LOCUS       NM_001310634            9666 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus microtubule-associated protein 2 (Map2), transcript
            variant 3, mRNA.
ACCESSION   NM_001310634
VERSION     NM_001310634.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9666)
  AUTHORS   Amato,E. Jr., Taroc,E.Z.M. and Forni,P.E.
  TITLE     Illuminating the terminal nerve: Uncovering the link between GnRH-1
            neuron and olfactory development
  JOURNAL   J Comp Neurol 532 (3), e25599 (2024)
   PUBMED   38488687
REFERENCE   2  (bases 1 to 9666)
  AUTHORS   Barman,B. and Thakur,M.K.
  TITLE     Neuropsin promotes hippocampal synaptogenesis by regulating the
            expression and cleavage of L1CAM
  JOURNAL   J Cell Sci 137 (3) (2024)
   PUBMED   38206094
REFERENCE   3  (bases 1 to 9666)
  AUTHORS   Matsuki,T., Hamada,N., Ito,H., Sugawara,R., Iwamoto,I., Nakayama,A.
            and Nagata,K.I.
  TITLE     Expression analysis of type I ARF small GTPases ARF1-3 during mouse
            brain development
  JOURNAL   Mol Biol Rep 51 (1), 106 (2024)
   PUBMED   38227057
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9666)
  AUTHORS   Jiang,Y., Li,L., Wu,R., Wu,L., Zhang,B., Wang,J.Z., Liu,R., Liu,F.,
            Wang,J. and Wang,X.
  TITLE     c-Src regulates delta-secretase activation and truncated Tau
            production by phosphorylating the E3 ligase Traf6
  JOURNAL   J Biol Chem 299 (12), 105462 (2023)
   PUBMED   37977223
REFERENCE   5  (bases 1 to 9666)
  AUTHORS   Hara,Y., Katsuyama,T., Fukaya,M., Sugawara,T., Shiroshima,T.,
            Sadakata,T., Osumi,N. and Sakagami,H.
  TITLE     ADP Ribosylation Factor 4 (Arf4) Regulates Radial Migration through
            N-Cadherin Trafficking during Cerebral Cortical Development
  JOURNAL   eNeuro 10 (11) (2023)
   PUBMED   37848288
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9666)
  AUTHORS   Charriere-Bertrand,C. and Nunez,J.
  TITLE     Regulation of tubulin, Tau and microtubule associated protein 2
            expression during mouse brain development
  JOURNAL   Neurochem Int 21 (4), 535-541 (1992)
   PUBMED   1303735
REFERENCE   7  (bases 1 to 9666)
  AUTHORS   Aizawa,T., Maruyama,K., Kondo,H. and Yoshikawa,K.
  TITLE     Expression of necdin, an embryonal carcinoma-derived nuclear
            protein, in developing mouse brain
  JOURNAL   Brain Res Dev Brain Res 68 (2), 265-274 (1992)
   PUBMED   1394972
REFERENCE   8  (bases 1 to 9666)
  AUTHORS   Lafuse,W.P., Brown,D. and Zwilling,B.S.
  TITLE     Assignment of the microtubule-associated protein 2 gene to mouse
            chromosome 1
  JOURNAL   Mamm Genome 3 (1), 48-51 (1992)
   PUBMED   1581633
REFERENCE   9  (bases 1 to 9666)
  AUTHORS   Lewis,S.A., Wang,D.H. and Cowan,N.J.
  TITLE     Microtubule-associated protein MAP2 shares a microtubule binding
            motif with tau protein
  JOURNAL   Science 242 (4880), 936-939 (1988)
   PUBMED   3142041
REFERENCE   10 (bases 1 to 9666)
  AUTHORS   Lewis,S.A., Villasante,A., Sherline,P. and Cowan,N.J.
  TITLE     Brain-specific expression of MAP2 detected using a cloned cDNA
            probe
  JOURNAL   J Cell Biol 102 (6), 2098-2105 (1986)
   PUBMED   2423532
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF538767.1, AK141458.1, CV558214.1 and BC052446.1.
