LOCUS       NM_001290528            3693 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Mus musculus mitogen-activated protein kinase kinase kinase 10
            (Map3k10), mRNA.
ACCESSION   NM_001290528 XM_006540026
VERSION     NM_001290528.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3693)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3693)
  AUTHORS   Upadhyay,A., Hosseinibarkooie,S., Schneider,S., Kaczmarek,A.,
            Torres-Benito,L., Mendoza-Ferreira,N., Overhoff,M., Rombo,R.,
            Grysko,V., Kye,M.J., Kononenko,N.L. and Wirth,B.
  TITLE     Neurocalcin Delta Knockout Impairs Adult Neurogenesis Whereas Half
            Reduction Is Not Pathological
  JOURNAL   Front Mol Neurosci 12, 19 (2019)
   PUBMED   30853885
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3693)
  AUTHORS   Kant,S., Standen,C.L., Morel,C., Jung,D.Y., Kim,J.K., Swat,W.,
            Flavell,R.A. and Davis,R.J.
  TITLE     A Protein Scaffold Coordinates SRC-Mediated JNK Activation in
            Response to Metabolic Stress
  JOURNAL   Cell Rep 20 (12), 2775-2783 (2017)
   PUBMED   28930674
REFERENCE   4  (bases 1 to 3693)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   5  (bases 1 to 3693)
  AUTHORS   Ramo,K., Sugamura,K., Craige,S., Keaney,J.F. and Davis,R.J.
  TITLE     Suppression of ischemia in arterial occlusive disease by
            JNK-promoted native collateral artery development
  JOURNAL   Elife 5, e18414 (2016)
   PUBMED   27504807
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3693)
  AUTHORS   Pedraza,N., Rafel,M., Navarro,I., Encinas,M., Aldea,M. and
            Gallego,C.
  TITLE     Mixed lineage kinase phosphorylates transcription factor E47 and
            inhibits TrkB expression to link neuronal death and survival
            pathways
  JOURNAL   J Biol Chem 284 (47), 32980-32988 (2009)
   PUBMED   19801649
  REMARK    GeneRIF: Mixed lineage kinase phosphorylates transcription factor
            E47 and inhibits TrkB expression to link neuronal death and
            survival pathways
REFERENCE   7  (bases 1 to 3693)
  AUTHORS   Craig,E.A., Stevens,M.V., Vaillancourt,R.R. and Camenisch,T.D.
  TITLE     MAP3Ks as central regulators of cell fate during development
  JOURNAL   Dev Dyn 237 (11), 3102-3114 (2008)
   PUBMED   18855897
  REMARK    Review article
REFERENCE   8  (bases 1 to 3693)
  AUTHORS   Bisson,N., Tremblay,M., Robinson,F., Kaplan,D.R., Trusko,S.P. and
            Moss,T.
  TITLE     Mice lacking both mixed-lineage kinase genes Mlk1 and Mlk2 retain a
            wild type phenotype
  JOURNAL   Cell Cycle 7 (7), 909-916 (2008)
   PUBMED   18414056
  REMARK    GeneRIF: There is extensive functional redundancy between MLK1 and
            MLK2, and the other member of the family, MLK3, none of which are
            required for survival in mouse.
REFERENCE   9  (bases 1 to 3693)
  AUTHORS   Eckey,M., Tenbaum,S.P., Munoz,A. and Baniahmad,A.
  TITLE     Mixed lineage kinase 2 enhances trans-repression of Alien and
            nuclear receptors
  JOURNAL   Mol Cell Endocrinol 213 (1), 71-78 (2003)
   PUBMED   15062575
REFERENCE   10 (bases 1 to 3693)
  AUTHORS   Phelan,D.R., Loveland,K.L., Devereux,L. and Dorow,D.S.
  TITLE     Expression of mixed lineage kinase 2 in germ cells of the testis
  JOURNAL   Mol Reprod Dev 52 (2), 135-140 (1999)
   PUBMED   9890743
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK053830.1 and BC078445.1.
