LOCUS       NM_001358844            5450 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus mitogen-activated protein kinase kinase kinase 12
            (Map3k12), transcript variant 3, mRNA.
ACCESSION   NM_001358844
VERSION     NM_001358844.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5450)
  AUTHORS   Alkaslasi,M.R., Lloyd,E.Y.H., Gable,A.S., Silberberg,H.,
            Yarur,H.E., Tsai,V.S., Sohn,M., Margolin,G., Tejeda,H.A. and Le
            Pichon,C.E.
  TITLE     The transcriptional response of cortical neurons to concussion
            reveals divergent fates after injury
  JOURNAL   Nat Commun 16 (1), 1097 (2025)
   PUBMED   39870620
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5450)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5450)
  AUTHORS   Asghari Adib,E., Shadrach,J.L., Reilly-Jankowiak,L., Dwivedi,M.K.,
            Rogers,A.E., Shahzad,S., Passino,R., Giger,R.J., Pierchala,B.A. and
            Collins,C.A.
  TITLE     DLK signaling in axotomized neurons triggers complement activation
            and loss of upstream synapses
  JOURNAL   Cell Rep 43 (2), 113801 (2024)
   PUBMED   38363678
REFERENCE   4  (bases 1 to 5450)
  AUTHORS   Patel,S.D., Anand,D., Motohashi,H., Katsuoka,F., Yamamoto,M. and
            Lachke,S.A.
  TITLE     Deficiency of the bZIP transcription factors Mafg and Mafk causes
            misexpression of genes in distinct pathways and results in lens
            embryonic developmental defects
  JOURNAL   Front Cell Dev Biol 10, 981893 (2022)
   PUBMED   36092713
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5450)
  AUTHORS   Saikia,J.M., Chavez-Martinez,C.L., Kim,N.D., Allibhoy,S., Kim,H.J.,
            Simonyan,L., Smadi,S., Tsai,K.M., Romaus-Sanjurjo,D., Jin,Y. and
            Zheng,B.
  TITLE     A Critical Role for DLK and LZK in Axonal Repair in the Mammalian
            Spinal Cord
  JOURNAL   J Neurosci 42 (18), 3716-3732 (2022)
   PUBMED   35361703
REFERENCE   6  (bases 1 to 5450)
  AUTHORS   Matsui,N., Sarkar,G., Shuto,T., Marrs,J., Bronk,J.T., Mizuno,K. and
            Bolander,M.E.
  TITLE     Identification of a dual leucine zipper kinase involved in rat
            fracture repair
  JOURNAL   Biochem Biophys Res Commun 229 (2), 571-576 (1996)
   PUBMED   8954939
REFERENCE   7  (bases 1 to 5450)
  AUTHORS   Blouin,R., Beaudoin,J., Bergeron,P., Nadeau,A. and Grondin,G.
  TITLE     Cell-specific expression of the ZPK gene in adult mouse tissues
  JOURNAL   DNA Cell Biol 15 (8), 631-642 (1996)
   PUBMED   8769565
REFERENCE   8  (bases 1 to 5450)
  AUTHORS   Mata,M., Merritt,S.E., Fan,G., Yu,G.G. and Holzman,L.B.
  TITLE     Characterization of dual leucine zipper-bearing kinase, a mixed
            lineage kinase present in synaptic terminals whose phosphorylation
            state is regulated by membrane depolarization via calcineurin
  JOURNAL   J Biol Chem 271 (28), 16888-16896 (1996)
   PUBMED   8663324
REFERENCE   9  (bases 1 to 5450)
  AUTHORS   Hirai,S., Izawa,M., Osada,S., Spyrou,G. and Ohno,S.
  TITLE     Activation of the JNK pathway by distantly related protein kinases,
            MEKK and MUK
  JOURNAL   Oncogene 12 (3), 641-650 (1996)
   PUBMED   8637721
REFERENCE   10 (bases 1 to 5450)
  AUTHORS   Holzman,L.B., Merritt,S.E. and Fan,G.
