LOCUS       NM_173013               3284 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus microtubule-associated protein 1S (Map1s), mRNA.
ACCESSION   NM_173013
VERSION     NM_173013.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3284)
  AUTHORS   Shi,B., Wang,W., Ye,M., Liang,M., Yu,Z., Zhang,Y., Liu,Z.,
            Liang,X., Ao,J., Xu,F., Xu,G., Jiang,X., Zhou,X. and Liu,L.
  TITLE     Spermidine suppresses the activation of hepatic stellate cells to
            cure liver fibrosis through autophagy activator MAP1S
  JOURNAL   Liver Int 43 (6), 1307-1319 (2023)
   PUBMED   36892418
  REMARK    GeneRIF: Spermidine suppresses the activation of hepatic stellate
            cells to cure liver fibrosis through autophagy activator MAP1S.
REFERENCE   2  (bases 1 to 3284)
  AUTHORS   Yue,F., Li,W., Zou,J., Jiang,X., Xu,G., Huang,H. and Liu,L.
  TITLE     Spermidine Prolongs Lifespan and Prevents Liver Fibrosis and
            Hepatocellular Carcinoma by Activating MAP1S-Mediated Autophagy
  JOURNAL   Cancer Res 77 (11), 2938-2951 (2017)
   PUBMED   28386016
REFERENCE   3  (bases 1 to 3284)
  AUTHORS   Xu,G., Yue,F., Huang,H., He,Y., Li,X., Zhao,H., Su,Z., Jiang,X.,
            Li,W., Zou,J., Chen,Q. and Liu,L.
  TITLE     Defects in MAP1S-mediated autophagy turnover of fibronectin cause
            renal fibrosis
  JOURNAL   Aging (Albany NY) 8 (5), 977-985 (2016)
   PUBMED   27236336
  REMARK    GeneRIF: Depletion of MAP1S in mice leads to an accumulation of
            fibrosis-related proteins and the development of renal fibrosis in
            aged mice.
REFERENCE   4  (bases 1 to 3284)
  AUTHORS   Li,W., Zou,J., Yue,F., Song,K., Chen,Q., McKeehan,W.L., Wang,F.,
            Xu,G., Huang,H., Yi,J. and Liu,L.
  TITLE     Defects in MAP1S-mediated autophagy cause reduction in mouse
            lifespans especially when fibronectin is overexpressed
  JOURNAL   Aging Cell 15 (2), 370-379 (2016)
   PUBMED   26750654
  REMARK    GeneRIF: MAP1S-mediated autophagy plays an important role in
            maintaining mouse lifespan especially in the presence of extra
            amount of fibronectin.
REFERENCE   5  (bases 1 to 3284)
  AUTHORS   Shi,M., Zhang,Y., Liu,L., Zhang,T., Han,F., Cleveland,J., Wang,F.,
            McKeehan,W.L., Li,Y. and Zhang,D.
  TITLE     MAP1S Protein Regulates the Phagocytosis of Bacteria and Toll-like
            Receptor (TLR) Signaling
  JOURNAL   J Biol Chem 291 (3), 1243-1250 (2016)
   PUBMED   26565030
  REMARK    GeneRIF: Data (including data from studies in knockout mice)
            suggest that Map1s interacts directly with MyD88 (myeloid
            differentiation primary response gene 88), a key adaptor of
            Toll-like receptors, as phagocytosis of bacteria is initiated in
            macrophages.
REFERENCE   6  (bases 1 to 3284)
  AUTHORS   Xie,R., Nguyen,S., McKeehan,K., Wang,F., McKeehan,W.L. and Liu,L.
  TITLE     Microtubule-associated protein 1S (MAP1S) bridges autophagic
            components with microtubules and mitochondria to affect
            autophagosomal biogenesis and degradation
  JOURNAL   J Biol Chem 286 (12), 10367-10377 (2011)
   PUBMED   21262964
  REMARK    GeneRIF: clarify roles of MAP1S in bridging microtubules and
            mitochondria with autophagic and mitophagic initiation, maturation,
            trafficking, and lysosomal clearance.
REFERENCE   7  (bases 1 to 3284)
  AUTHORS   Ding,J., Allen,E., Wang,W., Valle,A., Wu,C., Nardine,T., Cui,B.,
            Yi,J., Taylor,A., Jeon,N.L., Chu,S., So,Y., Vogel,H., Tolwani,R.,
            Mobley,W. and Yang,Y.
