LOCUS       NM_011840               2310 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus mitogen-activated protein kinase kinase 5 (Map2k5),
            transcript variant 1, mRNA.
ACCESSION   NM_011840 XM_981477 XM_981529 XM_981569 XM_981608 XM_981645
VERSION     NM_011840.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2310)
  AUTHORS   Tsitsikov,E.N., Phan,K.P., Liu,Y., Tsytsykova,A.V., Kinter,M.,
            Selland,L., Garman,L., Griffin,C. and Dunn,I.F.
  TITLE     TRAF7 is an essential regulator of blood vessel integrity during
            mouse embryonic and neonatal development
  JOURNAL   iScience 26 (8), 107474 (2023)
   PUBMED   37583551
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2310)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2310)
  AUTHORS   Huang,Y., Wang,P., Morales,R., Luo,Q. and Ma,J.
  TITLE     Map2k5-Deficient Mice Manifest Phenotypes and Pathological Changes
            of Dopamine Deficiency in the Central Nervous System
  JOURNAL   Front Aging Neurosci 13, 651638 (2021)
   PUBMED   34168549
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2310)
  AUTHORS   Luiz,J.P.M., Toller-Kawahisa,J.E., Viacava,P.R., Nascimento,D.C.,
            Pereira,P.T., Saraiva,A.L., Prado,D.S., LeBert,M., Giurisato,E.,
            Tournier,C., Cunha,T.M., Cunha,F.Q., Quesniaux,V., Ryffel,B. and
            Alves-Filho,J.C.
  TITLE     MEK5/ERK5 signaling mediates IL-4-induced M2 macrophage
            differentiation through regulation of c-Myc expression
  JOURNAL   J Leukoc Biol 108 (4), 1215-1223 (2020)
   PUBMED   32745297
  REMARK    GeneRIF: MEK5/ERK5 signaling mediates IL-4-induced M2 macrophage
            differentiation through regulation of c-Myc expression.
REFERENCE   5  (bases 1 to 2310)
  AUTHORS   Sanchez-Fdez,A., Ortiz-Ruiz,M.J., Re-Louhau,M.F., Ramos,I.,
            Blanco-Munez,O., Ludena,D., Abad,M., Sanchez-Martin,M.,
            Pandiella,A. and Esparis-Ogando,A.
  TITLE     MEK5 promotes lung adenocarcinoma
  JOURNAL   Eur Respir J 53 (2), 1801327 (2019)
   PUBMED   30442718
  REMARK    GeneRIF: MEK5 promotes lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2310)
  AUTHORS   Nakamura,K. and Johnson,G.L.
  TITLE     PB1 domains of MEKK2 and MEKK3 interact with the MEK5 PB1 domain
            for activation of the ERK5 pathway
  JOURNAL   J Biol Chem 278 (39), 36989-36992 (2003)
   PUBMED   12912994
  REMARK    GeneRIF: PB1 domain mediates the association of MEKK2 and MEKK3
            with MEK5 and that the respective PB1 domains of these kinases are
            critical for regulation of the ERK5 pathway.
REFERENCE   7  (bases 1 to 2310)
  AUTHORS   Lamark,T., Perander,M., Outzen,H., Kristiansen,K., Overvatn,A.,
            Michaelsen,E., Bjorkoy,G. and Johansen,T.
  TITLE     Interaction codes within the family of mammalian Phox and Bem1p
            domain-containing proteins
  JOURNAL   J Biol Chem 278 (36), 34568-34581 (2003)
   PUBMED   12813044
REFERENCE   8  (bases 1 to 2310)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 2310)
  AUTHORS   Nicol,R.L., Frey,N., Pearson,G., Cobb,M., Richardson,J. and
            Olson,E.N.
  TITLE     Activated MEK5 induces serial assembly of sarcomeres and eccentric
            cardiac hypertrophy
  JOURNAL   EMBO J 20 (11), 2757-2767 (2001)
   PUBMED   11387209
REFERENCE   10 (bases 1 to 2310)
  AUTHORS   Kamakura,S., Moriguchi,T. and Nishida,E.
  TITLE     Activation of the protein kinase ERK5/BMK1 by receptor tyrosine
            kinases. Identification and characterization of a signaling pathway
            to the nucleus
  JOURNAL   J Biol Chem 274 (37), 26563-26571 (1999)
   PUBMED   10473620
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124753.3 and AC160392.2.