  TITLE     Identification, molecular cloning, and characterization of dual
            leucine zipper bearing kinase. A novel serine/threonine protein
            kinase that defines a second subfamily of mixed lineage kinases
  JOURNAL   J Biol Chem 269 (49), 30808-30817 (1994)
   PUBMED   7983011
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC137156.3.
            
            On Sep 7, 2022 this sequence version replaced NM_001358844.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK166435.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN01164131,
                                           SAMN01164139 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               AC137156.3         167002-167118       c
            118-204             AC137156.3         166337-166423       c
            205-312             AC137156.3         165708-165815       c
            313-791             AC137156.3         161508-161986       c
            792-975             AC137156.3         160888-161071       c
            976-1167            AC137156.3         160533-160724       c
            1168-1326           AC137156.3         160143-160301       c
            1327-1485           AC137156.3         159907-160065       c
            1486-1594           AC137156.3         159055-159163       c
            1595-1704           AC137156.3         158733-158842       c
            1705-1821           AC137156.3         158484-158600       c
            1822-1959           AC137156.3         158252-158389       c
            1960-2584           AC137156.3         157519-158143       c
            2585-2655           AC137156.3         157270-157340       c
            2656-2917           AC137156.3         156926-157187       c
            2918-5450           AC137156.3         154062-156594       c
FEATURES             Location/Qualifiers
     source          1..5450
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 57.63 cM"
     gene            1..5450
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; Zpk"
                     /note="mitogen-activated protein kinase kinase kinase 12"
                     /db_xref="GeneID:26404"
                     /db_xref="MGI:MGI:1346881"
     exon            1..117
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; Zpk"
                     /inference="alignment:Splign:2.1.0"
     exon            118..204
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; Zpk"
                     /inference="alignment:Splign:2.1.0"
     exon            205..312
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; Zpk"
                     /inference="alignment:Splign:2.1.0"
     exon            313..791
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; Zpk"
                     /inference="alignment:Splign:2.1.0"
     CDS             347..3013
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; Zpk"
                     /EC_number="2.7.11.25"
                     /note="MAPK-upstream kinase; mixed lineage kinase;
                     leucine-zipper protein kinase; dual leucine zipper bearing
                     kinase; zipper (leucine) protein kinase"
                     /codon_start=1
                     /product="mitogen-activated protein kinase kinase kinase
                     12"
                     /protein_id="NP_001345773.1"
                     /db_xref="CCDS:CCDS27885.1"
                     /db_xref="GeneID:26404"
                     /db_xref="MGI:MGI:1346881"
                     /translation="MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTP
