LOCUS       NM_011945               6978 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus mitogen-activated protein kinase kinase kinase 1
            (Map3k1), mRNA.
ACCESSION   NM_011945
VERSION     NM_011945.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6978)
  AUTHORS   Kimura,E., Mongan,M., Xiao,B., Christianto,A., Wang,J.,
            Carreira,V.S., Bolon,B., Zhang,X., Burns,K.A., Biesiada,J.,
            Medvedovic,M., Puga,A. and Xia,Y.
  TITLE     MAP3K1 regulates female reproductive tract development
  JOURNAL   Dis Model Mech 17 (3) (2024)
   PUBMED   38501211
  REMARK    GeneRIF: MAP3K1 regulates female reproductive tract development.
REFERENCE   2  (bases 1 to 6978)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 6978)
  AUTHORS   Fang,F. and Chen,C.
  TITLE     MiRNA let-7d-5p Alleviates Inflammatory Responses by Targeting
            Map3k1 and Inactivating ERK/p38 MAPK Signaling in Microglia
  JOURNAL   Crit Rev Immunol 44 (6), 13-25 (2024)
   PUBMED   38848290
  REMARK    GeneRIF: MiRNA let-7d-5p Alleviates Inflammatory Responses by
            Targeting Map3k1 and Inactivating ERK/p38 MAPK Signaling in
            Microglia.
REFERENCE   4  (bases 1 to 6978)
  AUTHORS   Wang,J., Xiao,B., Kimura,E., Mongan,M. and Xia,Y.
  TITLE     The combined effects of Map3k1 mutation and dioxin on
            differentiation of keratinocytes derived from mouse embryonic stem
            cells
  JOURNAL   Sci Rep 12 (1), 11482 (2022)
   PUBMED   35798792
  REMARK    GeneRIF: The combined effects of Map3k1 mutation and dioxin on
            differentiation of keratinocytes derived from mouse embryonic stem
            cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6978)
  AUTHORS   Wang,J., Kimura,E., Mongan,M. and Xia,Y.
  TITLE     Genetic Control of MAP3K1 in Eye Development and Sex
            Differentiation
  JOURNAL   Cells 11 (1), 34 (2021)
   PUBMED   35011600
  REMARK    GeneRIF: Genetic Control of MAP3K1 in Eye Development and Sex
            Differentiation.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6978)
  AUTHORS   Juriloff,D.M.
  TITLE     Prevention of the eye closure defect in lgMl/lgMl fetal mice by
            thyroxine
  JOURNAL   Teratology 32 (1), 73-86 (1985)
   PUBMED   4035594
REFERENCE   7  (bases 1 to 6978)
  AUTHORS   Harris,M.J., Juriloff,D.M. and Biddle,F.G.
  TITLE     Cortisone cure of the lidgap defect in fetal mice: a dose-response
            and time-response study
  JOURNAL   Teratology 29 (2), 287-295 (1984)
   PUBMED   6740513
REFERENCE   8  (bases 1 to 6978)
  AUTHORS   Stein,K.F. and Kettyle,C.N.
  TITLE     Further data on the slit-lid mutant in mice and the effect of
            cortisone and doca on its development
  JOURNAL   Teratology 8 (1), 51-54 (1973)
   PUBMED   4724491
REFERENCE   9  (bases 1 to 6978)
  AUTHORS   Stein,K.F., Norris,B.E. and Mason,J.
  TITLE     Development of an open eyelid mutant in mus musculus
  JOURNAL   Dev Biol 16 (4), 315-330 (1967)
   PUBMED   5630254
REFERENCE   10 (bases 1 to 6978)
  AUTHORS   Ricardo,N.S. and Miller,J.R.
  TITLE     Further observations on lg MI (lid-gap Miller) and other ope1-eye
            mutants in the house mouse
  JOURNAL   Can J Genet Cytol 9 (3), 596-605 (1967)
   PUBMED   4865553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC118704.17.