            
            [WARNING] On Jul 22, 2024 this sequence was replaced by
            NM_001310634.2.
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longest isoform (3).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660825.66248.1,
                                           SRR1660815.129109.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-374               CF538767.1         6-379
            375-4867            AK141458.1         2-4494
            4868-5519           CV558214.1         80-731
            5520-9666           BC052446.1         1299-5445
FEATURES             Location/Qualifiers
     source          1..9666
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 33.49 cM"
     gene            1..9666
                     /gene="Map2"
                     /gene_synonym="G1-397-34; MAP-2; Mtap-2; Mtap2; repro4"
                     /note="microtubule-associated protein 2"
                     /db_xref="GeneID:17756"
                     /db_xref="MGI:MGI:97175"
     exon            1..419
                     /gene="Map2"
                     /gene_synonym="G1-397-34; MAP-2; Mtap-2; Mtap2; repro4"
                     /inference="alignment:Splign:2.1.0"
     exon            420..484
                     /gene="Map2"
                     /gene_synonym="G1-397-34; MAP-2; Mtap-2; Mtap2; repro4"
                     /inference="alignment:Splign:2.1.0"
     exon            485..562
                     /gene="Map2"
                     /gene_synonym="G1-397-34; MAP-2; Mtap-2; Mtap2; repro4"
                     /inference="alignment:Splign:2.1.0"
     exon            563..847
                     /gene="Map2"
                     /gene_synonym="G1-397-34; MAP-2; Mtap-2; Mtap2; repro4"
                     /inference="alignment:Splign:2.1.0"
     CDS             586..6072
                     /gene="Map2"
                     /gene_synonym="G1-397-34; MAP-2; Mtap-2; Mtap2; repro4"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="microtubule-associated protein 2 isoform 3"
                     /protein_id="NP_001297563.1"
                     /db_xref="CCDS:CCDS83550.1"
                     /db_xref="GeneID:17756"
                     /db_xref="MGI:MGI:97175"
                     /translation="MADERKDEGKAPHWTSASLTEAAAHPHSPEMKDQGGAGEGLSRN
                     ANGFPYREEEEGAFGEHRSQGTYSDTKENGINGELTSADRETAEEVSARIVQVVTAEA
                     VAVLKGEQEKEAQHKDQPAALPLAAEETANLPPSPPPSPASEQTATVEEDLLTASKME
                     FPEQEKFPSSFAEPLDKGEMEFKMPSKPGEDFEHAALVPDTSKTPQDKKDLQGMEGEK
                     LPPVPFAQTFGTNLEDRKQSTEPSIVMPSIGLSAEPPAPKEPKDWFIEMPTESKKDEW
                     GLAAPISPGPLTPMREKDVLEDIPRWEGKQFDSPMPSPFHGGSFTLPLDTMKNERVSE
                     GPRPFAPVFFQSDDKVSLQDPSALATSKESSKDEEPLKDKADKVADVSISEVTTLLGN