                     TQCVLRDVVPLGGQGGGGPSPSPGGEPPPEPFANSVLQLHEQDTGGPGGATGSPESRA
                     SRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEVPFEEILD
                     LQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPC
                     YCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNML
                     ITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLW
                     ELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQ
                     ILLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRRE
                     ELRHALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKSH
                     PSRGLLHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKG
                     PPSPGRSRRGKTRHRKASAKGSCGDLPGLRAALPPHEPGGLGSPGGLGVGPSAWDACP
                     PALRGLHHDLLLRKMSSSSPDLLSAALGARGRGATGGARDPGSPPPPQGDTPPSEGSA
                     PGSTSPDSPGGAKGEPPPPVGPGEGVGLLGTGREGTAGRGGNRAGSQHLTPAALLYRA
                     AVTRSQKRGISSEEEEGEVDSEVELPPSQRWPQGPNMRQSLSTFSSENPSDVEEGTAS
                     EPSPSGTPEVGSTNTDERPDERSDDMCSQGSEIPLDLPTSEVVPEREASSLPMQHQDG
                     QGPNPEDSDCDSTELDNSNSIDALRPPASLPP"
     exon            792..975
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; Zpk"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1167
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; Zpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1326
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; Zpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1485
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; Zpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1594
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; Zpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1704
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; Zpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1821
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; Zpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1822..1959
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; Zpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2584
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; Zpk"
                     /inference="alignment:Splign:2.1.0"
     exon            2585..2655
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; Zpk"
                     /inference="alignment:Splign:2.1.0"
     exon            2656..2917
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; Zpk"
                     /inference="alignment:Splign:2.1.0"
     exon            2918..5450
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; Zpk"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3626..3631
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; Zpk"
                     /note="hexamer: AATATA"
     polyA_site      3651
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; Zpk"
                     /note="major polyA site"
     regulatory      3690..3695
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; Zpk"
                     /note="hexamer: AATACA"
     polyA_site      3722
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; Zpk"
     regulatory      3758..3763
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; Zpk"
                     /note="hexamer: CATAAA"
     polyA_site      3777
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; Zpk"
     regulatory      4043..4048
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; Zpk"
                     /note="hexamer: ATTAAA"
     polyA_site      4068
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; Zpk"
