LOCUS       NM_008634              11852 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus microtubule-associated protein 1B (Map1b), mRNA.
ACCESSION   NM_008634
VERSION     NM_008634.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 11852)
  AUTHORS   Zhang,Y., Kunii,M., Taniguchi,M., Yoshimura,S.I. and Harada,A.
  TITLE     Rab6-Mediated Polarized Transport of Synaptic Vesicle Precursors Is
            Essential for the Establishment of Neuronal Polarity and Brain
            Formation
  JOURNAL   J Neurosci 44 (27), e2334232024 (2024)
   PUBMED   38830762
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11852)
  AUTHORS   Messaoudi,S., Allam,A., Stoufflet,J., Paillard,T., Le Ven,A.,
            Fouquet,C., Doulazmi,M., Trembleau,A. and Caille,I.
  TITLE     FMRP regulates postnatal neuronal migration via MAP1B
  JOURNAL   Elife 12, 88782 (2024)
   PUBMED   38757694
  REMARK    GeneRIF: FMRP regulates postnatal neuronal migration via MAP1B.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 11852)
  AUTHORS   Peng,L., Zhang,D., Tu,H., Wu,D., Xiang,S., Yang,W., Zhao,Y. and
            Yang,J.
  TITLE     The role of Map1b in regulating osteoblast polarity, proliferation,
            differentiation and migration
  JOURNAL   Bone 181, 117038 (2024)
   PUBMED   38316337
  REMARK    GeneRIF: The role of Map1b in regulating osteoblast polarity,
            proliferation, differentiation and migration.
REFERENCE   4  (bases 1 to 11852)
  AUTHORS   Guo,Y., Xiang,P., Sun,X., Liu,W., Zhou,J., Yin,B., Hou,L.,
            Qiang,B., Li,H., Shu,P. and Peng,X.
  TITLE     Docking protein 6 (DOK6) selectively docks the neurotrophic
            signaling transduction to restrain peripheral neuropathy
  JOURNAL   Signal Transduct Target Ther 9 (1), 32 (2024)
   PUBMED   38351062
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 11852)
  AUTHORS   Salamon,I., Park,Y., Miskic,T., Kopic,J., Matteson,P., Page,N.F.,
            Roque,A., McAuliffe,G.W., Favate,J., Garcia-Forn,M., Shah,P.,
            Judas,M., Millonig,J.H., Kostovic,I., De Rubeis,S., Hart,R.P.,
            Krsnik,Z. and Rasin,M.R.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 11852)
  AUTHORS   Edelmann,W., Zervas,M., Costello,P., Roback,L., Fischer,I.,
            Hammarback,J.A., Cowan,N., Davies,P., Wainer,B. and Kucherlapati,R.
  TITLE     Neuronal abnormalities in microtubule-associated protein 1B mutant
            mice
  JOURNAL   Proc Natl Acad Sci U S A 93 (3), 1270-1275 (1996)
   PUBMED   8577753
REFERENCE   7  (bases 1 to 11852)
  AUTHORS   O'Brien,E.P., Novak,E.K., Zhen,L., Manly,K.F., Stephenson,D. and
            Swank,R.T.
  TITLE     Molecular markers near two mouse chromosome 13 genes, muted and
            pearl, which cause platelet storage pool deficiency (SPD)
  JOURNAL   Mamm Genome 6 (1), 19-24 (1995)
   PUBMED   7719021
REFERENCE   8  (bases 1 to 11852)
  AUTHORS   Durkin,A.S., Nierman,W.C., Zoghbi,H., Jones,C., Kozak,C.A. and
            Maglott,D.R.
  TITLE     Chromosome assignment of human brain expressed sequence tags (ESTs)
            by analyzing fluorescently labeled PCR products from hybrid cell
            panels
  JOURNAL   Cytogenet Cell Genet 65 (1-2), 86-91 (1994)
   PUBMED   8404072
REFERENCE   9  (bases 1 to 11852)
  AUTHORS   Garner,C.C., Garner,A., Huber,G., Kozak,C. and Matus,A.
  TITLE     Molecular cloning of microtubule-associated protein 1 (MAP1A) and
            microtubule-associated protein 5 (MAP1B): identification of
            distinct genes and their differential expression in developing
            brain
  JOURNAL   J Neurochem 55 (1), 146-154 (1990)
   PUBMED   2355215
REFERENCE   10 (bases 1 to 11852)
  AUTHORS   Noble,M., Lewis,S.A. and Cowan,N.J.
