LOCUS       NM_011943               2098 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus mitogen-activated protein kinase kinase 6 (Map2k6),
            transcript variant 1, mRNA.
ACCESSION   NM_011943
VERSION     NM_011943.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2098)
  AUTHORS   Nikolic,I., Ruiz-Garrido,I., Crespo,M., Romero-Becerra,R.,
            Leiva-Vega,L., Mora,A., Leon,M., Rodriguez,E., Leiva,M.,
            Plata-Gomez,A.B., Alvarez Flores,M.B., Torres,J.L.,
            Hernandez-Cosido,L., Lopez,J.A., Vazquez,J., Efeyan,A., Martin,P.,
            Marcos,M. and Sabio,G.
  TITLE     Lack of p38 activation in T cells increases IL-35 and protects
            against obesity by promoting thermogenesis
  JOURNAL   EMBO Rep 25 (6), 2635-2661 (2024)
   PUBMED   38730210
REFERENCE   2  (bases 1 to 2098)
  AUTHORS   Crespo,M., Nikolic,I., Mora,A., Rodriguez,E., Leiva-Vega,L.,
            Pintor-Chocano,A., Horrillo,D., Hernandez-Cosido,L., Torres,J.L.,
            Novoa,E., Nogueiras,R., Medina-Gomez,G., Marcos,M., Leiva,M. and
            Sabio,G.
  TITLE     Myeloid p38 activation maintains macrophage-liver crosstalk and BAT
            thermogenesis through IL-12-FGF21 axis
  JOURNAL   Hepatology 77 (3), 874-887 (2023)
   PUBMED   35592906
REFERENCE   3  (bases 1 to 2098)
  AUTHORS   Romero-Becerra,R., Mora,A., Manieri,E., Nikolic,I., Santamans,A.M.,
            Montalvo-Romeral,V., Cruz,F.M., Rodriguez,E., Leon,M.,
            Leiva-Vega,L., Sanz,L., Bondia,V., Filgueiras-Rama,D.,
            Jimenez-Borreguero,L.J., Jalife,J., Gonzalez-Teran,B. and Sabio,G.
  TITLE     MKK6 deficiency promotes cardiac dysfunction through
            MKK3-p38gamma/delta-mTOR hyperactivation
  JOURNAL   Elife 11, e75250 (2022)
   PUBMED   35971771
  REMARK    GeneRIF: MKK6 deficiency promotes cardiac dysfunction through
            MKK3-p38gamma/delta-mTOR hyperactivation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2098)
  AUTHORS   Rodriguez-Tirado,C., Kale,N., Carlini,M.J., Shrivastava,N.,
            Rodrigues,A.A., Khalil,B.D., Bravo-Cordero,J.J., Hong,Y.,
            Alexander,M., Ji,J., Behbod,F. and Sosa,M.S.
  TITLE     NR2F1 Is a Barrier to Dissemination of Early-Stage Breast Cancer
            Cells
  JOURNAL   Cancer Res 82 (12), 2313-2326 (2022)
   PUBMED   35471456
REFERENCE   5  (bases 1 to 2098)
  AUTHORS   Lee,S. and Lee,M.
  TITLE     MEK6 Overexpression Exacerbates Fat Accumulation and Inflammatory
            Cytokines in High-Fat Diet-Induced Obesity
  JOURNAL   Int J Mol Sci 22 (24), 13559 (2021)
   PUBMED   34948353
  REMARK    GeneRIF: MEK6 Overexpression Exacerbates Fat Accumulation and
            Inflammatory Cytokines in High-Fat Diet-Induced Obesity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2098)
  AUTHORS   Phillips,R.L., Ernst,R.E., Brunk,B., Ivanova,N., Mahan,M.A.,
            Deanehan,J.K., Moore,K.A., Overton,G.C. and Lemischka,I.R.
  TITLE     The genetic program of hematopoietic stem cells
  JOURNAL   Science 288 (5471), 1635-1640 (2000)
   PUBMED   10834841
REFERENCE   7  (bases 1 to 2098)
  AUTHORS   Wysk,M., Yang,D.D., Lu,H.T., Flavell,R.A. and Davis,R.J.
  TITLE     Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for
            tumor necrosis factor-induced cytokine expression
  JOURNAL   Proc Natl Acad Sci U S A 96 (7), 3763-3768 (1999)
   PUBMED   10097111
REFERENCE   8  (bases 1 to 2098)
  AUTHORS   Ben-Levy,R., Hooper,S., Wilson,R., Paterson,H.F. and Marshall,C.J.
  TITLE     Nuclear export of the stress-activated protein kinase p38 mediated
            by its substrate MAPKAP kinase-2
  JOURNAL   Curr Biol 8 (19), 1049-1057 (1998)
   PUBMED   9768359
  REMARK    Review article
REFERENCE   9  (bases 1 to 2098)
  AUTHORS   Cuenda,A., Alonso,G., Morrice,N., Jones,M., Meier,R., Cohen,P. and
            Nebreda,A.R.
