LOCUS       NM_008928               2177 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus mitogen-activated protein kinase kinase 3 (Map2k3),
            transcript variant 1, mRNA.
ACCESSION   NM_008928
VERSION     NM_008928.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2177)
  AUTHORS   Valuparampil Varghese,M., James,J., Bharti,D., Rischard,F.,
            Rafikova,O. and Rafikov,R.
  TITLE     Circulating free heme induces cytokine storm and pulmonary
            hypertension through the MKK3/p38 axis
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 327 (4), L574-L586 (2024)
   PUBMED   39197168
  REMARK    GeneRIF: Circulating free heme induces cytokine storm and pulmonary
            hypertension through the MKK3/p38 axis.
REFERENCE   2  (bases 1 to 2177)
  AUTHORS   Nikolic,I., Ruiz-Garrido,I., Crespo,M., Romero-Becerra,R.,
            Leiva-Vega,L., Mora,A., Leon,M., Rodriguez,E., Leiva,M.,
            Plata-Gomez,A.B., Alvarez Flores,M.B., Torres,J.L.,
            Hernandez-Cosido,L., Lopez,J.A., Vazquez,J., Efeyan,A., Martin,P.,
            Marcos,M. and Sabio,G.
  TITLE     Lack of p38 activation in T cells increases IL-35 and protects
            against obesity by promoting thermogenesis
  JOURNAL   EMBO Rep 25 (6), 2635-2661 (2024)
   PUBMED   38730210
REFERENCE   3  (bases 1 to 2177)
  AUTHORS   Crespo,M., Nikolic,I., Mora,A., Rodriguez,E., Leiva-Vega,L.,
            Pintor-Chocano,A., Horrillo,D., Hernandez-Cosido,L., Torres,J.L.,
            Novoa,E., Nogueiras,R., Medina-Gomez,G., Marcos,M., Leiva,M. and
            Sabio,G.
  TITLE     Myeloid p38 activation maintains macrophage-liver crosstalk and BAT
            thermogenesis through IL-12-FGF21 axis
  JOURNAL   Hepatology 77 (3), 874-887 (2023)
   PUBMED   35592906
REFERENCE   4  (bases 1 to 2177)
  AUTHORS   Romero-Becerra,R., Mora,A., Manieri,E., Nikolic,I., Santamans,A.M.,
            Montalvo-Romeral,V., Cruz,F.M., Rodriguez,E., Leon,M.,
            Leiva-Vega,L., Sanz,L., Bondia,V., Filgueiras-Rama,D.,
            Jimenez-Borreguero,L.J., Jalife,J., Gonzalez-Teran,B. and Sabio,G.
  TITLE     MKK6 deficiency promotes cardiac dysfunction through
            MKK3-p38gamma/delta-mTOR hyperactivation
  JOURNAL   Elife 11, e75250 (2022)
   PUBMED   35971771
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2177)
  AUTHORS   Rodriguez-Tirado,C., Kale,N., Carlini,M.J., Shrivastava,N.,
            Rodrigues,A.A., Khalil,B.D., Bravo-Cordero,J.J., Hong,Y.,
            Alexander,M., Ji,J., Behbod,F. and Sosa,M.S.
  TITLE     NR2F1 Is a Barrier to Dissemination of Early-Stage Breast Cancer
            Cells
  JOURNAL   Cancer Res 82 (12), 2313-2326 (2022)
   PUBMED   35471456
REFERENCE   6  (bases 1 to 2177)
  AUTHORS   Liao,P., Georgakopoulos,D., Kovacs,A., Zheng,M., Lerner,D., Pu,H.,
            Saffitz,J., Chien,K., Xiao,R.P., Kass,D.A. and Wang,Y.
  TITLE     The in vivo role of p38 MAP kinases in cardiac remodeling and
            restrictive cardiomyopathy
  JOURNAL   Proc Natl Acad Sci U S A 98 (21), 12283-12288 (2001)
   PUBMED   11593045
REFERENCE   7  (bases 1 to 2177)
  AUTHORS   Kontoyiannis,D., Kotlyarov,A., Carballo,E., Alexopoulou,L.,
            Blackshear,P.J., Gaestel,M., Davis,R., Flavell,R. and Kollias,G.
  TITLE     Interleukin-10 targets p38 MAPK to modulate ARE-dependent TNF mRNA
            translation and limit intestinal pathology
  JOURNAL   EMBO J 20 (14), 3760-3770 (2001)
   PUBMED   11447117
REFERENCE   8  (bases 1 to 2177)
  AUTHORS   Lu,H.T., Yang,D.D., Wysk,M., Gatti,E., Mellman,I., Davis,R.J. and
            Flavell,R.A.