     regulatory      5421..5426
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; Zpk"
                     /note="hexamer: ATTAAA"
     polyA_site      5450
                     /gene="Map3k12"
                     /gene_synonym="DLK; MUK; Zpk"
ORIGIN      
        1 agccccgcac cacgtgacgg tcgggaagga ggtcgacagg ggatggggcg ccgtggcagt
       61 aaccccttcc actccgcttg ccgcggtgcg gtcactggtg gccaggcggt ccagcagggc
      121 cttggatcct ctggaacagg agttataggg gttgtgagca ccatgtggat gctgggaatg
      181 gaaccccagt catctgcaag aacaacaaac tttcactcta tagcctaggc tggcctgaaa
      241 ctcactatga agccagagat gaccttgaac ttctgatcct ctcacctcca tccctgagtg
      301 ctgggactgc tgggcccgct gctcagcaca cctggctcca gaggccatgg cctgcctcca
      361 tgaaacccga acaccctccc cttcctttgg gggctttgtg tctactctaa gtgaggcttc
      421 tatgcgaaag ctggatccag acacttcaga ctgcaccccc gagaaagacc tgacgcccac
      481 ccaatgtgta cttcgagatg ttgtgcctct cggtgggcag ggtggaggag gacccagccc
      541 ctccccaggt ggagagcctc ccccagagcc ttttgccaat agtgtcctcc agctacatga
      601 gcaggataca ggtgggccag ggggagccac tgggtcacct gagagtcgag catctagagt
      661 tcgagctgat gaggtacgtc tgcagtgcca gagtggcagt ggcttccttg aaggtctttt
      721 tggctgcctg cgccctgtct ggacaatgat tggcaaagcc tactccacag aacacaagca
      781 acagcaggaa gacctttggg aagtcccctt tgaggaaatc ctggacctgc agtgggtagg
      841 ctcaggggct cagggtgctg ttttcctggg acgcttccac ggggaggagg tagctgtgaa
      901 gaaggttcga gatctcaagg agactgacat caagcatctt cgaaagctga agcaccccaa
      961 catcatcact ttcaagggtg tttgcacaca ggccccctgc tactgcatcc ttatggaatt
     1021 ctgcgctcaa ggacagctat atgaggtgct cagagccggc cgccctgtca ccccctcctt
     1081 gctggttgac tggtccatgg gcatcgctgg tggcatgaat tacctgcacc tgcacaagat
     1141 tatccacaga gacctgaagt cacccaacat gctaatcaca tacgacgatg tggtgaagat
     1201 ctcagatttt ggcacttcca aggagctgag tgacaagagc accaagatgt cctttgcagg
     1261 aacagtagcc tggatggctc ctgaagtgat cagaaatgaa cctgtgtctg agaaggttga
     1321 catctggtcc tttggggtgg tgctatggga actactgact ggagagattc cctacaaaga
     1381 tgtagattcc tcagccatca tctggggtgt gggaagcaac agtctccacc tgcctgtacc
     1441 ctccagctgc ccagatggtt ttaaaattct acttcgccag tgctggaaca gcaaaccacg
     1501 aaatcgccca tcattccgac agatcttgct gcacctggac atcgcctccg ctgatgtgct
     1561 ctctacaccc caggagactt actttaagtc ccaggcagag tggcgggaag aagtaaaact
     1621 gcactttgaa aagattaagt cagaagggac ctgtctgcac cgcctagaag aggaactggt
     1681 gatgcggaga agggaggagc tcagacatgc cctggacatc agggagcact atgaacggaa
     1741 gttggagaga gccaacaacc tgtacatgga actgaatgcc ctcatgctgc aactagaact
     1801 caaagagagg gaattgctca ggcgagagca ggctttagaa aggcggtgtc ctggtctact
     1861 aaagtcacac ccttctcggg gcctcctaca tggaaacact atggagaagc tcatcaagaa
     1921 aaggaacgtg ccacagaaac tgtcgcccca cagcaaaagg ccagatattc tcaagacaga
     1981 gtcgttgcta cctaaactag atgcagccct aagtggggtg gggcttcctg ggtgtcctaa
     2041 gggcccccct tcacctggaa ggagtcggcg tggcaagacc cgtcaccgaa aggccagtgc
     2101 caagggcagc tgtggagacc tgcctgggct tcgtgcagct ttgccacccc atgagcctgg
     2161 aggactagga agcccagggg gcctaggagt gggcccttca gcttgggatg cttgcccccc
     2221 tgctctccgt ggactccacc atgaccttct actccgaaag atgtcatcat catccccaga
     2281 cctgctatca gcagcgctgg gagcccgagg ccgaggggct acagggggag ctcgggatcc
     2341 tggctcacca cctccacccc agggcgatac tcctccaagt gagggatcag ctcctggttc
     2401 caccagccca gattcgcctg ggggagctaa aggggaaccc cctccaccag tagggcctgg
     2461 agaaggtgtg gggctgctgg gaactggaag ggaagggact gcaggccggg gaggaaaccg
     2521 ggctgggtcc cagcacttga cccccgctgc gctgctgtac agggctgctg tgactcgaag
     2581 tcagaaacgt ggtatctcat ctgaagaaga agaaggagag gtagacagtg aagtagagct