  TITLE     Gene targeting of GAN in mouse causes a toxic accumulation of
            microtubule-associated protein 8 and impaired retrograde axonal
            transport
  JOURNAL   Hum Mol Genet 15 (9), 1451-1463 (2006)
   PUBMED   16565160
  REMARK    GeneRIF: Axonal transport impairment may be a deleterious
            consequence of accumulated, toxic MAP8 protein.
REFERENCE   8  (bases 1 to 3284)
  AUTHORS   Ding,J., Valle,A., Allen,E., Wang,W., Nardine,T., Zhang,Y., Peng,L.
            and Yang,Y.
  TITLE     Microtubule-associated protein 8 contains two microtubule binding
            sites
  JOURNAL   Biochem Biophys Res Commun 339 (1), 172-179 (2006)
   PUBMED   16297881
  REMARK    GeneRIF: MAP8 is a novel microtubule associated protein containing
            two microtubule binding domains.
REFERENCE   9  (bases 1 to 3284)
  AUTHORS   Orban-Nemeth,Z., Simader,H., Badurek,S., Trancikova,A. and
            Propst,F.
  TITLE     Microtubule-associated protein 1S, a short and ubiquitously
            expressed member of the microtubule-associated protein 1 family
  JOURNAL   J Biol Chem 280 (3), 2257-2265 (2005)
   PUBMED   15528209
REFERENCE   10 (bases 1 to 3284)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB857804.1, AK032300.1, AK162124.1 and AA048974.1.
            
            On Dec 11, 2007 this sequence version replaced NM_173013.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK082854.1, SRR1660815.91214.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                BB857804.1         4-16
            14-2067             AK032300.1         2-2055
            2068-3239           AK162124.1         776-1947
            3240-3284           AA048974.1         387-431
FEATURES             Location/Qualifiers
     source          1..3284
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.41 cM"
     gene            1..3284
                     /gene="Map1s"
                     /gene_synonym="6430517J16Rik; Bpy2ip1; Map8; Mtap1s;
                     VCY2IP1"
                     /note="microtubule-associated protein 1S"
                     /db_xref="GeneID:270058"
                     /db_xref="MGI:MGI:2443304"
     exon            1..154
                     /gene="Map1s"
                     /gene_synonym="6430517J16Rik; Bpy2ip1; Map8; Mtap1s;
                     VCY2IP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..2952
                     /gene="Map1s"
                     /gene_synonym="6430517J16Rik; Bpy2ip1; Map8; Mtap1s;
                     VCY2IP1"
                     /note="BPY2 interacting protein 1; microtubule-associated
                     protein 8; MAP-1S"
                     /codon_start=1
                     /product="microtubule-associated protein 1S"
                     /protein_id="NP_766601.2"
                     /db_xref="CCDS:CCDS22387.1"
                     /db_xref="GeneID:270058"
                     /db_xref="MGI:MGI:2443304"
                     /translation="MAAVMAAPEAVEAPSSLLLLVVGGECGCPGLLAYVMEELERGVR
                     SWEDVDPAVCSLDEQLKAFVSRHSATFSSIVKGQRSLHHRGETLETLVLLNPSDKSLC
                     DELRNLLMDPAPHKLLVLAGPCLEETGELLLQTGGFSAHHFLQVLGDKEVQDALASAP
                     AAPALTVSCPTFGDWALLGPVPGLQLRLNPPAQLPASEGLRAFLEYVAESLEPPSPFE
                     LLEPPAAGGFLRLARPCCYVFPGGLGDAAFFAVNGFTVLVNGGSNPKSSFWKLVRHLD
                     RVDAVLVTHAGADSLPGLNSLLRRKLAEREAAAGPQGQHEERLRRLLSPALGVVFLNA