            
            On Apr 13, 2018 this sequence version replaced NM_011945.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14777535.2740140.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-491               AC118704.17        58247-58737
            492-642             AC118704.17        91222-91372
            643-843             AC118704.17        94444-94644
            844-1044            AC118704.17        97753-97953
            1045-1161           AC118704.17        98647-98763
            1162-1310           AC118704.17        99129-99277
            1311-1432           AC118704.17        103037-103158
            1433-1514           AC118704.17        103660-103741
            1515-1698           AC118704.17        104003-104186
            1699-1977           AC118704.17        107010-107288
            1978-2099           AC118704.17        109053-109174
            2100-2191           AC118704.17        110055-110146
            2192-2381           AC118704.17        110438-110627
            2382-3633           AC118704.17        110878-112129
            3634-3786           AC118704.17        112445-112597
            3787-3949           AC118704.17        113339-113501
            3950-4081           AC118704.17        114744-114875
            4082-4224           AC118704.17        115879-116021
            4225-4356           AC118704.17        116666-116797
            4357-6978           AC118704.17        118191-120812
FEATURES             Location/Qualifiers
     source          1..6978
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 63.36 cM"
     gene            1..6978
                     /gene="Map3k1"
                     /gene_synonym="MAPKKK1; Mekk; MEKK1"
                     /note="mitogen-activated protein kinase kinase kinase 1"
                     /db_xref="GeneID:26401"
                     /db_xref="MGI:MGI:1346872"
     exon            1..491
                     /gene="Map3k1"
                     /gene_synonym="MAPKKK1; Mekk; MEKK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..4506
                     /gene="Map3k1"
                     /gene_synonym="MAPKKK1; Mekk; MEKK1"
                     /EC_number="2.7.11.25"
                     /note="MEK kinase 1; MAPK/ERK kinase kinase 1"
                     /codon_start=1
                     /product="mitogen-activated protein kinase kinase kinase
                     1"
                     /protein_id="NP_036075.2"
                     /db_xref="CCDS:CCDS26771.1"
                     /db_xref="GeneID:26401"
                     /db_xref="MGI:MGI:1346872"
                     /translation="MAAAAGDRASSSGFPGAAAASPEAGGGGGGGGALQGSGAPAAGA
                     AGLLREPGSAGRERADWRRRQLRKVRSVELDQLPEQPLFLAAASPPCPSTSPSPEPAD
                     AAAGASRFQPAAGPPPPGAASRCGSHSAELAAARDSGARSPAGAEPPSAAAPSGREME
                     NKETLKGLHKMEDRPEERMIREKLKATCMPAWKHEWLERRNRRGPVVVKPIPIKGDGS
                     EMNNLAAEPQGEGQAGSAAPAPKGRRSPSPGSSPSGRSVKPESPGVRRKRVSPVPFQS
                     GRITPPRRAPSPDGFSPYSPEETSRRVNKVMRARLYLLQQIGPNSFLIGGDSPDNKYR
                     VFIGPQNCSCGRGAFCIHLLFVMLRVFQLEPSDPMLWRKTLKNFEVESLFQKYHSRRS
                     SRIKAPSRNTIQKFVSRMSNCHTLSSSSTSTSSSENSIKDEEEQMCPICLLGMLDEES
                     LTVCEDGCRNKLHHHCMSIWAEECRRNREPLICPLCRSKWRSHDFYSHELSSPVESPT
                     SLRAVQQPSSPQQPVAGSQRRNQESSFNLTHFGTQQIPSAYKDLAEPWIQVFGMELVG