     2641 acccccaagt caaaggtggc ctcagggccc gaacatgcgt cagtcactat ctacattcag
     2701 ctcagagaac ccatcagatg tggaggaagg tacagctagt gagccttccc caagtggcac
     2761 accagaagtt ggcagtacca acactgatga gcgaccagat gaacgatctg atgacatgtg
     2821 ctcacagggc tcagaaattc cactggacct acctacttca gaggtggtcc ctgaacgtga
     2881 agccagctcc ttgcccatgc aacaccagga tggccagggc cccaatcctg aagactcaga
     2941 ctgtgacagc actgaattgg acaactccaa cagcattgat gccttgcggc ccccagcctc
     3001 ccttcctcca tgaaagacac tcttattcct tgtacataga gaaatattta tataaataat
     3061 atatatgcgc cacataatca acagatagat ggggctttct tagccttaag ccaggcttga
     3121 gagtgaacga cgcccctgac caattaccga ataagttctg gggacactgg cagctgtgga
     3181 aatgaatgac tccgagtact accctagagc tataaagaaa ggaagctggc cccttcttgc
     3241 ttcaccccat tccttatgtt gaacaagcaa gtaggcaata gaaaagccag gcttgtctct
     3301 atactgtcta tccctgaaca ctggaggggc aggtagagga ttcacttaaa actgcacttt
     3361 tattttccgt ttactgttta cacattttgc acttgggagg agggaaagaa actaaggctg
     3421 ggtcatccct ctgaggtttc tcaggtggca atgtaactca tttctttgtt cctgtttctc
     3481 tgcccaaacc ctggctttgg gccagacgac taacagcatg tgatggctca ggctgaagaa
     3541 ctggggtgct gttagtcccc actgttatct tggtgcctgg taggggtggg gactgtcata
     3601 ttgtaacccc tgtgaacaac cttgaaatat aaccactcca tgcaggccca actgtcgagg
     3661 gttttcttgg tgaatgagta gagtggtata atacatggtt tcaacttgga tttaagattt
     3721 tatctgagga atttggacaa gttattttct aagttaacat aaatgatagc aggtaaactt
     3781 ttctaaatga tttcagaaca aggaggtctc aaaacaccta tggagaaaac taaatgaaca
     3841 attactagaa ctttaaagta tgcaaggtag aacaaggggc agccattccc aagtttacta
     3901 tccttactat ccacgagttc ctgcccagct ccataaatgc accagctgct ctacaatcct
     3961 agggtaagtg taattgtcaa tctccgtaaa caagttttca gaggctaccc agtatcatgg
     4021 agggggaggt gattgagggc aaattaaaaa aattggagtg gtaaaaaagg gaagaaagtc
     4081 cattaattct attgaaactg aatcagggct ctctggaagt taaaaggtat aaaaataaca
     4141 tcagacagga acaacaccca cgtaagtcac tgtggcatcc agtttctatt cacaaagaaa
     4201 aagctccagt ccatctttta attttttttt ttgaaaaatt cctgacatta cagaactaaa
     4261 ctgaaatgta ttaataatcc actcttacat ttccatgaca aacaaaaatt catgagccaa
     4321 acaaaaacaa aaaccaaaaa acaaaagggg gagaagctta taaaactaaa tatggatatc
     4381 tcagcgtaac tgctgaacag agaaaggaat taaaacactt taattaaaaa atcatgagtg
     4441 gatgataaag tgtgtagaaa ctgaaaattt acaaactatt ttaaaacctg gagtcgctga
     4501 ctgttcagaa actacacaga tggatcatgg gtggtgaaca gcaggattat ggatgggtct
     4561 gctctgttct agctgctccc catgccacct gtctccgagg aaagcctgta aaacacaaag
     4621 aagaataagt cagcttacct agctacaatt catcacacca aggtatttca aggtttctta
     4681 gattagctag taccatagtg cacaaggttg tttatgtaac accactacaa ccaaggttcc
     4741 tgaggtgttc tcagaagaac ataacaaatg atgttaagtt ggtgacactg tctcttcacg
     4801 ttttactctt tgcaaactga aagcatttct agagaacatt aggcttcaag gagttgatcc
     4861 tgtcgtgttt acactagaac agcccaccaa tgtgaaggaa ctttgtgttg ggagcctaac
     4921 atttaaagat attatgtaat tttaacaata cttaaaggga ggagcaagaa taggaactat
     4981 agtgaaaaat tgaattattg ttttcaagct tataatttta ggacaaatac caacaaaaaa
     5041 acaagtatca aagcttcaat tcagttcctt agctcactct tcaaaatcca aaacctgtgg
     5101 ccttactggt accaaattct ccttgtaaac atacctggct acagtgcctt tctacttgtt
     5161 tcaaataggt catttgaggt cctggaatac aattaagctt tgagagaaag gcattcagtg
     5221 tacatttcat tatcactggg tagcagcaaa atgcctcatt ctgaacacaa ctagaggtgt
     5281 ctcaggtcca caccacaagc ttaacttcac aaagagccaa ctgacatcca tttgtgatgt
     5341 ttggcttaat accatgtgca ctaaatgtac aaataccaca ggggaagggg tatatcccgg
     5401 aaactagaag tcattcttca attaaaatat gttttcttta acgtcagaaa
//
