctgggtgt cactcactga
     4501 ctgcgtcagc caaaatgaag tgcaggaggg actcagagca gtcttaacgt ttgatccctc
     4561 ctttgtttac actttatgtt gagacattga ttttaaaatt cagtctctaa tttttagctt
     4621 ataggaaaga tgaaggaact tgtactaaga aagcagtatt gttttgttaa attattccat
     4681 tttctatgaa ctgtagcagg actacacaga agagcttaag ttatggcatt attattcttg
     4741 tttttatttt atattgtcat aattttctgt tgaccagaag gtgtggctga cgatgtagca
     4801 caacggctgt ttattgctaa ccgtgaatta ttatggactt ctgtggtcct aagtgaaggc
     4861 tggggatgga gctgcctttt gtcactccca gcattcctca gtgttttccc tggtctcctg
     4921 actactgtag caatggtctg aggaggtgtg ctctgctctg acacccaacg ggtacactgt
     4981 gattcttttt tacttgattg taaaagctcc tgaatatgca ggtgaccaag tagtttaaag
     5041 gcttcaaaag ttataaactt tctaaagtgt tagaataaaa tcatgggact gtaagagagg
     5101 caaaaagaga ttgaacggtc cagacggcaa gacagagtgt ttctgtgagg actcatgagg
     5161 tagtttcaag agtggacagc aaaccgggtc atcatctcct tcttgctgag tcccacggat
     5221 tgggagaagc agagagacta acagagacat gtacaacacc agcaggatgt gcttctgtga
     5281 ctgcctcagg tccctcgttc ctgtcccaca caaagcggga gcagctgtct gtcccgtgca
     5341 caccattagt gacaacagtg agctctgaag agcagcttct gcccgcacct cccagaaaac
     5401 ccacccagta cctcagcctt catcagcatt ctgcattccc accctgcctg tgtgacaccc
     5461 caaggccacc ttaactggat tcaccgttat gggatgccac gctatgccag ggatgtgctg
     5521 ttgattccag tcatttgcta tagcatcaag atgggagtga agtccacatt tctgtagtag
     5581 aattaacgag gtttcaggaa aggaaaaaaa aaaaggtcct aagcaaggtt aaaagggaag
     5641 aacgttccct actccacctg ccttgtagga ttcaggaaac tcaactgact gtgtttcctt
     5701 gaaaacatta tagtcatcag aagggcctca agtggagaga tcggggaaca tgagagttca
     5761 attcttcagt gctgttagat gccaccatgc tttggtgctt tgaagatcct tgccagacca
     5821 atttcaagct tcaggacata ctgcgagatg aatggctaca ttctttgtcc agcttttttt
     5881 tttttttttg actgatgagt ctcattttct actgcaatca agcactagat ttttcttttt
     5941 tctagattat gtccctaagt aaaaatccct cttaaaataa tagcctagca cagtaatgga
     6001 gaagcctgtg tgcactttaa aacatacccc accaccacta agttgagagc tagctgcagg
     6061 actgggggag attctgccca tgacagggaa gatgacttgg gtggtctggt tgaagattga
     6121 gtattttaag tctttagttc caccaagtta atcctggaat taaagtcatt ttgagtcagt
     6181 actgtctagt gattattcag ggccattgtg ctaaattatt cccccaagct gctctgagtg
     6241 atggagacaa tggcgctgga gtccctgtta ctaacgcagg cttgtcagtg ctcccacaag
     6301 gtagccccga catcgtcccc ttgctcccca tgaggtagcc ctgacatcat cgtctctgtg
     6361 agcatgtgtt cctgttgatc cagtggttta ctggttttct ttttcttatg cccttacgtc
     6421 tcagatgttt gcaattatat gagaattgca tacccgtaaa tgacgagcta tgattatatt
     6481 cagtccatgc ccctctatat cccacctaaa ccaccctcct cccaagccca ggcttttggg
     6541 ttgttgtttt ggtaatccac taaacccagt tagtgccacc caggtatgcg tatggccatc
     6601 cactggagca agggacacaa acagcggatc gtttctacaa aagcgtgatt ctcctccctc
     6661 catagctgtc aactgccagt aactcctcag taagaatagg gccgagaga
//