                     VHSPVVEGYVGENISGEVKVTTDQEKKETSAPSVQEPTLTETEPQTKLDEKSTVSIEE
                     AVAKKEESFKLRDDKTGVIQTSTEQSFSKEDQKGQEHTIDELKQDSFPISLEQAVTDA
                     AMTSKTLGKVTSEPEAVSERREIQGLFEEKTADKNKLEGAGSATIAEVEMPFYEDKSG
                     MSKYFETSALKEDMTRSTELGSDYYELSDSRGSAQESLDTISPKNQHDEKELQAKASQ
                     PSPPAQEAGYSTLAQSYTPDHPSELPEEPSSPQERMFTIDPKVYGEKRDLHSKNKDDL
                     TLSRSLGLGGRSAIEQRSMSINLPMSCLDSIALGFNFGRGHDLSPLASDILTNTSGSM
                     DEGDDYLPPTTPAVEKMPCFPIESKEEEDKAEQAKVTGGQTIQVETSSESPFPAKEYY
                     KNGTVMAPDLPEMLDLAGTRSRLASVSADAEVARRKSVPSEAMLAESSTSLPPVADES
                     PVTVKPDSQLEDMGYCVFNKYTVPLPSPVQDSENLSGESGSFYEGTDDKVRRDLATDL
                     SLIEVKLAAAGRVKDEFTAEKEASPPTSADKSRLSREFDHDRKANDKLDTVLEKSEEH
                     IDSKEHAKESEEMGGKVELFGLGITYDQASTKELITTKDTSPEKTEKGLSSVPEVAEV
                     EPTTKADQGLDFAATKAEPSQLDIKVSDFGQMASGMNVDAGKAIELKFEVAQELTLSS
                     EAPQEADSFMGVESGHIKEGGKVNETEVKEKVTKPDLVHQEAVDKEESYESSGEHESL
                     TMESLKPDEGKKETSPETSLIQDEVALKLSVEIPCPPPVSEADLSTDEKGEVQMEFIQ
                     LPKEESTETPDIPAIPSDVTQPQPEAIVSEPAEVPSEEEEIEAGGEYDKLLFRSDTLQ
                     ISDLLVSESREEFVETCPGELKGVVESVVTIEDDFITVVQTTTDEGESGSHSVRFAAP
                     AQPEEERRPRPHDEELEIEMAAEAQAEPKDGSPDAPATPEKEEVAFSEYKTETYDDYK
                     DETTIDDSIMDADSLWVDTQDDDRSILTEQLETIPKEERAEKDARRPSLEKHRKEKPF
                     KTGRGRISTPERKVAKKEPSTVSRDEVRRKKAVYKKAELAKKSEVQAHSPSRKLILKP
                     AIKYTRPTHLSCVKRKTTAASGDLAQAPGAFKQAKDKVTDGISKSPEKRSSLPRPSSI
                     LPPRRGVSGDREENSFSLNSSISSARRTTRSEPIRRAGKSGTSTPTTPGSTAITPGTP
                     PSYSSRTPGTPGTPSYPRTPGTPKSGILVPSEKKVAIIRTPPKSPATPKQLRLINQPL
                     PDLKNVKSKIGSTDNIKYQPKGGQVQIVTKKIDLSHVTSKCGSLKNIRHRPGGGRVKI
                     ESVKLDFKEKAQAKVGSLDNAHHVPGGGNVKIDSQKLNFREHAKARVDHGAEIITQSP
                     SRSSVASPRRLSNVSSSGSINLLESPQLATLAEDVTAALAKQGL"
     exon            848..961
                     /gene="Map2"
                     /gene_synonym="G1-397-34; MAP-2; Mtap-2; Mtap2; repro4"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1039
                     /gene="Map2"
                     /gene_synonym="G1-397-34; MAP-2; Mtap-2; Mtap2; repro4"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..4780
                     /gene="Map2"
                     /gene_synonym="G1-397-34; MAP-2; Mtap-2; Mtap2; repro4"
                     /inference="alignment:Splign:2.1.0"
     exon            4781..4987
                     /gene="Map2"
                     /gene_synonym="G1-397-34; MAP-2; Mtap-2; Mtap2; repro4"
                     /inference="alignment:Splign:2.1.0"
     exon            4988..5122
                     /gene="Map2"
