LOCUS       NM_001418345            3788 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus mitogen-activated protein kinase kinase kinase 11
            (Map3k11), transcript variant 4, mRNA.
ACCESSION   NM_001418345 XM_006531753
VERSION     NM_001418345.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3788)
  AUTHORS   Ha,A.T., Cho,J.Y. and Kim,D.
  TITLE     MLK3 Regulates Inflammatory Response via Activation of AP-1 Pathway
            in HEK293 and RAW264.7 Cells
  JOURNAL   Int J Mol Sci 23 (18), 10874 (2022)
   PUBMED   36142785
  REMARK    GeneRIF: MLK3 Regulates Inflammatory Response via Activation of
            AP-1 Pathway in HEK293 and RAW264.7 Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3788)
  AUTHORS   Liu,P.W., Martin,G.L., Lin,W., Huang,W., Pande,S., Aronovitz,M.J.,
            Davis,R.J. and Blanton,R.M.
  TITLE     Mixed lineage kinase 3 requires a functional CRIB domain for
            regulation of blood pressure, cardiac hypertrophy, and left
            ventricular function
  JOURNAL   Am J Physiol Heart Circ Physiol 323 (3), H513-H522 (2022)
   PUBMED   35867711
  REMARK    GeneRIF: Mixed lineage kinase 3 requires a functional CRIB domain
            for regulation of blood pressure, cardiac hypertrophy, and left
            ventricular function.
REFERENCE   3  (bases 1 to 3788)
  AUTHORS   Chen,X., Qi,G., Fang,F., Miao,Y. and Wang,L.
  TITLE     Silence of MLK3 alleviates lipopolysaccharide-induced lung
            epithelial cell injury via inhibiting p53-mediated ferroptosis
  JOURNAL   J Mol Histol 53 (2), 503-510 (2022)
   PUBMED   35247112
  REMARK    GeneRIF: Silence of MLK3 alleviates lipopolysaccharide-induced lung
            epithelial cell injury via inhibiting p53-mediated ferroptosis.
REFERENCE   4  (bases 1 to 3788)
  AUTHORS   Calamaras,T.D., Pande,S., Baumgartner,R.A., Kim,S.K.,
            McCarthy,J.C., Martin,G.L., Tam,K., McLaughlin,A.L., Wang,G.R.,
            Aronovitz,M.J., Lin,W., Aguirre,J.I., Baca,P., Liu,P.,
            Richards,D.A., Davis,R.J., Karas,R.H., Jaffe,I.Z. and Blanton,R.M.
  TITLE     MLK3 mediates impact of PKG1alpha on cardiac function and controls
            blood pressure through separate mechanisms
  JOURNAL   JCI Insight 6 (18), e149075 (2021)
   PUBMED   34324442
  REMARK    GeneRIF: MLK3 mediates impact of PKG1alpha on cardiac function and
            controls blood pressure through separate mechanisms.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3788)
  AUTHORS   Wang,J., Deng,B., Liu,Q., Huang,Y., Chen,W., Li,J., Zhou,Z.,
            Zhang,L., Liang,B., He,J., Chen,Z., Yan,C., Yang,Z., Xian,S. and
            Wang,L.
  TITLE     Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3)
            signaling in cardiomyocytes are essential for myocardial fibrosis
            in response to pressure overload
  JOURNAL   Cell Death Dis 11 (7), 574 (2020)
   PUBMED   32710001
  REMARK    GeneRIF: Pyroptosis and ferroptosis induced by mixed lineage kinase
            3 (MLK3) signaling in cardiomyocytes are essential for myocardial
            fibrosis in response to pressure overload.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3788)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 3788)
  AUTHORS   Lambert,J.M., Karnoub,A.E., Graves,L.M., Campbell,S.L. and Der,C.J.
  TITLE     Role of MLK3-mediated activation of p70 S6 kinase in Rac1
            transformation
  JOURNAL   J Biol Chem 277 (7), 4770-4777 (2002)
   PUBMED   11713255
REFERENCE   8  (bases 1 to 3788)
  AUTHORS   Saridaki,A., Ferraz,C., Demaille,J., Scherer,G. and Roux,A.F.