  TITLE     Defective IL-12 production in mitogen-activated protein (MAP)
            kinase kinase 3 (Mkk3)-deficient mice
  JOURNAL   EMBO J 18 (7), 1845-1857 (1999)
   PUBMED   10202148
REFERENCE   9  (bases 1 to 2177)
  AUTHORS   Wysk,M., Yang,D.D., Lu,H.T., Flavell,R.A. and Davis,R.J.
  TITLE     Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for
            tumor necrosis factor-induced cytokine expression
  JOURNAL   Proc Natl Acad Sci U S A 96 (7), 3763-3768 (1999)
   PUBMED   10097111
REFERENCE   10 (bases 1 to 2177)
  AUTHORS   Moriguchi,T., Toyoshima,F., Gotoh,Y., Iwamatsu,A., Irie,K.,
            Mori,E., Kuroyanagi,N., Hagiwara,M., Matsumoto,K. and Nishida,E.
  TITLE     Purification and identification of a major activator for p38 from
            osmotically shocked cells. Activation of mitogen-activated protein
            kinase kinase 6 by osmotic shock, tumor necrosis factor-alpha, and
            H2O2
  JOURNAL   J Biol Chem 271 (43), 26981-26988 (1996)
   PUBMED   8900184
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL603830.7.
            
            On Jul 3, 2018 this sequence version replaced NM_008928.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008141.1, AK150067.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-218               AL603830.7         57212-57429         c
            219-285             AL603830.7         47537-47603         c
            286-334             AL603830.7         47130-47178         c
            335-448             AL603830.7         46219-46332         c
            449-568             AL603830.7         45877-45996         c
            569-685             AL603830.7         44702-44818         c
            686-737             AL603830.7         43921-43972         c
            738-865             AL603830.7         42712-42839         c
            866-943             AL603830.7         42295-42372         c
            944-1083            AL603830.7         39423-39562         c
            1084-1129           AL603830.7         38280-38325         c
            1130-2177           AL603830.7         36672-37719         c
FEATURES             Location/Qualifiers
     source          1..2177
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.95 cM"
     gene            1..2177
                     /gene="Map2k3"
                     /gene_synonym="MAPKK 3; MEK3; MKK3; MKK3b; Prkmk3"
                     /note="mitogen-activated protein kinase kinase 3"
                     /db_xref="GeneID:26397"
                     /db_xref="MGI:MGI:1346868"
     exon            1..218
                     /gene="Map2k3"
                     /gene_synonym="MAPKK 3; MEK3; MKK3; MKK3b; Prkmk3"
                     /inference="alignment:Splign:2.1.0"
     exon            219..285
                     /gene="Map2k3"
                     /gene_synonym="MAPKK 3; MEK3; MKK3; MKK3b; Prkmk3"
                     /inference="alignment:Splign:2.1.0"
     exon            286..334
                     /gene="Map2k3"
                     /gene_synonym="MAPKK 3; MEK3; MKK3; MKK3b; Prkmk3"
                     /inference="alignment:Splign:2.1.0"
     exon            335..448
                     /gene="Map2k3"
                     /gene_synonym="MAPKK 3; MEK3; MKK3; MKK3b; Prkmk3"
                     /inference="alignment:Splign:2.1.0"
     exon            449..568
                     /gene="Map2k3"
                     /gene_synonym="MAPKK 3; MEK3; MKK3; MKK3b; Prkmk3"
                     /inference="alignment:Splign:2.1.0"
     exon            569..685
                     /gene="Map2k3"
                     /gene_synonym="MAPKK 3; MEK3; MKK3; MKK3b; Prkmk3"
                     /inference="alignment:Splign:2.1.0"
     exon            686..737
                     /gene="Map2k3"
                     /gene_synonym="MAPKK 3; MEK3; MKK3; MKK3b; Prkmk3"