                     REAASRLRGGEDEAVCARSLLRSLGIAPLPLQRGPQPSCPTVLFEKLGVGRLELFVLH
                     PPPGDPAAPACALLVWQPAAPGDKVVRVLFPGRTPPARLLDGLQRLQHLPCLRRPVVT
                     THDLEAPSRANSQDSLASRDSARKEPVRGTVGSIANRSTVRREPALATRDQKKDTRSG
                     PTQPTARDTRRSGPGVVNTKPRVSQNGPRAPVLAAPLTAPVAECPGEAENILESERPP
                     APSPTLSPAQSPPPTAPGNSPERLSLSPLRPEPAPDASPSATTPTLTTPSLPAELGSP
                     HSTEVDESLSVSFEQVLPAGDPGLSLPLRLARRSTSPHDVDLCLVSPCEFSHRKPPPP
                     ASPGSSDSSARSQERPPETPPTSVSESLPTLSDSDPVPVADSDDDAGSESAARDPPPT
                     PRVPPPLPDVPGICMVDPEALPPRARQPLNTTNPSRSRKAPARPSSASATPRAATVAA
                     KTKGPAGDRNRPLSARSEPADRPGRVPLTRKPSVPKTVPKMASATRLSSGPSGRPAPL
                     AAGSPVYLDLAYLPGGGAGHLDQNFFLRVRALCYVISGQGQRQEEGLRAVLDALLAGK
                     RQWDLDLQVTLIPTFDSAVMHRWYEETHAQHQALGIRVLGSGSLVSMQDEAFPACKVE
                     F"
     exon            155..259
                     /gene="Map1s"
                     /gene_synonym="6430517J16Rik; Bpy2ip1; Map8; Mtap1s;
                     VCY2IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            260..342
                     /gene="Map1s"
                     /gene_synonym="6430517J16Rik; Bpy2ip1; Map8; Mtap1s;
                     VCY2IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            343..483
                     /gene="Map1s"
                     /gene_synonym="6430517J16Rik; Bpy2ip1; Map8; Mtap1s;
                     VCY2IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            484..2572
                     /gene="Map1s"
                     /gene_synonym="6430517J16Rik; Bpy2ip1; Map8; Mtap1s;
                     VCY2IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2573..2796
                     /gene="Map1s"
                     /gene_synonym="6430517J16Rik; Bpy2ip1; Map8; Mtap1s;
                     VCY2IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2797..3274
                     /gene="Map1s"
                     /gene_synonym="6430517J16Rik; Bpy2ip1; Map8; Mtap1s;
                     VCY2IP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3255..3260
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Map1s"
                     /gene_synonym="6430517J16Rik; Bpy2ip1; Map8; Mtap1s;
                     VCY2IP1"
                     /note="hexamer: AATAAA"
     polyA_site      3274
                     /gene="Map1s"
                     /gene_synonym="6430517J16Rik; Bpy2ip1; Map8; Mtap1s;
                     VCY2IP1"
                     /note="major polyA site"
ORIGIN      
        1 gggcgctcag agcgtcgggg cggtgcgaag atggcggcag tgatggcggc gccggaggct
       61 gtggaggcgc ccagctccct actgttgctg gtggtgggtg gcgagtgtgg ctgccccggg
      121 ctgctggcct acgtcatgga ggagttggaa cgaggtgttc gctcctggga ggatgtggac
      181 cccgctgtct gcagcctgga tgagcagctc aaggccttcg tgtcccggca ttcagccacc
      241 ttctccagca ttgtgaaagg gcagcggagc ctgcaccacc gtggagagac cttggagacg
      301 ctggtcctgc tgaacccctc agacaagtcc ctgtgtgatg agctccggaa cctcctgatg
      361 gaccccgccc ctcacaagct gctggtcctg gccgggccct gcctggagga gactggggaa
      421 ctgctgttgc agactggggg gttctcggcc caccacttcc tgcaggtgct gggggacaaa
      481 gaggtccagg atgcactggc ctcagcacca gctgccccag ccctcactgt gtcctgtcca
      541 acctttgggg actgggcact gttgggccct gtgcccgggc tgcagctgcg actaaatccg