  TITLE     Purification and cDNA cloning of SAPKK3, the major activator of
            RK/p38 in stress- and cytokine-stimulated monocytes and epithelial
            cells
  JOURNAL   EMBO J 15 (16), 4156-4164 (1996)
   PUBMED   8861944
REFERENCE   10 (bases 1 to 2098)
  AUTHORS   Han,J., Lee,J.D., Jiang,Y., Li,Z., Feng,L. and Ulevitch,R.J.
  TITLE     Characterization of the structure and function of a novel MAP
            kinase kinase (MKK6)
  JOURNAL   J Biol Chem 271 (6), 2886-2891 (1996)
   PUBMED   8621675
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY280286.1, AK043482.1 and AI429449.1.
            
            On Sep 30, 2017 this sequence version replaced NM_011943.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK043482.1, AK077712.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                BY280286.1         2-21
            21-2084             AK043482.1         2-2065
            2085-2098           AI429449.1         1-14                c
FEATURES             Location/Qualifiers
     source          1..2098
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 73.6 cM"
     gene            1..2098
                     /gene="Map2k6"
                     /gene_synonym="MAPKK 6; MAPKK6; MEK6; MKK6; Prkmk6;
                     SAPKK3"
                     /note="mitogen-activated protein kinase kinase 6"
                     /db_xref="GeneID:26399"
                     /db_xref="MGI:MGI:1346870"
     exon            1..324
                     /gene="Map2k6"
                     /gene_synonym="MAPKK 6; MAPKK6; MEK6; MKK6; Prkmk6;
                     SAPKK3"
                     /inference="alignment:Splign:2.1.0"
     CDS             309..1313
                     /gene="Map2k6"
                     /gene_synonym="MAPKK 6; MAPKK6; MEK6; MKK6; Prkmk6;
                     SAPKK3"
                     /EC_number="2.7.12.2"
                     /note="isoform 1 is encoded by transcript variant 1; dual
                     specificity mitogen-activated protein kinase kinase 6;
                     MAPK/ERK kinase 6; protein kinase, mitogen activated,
                     kinase 6; MAP kinase kinase 6"
                     /codon_start=1
                     /product="dual specificity mitogen-activated protein
                     kinase kinase 6 isoform 1"
                     /protein_id="NP_036073.1"
                     /db_xref="CCDS:CCDS25592.1"
                     /db_xref="GeneID:26399"
                     /db_xref="MGI:MGI:1346870"
                     /translation="MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQ
                     NFEVKADDLEPIVELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDV
                     SMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAV
                     SIVKALEHLHSKLSVIHRDVKPSNVLINTLGQVKMCDFGISGYLVDSVAKTIDAGCKP
                     YMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSP
                     QLPADKFSADFVDFTSQCLKKNSKERPTYPELMQHPFFTVHESKAADVASFVKLILGD
                     "
     exon            325..391
                     /gene="Map2k6"
                     /gene_synonym="MAPKK 6; MAPKK6; MEK6; MKK6; Prkmk6;
                     SAPKK3"
                     /inference="alignment:Splign:2.1.0"
     exon            392..440
                     /gene="Map2k6"
                     /gene_synonym="MAPKK 6; MAPKK6; MEK6; MKK6; Prkmk6;
                     SAPKK3"
                     /inference="alignment:Splign:2.1.0"
     exon            441..554
                     /gene="Map2k6"
                     /gene_synonym="MAPKK 6; MAPKK6; MEK6; MKK6; Prkmk6;
                     SAPKK3"
                     /inference="alignment:Splign:2.1.0"
     exon            555..674
                     /gene="Map2k6"
                     /gene_synonym="MAPKK 6; MAPKK6; MEK6; MKK6; Prkmk6;
                     SAPKK3"
                     /inference="alignment:Splign:2.1.0"
     exon            675..791
                     /gene="Map2k6"
                     /gene_synonym="MAPKK 6; MAPKK6; MEK6; MKK6; Prkmk6;
                     SAPKK3"
                     /inference="alignment:Splign:2.1.0"
     exon            792..843
                     /gene="Map2k6"