            
            On Mar 14, 2014 this sequence version replaced XM_006540026.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078445.1, SRR7974084.26664.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-961               AK053830.1         1-961
            962-3693            BC078445.1         1-2732
FEATURES             Location/Qualifiers
     source          1..3693
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 15.95 cM"
     gene            1..3693
                     /gene="Map3k10"
                     /gene_synonym="Mlk2; MST"
                     /note="mitogen-activated protein kinase kinase kinase 10"
                     /db_xref="GeneID:269881"
                     /db_xref="MGI:MGI:1346879"
     exon            1..1239
                     /gene="Map3k10"
                     /gene_synonym="Mlk2; MST"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1420
                     /gene="Map3k10"
                     /gene_synonym="Mlk2; MST"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1569
                     /gene="Map3k10"
                     /gene_synonym="Mlk2; MST"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1745
                     /gene="Map3k10"
                     /gene_synonym="Mlk2; MST"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1992
                     /gene="Map3k10"
                     /gene_synonym="Mlk2; MST"
                     /inference="alignment:Splign:2.1.0"
     exon            1993..2109
                     /gene="Map3k10"
                     /gene_synonym="Mlk2; MST"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2263
                     /gene="Map3k10"
                     /gene_synonym="Mlk2; MST"
                     /inference="alignment:Splign:2.1.0"
     exon            2264..2376
                     /gene="Map3k10"
                     /gene_synonym="Mlk2; MST"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..3057
                     /gene="Map3k10"
                     /gene_synonym="Mlk2; MST"
                     /inference="alignment:Splign:2.1.0"
     exon            3058..3669
                     /gene="Map3k10"
                     /gene_synonym="Mlk2; MST"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3642..3647
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Map3k10"
                     /gene_synonym="Mlk2; MST"
                     /note="hexamer: ATTAAA"
     polyA_site      3665
                     /gene="Map3k10"
                     /gene_synonym="Mlk2; MST"
                     /note="major polyA site"
ORIGIN      
        1 gagggactta gggggccgac caggagccgg ctgaggagga tgggggccgc ccacgcgttc
       61 ctcgcgtgag gaggccgagg ggcgcgccac cccatcccgg ggcggccgcc cccggggcgc
      121 cgccatccct gcccggccct gcggtcgtgg ctgaggatgc ggagccgggg gccgccggtg
      181 gagctgcgcg gggtgagagg cgcggggagg ggcggccgct tgctgccctc ggcctcggcc
      241 tccgccggcg ggccccgctc gacccggccc tccctgcgcc ctgacatcgt tggggacagg
      301 tgaacctaac gcctctcctg cacagccaaa tccgagggat cggtcctatc gtttgaaaaa
      361 ggtgtttttt aggtttttgg ggtttttttt ctttttaatt ccttcgctcc agcggaggcc
      421 cctcccccag ctatggtccc caggagcccc ccggggtccg cagggactgt ctcccatccc
      481 ggcctcccgg ccccgcgctc agcattccgc gggcagcctg cgtgaagcgg cctcccgcag
      541 cccccggccc ctcccccatg gaggaggagg agggggcggc ggccagagag tggggcgcga
      601 cccccgcggg gccagtgtgg accgccgtgt tcgactacga ggcggtgggc gacgaggagc
      661 tgaccctgcg gagaggcgac cgcgtccagg tgctttccca ggactgtgcg gtgtctggag
      721 atgagggctg gtggacaggg cagctgccca gcggccgtgt gggcgtcttc cccagcaact
      781 acgtggcccc cgctgcaccc gccgcaccct cagacctcca gctgccacag gagatcccct