            
            On Jun 19, 2018 this sequence version replaced NM_011840.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK159261.1, AB019374.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-780               AC124753.3         37451-38230
            781-829             AC124753.3         43568-43616
            830-897             AC124753.3         57293-57360
            898-967             AC124753.3         71897-71966
            968-1008            AC124753.3         76232-76272
            1009-1076           AC124753.3         77201-77268
            1077-1125           AC124753.3         85397-85445
            1126-1190           AC124753.3         93086-93150
            1191-1230           AC124753.3         112193-112232
            1231-1299           AC124753.3         121589-121657
            1300-1381           AC124753.3         121748-121829
            1382-1443           AC124753.3         128893-128954
            1444-1492           AC124753.3         134286-134334
            1493-1566           AC160392.2         17407-17480
            1567-1617           AC160392.2         18400-18450
            1618-1689           AC160392.2         23546-23617
            1690-1719           AC160392.2         45276-45305
            1720-1746           AC160392.2         63229-63255
            1747-1779           AC160392.2         63569-63601
            1780-1841           AC160392.2         83222-83283
            1842-1887           AC160392.2         86347-86392
            1888-2310           AC160392.2         116404-116826
FEATURES             Location/Qualifiers
     source          1..2310
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 33.96 cM"
     gene            1..2310
                     /gene="Map2k5"
                     /gene_synonym="Mapkk5; MEK5; Prkmk5"
                     /note="mitogen-activated protein kinase kinase 5"
                     /db_xref="GeneID:23938"
                     /db_xref="MGI:MGI:1346345"
     exon            1..780
                     /gene="Map2k5"
                     /gene_synonym="Mapkk5; MEK5; Prkmk5"
                     /inference="alignment:Splign:2.1.0"
     CDS             646..1992
                     /gene="Map2k5"
                     /gene_synonym="Mapkk5; MEK5; Prkmk5"
                     /EC_number="2.7.12.2"
                     /note="isoform 1 is encoded by transcript variant 1; dual
                     specificity mitogen-activated protein kinase kinase 5; MAP
                     kinase kinase 5; MAPK/ERK kinase 5"
                     /codon_start=1
                     /product="dual specificity mitogen-activated protein
                     kinase kinase 5 isoform 1"
                     /protein_id="NP_035970.1"
                     /db_xref="CCDS:CCDS23269.1"
                     /db_xref="GeneID:23938"
                     /db_xref="MGI:MGI:1346345"
                     /translation="MLWLALGPFCAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDV
                     LDVIGQVLPEATTTAFEYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPL
                     QIFPRACKPPGERNIHGLKVNTRAGPSQHTSPVVSDSLPSNSLKKSSAELRKILANGQ
                     MNEQDIRYRDTLGHGNGGTVYKAHHVPSGKILAVKVILLDITLELQKQIMSELEILYK
                     CDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKIPEHVLGRIAVAVVKGLTYLWS
                     LKILHRDVKPSNMLVNTGGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYG
                     IHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPLGEFSEPF
                     VHFITQCMRKQPKERPAPEELMGHPFIVQFNDGNSTVVSMWVCRALEERRSQQGPP"
     exon            781..829
                     /gene="Map2k5"
                     /gene_synonym="Mapkk5; MEK5; Prkmk5"
                     /inference="alignment:Splign:2.1.0"
     exon            830..897
                     /gene="Map2k5"
                     /gene_synonym="Mapkk5; MEK5; Prkmk5"
                     /inference="alignment:Splign:2.1.0"
     exon            898..967
                     /gene="Map2k5"
                     /gene_synonym="Mapkk5; MEK5; Prkmk5"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1008
                     /gene="Map2k5"
                     /gene_synonym="Mapkk5; MEK5; Prkmk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1076
                     /gene="Map2k5"
                     /gene_synonym="Mapkk5; MEK5; Prkmk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1125
                     /gene="Map2k5"
                     /gene_synonym="Mapkk5; MEK5; Prkmk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1190
                     /gene="Map2k5"
                     /gene_synonym="Mapkk5; MEK5; Prkmk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1230
                     /gene="Map2k5"
                     /gene_synonym="Mapkk5; MEK5; Prkmk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1299
                     /gene="Map2k5"
                     /gene_synonym="Mapkk5; MEK5; Prkmk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1381
