LOCUS       NM_026160               2455 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus microtubule-associated protein 1 light chain 3 beta
            (Map1lc3b), transcript variant 1, mRNA.
ACCESSION   NM_026160
VERSION     NM_026160.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2455)
  AUTHORS   Drazic Maras,E., Kelam,N., Racetin,A., Haque,E., Drazic,M.,
            Vukojevic,K., Katsuyama,Y., Saraga-Babic,M. and Filipovic,N.
  TITLE     Autophagy markers expression pattern in developing liver of the
            yotari (dab1-/-) mice and humans
  JOURNAL   Acta Histochem 127 (1), 152224 (2025)
   PUBMED   39647211
REFERENCE   2  (bases 1 to 2455)
  AUTHORS   Eibach,Y., Kreher,S., Poetsch,M.S., Kho,A.L., Gaertner,U.,
            Clemen,C.S., Schroder,R., Guo,K., Milting,H., Meder,B., Potente,M.,
            Richter,M., Schneider,A., Meiners,S., Gautel,M. and Braun,T.
  TITLE     The deubiquitinase USP5 prevents accumulation of protein aggregates
            in cardiomyocytes
  JOURNAL   Sci Adv 11 (4), eado3852 (2025)
   PUBMED   39841822
REFERENCE   3  (bases 1 to 2455)
  AUTHORS   Dong,M.Z., Ouyang,Y.C., Gao,S.C., Gu,L.J., Guo,J.N., Sun,S.M.,
            Wang,Z.B. and Sun,Q.Y.
  TITLE     Protein phosphatase 4 maintains the survival of primordial
            follicles by regulating autophagy in oocytes
  JOURNAL   Cell Death Dis 15 (9), 658 (2024)
   PUBMED   39245708
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2455)
  AUTHORS   Zhang,D., Deng,W., Jiang,T., Zhao,Y., Bai,D., Tian,Y., Kong,S.,
            Zhang,L., Wang,H., Gao,S. and Lu,Z.
  TITLE     Maternal Ezh1/2 deficiency impairs the function of mitochondria in
            mouse oocytes and early embryos
  JOURNAL   J Cell Physiol 239 (6), e31244 (2024)
   PUBMED   38529784
REFERENCE   5  (bases 1 to 2455)
  AUTHORS   Sakuma,C., Shizukuishi,S., Ogawa,M., Honjo,Y., Takeyama,H.,
            Guan,J.L., Weiser,J., Sasai,M., Yamamoto,M., Ohnishi,M. and
            Akeda,Y.
  TITLE     Individual Atg8 paralogs and a bacterial metabolite sequentially
            promote hierarchical CASM-xenophagy induction and transition
  JOURNAL   Cell Rep 43 (5), 114131 (2024)
   PUBMED   38656870
  REMARK    GeneRIF: Individual Atg8 paralogs and a bacterial metabolite
            sequentially promote hierarchical CASM-xenophagy induction and
            transition.
REFERENCE   6  (bases 1 to 2455)
  AUTHORS   Tanida,I., Ueno,T. and Kominami,E.
  TITLE     LC3 conjugation system in mammalian autophagy
  JOURNAL   Int J Biochem Cell Biol 36 (12), 2503-2518 (2004)
   PUBMED   15325588
  REMARK    Review article
REFERENCE   7  (bases 1 to 2455)
  AUTHORS   Nemoto,T., Tanida,I., Tanida-Miyake,E., Minematsu-Ikeguchi,N.,
            Yokota,M., Ohsumi,M., Ueno,T. and Kominami,E.
  TITLE     The mouse APG10 homologue, an E2-like enzyme for Apg12p
            conjugation, facilitates MAP-LC3 modification
  JOURNAL   J Biol Chem 278 (41), 39517-39526 (2003)
   PUBMED   12890687
REFERENCE   8  (bases 1 to 2455)
  AUTHORS   Gonzalez-Billault,C., Owen,R., Gordon-Weeks,P.R. and Avila,J.
  TITLE     Microtubule-associated protein 1B is involved in the initial stages
            of axonogenesis in peripheral nervous system cultured neurons
  JOURNAL   Brain Res 943 (1), 56-67 (2002)
   PUBMED   12088839
  REMARK    GeneRIF: MAP1B is involved in the initial stages of axonogenesis,
            as shown by reduced axon length and increased growth cone size of
            cultured dorsal root ganglion neurons from MAP1B deficient mice.