                     /inference="alignment:Splign:2.1.0"
     exon            738..865
                     /gene="Map2k3"
                     /gene_synonym="MAPKK 3; MEK3; MKK3; MKK3b; Prkmk3"
                     /inference="alignment:Splign:2.1.0"
     exon            866..943
                     /gene="Map2k3"
                     /gene_synonym="MAPKK 3; MEK3; MKK3; MKK3b; Prkmk3"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1083
                     /gene="Map2k3"
                     /gene_synonym="MAPKK 3; MEK3; MKK3; MKK3b; Prkmk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1129
                     /gene="Map2k3"
                     /gene_synonym="MAPKK 3; MEK3; MKK3; MKK3b; Prkmk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..2177
                     /gene="Map2k3"
                     /gene_synonym="MAPKK 3; MEK3; MKK3; MKK3b; Prkmk3"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2070
                     /gene="Map2k3"
                     /gene_synonym="MAPKK 3; MEK3; MKK3; MKK3b; Prkmk3"
                     /note="major polyA site"
ORIGIN      
        1 agtgtggctt tggcgccgcc cgcctcggac gcttggaacc gtcgcgtctg tgtcgcctgt
       61 cgcccatcgc ctgccgccgc tgccagccac cagcagccat gagcgcgccc ggccccggtg
      121 tagtctgctg tcctctagat tagtgctctc cgccgcgacg gtccgcagca tggagtcgcc
      181 cgccgcgagc ccgccggcca gcttgcctca gaccaaagga aaatccaaaa ggaaaaagga
      241 cttacggata tcctgcgtgt ccaagccacc tgtgtccaac cccacacccc cccggaacct
      301 ggactcccgg accttcatca ctatcggaga cagaaacttc gaagtggagg ctgatgactt
      361 ggtgaccatc tcagagctgg gtcgtggagc ctatggggtg gtagagaaag tgcggcatgc
      421 tcagagtggt accatcatgg ctgtcaagcg catccgggcc acagtgaaca cacaggagca
      481 gaaacgtctg cttatggacc tagacatcaa catgcgcacg gtcgactgct tctacactgt
      541 caccttctat ggtgccctct tcagagaggg ggatgtatgg atctgcatgg agctcatgga
      601 cacttccctg gataagttct accggaaggt gctggagaag aacatgaaaa ttccggaaga
      661 catcctgggg gagatcgctg tgtctatcgt gcgggccctg gagcacctgc atagcaagct
      721 gtctgtgatc cacagagatg tgaagccatc caatgtcctc atcaacaagg aagggcatgt
      781 gaagatgtgc gactttggca tcagtggcta cctggtggac tctgtggcaa agacaatgga
      841 tgctggctgc aagccttaca tggcccctga gaggatcaac cctgaactga atcagaaggg
      901 ctacaatgtc aagtctgatg tctggagcct cggcatcacc atgatcgaga tggccattct
      961 gcgattccct tatgagtctt ggggcacacc gttccagcag ctgaagcagg tggtggagga
     1021 gccatcccca cagctcccag cggaccagtt ctcccctgag tttgtggact tcactagcca
     1081 gtgcctaagg aagaaccctg cagagcgcat gagctacctg gagctgatgg aacacccatt
     1141 cttcaccttg cacaaaacta agaagacaga cattgctgcc tttgtgaagg agatcctggg
     1201 agaggattca tagggactgg cccaggaccc cactggtctg ccagcatcca tacatccgtg
     1261 ctggggcagc acttacctac agccataagc tactgccatt ctgttcctgg gcatttgaga
     1321 aattaagggg ttgttcctgt cggtctctgc aactagctgt cccaagtgcc aaagaaccag
     1381 acctcagggg ctcccagcca ggccatatgt gccccacagt gcctctgctg ttgctgctcc
     1441 cagggtctca ggcctctacc caagggatga atctgacagg gcctgtgtac cccggcaaac
     1501 gctgtcgctt ctgaagagca ggcagctggt gtctctctgg acaggccata gccttggtac
     1561 tgtcctggat gccatgcagg ttgtatatat attttaaatc acaactgaat gaatggactt
     1621 cgtacactgt ggcctggatc agggacatct ctatcctgtc tcaggtgctg aggacacact
     1681 atggggatga atctcctaag actttcctga gagacgtact gagcttccca aggccttccc
     1741 cccagcactg gccaatggtc tctgagggac acactgtcct cagacagcct ctggttacca
     1801 cctttagtgg tatctgcctt tccctttgaa ctattattcc tgttgccttt tgctttgtgg
     1861 gtattgctgg gttttcttgc atggtttgga gctgaccact taaccctggg tgccagcagg
     1921 ctcacagccg cccagtgctc ggactggagt ctgcaaggat ggctcaagct cttggctcaa
     1981 agccacgagg gagctgtaac aactctccag gtgtgaccag ctcttggaag ctaataggtt
     2041 tactttggtg gtgtttttaa aaaaaaagaa gaaaatctat ttttgtgaag aaaggcctgc
     2101 ctcttccagc cttttcctgg gcaggaacct attgctgttt taattaaaaa aaaaaaaaaa
     2161 aatcgtgtga gactgac
//