                     /gene_synonym="G1-397-34; MAP-2; Mtap-2; Mtap2; repro4"
                     /inference="alignment:Splign:2.1.0"
     exon            5123..5184
                     /gene="Map2"
                     /gene_synonym="G1-397-34; MAP-2; Mtap-2; Mtap2; repro4"
                     /inference="alignment:Splign:2.1.0"
     exon            5185..5329
                     /gene="Map2"
                     /gene_synonym="G1-397-34; MAP-2; Mtap-2; Mtap2; repro4"
                     /inference="alignment:Splign:2.1.0"
     exon            5330..5661
                     /gene="Map2"
                     /gene_synonym="G1-397-34; MAP-2; Mtap-2; Mtap2; repro4"
                     /inference="alignment:Splign:2.1.0"
     exon            5662..5743
                     /gene="Map2"
                     /gene_synonym="G1-397-34; MAP-2; Mtap-2; Mtap2; repro4"
                     /inference="alignment:Splign:2.1.0"
     exon            5744..5856
                     /gene="Map2"
                     /gene_synonym="G1-397-34; MAP-2; Mtap-2; Mtap2; repro4"
                     /inference="alignment:Splign:2.1.0"
     exon            5857..9648
                     /gene="Map2"
                     /gene_synonym="G1-397-34; MAP-2; Mtap-2; Mtap2; repro4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9627..9632
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Map2"
                     /gene_synonym="G1-397-34; MAP-2; Mtap-2; Mtap2; repro4"
                     /note="hexamer: AATAAA"
     polyA_site      9648
                     /gene="Map2"
                     /gene_synonym="G1-397-34; MAP-2; Mtap-2; Mtap2; repro4"
                     /note="major polyA site"
ORIGIN      
        1 tcgtaggctt atagacttga ctcctgggga cacatttgga tggaggcaat taaaatgcct
       61 gtcaggcatt tggtaccaga agtccccatg gcaaaccgct aaatcctaag ccagaggcag
      121 catccttttg tcagtgaatg atggcggagc tgagtggctt gtcatcattc tcgaaaattc
      181 taagcctagt gagctctctc tccctctcct acttgcctta ttttcctttc cgccactgcg
      241 gggacttttt ctaatttgca gcttcccttt ccacggcaca cacagacagg agctggtggc
      301 tttcagactg cgtctgtctg gagctagcga cacagaacag agggagtgtt cctgaagcag
      361 ggttctgcgg tggcagctct tacagactcc attcgagggg tattgctgca tatctaccgg
      421 ttcctcagct tgtctctaac agaggaagca ctgattggga agcactcagt cagaaaatta
      481 aaagaaagaa gccagaacat accaccagcc gtttgagaat acaacatagc aaacttcact
      541 actttacaac ttccttgaat tggcgacagt acagagatct gaaagatggc cgacgagcgg
      601 aaagatgaag gaaaggcacc acactggaca tcagcctcac tcacagaggc agctgcacac
      661 cctcactctc cagagatgaa ggaccagggt ggggcagggg aagggctgag ccgcaacgcc
      721 aatggatttc catacagaga ggaggaggaa ggcgcctttg gggagcacag gtcacagggc
      781 acctattcag ataccaaaga gaacgggatc aacggagagc tgacctcagc tgacagagaa