  TITLE     Genomic sequencing reveals the structure of the Kcnk6 and map3k11
            genes and their close vicinity to the sipa1 gene on mouse
            chromosome 19
  JOURNAL   Cytogenet Cell Genet 89 (1-2), 85-88 (2000)
   PUBMED   10894943
REFERENCE   9  (bases 1 to 3788)
  AUTHORS   Fernandes,M., Poirier,C., Lassam,N.J., Larsson,C., Guenet,J.,
            Gaudray,P. and Carle,G.F.
  TITLE     The mouse homologs of RELA and MLK3 are located within a 120-kb
            fragment on chromosome 19
  JOURNAL   Mamm Genome 8 (7), 513-515 (1997)
   PUBMED   9195998
REFERENCE   10 (bases 1 to 3788)
  AUTHORS   Kiefer,F., Tibbles,L.A., Anafi,M., Janssen,A., Zanke,B.W.,
            Lassam,N., Pawson,T., Woodgett,J.R. and Iscove,N.N.
  TITLE     HPK1, a hematopoietic protein kinase activating the SAPK/JNK
            pathway
  JOURNAL   EMBO J 15 (24), 7013-7025 (1996)
   PUBMED   9003777
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134563.5.
            
            On Mar 18, 2023 this sequence version replaced XM_006531753.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422598.1675898.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AC134563.5         92368-92399         c
            33-68               AC134563.5         91629-91664         c
            69-1368             AC134563.5         90153-91452         c
            1369-1456           AC134563.5         88120-88207         c
            1457-1637           AC134563.5         85800-85980         c
            1638-1786           AC134563.5         85496-85644         c
            1787-1962           AC134563.5         85234-85409         c
            1963-2206           AC134563.5         84891-85134         c
            2207-2320           AC134563.5         84344-84457         c
            2321-2456           AC134563.5         83662-83797         c
            2457-2548           AC134563.5         83492-83583         c
            2549-2929           AC134563.5         80171-80551         c
            2930-3788           AC134563.5         78276-79134         c
FEATURES             Location/Qualifiers
     source          1..3788
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.34 cM"
     gene            1..3788
                     /gene="Map3k11"
                     /gene_synonym="2610017K16Rik; Mlk3; PTK1; SPRK"
                     /note="mitogen-activated protein kinase kinase kinase 11"
                     /db_xref="GeneID:26403"
                     /db_xref="MGI:MGI:1346880"
     exon            1..32
                     /gene="Map3k11"
                     /gene_synonym="2610017K16Rik; Mlk3; PTK1; SPRK"
                     /inference="alignment:Splign:2.1.0"
     exon            33..68
                     /gene="Map3k11"
                     /gene_synonym="2610017K16Rik; Mlk3; PTK1; SPRK"
                     /inference="alignment:Splign:2.1.0"
     exon            69..1368
                     /gene="Map3k11"
                     /gene_synonym="2610017K16Rik; Mlk3; PTK1; SPRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1456
                     /gene="Map3k11"
                     /gene_synonym="2610017K16Rik; Mlk3; PTK1; SPRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1637
                     /gene="Map3k11"
                     /gene_synonym="2610017K16Rik; Mlk3; PTK1; SPRK"
                     /inference="alignment:Splign:2.1.0"
     CDS             1489..3267
                     /gene="Map3k11"
                     /gene_synonym="2610017K16Rik; Mlk3; PTK1; SPRK"
                     /EC_number="2.7.11.25"
                     /note="isoform 2 is encoded by transcript variant 4; mixed
                     lineage kinase 3"
                     /codon_start=1
                     /product="mitogen-activated protein kinase kinase kinase