  TITLE     The microtubule binding domain of microtubule-associated protein
            MAP1B contains a repeated sequence motif unrelated to that of MAP2
            and tau
  JOURNAL   J Cell Biol 109 (6 Pt 2), 3367-3376 (1989)
   PUBMED   2480963
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY003859.1, BC037105.1, AC170188.2 and AK148870.1.
            
            On Apr 1, 2008 this sequence version replaced NM_008634.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X51396.1, SRR1660817.228093.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-377               BY003859.1         1-377
            378-2179            BC037105.1         323-2124
            2180-7112           AC170188.2         40515-45447         c
            7113-7682           AK148870.1         578-1147
            7683-11852          AC170188.2         32764-36933         c
FEATURES             Location/Qualifiers
     source          1..11852
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 52.9 cM"
     gene            1..11852
                     /gene="Map1b"
                     /gene_synonym="A230055D22; LC1; MAP5; Mtap-5; Mtap1b;
                     Mtap5"
                     /note="microtubule-associated protein 1B"
                     /db_xref="GeneID:17755"
                     /db_xref="MGI:MGI:1306778"
     exon            1..299
                     /gene="Map1b"
                     /gene_synonym="A230055D22; LC1; MAP5; Mtap-5; Mtap1b;
                     Mtap5"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..7510
                     /gene="Map1b"
                     /gene_synonym="A230055D22; LC1; MAP5; Mtap-5; Mtap1b;
                     Mtap5"
                     /note="MAP-1B; MAP1.2; MAP1(X); microtubule-associated
                     protein 5; Microtubule-associated protein 1B (MAP 1B)
                     (MAP1.2) (MAP1(X))"
                     /codon_start=1
                     /product="microtubule-associated protein 1B"
                     /protein_id="NP_032660.2"
                     /db_xref="CCDS:CCDS26723.1"
                     /db_xref="GeneID:17755"
                     /db_xref="MGI:MGI:1306778"
                     /translation="MATVVVEATEPEPSGSIGNPAASTSPSLSHRFLDSKFYLLVVVG
                     ETVTEEHLRRAIGNIELGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVPGQKILHH
                     RSDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQ
                     NFIEIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSAS
                     ILPEMEGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFA
                     VNGFNMLINGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEE
                     RSQGSTSNSDWMKNLISPDLGVVFLNVPENLKDPEPNIKMKRSIEEACFTLQYLNKLS
                     MKPEPLFRSVGNTIEPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQWTGTNKDKAE
                     LILPNGQEVDIPISYLTSVSSLIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHL
                     DFLKQPLATQKDLTGQVPTPPVKQVKLKQRADSRESLKPATKPVASKSVRKESKEETP
                     EVTKTSQVEKTPKVESKEKVLVKKDKPVKTESKPSVTEKEVSSKEEQSPVKAEVAEKQ
                     ATESKPKVTKDKVVKKEIKTKLEEKKEEKPKKEVVKKEDKTPLKKDEKPRKEEVKKEI
                     KKEIKKEERKELKKEVKKETPLKDAKKEVKKEEKKEVKKEEKEPKKEIKKISKDIKKS