      841 acagcagagg aggtatctgc aaggatagtt caagtagtca cagctgaagc tgtagcagtc
      901 ctgaaaggtg aacaagagaa ggaagcccaa cacaaggacc agcctgcagc tctgcctcta
      961 gcagccgaag aaacagctaa tctgccacct tcgccaccac catcgccagc ctcagaacaa
     1021 acagccacag tggaggaaga tttacttaca gcctcgaaga tggaattccc tgagcaggag
     1081 aaatttcctt cctcattcgc tgagccttta gacaagggag aaatggagtt taagatgcca
     1141 agtaagcctg gtgaagactt tgaacatgct gccttagttc ctgacacaag taaaactcct
     1201 caggataaaa aggatctcca aggcatggaa ggagaaaagt tgcctccagt tccatttgcg
     1261 cagactttcg gtaccaacct ggaagacaga aaacagagca cagaaccaag catagtgatg
     1321 cctagcattg gcctctcggc agagccccca gctccaaaag agccaaaaga ctggttcatt
     1381 gaaatgccca cggaatcaaa gaaggatgaa tggggtttag ctgccccaat atctcctggc
     1441 cccttgacac ccatgaggga aaaagatgtg ctagaggata tcccaagatg ggaagggaag
     1501 cagtttgact ctcccatgcc aagccccttc catggtggaa gtttcactct tcccttagac
     1561 actatgaaga atgagagagt ctcagaagga ccacgaccct ttgcccctgt cttcttccaa
     1621 tcagatgaca aagtgtctct gcaggacccc agtgctctag ctacttccaa agagagttct
     1681 aaagatgagg agccactgaa agataaagca gacaaagtgg cagatgtttc catctcagaa
     1741 gttaccactt tactgggaaa tgttcatagt ccagttgtgg aaggctatgt tggggagaac
     1801 atttcaggag aagtaaaggt taccacagat caagagaaaa aggagacttc tgcacccagt
     1861 gtacaggaac ctacactcac tgaaactgaa ccacagacaa agcttgatga gaaatcaact
     1921 gtttctatcg aagaagctgt ggcaaaaaaa gaggaatcct ttaaactaag agatgataaa
     1981 acaggtgtaa ttcagacttc caccgagcag tctttctcca aggaagacca gaaaggccaa
     2041 gaacacacga ttgatgagtt aaaacaagac tccttcccta taagtctgga acaagcagtt
     2101 acagatgcag ccatgacctc caagaccttg ggaaaagtta catctgagcc agaggcagta
     2161 agtgaaagga gagaaatcca gggacttttt gaagagaaaa cagctgacaa aaataagctt
     2221 gaaggcgctg gatctgcgac aatagccgag gttgagatgc cgttttatga agataaatca
     2281 gggatgtcta agtactttga aacatctgca ttgaaagaag acatgacgag aagcactgag
     2341 ttgggcagtg attactatga gctgagtgac tccagaggaa gtgcccagga atctcttgat
     2401 actatatctc ctaagaacca acatgatgaa aaggaacttc aggcaaaagc atcccagcct
     2461 agtcctccag cacaggaagc agggtacagc actcttgctc agagttatac acccgatcat
     2521 ccatccgagt tacctgaaga accaagttct cctcaagaga gaatgttcac tattgacccc
     2581 aaagtttatg gagagaaaag ggaccttcat agtaagaata aggacgatct gacacttagt
     2641 cgaagcttag ggcttggtgg aaggtctgca atagaacaaa gaagcatgtc tatcaacttg
     2701 cctatgtctt gccttgattc cattgccctt gggtttaact ttggccgggg ccatgatctt
     2761 tcccctctgg cttctgatat tctaaccaac actagtggaa gcatggatga aggagatgat
     2821 tacctgcccc ccaccacacc tgcagtggag aagatgcctt gctttcctat agagagcaaa
     2881 gaggaagaag ataaagcaga gcaagcaaaa gtgactggag ggcaaactat ccaagttgaa
     2941 acatcctcag agtcaccctt tccagccaaa gaatattaca aaaatggtac tgtcatggcc
     3001 cctgacctgc ccgagatgct agatctggca ggaaccaggt ccagattagc ttctgtgagt
