LOCUS       NM_022012               4193 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus mitogen-activated protein kinase kinase kinase 11
            (Map3k11), transcript variant 1, mRNA.
ACCESSION   NM_022012 XM_979737
VERSION     NM_022012.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4193)
  AUTHORS   Ha,A.T., Cho,J.Y. and Kim,D.
  TITLE     MLK3 Regulates Inflammatory Response via Activation of AP-1 Pathway
            in HEK293 and RAW264.7 Cells
  JOURNAL   Int J Mol Sci 23 (18), 10874 (2022)
   PUBMED   36142785
  REMARK    GeneRIF: MLK3 Regulates Inflammatory Response via Activation of
            AP-1 Pathway in HEK293 and RAW264.7 Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4193)
  AUTHORS   Liu,P.W., Martin,G.L., Lin,W., Huang,W., Pande,S., Aronovitz,M.J.,
            Davis,R.J. and Blanton,R.M.
  TITLE     Mixed lineage kinase 3 requires a functional CRIB domain for
            regulation of blood pressure, cardiac hypertrophy, and left
            ventricular function
  JOURNAL   Am J Physiol Heart Circ Physiol 323 (3), H513-H522 (2022)
   PUBMED   35867711
  REMARK    GeneRIF: Mixed lineage kinase 3 requires a functional CRIB domain
            for regulation of blood pressure, cardiac hypertrophy, and left
            ventricular function.
REFERENCE   3  (bases 1 to 4193)
  AUTHORS   Chen,X., Qi,G., Fang,F., Miao,Y. and Wang,L.
  TITLE     Silence of MLK3 alleviates lipopolysaccharide-induced lung
            epithelial cell injury via inhibiting p53-mediated ferroptosis
  JOURNAL   J Mol Histol 53 (2), 503-510 (2022)
   PUBMED   35247112
  REMARK    GeneRIF: Silence of MLK3 alleviates lipopolysaccharide-induced lung
            epithelial cell injury via inhibiting p53-mediated ferroptosis.
REFERENCE   4  (bases 1 to 4193)
  AUTHORS   Calamaras,T.D., Pande,S., Baumgartner,R.A., Kim,S.K.,
            McCarthy,J.C., Martin,G.L., Tam,K., McLaughlin,A.L., Wang,G.R.,
            Aronovitz,M.J., Lin,W., Aguirre,J.I., Baca,P., Liu,P.,
            Richards,D.A., Davis,R.J., Karas,R.H., Jaffe,I.Z. and Blanton,R.M.
  TITLE     MLK3 mediates impact of PKG1alpha on cardiac function and controls
            blood pressure through separate mechanisms
  JOURNAL   JCI Insight 6 (18), e149075 (2021)
   PUBMED   34324442
  REMARK    GeneRIF: MLK3 mediates impact of PKG1alpha on cardiac function and
            controls blood pressure through separate mechanisms.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4193)
  AUTHORS   Wang,J., Deng,B., Liu,Q., Huang,Y., Chen,W., Li,J., Zhou,Z.,
            Zhang,L., Liang,B., He,J., Chen,Z., Yan,C., Yang,Z., Xian,S. and
            Wang,L.
  TITLE     Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3)
            signaling in cardiomyocytes are essential for myocardial fibrosis
            in response to pressure overload
  JOURNAL   Cell Death Dis 11 (7), 574 (2020)
   PUBMED   32710001
  REMARK    GeneRIF: Pyroptosis and ferroptosis induced by mixed lineage kinase
            3 (MLK3) signaling in cardiomyocytes are essential for myocardial
            fibrosis in response to pressure overload.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4193)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 4193)
  AUTHORS   Lambert,J.M., Karnoub,A.E., Graves,L.M., Campbell,S.L. and Der,C.J.
  TITLE     Role of MLK3-mediated activation of p70 S6 kinase in Rac1
            transformation
  JOURNAL   J Biol Chem 277 (7), 4770-4777 (2002)
   PUBMED   11713255
REFERENCE   8  (bases 1 to 4193)
  AUTHORS   Saridaki,A., Ferraz,C., Demaille,J., Scherer,G. and Roux,A.F.
  TITLE     Genomic sequencing reveals the structure of the Kcnk6 and map3k11
            genes and their close vicinity to the sipa1 gene on mouse
            chromosome 19
  JOURNAL   Cytogenet Cell Genet 89 (1-2), 85-88 (2000)
   PUBMED   10894943
REFERENCE   9  (bases 1 to 4193)
  AUTHORS   Fernandes,M., Poirier,C., Lassam,N.J., Larsson,C., Guenet,J.,
            Gaudray,P. and Carle,G.F.