                     TPLSDTKKPSALKPKVAKKEESTKKEPLAAGKLKDKGKVKVIKKEGKTTEAAATAVGT
                     AATTAAVVAAAGIAASGPVKELEAERSLMSSPEDLTKDFEELKAEEIDVAKDIKPQLE
                     LIEDEEKLKETQPGEAYVIQKETEVSKGSAESPDEGITTTEGEGECEQTPEELEPVEK
                     QGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEDNASGSASKHSPTEDD
                     ESAKAEADVHLKEKRESVVSGDDRAEEDMDDVLEKGEAEQSEEEGEEEDKAEDAREEG
                     YEPDKTEAEDYVMAVADKAAEAGVTEEQYGYLGTSAKQPGIQSPSREPASSIHDETLP
                     GGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPMDEMSTPRDVMSDETNN
                     EETESPSQEFVNITKYESSLYSQEYSKPAVASFNGLSEGSKTDATDGKDYNASASTIS
                     PPSSMEEDKFSKSALRDAYCSEEKELKASAELDIKDVSDERLSPAKSPSLSPSPPSPI
                     EKTPLGERSVNFSLTPNEIKVSAEGEARSVSPGVTQAVVEEHCASPEEKTLEVVSPSQ
                     SVTGSAGHTPYYQSPTDEKSSHLPTEVTEKPQAVPVSFEFSEAKDENERASLSPMDEP
                     VPDSESPVEKVLSPLRSPPLLGSESPYEDFLSADSKVLGRRSESPFEGKNGKQGFPDR
                     ESPVSDLTSTGLYQDKQEEKSTGFIPIKEDFGPEKKTSDVETMSSQSALALDERKLGG
                     DVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAEDTYSHMEGVASVSTAS
                     VATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTFQETEMSPSKEECP
                     RPMSISPPDFSPKTAKSRTPVQDHRSEQSSMSIEFGQESPEHSLAMDFSRQSPDHPTL
                     GASVLHITENGPTEVDYSPSDIQDSSLSHKIPPTEEPSYTQDNDLSELISVSQVEASP
                     STSSAHTPSQIASPLQEDTLSDVVPPREMSLYASLASEKVQSLEGEKLSPKSDISPLT
                     PRESSPLYSPGFSDSTSAAKETAAAHQASSSPPIDAATAEPYGFRSSMLFDTMQHHLA
                     LNRDLTTSSVEKDSGGKTPGDFNYAYQKPENAAGSPDEEDYDYESQEKTIRTHDVGGY
                     YYEKTERTIKSPCDSGYSYETIEKTIKTPEDGGYTCEITEKTTRTPEEGGYSYEISEK
                     TTRTPEVSGYTYEKTERSRRLLDDISNGYDDTEDGGHTLGDCSYSYETTEKITSFPES
                     ESYSYETSTKTTRSPDTSAYCYETMEKITKTPQASTYSYETSDRCYTTEKKSPSEARQ
                     DVDLCLVSSCEFKHPKTELSPSFINPNPLEWFAGEEPTEESEKPLTQSGGAPPPSGGK
                     QQGRQCDETPPTSVSESAPSQTDSDVPPETEECPSITADANIDSEDESETIPTDKTVT
                     YKHMDPPPAPMQDRSPSPRHPDVSMVDPDALAVDQNLGKALKKDLKEKTKTKKPGTKT
                     KSSSPVKKGDGKSKPLAASPKPGALKESSDKVSRVASPKKKESVEKATKTTTTPEVKA
                     TRGEEKDKETKNAANASASKSAKTATAGPGTTKTAKSSTVPPGLPVYLDLCYIPNHSN
                     SKNVDVEFFKRVRSSYYVVSGNDPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDS
                     EVMREWYQETHEKQQDLNIMVLASSSTVVMQDESFPACKIEL"
     exon            300..401
                     /gene="Map1b"
                     /gene_synonym="A230055D22; LC1; MAP5; Mtap-5; Mtap1b;
                     Mtap5"
                     /inference="alignment:Splign:2.1.0"
     exon            402..484
                     /gene="Map1b"
                     /gene_synonym="A230055D22; LC1; MAP5; Mtap-5; Mtap1b;
                     Mtap5"
                     /inference="alignment:Splign:2.1.0"
     exon            485..625
                     /gene="Map1b"
                     /gene_synonym="A230055D22; LC1; MAP5; Mtap-5; Mtap1b;
                     Mtap5"
                     /inference="alignment:Splign:2.1.0"
     exon            626..7115
                     /gene="Map1b"
                     /gene_synonym="A230055D22; LC1; MAP5; Mtap-5; Mtap1b;
                     Mtap5"
                     /inference="alignment:Splign:2.1.0"