      841 tccacgagct gcagctggag gagatcatcg gtgtcggggg ctttggcaaa gtctatcgcg
      901 ccgtatggcg tggagaggaa gtagcggtca aggccgctcg gctggaccct gaacgggacc
      961 cggcagtgac agcggagcag gtccgccagg aggcccggct ctttggagcc ctgcagcacc
     1021 ccaacatcat tgccctgagg ggcgcctgcc tcagcccccc aaacctctgc ctggtgatgg
     1081 aatatgctcg gggaggtgca ttgagcaggg tactggcagg tcgccgggtc ccccctcatg
     1141 tgctggtcaa ctgggctgtg caggtggctc ggggcatgaa ctatctacac aatgatgccc
     1201 ctgtgcccat cattcaccgg gacctcaagt ccatcaacat cctaatcctg gaggccattg
     1261 agaaccacaa cctcgctgac acggtgctca agatcacaga cttcggcctt gcccgagagt
     1321 ggcacaagac gaccaaaatg agtgcagcgg ggacctacgc ctggatggct cctgaggtta
     1381 tccgcctgtc cctcttctcc aaaagcagcg acgtctggag cttcggggtt cttctttggg
     1441 agctgctgac cggggaggtc ccctaccgag aaatcgacgc cttggccgtg gcttacggtg
     1501 tggctatgaa caagctgacg ctacccatcc cctccacgtg ccccgagccc tttgcccgcc
     1561 tactggagga atgctgggac ccagaccctc acgggcgacc agattttggc agcatcctga
     1621 agcagctgga ggtcatcgag cagtcagccc tgttccagat gccactggag tccttccact
     1681 ccctgcagga agactggaag ctggagattc agcatatgtt tgatgacctt cggaccaagg
     1741 agaaggagtt gcgcagccgg gaagaggagc tattgcgggc tgcacaggag cagcgttttc
     1801 aggaagagca gctacggcgt cgggagcagg agctggcaga gcgagagatg gacatcgtag
     1861 aacgtgagct gcacctgctc atgagccagc tgagccagga gaagcccagg gtccgaaaac
     1921 gcaagggcaa cttcaagcgc agccgcttgc tcaagctacg ggaaggaagc agccacatca
     1981 gcctgccctc tggatttgaa cataagatca ccgtccaggc ctccccaacc ctggacaaga
     2041 ggaaaggatc cgatggggcc agccctcctg ccagccccag catcattccc cggttgaggg
     2101 ccattcgatt gactcccatg gactgtggtg gcagcagtgg tagtggaaca tggagccgca
     2161 gtgggccacc aaagaaggaa gaactggttg ggggcaagaa gaaaggcagg acatggggcc
     2221 ccagttccac tttgcagaag gagcgagctg gaggagagga gaggctcaag gccctggggg
     2281 aaggaagcaa gcagtggtcc tcgagcgccc ccaacctggg caaatcccct aagcacaccc
     2341 ccatggcccc aggcttcgcc agcctcaacg agatggaaga atttgcggag gcagatgaag
     2401 gcaacaacgt gcccccttct ccctactcca ccccgtccta cctcaaggtg cctctgcccg
     2461 ccgagccttc tccttgtgtt caggcgcctt gggagccgcc ggctgtcacc ccttcccggc
     2521 caggacacgg agctcgtagg cgctgcgacc tggcgctgct aagctgtgcc acgctgctga
     2581 gtgcggtggg cctgggcgcc gacgtggccg aggcacgggc cggggacggt gaggagcagc
     2641 ggcgctggct ggacagtctc ttcttcccgc gccccggccg cttccctcgc ggtctcagcc
     2701 caaccgggcg ccccggaggt cgccgcgaag acacagcccc aggcttgggt ctggcaccct
     2761 cggccaccct ggtgtcatta tcctctgtat cggattgtaa ctctacgcgc tcattgctgc
     2821 gctctgacag tgacgaggct gcccctgccg ccccctcccc gccgccttct ccgctcgcgc
     2881 cctcacccag caccaatcct ctcgtggacg tggagttgga gagcttcaag aaggaccccc
     2941 ggcagtcact tacgcccacc cacgtcactg ccgcccacgc tgtgagccgt ggacacaggc
     3001 ggacgccatc agatggggct ttgagacaac gggagcctct ggagctcacc aaccacggtc
     3061 ctcgagaccc cctggacttc cctcgactgc ccgaccccca ggccctgttc cctacccgac
     3121 gccggcccct ggagttccct ggccgcccca ccaccctcac ttttgcccca agaccccggc
     3181 ctgctgccag ccgcccccgt ctggatccct ggaaactggt ctcctttggc cggacactca
     3241 gcatctcgcc tccaagcagg ccagacactc cagagagccc tgggcccccc agcgtgcaac
     3301 ccacgttgct ggacatggac atggagggcc agagccagga caatacagtg cccctatgtg
     3361 gggtctatgg ctctcactga gacctgccca ccaccacccg cctgggcagc catgaatgta
     3421 gcgccccagg cctgccacag cccaccattt gccaaggtgg gggaggccct gggcaggata
     3481 ctcactctat ttattgggga aggggggagg ggaggacact taatttattc ctttgtaccc
     3541 caggttgtgg agctctgagc ccaatctgct gtggggagag ggtgggtggg cagggatact
     3601 cagggacaga atattgtggg ggatctggca caaggcgcag cattaaaggt aagccctgcc
     3661 ccctaccaaa aaaaaaaaaa aaaaaaaaaa aaa
//