REFERENCE   9  (bases 1 to 2455)
  AUTHORS   Tanida,I., Tanida-Miyake,E., Nishitani,T., Komatsu,M., Yamazaki,H.,
            Ueno,T. and Kominami,E.
  TITLE     Murine Apg12p has a substrate preference for murine Apg7p over
            three Apg8p homologs
  JOURNAL   Biochem Biophys Res Commun 292 (1), 256-262 (2002)
   PUBMED   11890701
REFERENCE   10 (bases 1 to 2455)
  AUTHORS   Gonzalez-Billault,C., Demandt,E., Wandosell,F., Torres,M.,
            Bonaldo,P., Stoykova,A., Chowdhury,K., Gruss,P., Avila,J. and
            Sanchez,M.P.
  TITLE     Perinatal lethality of microtubule-associated protein 1B-deficient
            mice expressing alternative isoforms of the protein at low levels
  JOURNAL   Mol Cell Neurosci 16 (4), 408-421 (2000)
   PUBMED   11085878
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC182458.2.
            
            On Jun 14, 2018 this sequence version replaced NM_026160.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132329.1, BC068180.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               AC182458.2         184592-184718
            128-183             AC182458.2         187644-187699
            184-290             AC182458.2         190140-190246
            291-2455            AC182458.2         190750-192914
FEATURES             Location/Qualifiers
     source          1..2455
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 70.67 cM"
     gene            1..2455
                     /gene="Map1lc3b"
                     /gene_synonym="1010001C15Rik; Atg8; LC3b; MAP1A/MAP1B;
                     Map1lc3"
                     /note="microtubule-associated protein 1 light chain 3
                     beta"
                     /db_xref="GeneID:67443"
                     /db_xref="MGI:MGI:1914693"
     exon            1..127
                     /gene="Map1lc3b"
                     /gene_synonym="1010001C15Rik; Atg8; LC3b; MAP1A/MAP1B;
                     Map1lc3"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..465
                     /gene="Map1lc3b"
                     /gene_synonym="1010001C15Rik; Atg8; LC3b; MAP1A/MAP1B;
                     Map1lc3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     microtubule-associated proteins 1A/1B light chain 3B;
                     MAP1A/MAP1B light chain 3 B; autophagy-related protein LC3
                     B; MAP1 light chain 3-like protein 2; autophagy-related
                     ubiquitin-like modifier LC3 B"
                     /codon_start=1
                     /product="microtubule-associated protein 1 light chain 3
                     beta isoform 1"
                     /protein_id="NP_080436.1"
                     /db_xref="CCDS:CCDS22726.1"
                     /db_xref="GeneID:67443"
                     /db_xref="MGI:MGI:1914693"
                     /translation="MPSEKTFKQRRSFEQRVEDVRLIREQHPTKIPVIIERYKGEKQL
                     PVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESE
                     RDEDGFLYMVYASQETFGTAMAV"
     exon            128..183
                     /gene="Map1lc3b"
                     /gene_synonym="1010001C15Rik; Atg8; LC3b; MAP1A/MAP1B;
                     Map1lc3"
                     /inference="alignment:Splign:2.1.0"
     exon            184..290
                     /gene="Map1lc3b"
                     /gene_synonym="1010001C15Rik; Atg8; LC3b; MAP1A/MAP1B;
                     Map1lc3"
                     /inference="alignment:Splign:2.1.0"
     exon            291..2455
                     /gene="Map1lc3b"
                     /gene_synonym="1010001C15Rik; Atg8; LC3b; MAP1A/MAP1B;
                     Map1lc3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1721..1726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Map1lc3b"
                     /gene_synonym="1010001C15Rik; Atg8; LC3b; MAP1A/MAP1B;