     exon            7116..7354
                     /gene="Map1b"
                     /gene_synonym="A230055D22; LC1; MAP5; Mtap-5; Mtap1b;
                     Mtap5"
                     /inference="alignment:Splign:2.1.0"
     exon            7355..11852
                     /gene="Map1b"
                     /gene_synonym="A230055D22; LC1; MAP5; Mtap-5; Mtap1b;
                     Mtap5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7716..7721
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Map1b"
                     /gene_synonym="A230055D22; LC1; MAP5; Mtap-5; Mtap1b;
                     Mtap5"
                     /note="hexamer: AATAGA"
     polyA_site      7739
                     /gene="Map1b"
                     /gene_synonym="A230055D22; LC1; MAP5; Mtap-5; Mtap1b;
                     Mtap5"
                     /note="major polyA site"
     polyA_site      11805
                     /gene="Map1b"
                     /gene_synonym="A230055D22; LC1; MAP5; Mtap-5; Mtap1b;
                     Mtap5"
                     /note="major polyA site"
     regulatory      11831..11836
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Map1b"
                     /gene_synonym="A230055D22; LC1; MAP5; Mtap-5; Mtap1b;
                     Mtap5"
                     /note="hexamer: AATACA"
     polyA_site      11852
                     /gene="Map1b"
                     /gene_synonym="A230055D22; LC1; MAP5; Mtap-5; Mtap1b;
                     Mtap5"
                     /note="major polyA site"
ORIGIN      
        1 ggacgcaggg ggcggagcgg agacagcacc ttcggagata atcctttctc ctgccgcaga
       61 gcagaggagc ggcgggagag gaacacttct ctcaggcttg agcagagccg gcaggatggc
      121 gaccgtggtg gtggaagcca ccgaaccgga gccatcgggc agcatcggca acccggcggc
      181 gtccacctcg cccagcctgt cgcaccgctt cctagacagc aagttctact tgctggtggt
      241 ggtcggcgag accgtaaccg aagagcacct gaggcgtgcc atcggcaaca tcgagctggg
      301 gatccgatcg tgggacacaa acctgattga gtgcaacttg gaccaggaac tcaaactttt
      361 cgtatctcga cactctgcaa gattctctcc tgaagttcca ggacaaaaga ttcttcatca
      421 ccgaagtgac gtcttagaaa cagtcgttct gatcaaccct tcagatgaag ccgtcagcac
      481 tgaggtgcgt ttgatgatca ctgacgctgc ccgccataaa ctgctggtgc tcaccggaca
      541 gtgctttgag aacactggcg agctcatcct gcagtctggc tctttctcct tccagaactt
      601 catagagatt ttcacagatc aagagattgg tgagctccta agcaccaccc accctgccaa
      661 caaagccagc ctcaccctct tctgtcccga ggagggagac tggaagaact ccaaccttga
      721 cagacacaat ctccaagact tcatcaacat taagctcaac tcagcttcta tcttgccaga
      781 aatggaggga ctttctgagt tcaccgagta tctctcagag tctgtagaag tcccctctcc
      841 ctttgacatc ctggaacccc caacctcggg cggctttctg aagctctcca agccttgctg
      901 ttacattttc ccagggggcc gtggggactc ggccctgttt gcagtgaacg gattcaacat
      961 gctcatcaac ggaggatcag agagaaagtc ttgcttctgg aagctcatcc ggcacttgga
     1021 ccgtgtggac tccatcctgc tcacccacat tggggatgac aatttgcctg ggatcaatag
     1081 catgctgcag cgcaagattg cagagctgga agaggagcgg tcccaggggt ccaccagcaa
     1141 cagtgactgg atgaaaaacc tcatctcccc tgacctgggg gttgtgtttc tcaacgtacc
     1201 tgaaaacctg aaagacccag aacccaacat caagatgaag agaagcatag aagaagcatg
     1261 cttcactctc cagtacttaa acaaactgtc catgaaacca gagcctctat ttagaagtgt
     1321 aggcaatacc attgagcctg tcatcctgtt ccagaagatg ggagtgggca agcttgagat