  TITLE     The mouse homologs of RELA and MLK3 are located within a 120-kb
            fragment on chromosome 19
  JOURNAL   Mamm Genome 8 (7), 513-515 (1997)
   PUBMED   9195998
REFERENCE   10 (bases 1 to 4193)
  AUTHORS   Kiefer,F., Tibbles,L.A., Anafi,M., Janssen,A., Zanke,B.W.,
            Lassam,N., Pawson,T., Woodgett,J.R. and Iscove,N.N.
  TITLE     HPK1, a hematopoietic protein kinase activating the SAPK/JNK
            pathway
  JOURNAL   EMBO J 15 (24), 7013-7025 (1996)
   PUBMED   9003777
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134563.5.
            
            On Mar 18, 2023 this sequence version replaced NM_022012.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC095963.1, SRR13422597.938972.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-525               AC134563.5         91875-92399         c
            526-561             AC134563.5         91629-91664         c
            562-1861            AC134563.5         90153-91452         c
            1862-2042           AC134563.5         85800-85980         c
            2043-2191           AC134563.5         85496-85644         c
            2192-2367           AC134563.5         85234-85409         c
            2368-2611           AC134563.5         84891-85134         c
            2612-2725           AC134563.5         84344-84457         c
            2726-2861           AC134563.5         83662-83797         c
            2862-2953           AC134563.5         83492-83583         c
            2954-3334           AC134563.5         80171-80551         c
            3335-4193           AC134563.5         78276-79134         c
FEATURES             Location/Qualifiers
     source          1..4193
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.34 cM"
     gene            1..4193
                     /gene="Map3k11"
                     /gene_synonym="2610017K16Rik; Mlk3; PTK1; SPRK"
                     /note="mitogen-activated protein kinase kinase kinase 11"
                     /db_xref="GeneID:26403"
                     /db_xref="MGI:MGI:1346880"
     exon            1..525
                     /gene="Map3k11"
                     /gene_synonym="2610017K16Rik; Mlk3; PTK1; SPRK"
                     /inference="alignment:Splign:2.1.0"
     exon            526..561
                     /gene="Map3k11"
                     /gene_synonym="2610017K16Rik; Mlk3; PTK1; SPRK"
                     /inference="alignment:Splign:2.1.0"
     exon            562..1861
                     /gene="Map3k11"
                     /gene_synonym="2610017K16Rik; Mlk3; PTK1; SPRK"
                     /inference="alignment:Splign:2.1.0"
     CDS             1120..3672
                     /gene="Map3k11"
                     /gene_synonym="2610017K16Rik; Mlk3; PTK1; SPRK"
                     /EC_number="2.7.11.25"
                     /note="isoform 1 is encoded by transcript variant 1; mixed
                     lineage kinase 3"
                     /codon_start=1
                     /product="mitogen-activated protein kinase kinase kinase
                     11 isoform 1"
                     /protein_id="NP_071295.2"
                     /db_xref="CCDS:CCDS29476.1"
                     /db_xref="GeneID:26403"
                     /db_xref="MGI:MGI:1346880"
                     /translation="MEPLKNLFLKSPLGSWNGSGSGGGGGTGGVRPEGSPKATAAYAN
                     PVWTALFDYEPNGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVS
                     RGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAE
                     SVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVN
                     WAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIEGDDMEHKTLKITDFGLAREWH
                     KTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYG
                     VAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDS
                     FHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWE
                     LEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQAS
                     PGLDRRRNVFEVGAGDSPTFPRFRAIQLEPTESGQTWGRQSPRRLEDSSNGERRACWA
                     WGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSPEPEEP
                     RRAGPTERGNSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGLSRERGESPTAPPPA
                     QMPSPCPPELPSTPLIRLSQTTPDAHSSPTPGPLLLDLGVPSGQPSAKSPRREETRGR
                     TVSPPPGISRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQ
                     PAPRRAPWTLFPDSDPFWDSPPANPFRGGSQDCRTQTKDMGAQAPWAPEAGP"
     exon            1862..2042
                     /gene="Map3k11"
                     /gene_synonym="2610017K16Rik; Mlk3; PTK1; SPRK"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2191
                     /gene="Map3k11"
                     /gene_synonym="2610017K16Rik; Mlk3; PTK1; SPRK"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..2367
                     /gene="Map3k11"
                     /gene_synonym="2610017K16Rik; Mlk3; PTK1; SPRK"
                     /inference="alignment:Splign:2.1.0"
     exon            2368..2611
                     /gene="Map3k11"
                     /gene_synonym="2610017K16Rik; Mlk3; PTK1; SPRK"
                     /inference="alignment:Splign:2.1.0"
     exon            2612..2725
                     /gene="Map3k11"
                     /gene_synonym="2610017K16Rik; Mlk3; PTK1; SPRK"
                     /inference="alignment:Splign:2.1.0"
     exon            2726..2861
                     /gene="Map3k11"
                     /gene_synonym="2610017K16Rik; Mlk3; PTK1; SPRK"
                     /inference="alignment:Splign:2.1.0"
     exon            2862..2953
                     /gene="Map3k11"
                     /gene_synonym="2610017K16Rik; Mlk3; PTK1; SPRK"
                     /inference="alignment:Splign:2.1.0"
     exon            2954..3334
                     /gene="Map3k11"
                     /gene_synonym="2610017K16Rik; Mlk3; PTK1; SPRK"
                     /inference="alignment:Splign:2.1.0"
     exon            3335..4193
                     /gene="Map3k11"
                     /gene_synonym="2610017K16Rik; Mlk3; PTK1; SPRK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4167..4172
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Map3k11"
                     /gene_synonym="2610017K16Rik; Mlk3; PTK1; SPRK"
                     /note="hexamer: AATAAA"
     polyA_site      4193
                     /gene="Map3k11"
                     /gene_synonym="2610017K16Rik; Mlk3; PTK1; SPRK"
                     /note="major polyA site"
ORIGIN      
        1 gcggagaagt agcgaagtga cgggatgcag aggtatctta ggcgcgcgcg cagtcaaatt
       61 ctagagccac caaaatatgg gacggccggg tgagtcgcca ttgggtaacg acttgatgac
      121 tggcgcaaag cttttccaat gcgttacagg aggcggggaa aagctggaga atgggactcc
      181 tcacggctac ttccagtttg cgttaccggg tcacaccccc gacttgggcc gcctctcctt
      241 agtgcgagac cgtaaatcat ggttgtcgct tggcttacgc ctctacttcc gggtcagagc
      301 ttagccgaag cagagagtga tcctgatcag gcctgagtag tcgaacagga tgacataggc
      361 tttcttaaag taacagacac aggacaagtg atgaactaac gaagaggttg ttgaaggccc
      421 ttcaactctg aatctaatcc cgggcaaagt tctgaacgac agtttcaggt ttttgcctct
      481 cgggtgaaag gaagataatt ttaaatggtt ccaagagctt caagtagatc cacttcgacc
      541 gtgagcagag gagcacctaa cgagggagaa gagcggaaaa aagtgaaact ccaccctcca
      601 cctctgcctc ccgcccccgg ggccaaagta caaagggagg aggaagaagg gaccggggtc
      661 ggagctgtcg gggcccaagg cactagccca agaagaggta gcttcggctc aactggggac
      721 tttctcttac ctcttgtgcc tggagacaac aaccagagtc cgggcgctga ccctggcagg
      781 ccccacctta cggtaggcgg gcgctgaagc caggttccca ggactacttc ggaactgagg
      841 gactctgctg ctccaattca gccatggtga ggcgccggag gccagtgggc cccacccctc
      901 cagcctgacc acactgccct tggtgccctc ctccaaaagc ccgagatgcg gggggccggg
      961 aggcgacact cctggctccc cagagaggcg tgggtctggg gctgagggcc agggcccgga
     1021 tgcccaggtt ccggctctag ggcctcacaa gccagcgggg gtggatacca cgggcacccg