                     CLFSRNWNVREMALRRLSHDVSGALLLANGESTGNSGGGSGGSLSAGAASGSSQPSIS
                     GDVVEACCSVLSIVCADPVYKVYVAALKTLRAMLVYTPCHSLAERIKLQRLLRPVVDT
                     ILVKCADANSRTSQLSISTVLELCKGQAGELAVGREILKAGSIGVGGVDYVLSCILGN
                     QAESNNWQELLGRLCLIDRLLLEFPAEFYPHIVSTDVSQAEPVEIRYKKLLSLLTFAL
                     QSIDNSHSMVGKLSRRIYLSSARMVTAVPAVFSKLVTMLNASGSTHFTRMRRRLMAIA
                     DEVEIAEVIQLGVEDTVDGHQDSLQVLAPASCLENSSLEHTVHREKTGKGLSATRLSA
                     SSEDISDRLAGVSVGLPSSTTTEQPKPAVQTKGRPHSQCLNSSPLSHAQLMFPAPSAP
                     CSSAPSVPDISKHRPQAFVPCKIPSASPQTQRKFSLQFQRNCSEHRDSDQLSPVFTQS
                     RPPPSSNIHRPKPSRPVPGSTSKLGDATKSSMTLDLGSASRCDDSFGGGGNSGNAVIP
                     SEETVFTPVEDKCRLDVNTELNSSIEDLLEASMPSSDTTVTFKSEVAVLSPEKAENDD
                     TYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQDALPIVPQLQVENGEDIIIIQQDT
                     PETLPGHTKAKQPYREDAEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTS
                     SEQEEVVEALREEIRMMGHLNHPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYG
                     AFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLAS
                     KGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHS
                     NHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELLKHPVFRTTW"
     exon            492..642
                     /gene="Map3k1"
                     /gene_synonym="MAPKKK1; Mekk; MEKK1"
                     /inference="alignment:Splign:2.1.0"
     exon            643..843
                     /gene="Map3k1"
                     /gene_synonym="MAPKKK1; Mekk; MEKK1"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1044
                     /gene="Map3k1"
                     /gene_synonym="MAPKKK1; Mekk; MEKK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1161
                     /gene="Map3k1"
                     /gene_synonym="MAPKKK1; Mekk; MEKK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1310
                     /gene="Map3k1"
                     /gene_synonym="MAPKKK1; Mekk; MEKK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1432
                     /gene="Map3k1"
                     /gene_synonym="MAPKKK1; Mekk; MEKK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1514
                     /gene="Map3k1"
                     /gene_synonym="MAPKKK1; Mekk; MEKK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1698
                     /gene="Map3k1"
                     /gene_synonym="MAPKKK1; Mekk; MEKK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1977
                     /gene="Map3k1"
                     /gene_synonym="MAPKKK1; Mekk; MEKK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1978..2099
                     /gene="Map3k1"
                     /gene_synonym="MAPKKK1; Mekk; MEKK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2191
                     /gene="Map3k1"
                     /gene_synonym="MAPKKK1; Mekk; MEKK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..2381
                     /gene="Map3k1"
                     /gene_synonym="MAPKKK1; Mekk; MEKK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2382..3633
                     /gene="Map3k1"
                     /gene_synonym="MAPKKK1; Mekk; MEKK1"
                     /inference="alignment:Splign:2.1.0"
     exon            3634..3786
