LOCUS       NM_001347144            2416 bp    mRNA    linear   ROD 23-JAN-2024
DEFINITION  Mus musculus mitogen-activated protein kinase kinase 2 (Map2k2),
            transcript variant 2, mRNA.
ACCESSION   NM_001347144 XM_006513682
VERSION     NM_001347144.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2416)
  AUTHORS   Zhang,S., Sun,Y., Xiao,Q., Niu,M., Pan,X. and Zhu,X.
  TITLE     Lnc_000048 Promotes Histone H3K4 Methylation of MAP2K2 to Reduce
            Plaque Stability by Recruiting KDM1A in Carotid Atherosclerosis
  JOURNAL   Mol Neurobiol 60 (5), 2572-2586 (2023)
   PUBMED   36689133
  REMARK    GeneRIF: Lnc_000048 Promotes Histone H3K4 Methylation of MAP2K2 to
            Reduce Plaque Stability by Recruiting KDM1A in Carotid
            Atherosclerosis.
REFERENCE   2  (bases 1 to 2416)
  AUTHORS   Kwon,H.N., Kurtzeborn,K., Iaroshenko,V., Jin,X., Loh,A.,
            Escande-Beillard,N., Reversade,B., Park,S. and Kuure,S.
  TITLE     Omics profiling identifies the regulatory functions of the MAPK/ERK
            pathway in nephron progenitor metabolism
  JOURNAL   Development 149 (19) (2022)
   PUBMED   36189831
REFERENCE   3  (bases 1 to 2416)
  AUTHORS   Kim,J.M., Yang,Y.S., Hong,J., Chaugule,S., Chun,H., van der
            Meulen,M.C.H., Xu,R., Greenblatt,M.B. and Shim,J.H.
  TITLE     Biphasic regulation of osteoblast development via the ERK MAPK-mTOR
            pathway
  JOURNAL   Elife 11, e78069 (2022)
   PUBMED   35975983
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2416)
  AUTHORS   Kurtzeborn,K., Kwon,H.N., Iaroshenko,V., Faisal,I., Ambroz,M.,
            Jin,X., Qureshi,T., Kupari,J., Ihermann-Hella,A., Vaananen,J.,
            Tyynismaa,H., Bousova,I., Park,S. and Kuure,S.
  TITLE     Comparative whole-genome transcriptome analysis in renal cell
            populations reveals high tissue specificity of MAPK/ERK targets in
            embryonic kidney
  JOURNAL   BMC Biol 20 (1), 112 (2022)
   PUBMED   35550069
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2416)
  AUTHORS   Falcomata,C., Barthel,S., Widholz,S.A., Schneeweis,C.,
            Montero,J.J., Toska,A., Mir,J., Kaltenbacher,T., Heetmeyer,J.,
            Swietlik,J.J., Cheng,J.Y., Teodorescu,B., Reichert,O., Schmitt,C.,
            Grabichler,K., Coluccio,A., Boniolo,F., Veltkamp,C., Zukowska,M.,
            Vargas,A.A., Paik,W.H., Jesinghaus,M., Steiger,K., Maresch,R.,
            Ollinger,R., Ammon,T., Baranov,O., Robles,M.S., Rechenberger,J.,
            Kuster,B., Meissner,F., Reichert,M., Flossdorf,M., Rad,R.,
            Schmidt-Supprian,M., Schneider,G. and Saur,D.
  TITLE     Selective multi-kinase inhibition sensitizes mesenchymal pancreatic
            cancer to immune checkpoint blockade by remodeling the tumor
            microenvironment
  JOURNAL   Nat Cancer 3 (3), 318-336 (2022)
   PUBMED   35122074
REFERENCE   6  (bases 1 to 2416)
  AUTHORS   Pages,G., Stanley,E.R., Le Gall,M., Brunet,A. and Pouyssegur,J.
  TITLE     The mouse p44 mitogen-activated protein kinase (extracellular
            signal-regulated kinase 1) gene. Genomic organization and structure
            of the 5'-flanking regulatory region
  JOURNAL   J Biol Chem 270 (45), 26986-26992 (1995)
   PUBMED   7592946
REFERENCE   7  (bases 1 to 2416)
  AUTHORS   Cazaubon,S.M., Ramos-Morales,F., Fischer,S., Schweighoffer,F.,
            Strosberg,A.D. and Couraud,P.O.