     1381 gtacgtgctt aacccagtca aaagcagcaa ggaaatgcag tattttatgc aacagtggac
     1441 tggcaccaac aaagacaagg ccgaactaat cctgcccaat ggtcaagaag tagacatccc
     1501 gatttcctac ttaacctcag tctcatcttt gattgtgtgg catccggcca accccgctga
     1561 gaaaatcatt cgggttctgt ttcccggaaa cagtacccag tacaacatcc tagaaggact
     1621 ggagaaactc aaacatctag atttcctaaa gcagccactg gccacccaaa aagatctcac
     1681 tggccaggtg cccacccccc cagtgaaaca ggtcaaactg aaacagcggg ctgacagccg
     1741 agagagtctg aagccagcca cgaaaccagt tgccagtaaa tctgtgagga aggagtccaa
     1801 ggaggaaacc cctgaagtca caaagactag tcaagtggag aaaacaccca aagttgaaag
     1861 caaagagaaa gtgttagtga aaaaagacaa gcctgtaaag acagaaagta aaccttcagt
     1921 gacagaaaag gaggtgtcca gcaaggaaga gcagtcccca gtgaaagccg aggtcgctga
     1981 gaagcaagcc actgagagca aacccaaagt caccaaggac aaagtggtaa aaaaggaaat
     2041 aaagacaaaa ctcgaggaaa agaaagagga gaagcccaag aaagaagtgg ttaagaagga
     2101 agacaaaaca cccctcaaga aagacgagaa gccaagaaag gaagaggtga agaaggagat
     2161 caagaaagaa atcaaaaaag aagagagaaa ggagctgaag aaagaggtga agaaggaaac
     2221 acccctgaag gatgccaaga aggaggtgaa gaaagaggag aagaaagaag ttaaaaagga
     2281 agagaaggaa cccaaaaagg aaatcaagaa gatctccaag gacataaaga aatcaactcc
     2341 tctgtcagac acaaagaagc catctgcgtt aaaaccaaaa gtagcgaaga aagaagagtc
     2401 cactaagaag gagcctcttg ctgctgggaa actcaaggac aaggggaaag tcaaagtcat
     2461 taaaaaggaa ggcaagacca cagaagcagc tgccacagct gttggcactg ctgccaccac
     2521 agctgccgtg gtggctgcag ctggaatagc ggccagtggt cctgtcaaag aactggaagc
     2581 tgagaggtcc cttatgtcct cccctgagga tctaaccaag gactttgagg agctaaaggc
     2641 tgaggagatt gatgtggcca aggacatcaa gcctcagctg gagctcattg aagatgaaga
     2701 gaaactgaag gaaacccagc cgggagaagc ctacgtcatc cagaaagaga cggaagtcag
     2761 caaaggttcc gctgagtcac ccgatgaggg aatcaccacc accgaggggg agggcgagtg
     2821 tgagcaaacc cctgaggagc tggagccagt tgagaagcag ggcgtggatg acattgagaa
     2881 gtttgaagat gaaggagctg gttttgaaga atcctcagag accggagact acgaagagaa
     2941 ggcggaaact gaggaggctg aggaaccgga agaggacggg gaagacaatg cgagcgggag
     3001 tgcctctaag cacagcccca cagaagatga cgaaagcgca aaggctgagg cggacgtgca
     3061 cctcaaggag aagagggagt ctgtggtcag tggtgacgac cgggcggaag aagacatgga
     3121 tgatgtgctt gagaaaggag aagctgaaca gtctgaggaa gagggcgaag aggaggacaa
     3181 agcagaggat gccagagagg aaggctatga gcccgacaaa actgaggctg aggattatgt
     3241 gatggccgtg gctgacaagg cggctgaggc tggagtcaca gaggagcagt acggatacct
     3301 gggcacgtcg gccaagcaac ctggaatcca gtctcctagc cgagaacctg catcttcaat
     3361 tcatgatgag accctacctg gaggctctga gagcgaggcc actgcttcgg atgaggagaa
     3421 tcgggaagac cagcctgagg aattcactgc tacctctgga tatactcagt ctaccattga
     3481 gatatctagt gagcctacgc caatggatga gatgtctact cctcgtgatg tgatgagcga
     3541 cgagaccaac aacgaggaga cagagtcccc atctcaggag ttcgtaaaca ttaccaaata
     3601 tgagtcctcg ctgtattctc aggagtactc caaacctgct gttgcatcat tcaatggatt
     3661 gtcagaaggg tcaaaaacag acgccactga tggtaaggat tacaacgctt ccgcctccac
     3721 catatcacca ccttcgtcca tggaagaaga caaattcagc aagtctgctc ttcgtgatgc
     3781 ttactgctca gaagagaaag agttgaaagc cagtgccgag ttagacatca aagatgtttc
     3841 agatgagaga cttagcccag ccaagagtcc atccctgagt ccttctccgc catcccccat
     3901 agagaagact cccctgggtg aacgtagcgt gaatttctct ctgacaccca atgagattaa
     3961 agtgtcagca gagggagaag caaggtcagt gtcccctgga gtgacccagg cagtagttga