                     /gene_synonym="MAPKK 6; MAPKK6; MEK6; MKK6; Prkmk6;
                     SAPKK3"
                     /inference="alignment:Splign:2.1.0"
     exon            844..971
                     /gene="Map2k6"
                     /gene_synonym="MAPKK 6; MAPKK6; MEK6; MKK6; Prkmk6;
                     SAPKK3"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1049
                     /gene="Map2k6"
                     /gene_synonym="MAPKK 6; MAPKK6; MEK6; MKK6; Prkmk6;
                     SAPKK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1189
                     /gene="Map2k6"
                     /gene_synonym="MAPKK 6; MAPKK6; MEK6; MKK6; Prkmk6;
                     SAPKK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1235
                     /gene="Map2k6"
                     /gene_synonym="MAPKK 6; MAPKK6; MEK6; MKK6; Prkmk6;
                     SAPKK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..2088
                     /gene="Map2k6"
                     /gene_synonym="MAPKK 6; MAPKK6; MEK6; MKK6; Prkmk6;
                     SAPKK3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2068..2073
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Map2k6"
                     /gene_synonym="MAPKK 6; MAPKK6; MEK6; MKK6; Prkmk6;
                     SAPKK3"
                     /note="hexamer: AATACA"
     polyA_site      2088
                     /gene="Map2k6"
                     /gene_synonym="MAPKK 6; MAPKK6; MEK6; MKK6; Prkmk6;
                     SAPKK3"
                     /note="major polyA site"
ORIGIN      
        1 gtctgcgcac taagatactc agttccaagt ttggagcttt tagctgccag ccctggccca
       61 tcatgtagct gcagcacagc cttccctaac gttgcaactg ggggaaaaat cactttctag
      121 actgttttgc aaggtgtgca attccacctt gactccctga aagtccatct gctgcatcgg
      181 tcaagagaaa ctccacttgc atgaagattg cacgcctgca gcttgcatct ttgttgcaaa
      241 actagctaca gaagagaagc aaggcaaagt cttttgtgct cccctccccc atcaaaggaa
      301 aggggaaaat gtctcagtcg aaaggcaaga agcgaaaccc gggccttaag attccaaaag
      361 aagcgtttga acagcctcag accagttcca cgccgcctcg ggatttagac tccaaggctt
      421 gcatatctat tggaaaccag aactttgagg tgaaggcaga tgacctggag ccgatagtgg
      481 agctgggacg aggtgcgtac ggggtggtgg agaagatgcg tcacgtgccc agcgggcaga
      541 tcatggcagt gaagcggata cgggccacag ttaatagcca ggaacagaaa cggctgctga
      601 tggatttgga tgtctccatg aggacggtgg actgtccatt caccgtgacc ttctacggtg
      661 cactcttccg ggagggcgac gtgtggatct gcatggagct catggatacg tcactagata
      721 aattctacaa acaagttatt gataaaggcc aaacaattcc agaggatatc ttaggaaaga
      781 tagcagtttc tattgtaaaa gcgttagaac atttacacag taagctgtct gttatccatc
      841 gagacgtcaa gccttctaat gtgctcatta acacactggg ccaggtgaag atgtgtgact
      901 ttggaatcag tggctacctg gtcgactctg ttgctaaaac gatcgatgcc ggttgcaaac
      961 catacatggc tcctgaacga ataaatccag agctcaacca gaaggggtac agtgtgaagt
     1021 ctgacatttg gagcctgggc atcaccatga tcgagctggc catccttcgg tttccttatg
     1081 attcttgggg aacgcccttc cagcagctaa agcaggtggt cgaagagccc tctcctcagc
     1141 tcccagcaga caagttctcc gcggactttg ttgactttac ctcacagtgc ttgaagaaaa
     1201 attccaaaga acggcccaca tatccagagc ttatgcaaca tccatttttc accgtacatg
     1261 aatccaaagc agcagacgtg gcatcttttg taaaactgat acttggggac taaaaagcca
     1321 tggacttaac tggtcgaccc tactgtggat tggtgggttt acagggtgaa gaaagttcac
     1381 tacagagcca acagaaagtc atcttgaggt cattgaaccc tgcctttctg aggggtttcc
     1441 tctccccgtt tttctttttc ctctccaaag ggggccttgg aatctctagc gtaggctgaa
     1501 ctctctagat ggatgaaata caacaaaggc ttaggacttg aaatggtgat taaatattta
     1561 atggcaagtc atacgggtgg gtcctcgagc ttctcagatc tctcgtgttc tttacgaaat
     1621 gaatgcaatt ggccctggta acaaggtgct acagtagtga agagattgtg aagtagattt
     1681 gtagcgtatc ccacttatta ttttaatatt tatgtttcag tgcttggttg gaaatattcc
     1741 attttatgca agaagggaga tacagagaca gggctgactc ggcagtattt atagggcttt
     1801 tatttttttt gagttcaatc atgtctgtgg tccagaggaa gttatttaat atgcattttt
     1861 aaggatatta taaaaatctc cagcaaaggg gctcttcctg tacagtgtgg cttgcagctc
     1921 tcatggctgc tgctcccgac tgtcaactca accgtggctg atcatcgcat cgtttgaatg
     1981 aactgtcaaa gttaatgtcc ccccgcctcc ctcccccaac tttggaaacc atgaaagtca
     2041 cttgtatcac ggctcaaaga gtaaaaaaat acaatggttc tcttcaaaaa aaaaaaaa
//