                     Map1lc3"
                     /note="hexamer: AATAAA"
     polyA_site      1741
                     /gene="Map1lc3b"
                     /gene_synonym="1010001C15Rik; Atg8; LC3b; MAP1A/MAP1B;
                     Map1lc3"
                     /note="major polyA site"
     regulatory      2431..2436
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Map1lc3b"
                     /gene_synonym="1010001C15Rik; Atg8; LC3b; MAP1A/MAP1B;
                     Map1lc3"
                     /note="hexamer: ATTAAA"
     polyA_site      2454
                     /gene="Map1lc3b"
                     /gene_synonym="1010001C15Rik; Atg8; LC3b; MAP1A/MAP1B;
                     Map1lc3"
ORIGIN      
        1 cacctgactc ggctgcggac tgagacacac acaagggaag tgatcgtcgc cggagtcaga
       61 tcgtctggct cgggaccccc gcgcgccatg ccgtccgaga agaccttcaa gcagcgccgg
      121 agctttgaac aaagagtgga agatgtccgg ctcatccggg agcagcaccc caccaagatc
      181 ccagtgatta tagagcgata caagggggag aagcagctgc ccgtcctgga caagaccaag
      241 ttcctggtgc ctgaccacgt gaacatgagc gagctcatca agataatcag acggcgcttg
      301 cagctcaatg ctaaccaagc cttcttcctc ctggtgaatg ggcacagcat ggtgagtgtg
      361 tccactccca tctccgaagt gtacgagagt gagagagatg aagacggctt cctgtacatg
      421 gtttatgcct cgcaggagac attcgggaca gcaatggctg tgtaagactc caacaaagcc
      481 aatggttgtt aagcccttac caaggcaaaa agggatgtta ccagcggacg ctggacggct
      541 caccacccac agatgagaac gtaggcaccc acatagggta ttaggaactg ttcatcagcc
      601 agaaactgag ctccatgcaa gtgcactcag cttggaaact cgtctaaact aggctatttt
      661 gtgttcaaac tttagaagtt aaaaataaaa tactttttgc atcctaagtt gccaataaaa
      721 agatcaagtt attttgacat ttttctccct agtagggact taaaacagaa gagcagtgtc
      781 aggggcagtc tcttcctggg acctgctgcc ttctctaaaa gggctcccac tcagcagaga
      841 agcccctctg aaggcccagg ttgcctagca gaggccccca gagggccctg gctttgccct
      901 aagcaggtct ggtgttgtag gatatagctc taagccgggt cctggtcttg accccagcca
      961 caccctttca ctcagcagtg cagggacatg cagctcgctg ctgtctagat gttaccatac
     1021 gcccttctgc tgaggccagg tctccgcttg tccaggggtt gctgacccag cttaagcgac
     1081 tggagagctg tttctctcct ggtttgaatt ctgtctggtc catgcctgct tcagggagag
     1141 caagcgctgg ccttaggatg tggttgtcaa gtggtagact gcaagtccaa tgctccagac
     1201 ttggctcaca gctctttgtt ggtgtgtaac tgtctctgta agggtggttc tgacagctgt
     1261 tgggatttcc ccatttcatg tcagtacata catgtcagct gtgaggacaa cagcaacaga
     1321 agacatgctt ttgatagaca tgccacttca gctaaagcta gcctctgctt cctgcatgtg
     1381 gcccgctgtg acaccaggcc atccctggtc actcactcac tcgtggtctg aggatctcag
     1441 agctgcctgc tgtcatggac tgaagccagc atagccacct cccacctagc tccccacagg
     1501 cacccacctt ccctgcatgc agctgtcttt gctaaccctc aatgttattt tacactgtaa
     1561 attctcactg ctctgtcttg tgtaggttgt atacgtcatt atgtccctgg tttttataac
     1621 tatggtgcga tcagtaagga ttcctgtaat actgctttaa agatgctgct cagagggcgg
     1681 gcggcctcca ttataggaca cctgtacact ctgatgcact aataaaggca caacgaacct
     1741 gtcctgagtg atgtctcatt gtcatcgtgg gaactgggct ctgcagtata cccaggctgc
     1801 tcttgctggg gaggagagga gaggggaggg gcggtaacct cctttccttg gtcgatacct
     1861 tgccaccagc tcctgctttt aaactcaatc tctgactgac ctgccagcta tcaggtgccc
     1921 tctggtgcca tgggaacaca ccaaaagatt tactcatgtg gatagctgct ggcacttggg
     1981 aggacattgt aaccaacttc agcttagagc agacggcagg ctctgcaaag ctgctgcagt
     2041 ctcctcgggg cagcctggac actactctgg gtggcaggcg cctttggggt ccagcagtgt
     2101 tgtcagcagg tcctcatcct ggaagggcag ggcaagtgat agcctagagt cctatgtaac
     2161 aatgtttaaa gctgagaacc ttgacagcca cgaatgacaa aagatctgag aatggcccta
     2221 tgtggtggcg catgccttta gcctttaatc ccagcactcg ggaggcagag gcaggcggat
     2281 ttctgagttc gatcgaggcc agcctggtct acaaagtgag ttccaggaca gccagggcta
     2341 tacagagaaa ccgtcttacc ccccgccccc ccaaaaaatc tgagaatggt gaacatgttg
     2401 agtttttttt ttaattttta ttttccgtac attaaattta ctcataaaaa cagtc
//