     4021 agaacattgt gccagtcctg aggagaagac cctggaagta gtgtcgccat cccagtctgt
     4081 gacaggcagt gctggccaca caccttacta ccaatctccc accgatgaga agtccagtca
     4141 cctacccaca gaagtcactg aaaagccaca ggcagttcca gtgagctttg aattcagtga
     4201 ggccaaagat gagaacgaga gagcgtccct aagccccatg gatgagcctg tgcctgactc
     4261 agagtctcct gtggagaagg ttctgtctcc tttacgcagt cctccccttc ttggatctga
     4321 gtccccatat gaagacttcc tgagtgctga tagcaaggtt cttggcagac gttccgaaag
     4381 cccctttgaa gggaagaatg gaaagcaggg cttcccagac agagaaagcc cagtttctga
     4441 cctgacttcc actggtcttt accaagacaa acaggaagag aaaagcacgg gcttcatacc
     4501 cataaaggaa gactttggtc cagaaaagaa aaccagtgat gttgaaacca tgagttctca
     4561 atcagctcta gctttggatg aaaggaaatt gggaggagat gtatctccaa cacaaataga
     4621 cgtcagtcag tttggctctt tcaaagaaga caccaagatg tccatttcag aaggcactgt
     4681 ttcagacaag tcagccacac ctgtggatga gggtgtggca gaagacacct actcccacat
     4741 ggagggtgtg gcctccgtct ctactgcctc tgtggctaca agttcgtttc cagagccaac
     4801 cacagatgac gtgtctcctt ctctgcatgc cgaggtgggt tctccacatt ccacagaagt
     4861 tgatgactcc ctgtccgttt ctgtggtgca aacacctacc acgttccagg aaacagaaat
     4921 gtctccatct aaagaagagt gcccaagacc gatgtcaatt tctcctccag acttctcccc
     4981 caagacagcc aaatccagga caccagttca agatcaccga tctgaacagt cttctatgtc
     5041 tattgagttc ggccaggaat cccctgagca ttctcttgct atggacttta gtcggcagtc
     5101 tccagatcac cctactctgg gtgccagtgt gcttcatatc actgaaaacg ggccaactga
     5161 agtggactat agtccctctg atatccagga ctctagtttg tcgcataaga tcccgccaac
     5221 ggaagagcca tcctacaccc aggataatga tctgtctgag ctcatctctg tgtctcaggt
     5281 agaggcttcc ccgtccacct cttcagctca caccccttct cagatagcct ctcctcttca
     5341 ggaagacact ctctctgatg ttgttcctcc cagagagatg tccttatatg cctcacttgc
     5401 gtctgaaaaa gtgcagagcc tggaaggaga gaagctctct ccgaaatctg atatttctcc
     5461 actcacccca cgagagtcct cacctttata ttcacctggc ttttcagatt ctacctctgc
     5521 agctaaagag actgcagcag ctcaccaagc ctcctcttcc ccaccaatag atgcagcaac
     5581 agcagagccc tatggcttcc gctcctcaat gctatttgat acaatgcaac atcatctggc
     5641 cttgaataga gatttgacta catctagtgt ggagaaagac agcggaggga agacacccgg
     5701 agactttaac tatgcctatc aaaagcctga gaatgccgcc ggatctccag atgaagaaga
     5761 ttatgactat gaatctcaag agaaaaccat ccggacccac gacgtgggtg gttactacta
     5821 tgagaagaca gagagaacca taaaatcccc atgtgacagt gggtactcct atgagaccat
     5881 tgagaagacc atcaagaccc cagaagatgg tggctacacc tgtgaaatta ccgagaaaac
     5941 cactcggacc ccagaagagg gtggctattc atatgagatc agcgagaaga cgacacggac
     6001 ccctgaagta agcggctaca cctatgaaaa gactgagagg tccagaaggc tcctggatga
     6061 cattagcaat ggctatgatg acactgagga tggcggccac acacttggcg actgtagcta
     6121 ctcctatgaa accactgaga aaattaccag ctttcctgag tctgaaagct attcctacga
     6181 gacaagtaca aaaacaacac ggagtccaga cacctctgca tactgttacg agaccatgga
     6241 gaagatcacc aagaccccac aggcatccac atactcctat gagacctcag accgatgcta
     6301 cactacggaa aagaagtccc cctcagaggc acgccaggat gttgatttat gtctggtgtc
     6361 ctcctgtgaa ttcaagcatc ccaagacgga gctctcgcct tccttcatta atccaaatcc
     6421 tcttgagtgg tttgctggtg aagagcccac tgaagaatca gagaagcccc tcactcagtc
     6481 tggaggagcc cccccacctt caggaggaaa acaacagggc aggcaatgcg atgaaacgcc
     6541 acccacctca gtcagtgagt cagccccatc ccagacagac tctgatgttc ccccagagac