                     /gene="Map3k1"
                     /gene_synonym="MAPKKK1; Mekk; MEKK1"
                     /inference="alignment:Splign:2.1.0"
     exon            3787..3949
                     /gene="Map3k1"
                     /gene_synonym="MAPKKK1; Mekk; MEKK1"
                     /inference="alignment:Splign:2.1.0"
     exon            3950..4081
                     /gene="Map3k1"
                     /gene_synonym="MAPKKK1; Mekk; MEKK1"
                     /inference="alignment:Splign:2.1.0"
     exon            4082..4224
                     /gene="Map3k1"
                     /gene_synonym="MAPKKK1; Mekk; MEKK1"
                     /inference="alignment:Splign:2.1.0"
     exon            4225..4356
                     /gene="Map3k1"
                     /gene_synonym="MAPKKK1; Mekk; MEKK1"
                     /inference="alignment:Splign:2.1.0"
     exon            4357..6978
                     /gene="Map3k1"
                     /gene_synonym="MAPKKK1; Mekk; MEKK1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6953..6958
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Map3k1"
                     /gene_synonym="MAPKKK1; Mekk; MEKK1"
                     /note="hexamer: AATAAA"
     polyA_site      6973
                     /gene="Map3k1"
                     /gene_synonym="MAPKKK1; Mekk; MEKK1"
                     /note="major polyA site"
ORIGIN      
        1 agcgaatgta gcccgcgaga gaaaatggcg gcggcggcgg gcgatcgcgc ctcgtcgtcg
       61 ggattcccgg gcgccgcggc ggcgagtccc gaggcgggcg gcggcggcgg aggaggagga
      121 gctctccagg gaagcggcgc gcccgcagcg ggcgcggcgg ggctgctgcg ggagcctggc
      181 agcgcgggcc gcgagcgcgc ggactggcgg cggcggcagc tgcgcaaagt gcggagtgtg
      241 gagctggacc agctgccgga gcagccgctc ttcctcgccg ccgcctcgcc gccctgccca
      301 tctacttccc cgtcgccgga gcccgcggac gcggctgcag gagcgagtcg cttccagccc
      361 gcggcgggac cgccaccccc gggagcggcg agtcgctgcg gctcccactc tgccgagctg
      421 gcggccgcgc gggacagcgg cgcccggagc cccgcggggg ccgagccgcc ctctgcagcg
      481 gccccctccg gtcgagagat ggagaataaa gaaaccctca aaggactgca caagatggag
      541 gatcgcccgg aggagagaat gatccgggag aagctcaagg cgacctgtat gcccgcctgg
      601 aagcacgagt ggttggagag gaggaacagg agaggccctg tggtggtgaa gccaatccct
      661 attaaaggag atggatctga aatgaataac ttggcagctg agccccaagg agagggccag
      721 gcaggttccg ctgcaccagc ccccaagggc cgacgaagcc catctcctgg cagctctccg
      781 tcagggcgct cggtgaagcc ggaatcccca ggagtgagac ggaaacgagt gtccccggtg
      841 cctttccaga gtggcagaat cacaccaccc cgaagagccc cgtcaccgga tggcttctcc
      901 ccgtacagcc cagaggagac gagccgccgc gtgaacaaag tgatgagagc caggctgtac
      961 ctgctgcagc agataggacc caactctttc ctgattggag gagacagtcc agacaataaa
     1021 taccgggtgt ttattgggcc acagaactgc agctgtgggc gtggagcatt ctgtattcac
     1081 ctcttgtttg tcatgctccg ggtgtttcag ctagaaccct ctgaccccat gttatggaga
     1141 aaaactttaa aaaatttcga ggttgagagt ttgttccaga aataccacag taggcgtagc
     1201 tcgagaatca aagctccatc ccggaacacc atccagaagt ttgtgtcacg catgtcaaat
     1261 tgtcacacac tgtcatcgtc tagcacatcc acatctagtt cagaaaacag catcaaggat
     1321 gaagaggagc agatgtgtcc catctgcttg ctgggcatgc tggatgagga gagcctgact
     1381 gtgtgtgaag atggctgcag gaacaagctg caccaccatt gcatgtccat ctgggcggaa
     1441 gagtgtagaa gaaatagaga gcctttaata tgtccccttt gtagatctaa gtggagatcc
     1501 catgacttct acagccatga gttatcaagc cccgtggagt cccccacctc cctgcgagct
     1561 gtccagcagc catcctcccc acagcagccc gtggccggat cacagcgaag gaatcaggag