     3061 gcagatgctg aggttgccag gaggaaatca gtcccatcag aggctatgct tgcagagagt
     3121 agtaccagtt tgccacctgt cgctgatgaa agcccagtca ctgtaaaacc agatagtcaa
     3181 cttgaagaca tgggatactg tgtgttcaac aagtacacag tccctctccc atcaccagtt
     3241 caagacagtg agaatttgtc aggagagagt ggttcatttt atgaaggaac cgatgacaaa
     3301 gtccgtagag atttggccac cgacctttca ctaattgaag taaaacttgc agctgctgga
     3361 agagtcaaag atgagttcac tgctgagaaa gaggcatctc cacccacttc tgctgacaaa
     3421 tcaagactga gtagggagtt tgaccatgac aggaaagcta atgacaagct ggatactgtc
     3481 ctagaaaaga gtgaagagca tattgattca aaagaacatg ccaaggagtc agaagagatg
     3541 gggggtaaag tagagctctt tggattaggt ataacttatg atcaagcctc caccaaagaa
     3601 ctgataacaa ctaaggatac atcacctgag aaaacagaga aaggtctcag ttcagtgcca
     3661 gaggtagctg aggtcgagcc aaccacaaaa gctgatcaag gtctagattt tgctgcaacg
     3721 aaagctgagc caagtcagtt agatataaaa gtcagtgact ttggacagat ggcttctggg
     3781 atgaatgtag atgctgggaa agccatagag cttaagtttg aggttgctca ggagctgacg
     3841 ctctcatccg aagcacctca agaagcagat tccttcatgg gtgttgagtc cggccacatc
     3901 aaggaaggtg gcaaagtcaa tgaaacagaa gtcaaggaaa aggtgacaaa gcctgatttg
     3961 gtgcatcagg aggctgtaga caaagaagag tcctatgagt ctagcggtga gcatgaaagc
     4021 ctcactatgg agtctctgaa gcctgatgag ggcaagaaag aaacatctcc agagacatca
     4081 ctgatccaag atgaagttgc cctcaagctg tctgtagaaa tcccttgccc gcctccagtt
     4141 tccgaagctg atttatccac ggatgagaag ggtgaggtcc agatggaatt cattcagctg
     4201 ccaaaggaag agagcacaga gactccggat atacctgcca taccttctga tgtcacccag
     4261 ccacagcctg aagccattgt gtccgaacca gcagaggtcc caagtgagga agaagagata
     4321 gaagctgggg gagagtatga caaactgctc ttccgctcag ataccctcca gatctccgac
     4381 ctgcttgttt cagaaagtag ggaggagttt gtggagacct gcccaggtga gctcaaaggt
     4441 gtggttgagt ctgtggtgac cattgaggat gattttatca ctgtagtaca aaccacaact
     4501 gatgaggggg agtcggggtc ccacagtgtg cgcttcgcag ctccagctca gccggaggaa
     4561 gaaaggagac cacgccctca cgatgaagag cttgaaatag agatggcagc agaagcccag
     4621 gcagaaccca aggatggctc tccagatgct ccagctaccc ctgagaaaga agaggttgcg
     4681 ttctcagaat ataaaacaga aacttacgac gattacaaag acgagaccac cattgatgac
     4741 tccattatgg acgccgacag cctgtgggtg gacactcaag atgatgatag aagcatcttg
     4801 acagagcagt tagaaactat tcctaaagag gagagagctg agaaggatgc tcggagaccg
     4861 tctctcgaga aacatagaaa agaaaagcct tttaaaaccg ggagaggcag aatttccact
     4921 cctgaaagaa aagtagctaa aaaggaacct agcacggtct ccagggatga agtgagaagg
     4981 aaaaaagcag tttataagaa ggctgaactt gctaaaaaat cagaagttca ggcccactct
     5041 ccttccagga aactcatttt aaaacctgct atcaaataca ctagaccaac tcatctctcc
     5101 tgtgttaagc ggaaaaccac agcagcaagt ggtgacttgg ctcaggctcc tggtgctttt
     5161 aaacaggcga aggataaagt cactgatgga ataagcaaga gcccagagaa acgttcttcc
     5221 ctcccaagac cttcctccat cctccctcct cgcaggggtg tatcaggaga cagggaggag