     6601 ggaagagtgc ccctccatca cagccgacgc caatattgac tctgaagatg agtcagaaac
     6661 tatccccaca gacaaaaccg tcacatacaa acacatggac ccacctccag cccccatgca
     6721 agaccgaagc ccttctcctc gccaccccga cgtgtccatg gtggacccag acgccttggc
     6781 cgttgatcag aacctaggca aggctctgaa aaaagacctg aaggagaaga ccaagaccaa
     6841 gaagccaggc acaaagacca agtcctcttc acctgtcaaa aagggtgatg ggaagtccaa
     6901 gcctttagca gcttccccca aaccaggagc tttgaaggaa tcctccgaca aggtgtccag
     6961 agtggcttct cccaagaaga aagaatccgt ggaaaaagct acaaagacca ccaccactcc
     7021 tgaggtcaaa gccacacgcg gagaagagaa ggacaaggag accaagaacg cagctaacgc
     7081 ctctgcatcc aaatcagcga agaccgcaac ggcaggacca ggaaccacta agacagccaa
     7141 gtcgtccacc gtgcctccag gcctccctgt gtatttggac ctgtgctata ttcccaacca
     7201 cagcaacagt aagaatgtcg atgttgagtt cttcaagaga gtgaggtcat cttactacgt
     7261 ggtgagtggg aacgaccctg ccgcggagga gcccagccgg gctgtcctgg atgccttgtt
     7321 ggaagggaag gctcagtggg gaagcaacat gcaggtgact ctgattccga cacatgactc
     7381 cgaggtgatg agggagtggt accaggagac ccacgagaag cagcaggacc tcaacatcat
     7441 ggtcttagca agcagcagta cagtggtcat gcaagacgag tccttccccg catgcaagat
     7501 agaactgtag agaccgcagc cggccacacc acaggatttg aactgtgttt ccagaaattc
     7561 ttgaatttga aactaccttt tctaaaacgt ccattcatcc aattaagtca ctgaacagtt
     7621 attacctgcc agatgctata ctatgtcatg gtgatgcaag tcactgatag ttctcaattt
     7681 ttgctgactg ctaagggaag taaccatatt cccacaatag atttcgagtt actgcaaaat
     7741 tgcctacccc cgttcatctc tgctgaacat tcggaagcca tgcactcacg cacccaactg
     7801 acttctgcta ggtattggca tttatcatag agagagaaag agagggaaag agagtcagcg
     7861 ggaggggagg gagagaggcg ggagagaggg acaaagagac tgcaggagag agagagagag
     7921 tgagagggga agaatcagaa agaaaaagaa tgcaagagac aaaggtagag agttctgatg
     7981 agatgcccag ggagagagag tgggcaagat ggggtataga gaagacacca gcaaccaggt
     8041 ctgcattttc tcagaccaca gctattctgt ggtctacaca ggtggagttt cccattttca
     8101 tcagagtcat cagaaagagt cttattctcc taaagcgtgt ttctaaagaa caaaaagaat
     8161 gaagcctgtt acgagggcat gagctttttc acgccttaat tcaatgcctt tgctattata
     8221 aaggctgcac acggcataat gtagcaagtg tagactggat gagtgagtgg tttgcgcccc
     8281 attcagaact ctcagacttt tcgaacacgt gagtaggttg atctaaggca tgctcccagc
     8341 atttgtctac ccaagtccac accaagtcaa gctgcatgca gcaacaccca agtccacccc
     8401 ggttaactga agcaaatacc aaagcaggtg ggagtacaca tgggagacat tttgccttag
     8461 gaagtgactt gaatgtacaa agacacctga tgcacttatt ttttaatgtg agacagcaag
     8521 tttttaaacc atccatgtag gattgtagat actccaggga aaggagcgtg tggggaggga
     8581 aggtaccaga agctcatctg attggcccaa cggtttagtg cagagtcatg cttggtgaac
     8641 atcaccactt ctgatgtacc cgtggccact caaccaaatc cgttgcacct ttcgtagctt
     8701 ctttaattct tcaagttcaa gaccggaatg gcttctttga tcagaaccag gaaaacagtg
     8761 aatcttatgg tggaagagct ctcagcaagt gtacagcatc tgccttcctt tgtcttgcat
     8821 tggctatttt aattttccat taatttcaac acatgggaac acatgtacag aagatttttt
     8881 tttttttttt tttttttttt agctactcga gaacttttca tagatgaact ttttaacaaa
     8941 tgttttcatt tacaggaaaa cgcaaagaaa attttgaaac gatggtcttt ctttttaatt
     9001 attattttaa gtgttttttg taagacaaaa attgaagttt ttttaaggtt ctggcaagat
     9061 ttgaagtctg atattgaagt catgatattt atttttaaaa acctgtcact accagaaacg
     9121 gtggtacctc ctgccctttg actctcatac cgtgaaagtt gagtccgtgc tgtttgagag
     9181 tgggtaggtg gcggggtagg ctactgtccg gggcatcacc cagtgctatc ccctcctcct