                     /gene="Map2k5"
                     /gene_synonym="Mapkk5; MEK5; Prkmk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1443
                     /gene="Map2k5"
                     /gene_synonym="Mapkk5; MEK5; Prkmk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1492
                     /gene="Map2k5"
                     /gene_synonym="Mapkk5; MEK5; Prkmk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1566
                     /gene="Map2k5"
                     /gene_synonym="Mapkk5; MEK5; Prkmk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1617
                     /gene="Map2k5"
                     /gene_synonym="Mapkk5; MEK5; Prkmk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1689
                     /gene="Map2k5"
                     /gene_synonym="Mapkk5; MEK5; Prkmk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1719
                     /gene="Map2k5"
                     /gene_synonym="Mapkk5; MEK5; Prkmk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1746
                     /gene="Map2k5"
                     /gene_synonym="Mapkk5; MEK5; Prkmk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1779
                     /gene="Map2k5"
                     /gene_synonym="Mapkk5; MEK5; Prkmk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1841
                     /gene="Map2k5"
                     /gene_synonym="Mapkk5; MEK5; Prkmk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..1887
                     /gene="Map2k5"
                     /gene_synonym="Mapkk5; MEK5; Prkmk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..2310
                     /gene="Map2k5"
                     /gene_synonym="Mapkk5; MEK5; Prkmk5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2288..2293
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Map2k5"
                     /gene_synonym="Mapkk5; MEK5; Prkmk5"
                     /note="hexamer: AATAAA"
     polyA_site      2310
                     /gene="Map2k5"
                     /gene_synonym="Mapkk5; MEK5; Prkmk5"
                     /note="major polyA site"
ORIGIN      
        1 ggttccggag taacagcggt ctaacggccg ccttcctcct cctctcgccg ccacctccgc
       61 tgccgggacg cgggcctcag tcggacgatc ctgcacgcgc cgcgccctcc ggttccggct
      121 gcggtccggg acccgcccct tgaccccgcg gccctgggcc cccctgcctg gttggagggc
      181 aggcgccacc ggtgcacctc cgaaacagcc ccgacccagc ccgcggcgcc cggccaccgt
      241 ccccttgccc accgagacac tcaggacggc aggaccctgg ccactgtacc tgccttaaac
      301 caggccgttg ctccgctgtc tcctcttact cacaaggact acagaatgct tgtgggttct
      361 gttttgtcca cttttgtaac tccaggacct tccgctctct actaattcct cttggccggt
      421 cccccaacag tgcatcctct cctagggaca ctccacacga cctgggcctg gttttgggcc
      481 tgcaagctcc ctcctgatcg ctcctcttca cttctcccca tcttcttgct ccctatttat
      541 cgcctgcctt ctgtctatcg ttccccttgt cacttcttgg ggctcctcct aagtaggggc
      601 aggtcggtac ccctcgcccc aggatgtgag accctttaac ctgtaatgct gtggctggcc
      661 cttggcccct tctgtgccat ggagaaccag gtgctggtga ttcggatcaa gattccaaat
      721 agtggcgcgg tggactggac cgtgcactcc gggccgcagt tactcttcag ggatgttctg
      781 gatgtgatag gccaggttct gcctgaagcg acgacgacag cgtttgaata tgaagatgaa
      841 gatggtgata ggattacagt aagaagcgat gaagagatga aggcaatgct gtcctactat
      901 tattccacag taatggaaca gcaagtaaat ggccagctaa tagagccgct gcagatattt
      961 ccaagagcct gcaagcctcc tggggaacgg aacatacatg gcctgaaggt gaatacacgg
     1021 gctgggccat ctcaacacac cagccctgtg gtctcagatt cgcttccaag caatagcttg
     1081 aagaagtcct cagctgaact gagaaagata ctggccaacg gccagatgaa tgaacaagac
     1141 atacggtatc gagacaccct tggtcatggc aacggaggca cagtctacaa agcacatcat
     1201 gtcccaagtg ggaaaatttt agctgtaaag gttattctgt tagacattac actggagctt
     1261 cagaagcaga tcatgtctga gctggaaatc ctttataagt gtgactcatc gtatatcata
     1321 ggattttacg gggcattttt cgtagaaaac aggatttcaa tttgtacaga attcatggat
     1381 ggggggtctt tggatgtata taggaaaatt ccagagcacg tccttggaag aattgcagtt
     1441 gcagttgtta aaggccttac ctatctgtgg agtttaaaga ttttacacag agatgtgaag
     1501 ccctccaaca tgcttgtaaa cacaggcgga caggtcaagc tgtgtgactt tggcgtgagc
     1561 acacagctgg tgaattctat agccaagacg tatgttggaa caaatgctta catggcacca
     1621 gaaagaattt caggagagca gtatgggatc cattctgacg tgtggagctt aggaatctct
     1681 ttcatggagc ttgctcttgg gaggtttcca tatcctcaga ttcagaaaaa ccagggatct
     1741 ttaatgcctc tccagcttct gcagtgcatt gttgatgagg attcgccggt ccttccgctt
     1801 ggagagttct cggagccgtt tgtacatttc atcactcagt gcatgaggaa gcagcccaag
     1861 gagagaccgg cgcctgagga gctgatgggt cacccattca tcgtgcagtt caatgatgga
     1921 aactccactg tggtgtccat gtgggtgtgc cgagctctag aggagaggcg gagccagcag
     1981 ggacccccgt gagacctcag caggacactg accactgagg accagtcatc atgacacagc
     2041 aagccgtgac ccctctgtct gctgtactgg cccagcctcc tgctcgcacc tcctgcccta
     2101 cctaggaagc cctccagagg gccagcctct gctgagcggg ggaagtgggc actgactaca
     2161 gcaggtggag atggtgcagg gcggggtgat gaggttataa aactatggaa cctcctctgg
     2221 ccccaccccc ttatctttcc ctactgttca ttgtaaaggg tcaggcccta tcagcagcac
     2281 tgatgggaat aaaagtatta ttgctttgga
//