     5281 aactctttct ctctgaatag ctccatctct tcagcacgac ggaccaccag gtcagaacca
     5341 attcgcagag caggaaaaag tggcacctcc acacctacta cccctggatc aactgcaatc
     5401 acccctggaa ctcccccaag ctactcttca cgtaccccag gcaccccggg aaccccgagc
     5461 taccccagga caccaggaac ccccaaatct ggcatcctgg tgcccagtga gaagaaagtt
     5521 gccatcatcc gcactcctcc aaagtcccca gctactccta agcagcttcg gcttattaac
     5581 caaccactgc cggacctgaa gaatgtcaag tccaaaatcg gatcaactga caacatcaaa
     5641 taccagccta aggggggtca ggtacaaatt gttactaaga agatagactt aagccatgtg
     5701 acatccaaat gtggctctct aaagaacatc cgtcacaggc caggtggtgg acgtgtgaaa
     5761 attgagagtg taaaactgga tttcaaggaa aaggcccaag ctaaagttgg ctcacttgac
     5821 aatgctcacc acgtacctgg aggtggtaat gtgaagattg acagccaaaa gttgaacttc
     5881 agagagcatg caaaggcccg ggtagatcac ggggctgaga tcatcacaca gtccccaagc
     5941 aggtccagcg tggcatcacc ccgacgactc agcaacgtct catcttctgg aagcatcaac
     6001 ctgctcgaat cccctcagct tgccactttg gctgaggatg tcactgcggc gcttgctaag
     6061 cagggcttgt gaatacttct cctttagcac tggagtaaca tttaggcatg agctcttggc
     6121 aggagtgggc tctgagcagg tgtcatattc attctttaca aaccatagag aaataatttc
     6181 atcccccaac tgtagtaatt gttacaattt tatataaaaa attaatagta tatgcagaaa
     6241 atgacctgaa ttccatccgc aacaaggaca catggcttta catggataca atcggacaat
     6301 tattttcgct ctgctctgtt ttgcatggag tattattatt attttttaaa ttgcattttt
     6361 acctttcatg tgcctgaagg ctatccaata cattctgaaa ggccttgtta aaaatccaag
     6421 ctgctcattt ccctattctg tttatggttg aaaagattaa aacctaccca ttgttactta
     6481 ctacaggttc gatgaaatca aggagtctga ttgcaggaag gaaagagcat gtaagaaaca
     6541 cattttttaa agtgttattt tgtataaatg ggaagaaaga cgcaattaag ttattgacac
     6601 ttgggacctg gacgagtata tcagagtatg ccattccaat aaattattga actacaagct
     6661 agatttaagg catttgagcg ttggttgaag aagtggtgtc aaagtgcatc tcttaggatt
     6721 gatgcacttt tgttaggatg ggcttgtgtc tgattagaat gtcagtcgat tggctagatt
     6781 tatatccaca caatcagttt cacaccccca ttccatctgt ttgatacagt attatagata
     6841 taaatatata tatatatttc tctgtggcca tttgtgatac ttcctcatat acttgaatat
     6901 gatacttctt tattcacagt atctgtgtct cctgcaccct ttggtgttgc aattttaggt
     6961 atgtgaaagt agatgttagc agggttctct ccctatttaa aaataaattt taaaaagaca
     7021 aagagtttta gcatgaagtt gctttctgta acaactcaaa gctgtaaccc tgtcttagtg
     7081 ccagaatcaa gtctttcctg tgatgctaga acattttact tttctttgct tccaccaaca
     7141 tggagtttgt ggagtgggtc cagttatgca taaaggggtt tacagatgtt ggttcaagga
     7201 ttatggattt atctcatgta taatcactaa ataggtcggg ttttatccct ctaattatcc
     7261 atgacaccaa tctcttacta ttcattactc tttcttctat ttcctttttc catttgctaa
     7321 agttgaaagt aggaaaaaat aattttgaat agcttttctt gttctccaaa cagtatctgt
     7381 tcattaaatt ctgtgataga atatatttgg cttccttccc ccaaagacct cttgatcaaa
     7441 gatgaaaaat acaacatata aagaagctat atatgtaata cttttgagac acagatatct