  TITLE     Endothelin induces tyrosine phosphorylation and GRB2 association of
            Shc in astrocytes
  JOURNAL   J Biol Chem 269 (40), 24805-24809 (1994)
   PUBMED   7929159
REFERENCE   8  (bases 1 to 2416)
  AUTHORS   Plath,K., Engel,K., Schwedersky,G. and Gaestel,M.
  TITLE     Characterization of the proline-rich region of mouse MAPKAP kinase
            2: influence on catalytic properties and binding to the c-abl SH3
            domain in vitro
  JOURNAL   Biochem Biophys Res Commun 203 (2), 1188-1194 (1994)
   PUBMED   8093038
REFERENCE   9  (bases 1 to 2416)
  AUTHORS   Brott,B.K., Alessandrini,A., Largaespada,D.A., Copeland,N.G.,
            Jenkins,N.A., Crews,C.M. and Erikson,R.L.
  TITLE     MEK2 is a kinase related to MEK1 and is differentially expressed in
            murine tissues
  JOURNAL   Cell Growth Differ 4 (11), 921-929 (1993)
   PUBMED   8297798
REFERENCE   10 (bases 1 to 2416)
  AUTHORS   Crews,C.M. and Erikson,R.L.
  TITLE     Purification of a murine protein-tyrosine/threonine kinase that
            phosphorylates and activates the Erk-1 gene product: relationship
            to the fission yeast byr1 gene product
  JOURNAL   Proc Natl Acad Sci U S A 89 (17), 8205-8209 (1992)
   PUBMED   1381507
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX204173.1, AK171584.1, AK036822.1, BQ032953.1 and AW123542.1.
            
            [WARNING] On Mar 29, 2024 this sequence was replaced by
            NM_001347144.2.
            
            On Nov 16, 2016 this sequence version replaced XM_006513682.3.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 1. The
            encoded isoform (2) has the same N- and C-termini, but is one amino
            acid shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.171966.1,
                                           SRR1660813.260493.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                CX204173.1         1-41
            42-1567             AK171584.1         2-1527
            1568-2042           AK036822.1         365-839
            2043-2399           BQ032953.1         21-377              c
            2400-2416           AW123542.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..2416
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..2416
                     /gene="Map2k2"
                     /gene_synonym="MEK2; MK2; Prkmk2"
                     /note="mitogen-activated protein kinase kinase 2"
                     /db_xref="GeneID:26396"
                     /db_xref="MGI:MGI:1346867"
     exon            1..324
                     /gene="Map2k2"
                     /gene_synonym="MEK2; MK2; Prkmk2"
                     /inference="alignment:Splign:2.1.0"
     exon            325..535
                     /gene="Map2k2"
                     /gene_synonym="MEK2; MK2; Prkmk2"
                     /inference="alignment:Splign:2.1.0"
     exon            536..682
                     /gene="Map2k2"
                     /gene_synonym="MEK2; MK2; Prkmk2"
                     /inference="alignment:Splign:2.1.0"
     exon            683..760
                     /gene="Map2k2"
                     /gene_synonym="MEK2; MK2; Prkmk2"
                     /inference="alignment:Splign:2.1.0"
     exon            761..812
                     /gene="Map2k2"
                     /gene_synonym="MEK2; MK2; Prkmk2"
                     /inference="alignment:Splign:2.1.0"
     exon            813..937
                     /gene="Map2k2"
                     /gene_synonym="MEK2; MK2; Prkmk2"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1151
                     /gene="Map2k2"