     9241 ttcaagatta ttcaccatga ggtaaaagag ccaagttcag aagtacccta gcacccagtt
     9301 tgcttgggtt ggttttttgt ttttgttttt cctggaaaac attcagtgag agaagtaata
     9361 gattgaaaac aaatgaattc tcaacttcta tgttgaccat gtagagagtt cagacataat
     9421 gtctgtcgat gtcatcactg aaccacagac ttgcgccgcc agatcgcgag gaaaactgtc
     9481 gccaagtttc aagtggcaga ttcacgtccc agggttcaga ggtggcaaac ttctcagtgg
     9541 cagctgtgct cggtcatgct acgtttcctg cagactctta agatctacgg ggtagtgaac
     9601 aatgacctca ttttattttc tatgttagtt atttatttca aaatttacat tttagtttat
     9661 tttcgtctgt aaagcgtatg tttcgcactg ctcttttact ctgagggttt aaacaatatt
     9721 tctccagggg tttcctcact gagaacccat gcagtctact taatgctgtg aatcacattt
     9781 tccaaatgtt taatttttta aagaaaatta atattctatt tttgttaggt gtctctagga
     9841 atgcagcttt tttatttatt atcctgtttc tttcaaaacc cgtaacagtg acacgttaaa
     9901 ggtacaaaac tgtcctatct gatggaaaag tcatcctgat gaaaacagag ttcgttgcct
     9961 gtaagcccac ttgcttctca cttcatcaga caagctcaat acacacaaga tagtaattta
    10021 atgggagctg ttaggctggt ccacacgtga agagaaacaa tttctagcct tcttgccaaa
    10081 tccagacctc tggttgactt ttctttcata gaagatggag ttatcttcca gttttccaac
    10141 ttaaatttat ttagccttta tattattttg ttttaatata tatatataaa taccttagaa
    10201 gagccatagc cagccttcag ttataaccac tcgaccccca tacctcttat tgtttctaca
    10261 gaatctaatg gggaaaaatg cttcacaaaa ctgtcactga tccattggct ctgattccta
    10321 cacaatctgg caggcaccct cctgcacccc tgtcctcagt gatggccacg gagccgagcc
    10381 gaggacacca gggtgaagta catttgcttt acaaggggct cctgacctcc caggcacctc
    10441 tcctacctgt gtggctaatc tgatcttgct agttccatac atacacaatt agtttagagg
    10501 tagccaccac aatgggaccg tgtacatttg tggtgaaagc taaaaaccga cacagacttc
    10561 tagaagattt gtgcatacga ttcttaatcc aattgtatag attgaatatt tgagtggaag
    10621 gcatttccac cctgtttaaa tgatggaatt ctattgagct agcactcctg atcatgacct
    10681 ttttagtagt atttgtaaac aaaattctac agagactaaa tcttagcgat aatcctccat
    10741 ttcaatttta accaattctg tcctcttttt ccaaaccccg aaccccatgc atgctttctc
    10801 agtcttgtga tgggactgga cacagtgacc gacccctcgc ccaaacacca ttttccatgg
    10861 aattcaaaag aaaatttttt tcccttaacg ttacatatca tagtgaatgg tttccccagt
    10921 gtatatgaat gttttaagtg tttccaatag cttatgaaat ttaggagctt tctaatactc
    10981 gttttataaa tttaatcatt tgctaatgga aattttacca cctcccactt ctgttacaaa
    11041 tcttagctcc cggagcggcg ctacaattcc agagttgttc tgctcacccc cctctgtcat
    11101 ttgtcacagg aggtccctgc ttggcaatga catttgtgag ttaggataat gactttcctt
    11161 ctcttctttt tttcctttcg tacttaagat ttaggagaaa aagattctgt ttccacctga
    11221 gaggaactgt aagcttttat catttaacca gctgaacacc acaccaaaag cagcctacgg
    11281 atgagcaccg ctttggtagc aattaggttt tattcacctg gtattaaaac tattcactat
    11341 ttcaaaacaa aaacaaaaac cgagacttta tgaattcatt tcaaggcagc atcaaaaaac
    11401 tgaaaaggaa ggaaaacaac aacagctaat aatcggcttc tccgcacgtg tggagctccg
    11461 gagaaacagg cgccccggag aagtggctct gctcagccgc ccgcccacgc cgcgccgccg
    11521 gtccttgctt tcccgcatgc gcccgcccgc ggcaacgtgc agtcctacgt ccggctgcgg
    11581 agaagtccac tctctctctt gttatgaatg gtgtttgtgt cggtctgcag ctgtgtatgg
    11641 tattatgtct tataatcctg catcacttcc atcctatcca gtcatatcta atgtagaaaa
    11701 attagtttcc agtgaaagta atatgtagtg cttttatgat atttgtgtgc aatatcccct
    11761 cttctatcaa ggatatttga tgtaaaggaa aaacaaacaa acaaacaaca gaaactcagt
    11821 tccacaataa aatacaaagt ggcaaaagtt ca
//