     7501 aaatccatct ctccaggatt cttcatgaac atggaacatg gtattactta ttcatgagta
     7561 aatgctattt ttttcttgct ttatatacaa tctagacatc acaactcaat tactatcatt
     7621 tacaaatcat acttaatgaa taagtaatag tcgatggccc aaaataaggc agagcattat
     7681 caaaccgagt ggactttttt tcttaatatt taatttgttc ttttgcttgc tcgggattgg
     7741 tgggtggaat atgcagagat aaatgtgaaa aagctgtctg ggtgttttat gtctctgaaa
     7801 taaaccaagc cctgtataca aaggagaagg tgaacatgaa caggatagga agatgtagga
     7861 gtgtctaaga cagaaggcaa gaggatgcaa aagtggagag aaacaggtgg cagtttagtg
     7921 acccattgag tattatgacc aatgtgacag tcacatagaa agcttagcat caaacagaga
     7981 cagtcttatt ggctagtagg cacacacaca ctacagtcgt ctttgtaaat tggttatttt
     8041 ttatataact ttaaaactac tgaatagtgg ttttcactct ggacaaccca ttccttacct
     8101 tctcttgaaa tgcacagaaa atggaagaag gaatgactgt gtgtggagaa gtacagtctt
     8161 ttcttacatg ttttgataga caaggatcaa agttgtctag gaaaaaaagg taccagatga
     8221 tccatgtggt tttaaactat gcagaaaata atttcaaccc agtttattat aaaaattaag
     8281 cctaagtaaa cattttcttt gtgttaaaat tcagtttctt atgatgcgtg ttcaaaaaaa
     8341 ttatgtaaac cccaatgtta atagatctag cactaaaata atcatttttt ctaatgtcaa
     8401 aacaattata atggatataa gtccttgttc tatgtgaaat gtgtttctct ataaagttat
     8461 cacaagaagg aatttttata ggagacagac agagaaatgc acaggctaaa atcatttcct
     8521 tatgggaatg tgggatggag ctcaccttac ctactctctt aagataatga ctcaaattaa
     8581 gctttttgga caccactttt gtggggatac acatacgctg atctagaaat gaaaggtgca
     8641 ctactgcatt tctagatcca ctaatgccag tttctctctg gctttagcct ttgagaacct
     8701 gtttaagaat acgtaagtat ccagagctcg gaagagttcc aaggcccact ttttcaataa
     8761 actcacacac tctgggtctc ctgcaactga caattgggta ccttgcaaca atgcaggaag
     8821 gatccgagtc tatgatgagt ttcaaaggcc aagttccttt aggaactgac tctctctgga
     8881 tctgcctgct gcgttccagc aggatgacgg gctgaaatcc cacccatagg aaagacccct
     8941 gtgcaattcc agctcagttt ggctgaaggt agctgaagaa gagagccagt aaagggaaga
     9001 atagactgta gttgcccttc tccacacaca ctcacacaga tgtggggtag aagagagata
     9061 taatgccaaa tgtagcatta tgtcagtggt agtaaagaaa tgatataaaa gcaaataatt
     9121 ctgacttagc ctcatttata gctttcctct catatttcat gccacatggg ggaaaaaagg
     9181 aaatgattgt ggtagaagta gcaaagtaaa agtagattaa tcatttggaa aaggcaaatt
     9241 tcaggcattt ctccaagatt gatgtgctaa aattaatact tatgtttgtg tttttacacc
     9301 tagaagtttt agcctggaca tgtagattga ggccaagtcc ctctgtagga aaaggttttt
     9361 tttttttttc aaaaccccta aaaaaaatgc caatcatgaa agtccacttc aactttagca
     9421 aaaagggggg aaaattcaac aaaaagtata ctctgtatgc tgggatccca aggtttcaac
     9481 acaccatctg tggggggttc tttcttctga taattctaga gcctgttacc atagaaaggt
     9541 atttcttcaa tggctggttg tagttagttc atgtttttca atcaatttgc aaatgtattt
     9601 gttgctgtat agtgattgtt ttgcaaaata aaattgcttg tcacctaaaa aaaaaaaaaa
     9661 aaaaaa
//