     1621 agcagtttta accttactca ttttggaacc cagcagattc cttccgctta caaagatttg
     1681 gccgagccat ggattcaggt gtttggaatg gaactcgttg gctgcttatt ctctagaaac
     1741 tggaacgtaa gggaaatggc ccttaggcgt ctttcccacg acgttagtgg ggccctgttg
     1801 ttggcaaacg gggagagcac tggaaactct ggaggcggca gtgggggcag cttaagcgcg
     1861 ggagcggcca gcgggtcctc ccagcccagc atctcagggg atgtggtgga ggcgtgctgc
     1921 agtgtcctgt ctatagtctg cgctgaccct gtctacaaag tgtacgttgc tgctttaaaa
     1981 acattgagag ccatgctggt atacactcct tgccacagtc tggcagaaag aatcaaactt
     2041 cagagactcc tccggccagt tgtagacact atccttgtca agtgtgcaga tgccaacagc
     2101 cgcacgagtc agctgtccat atctacagtg ctggaactct gcaagggcca agcaggagag
     2161 ctggcggttg ggagagaaat acttaaagct gggtccatcg gggttggtgg tgtcgattac
     2221 gtcttaagtt gtatccttgg aaaccaagct gaatcaaaca actggcaaga actgctgggt
     2281 cgcctctgtc ttatagacag gttgctgttg gaatttcctg ctgaattcta tcctcatatt
     2341 gtcagtactg atgtctcaca agctgagcct gttgaaatca ggtacaagaa gctgctctcc
     2401 ctcttaacct ttgccttgca atccattgac aattcccact cgatggttgg caagctctct
     2461 cggaggatat atctgagctc tgccaggatg gtgaccgcag tgcccgctgt gttttccaag
     2521 ctggtaacca tgcttaatgc ttctggctcc acccacttca ccaggatgcg ccggcgtctg
     2581 atggctatcg cggatgaggt agaaattgcc gaggtcatcc agctgggtgt ggaggacact
     2641 gtggatgggc atcaggacag cttacaggtg ctggcccccg ccagctgtct agaaaacagc
     2701 tcccttgagc acacagtcca tagagagaaa actggaaaag gactaagtgc tacgagactg
     2761 agtgccagct cggaggacat ttctgacaga ctggccggcg tctctgtagg acttcccagc
     2821 tcaacaacaa cagaacaacc aaagccagcg gttcaaacaa aaggcagacc ccacagtcag
     2881 tgtttgaact cctccccttt gtctcatgct caattaatgt tcccagcacc atcagcccct
     2941 tgttcctctg ccccgtctgt cccagatatt tctaagcaca gaccccaggc atttgttccc
     3001 tgcaaaatac cttccgcatc tcctcagaca cagcgcaagt tctctctaca attccagagg
     3061 aactgctctg aacaccgaga ctcagaccag ctctccccag tcttcactca gtcaaggccc
     3121 ccaccctcca gtaacataca caggccaaag ccatcccgac ccgttccggg cagtacaagc
     3181 aaactagggg acgccacaaa aagtagcatg acacttgatc tgggcagtgc ttccaggtgt
     3241 gacgacagct ttggcggcgg cggcaacagt ggcaacgccg tcatacccag cgaagagaca
     3301 gtgttcacgc cggtggagga caagtgcagg ttagatgtga acaccgagct caactccagc
     3361 atcgaggacc ttcttgaagc atccatgcct tcaagtgaca cgacagtcac tttcaagtcc
     3421 gaagtcgccg tcctctctcc ggaaaaggcc gaaaatgacg acacctacaa agacgacgtc
     3481 aatcataatc aaaagtgcaa agaaaagatg gaagctgaag aggaggaggc tttagcgatc
     3541 gccatggcga tgtcagcgtc tcaggatgcc ctccccatcg tccctcagct gcaggtggaa
     3601 aatggagaag atattatcat cattcagcag gacacaccag aaactcttcc aggacatacc
     3661 aaagcgaaac agccttacag agaagacgct gagtggctga aaggccagca gataggcctc
     3721 ggagcatttt cttcctgtta ccaagcacag gatgtgggga ctgggacttt aatggctgtg
     3781 aaacaggtga cgtacgtcag aaacacatcc tccgagcagg aggaggtggt ggaagcgttg
     3841 agggaagaga tccggatgat gggtcacctc aaccatccaa acatcatccg gatgctgggg
     3901 gccacgtgcg agaagagcaa ctacaacctc ttcattgagt ggatggcggg aggatctgtg
     3961 gctcacctct tgagtaaata cggagctttc aaggagtcag tcgtcattaa ctacactgag
     4021 cagttactcc gtggcctttc ctatctccac gagaaccaga tcattcacag agacgtcaaa
     4081 ggtgccaacc tgctcattga cagcaccggt cagaggctga gaattgcaga ctttggagct
     4141 gctgccaggt tggcatcaaa aggaaccggt gcaggagagt tccagggaca gttactgggg
     4201 acaattgcat tcatggcgcc tgaggtccta agaggtcagc agtatggtag gagctgtgat