     1081 aagaaggtcc cccacacatt ccaacgccgg ctccctgcca tggagccctt gaagaacctc
     1141 ttcctcaaga gcccgctggg gtcatggaac ggcagtggca gtgggggcgg cgggggtacc
     1201 ggtggagtcc ggccggaggg gtctccgaag gcaacagcag cttatgccaa tcctgtctgg
     1261 acagccctgt tcgactatga gcccaatggg caggacgaac tagccctgag gaagggcgac
     1321 cgtgtggagg tgctgtccag ggatgcagcc atctcaggag atgagggctg gtgggcgggc
     1381 caggtgggtg gccaggtggg catttttcca tccaactatg tatctcgggg tggaggccca
     1441 cccccctgtg aggtggccag cttccaggag ctgcgactgg aggaggtgat cggcatcggt
     1501 ggcttcggca aggtctaccg tggcagctgg cgaggggagc tggtggctgt gaaggcagcc
     1561 cgacaggacc ctgatgagga catcagtgta acagctgaga gtgttcgaca ggaggcccgg
     1621 ctttttgcca tgctggccca tcccaacatc attgccctca aagctgtgtg cctggaggag
     1681 ccaaacctat gcctggtgat ggagtatgca gctggtgggc ctcttagccg ggccctggct
     1741 ggtcggcgtg tgccccccca tgtgctggtc aactgggctg tgcagattgc ccgaggaatg
     1801 cactacctgc actgtgaggc tctggtgcct gtgatacacc gagacctgaa gtccaacaac
     1861 attctgttgc tgcagcccat cgagggtgac gacatggaac acaagaccct aaagattact
     1921 gacttcggcc tcgcccgaga gtggcacaaa accacccaga tgagtgctgc gggcacctac
     1981 gcttggatgg ctcccgaggt tatcaaggcc tccaccttct ccaagggcag cgacgtctgg
     2041 agctttggag tgctgctgtg ggaactgctg actggggagg tgccctaccg tggcatcgac
     2101 tgtcttgccg tagcctatgg tgtggctgta aacaagttaa cgttacccat cccatctacc
     2161 tgccctgagc cctttgcaca actcatggct gactgctggg cacaggaccc ccaccgcagg
     2221 cccgacttcg cctccatcct gcagcagttg gaagctctag aagcgcaggt gctgcgggag
     2281 atgccacggg actccttcca ttccatgcag gaaggctgga aacgcgagat ccagggcctg
     2341 tttgatgagc tgcgggccaa ggaaaaggaa ctactgagcc gggaggagga actgacgcgc
     2401 gctgcacgtg agcagcggtc ccaggcggag cagctgcgac ggcgcgagca cctgctggcg
     2461 cagtgggagc tggaggtgtt cgagcgcgag ctgacgctgc tactgcagca ggtggaccga
     2521 gaacggccgc acgtgcgccg ccgccggggc accttcaagc ggagcaaact ccgagcaagg
     2581 gacggcggag aacgcatcag catgcccctg gatttcaaac accgcatcac agtgcaagcc
     2641 tctcctggcc tggatcggag gagaaacgtg ttcgaggttg gggctgggga ctcgcccacc
     2701 ttccctagat tccgagccat ccagttggaa cctacagaat caggccagac ttggggtcgc
     2761 cagtccccca gacgtcttga agattcaagc aatggagaga ggcgtgcttg ctgggcctgg
     2821 ggtcccagct cccccaagcc tggggaggcc cagaacggga ggagacggtc ccgcatggat
     2881 gaagccacgt ggtacctaga ttcagacgac tcgtccccat tagggtcccc tagtactccc
     2941 ccggcactca acggtaatcc tccaaggcct agccccgagc cagaggagcc acggagggcc
     3001 gggcccacgg agcgaggcaa tagctctggg acgcctaaac tgatccaacg tgcattgcta
     3061 cgggggaccg ctctgctggc ttccctaggc cttggccgag atctgcaacc tccaggaggc
     3121 ctgagccgtg aacgcgggga gtccccgaca gcaccacccc ctgcacagat gccctcaccc
     3181 tgcccacctg agctgccctc caccccgctc atccgcctct cacaaacaac acctgatgcc
     3241 catagttcac ccactcctgg acccttattg ctagacctag gtgttccctc tggccagcca
     3301 tcagccaaga gccctcgacg ggaagagaca cgtgggagaa ccgtctcacc cccaccagga
     3361 atatcacgct ctgctcctgg cacacctgga acccctcgct caccaccgtt gggcctaatc
     3421 agccgacctc ggccctcacc actccgtagc cgtattgacc catggagctt cgtgtcagct
     3481 gggccacggc cttcacccct gccctctcca cagcctgcac cccgacgggc accgtggacc
     3541 ttattcccag actcagatcc cttctgggac tccccacctg ccaacccctt ccggggaggc
     3601 tcccaggact gcaggacgca gaccaaagac atgggtgccc aggccccatg ggcaccagaa
     3661 gcagggccct gagtgggcca gaccacaccc cacgcttcgg ctgccttcga ggaggcatag
     3721 catacactgg aagaggaacc aggaggcctc tgtggctgcc ttggtttccc ccagggactc
     3781 tgaccctttg ggggtcagga acactacact gcacagaaag ccttcacact ggatgggggc
     3841 tacaccccac atgcctacaa actgtaggga cccctgactt actgccccac tggggcctga
     3901 cactgtacct agctggttag gaggaccaga gcctgtctca gggaattgcc cccaggagcg
     3961 gagcagggag cagggaggtc caggggaaag gggctgacct caggtgtcac cagcactttt
     4021 gaccaagtcc tgttactgtg gcccctgtct ccaaggctga gttcctggac ccccaaccct
     4081 ggaagttatt ggagccgggg ctctctgggt gcctttctac tgccccgcca aggttggagc
     4141 cttggcttgg ggagccaatg aagccaaata aacttgtaag ctgtctcccc aaa
//