                     11 isoform 2"
                     /protein_id="NP_001405274.1"
                     /db_xref="GeneID:26403"
                     /db_xref="MGI:MGI:1346880"
                     /translation="MEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSK
                     GSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCW
                     AQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKEL
                     LSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRR
                     GTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGAGDSPTFPRFRAI
                     QLEPTESGQTWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWY
                     LDSDDSSPLGSPSTPPALNGNPPRPSPEPEEPRRAGPTERGNSSGTPKLIQRALLRGT
                     ALLASLGLGRDLQPPGGLSRERGESPTAPPPAQMPSPCPPELPSTPLIRLSQTTPDAH
                     SSPTPGPLLLDLGVPSGQPSAKSPRREETRGRTVSPPPGISRSAPGTPGTPRSPPLGL
                     ISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPF
                     RGGSQDCRTQTKDMGAQAPWAPEAGP"
     exon            1638..1786
                     /gene="Map3k11"
                     /gene_synonym="2610017K16Rik; Mlk3; PTK1; SPRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1962
                     /gene="Map3k11"
                     /gene_synonym="2610017K16Rik; Mlk3; PTK1; SPRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2206
                     /gene="Map3k11"
                     /gene_synonym="2610017K16Rik; Mlk3; PTK1; SPRK"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2320
                     /gene="Map3k11"
                     /gene_synonym="2610017K16Rik; Mlk3; PTK1; SPRK"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..2456
                     /gene="Map3k11"
                     /gene_synonym="2610017K16Rik; Mlk3; PTK1; SPRK"
                     /inference="alignment:Splign:2.1.0"
     exon            2457..2548
                     /gene="Map3k11"
                     /gene_synonym="2610017K16Rik; Mlk3; PTK1; SPRK"
                     /inference="alignment:Splign:2.1.0"
     exon            2549..2929
                     /gene="Map3k11"
                     /gene_synonym="2610017K16Rik; Mlk3; PTK1; SPRK"
                     /inference="alignment:Splign:2.1.0"
     exon            2930..3788
                     /gene="Map3k11"
                     /gene_synonym="2610017K16Rik; Mlk3; PTK1; SPRK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3762..3767
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Map3k11"
                     /gene_synonym="2610017K16Rik; Mlk3; PTK1; SPRK"
                     /note="hexamer: AATAAA"
     polyA_site      3788
                     /gene="Map3k11"
                     /gene_synonym="2610017K16Rik; Mlk3; PTK1; SPRK"
                     /note="major polyA site"
ORIGIN      
        1 gcggagaagt agcgaagtga cgggatgcag agagatccac ttcgaccgtg agcagaggag
       61 cacctaacga gggagaagag cggaaaaaag tgaaactcca ccctccacct ctgcctcccg
      121 cccccggggc caaagtacaa agggaggagg aagaagggac cggggtcgga gctgtcgggg
      181 cccaaggcac tagcccaaga agaggtagct tcggctcaac tggggacttt ctcttacctc
      241 ttgtgcctgg agacaacaac cagagtccgg gcgctgaccc tggcaggccc caccttacgg
      301 taggcgggcg ctgaagccag gttcccagga ctacttcgga actgagggac tctgctgctc
      361 caattcagcc atggtgaggc gccggaggcc agtgggcccc acccctccag cctgaccaca
      421 ctgcccttgg tgccctcctc caaaagcccg agatgcgggg ggccgggagg cgacactcct
      481 ggctccccag agaggcgtgg gtctggggct gagggccagg gcccggatgc ccaggttccg
      541 gctctagggc ctcacaagcc agcgggggtg gataccacgg gcacccgaag aaggtccccc
      601 acacattcca acgccggctc cctgccatgg agcccttgaa gaacctcttc ctcaagagcc
      661 cgctggggtc atggaacggc agtggcagtg ggggcggcgg gggtaccggt ggagtccggc
      721 cggaggggtc tccgaaggca acagcagctt atgccaatcc tgtctggaca gccctgttcg