                     /gene_synonym="MEK2; MK2; Prkmk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1216
                     /gene="Map2k2"
                     /gene_synonym="MEK2; MK2; Prkmk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1278
                     /gene="Map2k2"
                     /gene_synonym="MEK2; MK2; Prkmk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1324
                     /gene="Map2k2"
                     /gene_synonym="MEK2; MK2; Prkmk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..2402
                     /gene="Map2k2"
                     /gene_synonym="MEK2; MK2; Prkmk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagatctcg cgagagctcg gcctgcgagc ttgtggccgc cccctgttcc ccgacctccc
       61 ggctgcgctg cagcgtcagc ttcactcggc ctcggcgtcg gtctgctcgc cccggcgctc
      121 cgggctcgtc cgccttccac cttctgcccg gcctaggccg cagccccggg cccgcgtcgc
      181 gccgccccct atgggccccg gctgaggcgt cgccgctggc cgtggagccc cgatgctggc
      241 ccggaggaag ccggtgttac cggcactcac tatcaaccct accatcgccg agggcccgtc
      301 ccccaccagc gagggcgcct ctgaggcaaa cctggtggac ctccagaaga agctggaaga
      361 gctggacctg gatgagcagc aaaggaagcg gctggaggcc ttccttaccc agaaggctaa
      421 ggtcggtgag ctcaaggacg acgactttga gaggatctca gagctgggtg ccggcaatgg
      481 cggagtggtc accaaggccc ggcataggcc gtcaggcctc atcatggcca gaaagctgat
      541 ccacctggag atcaaaccgg ccgtgcgcaa ccagatcatc cgggagctgc aggtgctgca
      601 cgagtgcaac tcgccctaca tcgtgggctt ctatggggcc ttctacagcg acggcgagat
      661 cagcatctgc atggagcaca tggatggtgg ctcactggac caggtactga aggaggccaa
      721 gcggattcct gaagacatct tggggaaggt cagcattgcg gtgctccggg gcctggccta
      781 cctccgagag aagcaccaga tcatgcacag agatgtgaag ccctccaaca tcctggtgaa
      841 ctctcgcggg gagattaagc tgtgtgactt cggggtgagc ggccagctga tcgactccat
      901 ggccaactcg tttgtaggga cgcgctccta catgtcccca gagcggctgc agggcaccca
      961 ctactctgtg cagtcggaca tctggagcat ggggctgtcg ctggtggagc tggccatcgg
     1021 gaggtatccc attcccccac ctgatgccaa ggaactagag gccagctttg gccggcctgt
     1081 ggtggacggg gcagacggag aaccccatag tgtctccccg aggcccaggc cccctggacg
     1141 ccccatcagt ggtcatggga tggacagccg accggccatg gccatctttg agctgctgga
     1201 ctacatagtg aacgagccac ctcccaagct gcccagtggt gtgttcagct cagacttcca
     1261 ggagtttgtg aataaatgtc tcattaagaa cccagcagag cgagcagatc tgaagctgct
     1321 gatgaaccac gccttcatca agcgctctga gggggaggaa gtggacttcg ccggctggct
     1381 gtgcagaacc ctgcggctga agcagcccag cacacccacg cggactgcag tgtgacagcc
     1441 agcgcccagc agtctgtgtc cttgtccctg tcggcacagt ggccgctgcc tctggggaca
     1501 gtgatgctgt ttgttgtggc aggggaccta tgcccatgca tttgaaaacc aaacaaaatg
     1561 aagaaagaga aagaaagaaa gaaagctagc tgcggctgtg ctcctgccca ttgcttgttg
     1621 tgacctcact cagcaggtgg aagaagggca ggccaaggga tgaggagaca ctaccctcac
     1681 ctcccttcct gggccccagc tcttgcagtg cacatgcagc ctccttccta gcagggggtg
     1741 tgggagcagg ggacccctct gggctccagg gagcatagct aactcagcat agtgcaaagg
     1801 cagtgccctg catgagatcc ggaggagacc ccagtggatc tgggtcatgg aactcaatga
     1861 gagcctcgcc acagcctgca gccaccccac cagggtccca cctatcccac cagtcagtca
     1921 gactcagcca cagtggcctg taagggaagc ctgaggcctc ctgcccacaa tctgaatgaa
     1981 gagcattcct gctaacacag agagatacac ttgctaatac agacctggtg cccgagcact
     2041 gtacaagtct ggggagtgtc tgcaccttct tgctgcccct ctcagggatg acaaaagtat
     2101 tcctttttca gatgccccaa ggaagccacc atgtggggct tcacatgctc cagccaggtt
     2161 gtccaagcag gtgccgtcca ccacactgct ggctgctctt gcactgtgca gggaccccta
     2221 ctgcctaggg gtgcccagtg tggtgtggga gagcaatgcc tactctccgc ctctgccatg
     2281 agctgcatcc atccctcaca ttcctaaata ctaggaaggc tgagtcggga aaacgacagg
     2341 ttttgggcca ctgtgggcta cctagtgaga atgtcttaca tcatggaaat ggtgcaatca
     2401 caaaaaaaaa aaaaaa
//