     4261 gtatggagtg ttggctgcgc cattatagaa atggcttgtg caaaaccacc ttggaatgca
     4321 gaaaaacact ccaatcatct cgccttgata tttaagattg ctagcgcaac tactgcaccg
     4381 tccatcccgt cacacctgtc cccgggtctg cgcgacgtgg cgctgcgctg cttagaactt
     4441 cagcctcagg accggcctcc gtccagagag ctgctgaaac atccggtctt ccgtaccacg
     4501 tggtagttaa ttgttcagat cagctctaat ggagacagga tatgcaacgc ggagagagaa
     4561 aagagaactt gtgggcgacc atgccgctaa cccgcaggcc ctcacgccac tgaacagcca
     4621 gaaacggggc cagcggggaa ccgtacctaa gcatgtgatt gacaaatcat gacctgtacc
     4681 taagctcgat atgcagacat ctacagctcg tgcaggaact gcacaccgtg cctttcacag
     4741 gactggctct gggggaccag gaaggcgatg gagtttgcat gactaaagaa cagaagcata
     4801 aatttatttt tggagcactt tttcagcaat attagcagct gagggctcag gatctatttt
     4861 gatgtgtcac ttcttccatt tcacctagtg gtcacagcag gggctctgca attccctttg
     4921 ggttaggttt ttgggttttt tttttttttt tttttttttt ttttttggtt tttttggttt
     4981 ttttgtcact ggctgtaaaa aaaaaaaatc attgcctggt cagagtgtgt atgagaagca
     5041 gtaaatacat gcgtttttaa agttaataac ttctttataa cccacagctg accccccccc
     5101 cccttttttt agctcctggt ttattgtggt tcactgtgca ttttactgtc ggcccgttca
     5161 tttcggtttt tttttttttg gaaaatatgg ttctgtattt tcacttcacc ttcattcgtg
     5221 ttgaatattc agggaaaggt gatctcttca aaccagaaaa aaagaaatag aaataggtgt
     5281 gaagtagttc attaagtctg tgtctatcgc aagagctctg ctttcttctc tcggcatgct
     5341 gtaaagaact cgctacatcg actcagtctc tgccctcact gtgcgggtta agcagaaact
     5401 cacttaggag tctgctgttc tcggatgcag cttacaaggc agggcaagat tgcctgaagg
     5461 ttgggtgaat tatttcatat tattttgcta gcctataggc agttcacacc attgaaatct
     5521 ttctctctgt cacgacccat cactcacccc gctgatcatt acataactac tgttttcctt
     5581 ctgccgtgca cgatatcttt atacgagact gggctgataa actcactcat ctaccgatcg
     5641 atcagtagcg tttttaaaca aatactaaat ttgctctgca tttagaaact gctcagaaag
     5701 aaaagtgagg ttgagtttca tttacacacg aattcctggc atttgcacag ctatttgtcc
     5761 tggcctcaag ttgaattcag atgcatggaa tcaggaagga aaaaaacggt agccctttgt
     5821 atgtgtgtct tctaaatcaa gtactggtta gctattaaat gtaactttga gatgttaagt
     5881 tttaactctt cagaagccag tgtgaaatag aattggttat tctcaaagac tcaggataaa
     5941 ctaaataagc tatatatata tatatatata tatgaagtac atttggaatg tacaacacaa
     6001 attggaagta aaataagttc caagataagt ttacagggat atattgcaaa taattttcaa
     6061 aggcagtttt atgtgaatgt gcttcttagt gaaattttac attcctttgt tttgaaagat
     6121 tggcaatatt tgaagagtta aaaataatac agaaatgtga agtttggtaa tgctaaatgt
     6181 attgtacttg acttttttct ttttactttt tactttttga ctacttagaa ttttcacaat
     6241 tctaataaga ttgtttccaa gtctctcatg tgcaagcttt aaaggacgca ctcttgccat
     6301 ttaccgtact ggaagatcat tcggtcagat tagcactgtg tctgacagag atataaactg
     6361 tagaaactga gggacctcag ctaatcagta ttaccatgta gatcaacatg cccgccacat
     6421 ttcaaactca gactgtcccc agatgtcaag atccactgtg tttgagtttg tttgcagttc
     6481 cctcagcttg ctggtaattg tggtgttttg ttttcgatgc aaatgtgatg taatattctt
     6541 attttctttg gatcaaagct ggactgaaaa ttgtactgtg taattatttt tgtgttttta
     6601 atgttatttg gtactcgaat tgtaaataac gtctactgct gtttattcca gtttctacta
     6661 cctcaggtgt cctatagatt tttcttctac caaagttcac tctcagaatg aaattctacg
     6721 tgctgtgtga ctatgactcc taagacttcc agggcttaag ggctaactcc tattagcacc
     6781 ttactatgta agcaaatgct acaaaaaaaa aaaaaactct gggttaaaaa aatttggctt
     6841 aaatgtatcc tttgttattt taaatatatc aagatatttt aattaaaatt tttacccctt
     6901 tgaaccaatt ttatagtatt tgtacctatt ttggtgtttt gtctttatag taaataaaag
     6961 tttttgaaca aaagttaa
//