      781 actatgagcc caatgggcag gacgaactag ccctgaggaa gggcgaccgt gtggaggtgc
      841 tgtccaggga tgcagccatc tcaggagatg agggctggtg ggcgggccag gtgggtggcc
      901 aggtgggcat ttttccatcc aactatgtat ctcggggtgg aggcccaccc ccctgtgagg
      961 tggccagctt ccaggagctg cgactggagg aggtgatcgg catcggtggc ttcggcaagg
     1021 tctaccgtgg cagctggcga ggggagctgg tggctgtgaa ggcagcccga caggaccctg
     1081 atgaggacat cagtgtaaca gctgagagtg ttcgacagga ggcccggctt tttgccatgc
     1141 tggcccatcc caacatcatt gccctcaaag ctgtgtgcct ggaggagcca aacctatgcc
     1201 tggtgatgga gtatgcagct ggtgggcctc ttagccgggc cctggctggt cggcgtgtgc
     1261 ccccccatgt gctggtcaac tgggctgtgc agattgcccg aggaatgcac tacctgcact
     1321 gtgaggctct ggtgcctgtg atacaccgag acctgaagtc caacaacagc ccaaggtctc
     1381 catcgagcat cacaacaata acttaggacc caggcaggat gcaaaacaag ctggaggaga
     1441 agctgaggac gcagagttct gttgctgcag cccatcgagg gtgacgacat ggaacacaag
     1501 accctaaaga ttactgactt cggcctcgcc cgagagtggc acaaaaccac ccagatgagt
     1561 gctgcgggca cctacgcttg gatggctccc gaggttatca aggcctccac cttctccaag
     1621 ggcagcgacg tctggagctt tggagtgctg ctgtgggaac tgctgactgg ggaggtgccc
     1681 taccgtggca tcgactgtct tgccgtagcc tatggtgtgg ctgtaaacaa gttaacgtta
     1741 cccatcccat ctacctgccc tgagcccttt gcacaactca tggctgactg ctgggcacag
     1801 gacccccacc gcaggcccga cttcgcctcc atcctgcagc agttggaagc tctagaagcg
     1861 caggtgctgc gggagatgcc acgggactcc ttccattcca tgcaggaagg ctggaaacgc
     1921 gagatccagg gcctgtttga tgagctgcgg gccaaggaaa aggaactact gagccgggag
     1981 gaggaactga cgcgcgctgc acgtgagcag cggtcccagg cggagcagct gcgacggcgc
     2041 gagcacctgc tggcgcagtg ggagctggag gtgttcgagc gcgagctgac gctgctactg
     2101 cagcaggtgg accgagaacg gccgcacgtg cgccgccgcc ggggcacctt caagcggagc
     2161 aaactccgag caagggacgg cggagaacgc atcagcatgc ccctggattt caaacaccgc
     2221 atcacagtgc aagcctctcc tggcctggat cggaggagaa acgtgttcga ggttggggct
     2281 ggggactcgc ccaccttccc tagattccga gccatccagt tggaacctac agaatcaggc
     2341 cagacttggg gtcgccagtc ccccagacgt cttgaagatt caagcaatgg agagaggcgt
     2401 gcttgctggg cctggggtcc cagctccccc aagcctgggg aggcccagaa cgggaggaga
     2461 cggtcccgca tggatgaagc cacgtggtac ctagattcag acgactcgtc cccattaggg
     2521 tcccctagta ctcccccggc actcaacggt aatcctccaa ggcctagccc cgagccagag
     2581 gagccacgga gggccgggcc cacggagcga ggcaatagct ctgggacgcc taaactgatc
     2641 caacgtgcat tgctacgggg gaccgctctg ctggcttccc taggccttgg ccgagatctg
     2701 caacctccag gaggcctgag ccgtgaacgc ggggagtccc cgacagcacc accccctgca
     2761 cagatgccct caccctgccc acctgagctg ccctccaccc cgctcatccg cctctcacaa
     2821 acaacacctg atgcccatag ttcacccact cctggaccct tattgctaga cctaggtgtt
     2881 ccctctggcc agccatcagc caagagccct cgacgggaag agacacgtgg gagaaccgtc
     2941 tcacccccac caggaatatc acgctctgct cctggcacac ctggaacccc tcgctcacca
     3001 ccgttgggcc taatcagccg acctcggccc tcaccactcc gtagccgtat tgacccatgg
     3061 agcttcgtgt cagctgggcc acggccttca cccctgccct ctccacagcc tgcaccccga
     3121 cgggcaccgt ggaccttatt cccagactca gatcccttct gggactcccc acctgccaac
     3181 cccttccggg gaggctccca ggactgcagg acgcagacca aagacatggg tgcccaggcc
     3241 ccatgggcac cagaagcagg gccctgagtg ggccagacca caccccacgc ttcggctgcc
     3301 ttcgaggagg catagcatac actggaagag gaaccaggag gcctctgtgg ctgccttggt
     3361 ttcccccagg gactctgacc ctttgggggt caggaacact acactgcaca gaaagccttc
     3421 acactggatg ggggctacac cccacatgcc tacaaactgt agggacccct gacttactgc
     3481 cccactgggg cctgacactg tacctagctg gttaggagga ccagagcctg tctcagggaa
     3541 ttgcccccag gagcggagca gggagcaggg aggtccaggg gaaaggggct gacctcaggt
     3601 gtcaccagca cttttgacca agtcctgtta ctgtggcccc tgtctccaag gctgagttcc
     3661 tggaccccca accctggaag ttattggagc cggggctctc tgggtgcctt tctactgccc
     3721 cgccaaggtt ggagccttgg cttggggagc caatgaagcc aaataaactt gtaagctgtc
     3781 tccccaaa
//