      601 cccgcgcagc tgccggcctc agagggcctt cgtgccttcc tggagtatgt ggctgagtcg
      661 ctggagccgc catcgccctt cgagttgttg gagccaccgg ctgcgggcgg ctttctgcgc
      721 ttagcaaggc cctgttgcta tgtgttcccg ggtggcttgg gagacgccgc cttcttcgct
      781 gtcaacggct ttacagtgct ggtgaatggt ggctccaacc ccaagtcgag cttctggaag
      841 ctggtgcgcc acctggatcg cgtggacgct gtccttgtga cccacgcggg tgctgacagc
      901 ttgccgggcc tcaacagcct gctgcgccgc aagctggcag agcgcgaagc agccgcagga
      961 ccacagggac agcatgagga gcggctacgt cgcctgctgt cgcctgcgct gggtgtggtg
     1021 ttcctgaatg ctcgtgaggc tgcttctcgg ttgcgtgggg gcgaagacga ggctgtgtgt
     1081 gctcggagcc tgctgcggag cctgggcatt gcgcctctgc cactgcagcg tggcccacag
     1141 ccctcttgcc ccactgtcct tttcgagaag ctgggcgtag gccgcctaga gctttttgtg
     1201 ctgcaccctc ctcctgggga ccctgcagcg cctgcctgtg ctctgctcgt gtggcagcca
     1261 gcggcgcctg gcgacaaggt tgtgcgtgta ctatttcctg gccgcacgcc gcccgcgcgc
     1321 ctgctggatg ggctacagcg cctgcagcac ctgccgtgcc tgcgcaggcc agtagttacc
     1381 acgcatgacc tggaagcgcc ctccagggcc aacagccaag acagtctggc ctcgcgggac
     1441 agtgcacgca aggagccagt ccgtggcact gttggcagca ttgccaacag gagtacagtg
     1501 cgaagggagc ctgccctggc cactcgtgac cagaagaagg acacaagatc tgggcccact
     1561 cagcctactg cccgagacac acgccgctcc gggcctggtg tggtcaacac aaagcctcgt
     1621 gtatcacaga atgggcctcg tgccccagtt ctggcagcgc cactcacagc tcctgtggct
     1681 gagtgccctg gagaagcgga gaacatcttg gagtctgagc ggccacctgc cccatcccca
     1741 actctgtccc cagctcagtc cccaccacct acagcacctg gtaatagccc tgagcgcctg
     1801 tcactcagcc ctctgcgccc agagcctgcc cctgatgcgt cgccctcagc cacgacgccc
     1861 acgctgacca cgccctcttt gcctgcggag ctgggctcac cccactcaac tgaggtggac
     1921 gagtcgctct ctgtgtcttt cgagcaagtc ctgccagcag gtgacccagg gcttagcctg
     1981 cccctgcgcc tcgcgcgccg ctccacgtct cctcatgatg tggacctgtg cctcgtgtca
     2041 ccctgtgagt tctctcatcg caagccaccc cctcctgcct ccccaggcag ctcggacagc
     2101 agtgctcggt cacaggagcg gccacctgag actccaccca cgtctgtgag cgagtcactg
     2161 cccacactat ctgactctga tcccgtgccc gtggcggatt ctgatgatga cgcaggcagc
     2221 gagagcgcgg ccagggaccc gccgcctaca cctcgtgtgc caccaccact gccagatgta
     2281 ccaggaatct gcatggtgga cccggaggcg ctaccgcctc gtgcccggca gcccctcaac
     2341 accaccaatc ccagccgtag ccgcaaggcc cctgcaaggc ctagctctgc ctctgccacc
     2401 cccagagctg caactgtagc tgccaagaca aagggccccg cgggggaccg gaaccggcca
     2461 ctcagcgccc gcagtgagcc tgcagacagg ccaggccgtg tgccccttac caggaagccc
     2521 tcagtcccta agaccgttcc caagatggcc tctgccacaa ggctctcctc cggacccagt
     2581 ggccgccctg caccgcttgc tgctggctcc cctgtatacc tggacctggc ctacctgcct
     2641 ggtggtggtg ccggtcacct ggaccagaac ttcttcctgc gtgtccgtgc actctgctat
     2701 gtcatcagtg ggcaaggcca gcgccaggaa gagggcctgc gagctgtgct ggatgcactg
     2761 ctggctggca agcggcagtg ggaccttgac ttgcaggtca cactgatccc caccttcgac
     2821 tctgcggtga tgcacaggtg gtatgaggag acgcatgcgc agcaccaggc actgggcatc
     2881 agggtgctgg gcagtggcag cctggtgtcc atgcaggacg aggccttccc cgcctgcaag
     2941 gtggagttct agccccacgc tgcagggcag cctgggaaca acagttcctc actgtgaccc
     3001 aggttggtgc tgtggctcca tgtgcaaagc tagatcccgt gcttaagtga gccaccgtgt
     3061 gacatcccag cttccatctc cagcactgag ggtgagaact gcgcgcttta tcacttgtcc
     3121 acgccccatc atgtgtcagg cacagctctc tatgccttct accctagaac tcaggttgca
     3181 gaggcaggag gatctatgca gagtccaggc cagcctgggc ttcatagtga atctttgttt
     3241 caaaaaccac aaaaaataaa gctgttggct gagaaaaaaa aaaa
//
