LOCUS       NM_032393              11837 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus microtubule-associated protein 1 A (Map1a), transcript
            variant 1, mRNA.
ACCESSION   NM_032393 XM_194040 XM_925297 XM_925300 XM_925308
VERSION     NM_032393.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 11837)
  AUTHORS   Cai,B., Shao,N., Ye,T., Zhou,P., Si,W., Song,H., Wang,G. and Kou,J.
  TITLE     Phosphorylation of MAP 1A regulates hyperphosphorylation of Tau in
            Alzheimer's disease model
  JOURNAL   Neuropathol Appl Neurobiol 49 (5), e12934 (2023)
   PUBMED   37705167
  REMARK    GeneRIF: Phosphorylation of MAP 1A regulates hyperphosphorylation
            of Tau in Alzheimer's disease model.
REFERENCE   2  (bases 1 to 11837)
  AUTHORS   Youn,S.Y., Min,H., Jeong,S.R., Lee,J., Moon,S.J., Bok,J. and
            Kim,C.H.
  TITLE     Microtubule-associated protein 1 A and tubby act independently in
            regulating the localization of stereocilin to the tips of inner ear
            hair cell stereocilia
  JOURNAL   Mol Brain 15 (1), 80 (2022)
   PUBMED   36104704
  REMARK    GeneRIF: Microtubule-associated protein 1 A and tubby act
            independently in regulating the localization of stereocilin to the
            tips of inner ear hair cell stereocilia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 11837)
  AUTHORS   Argent,L., Winter,F., Prickett,I., Carrasquero-Ordaz,M.,
            Olsen,A.L., Kramer,H., Lancaster,E. and Becker,E.B.E.
  TITLE     Caspr2 interacts with type 1 inositol 1,4,5-trisphosphate receptor
            in the developing cerebellum and regulates Purkinje cell morphology
  JOURNAL   J Biol Chem 295 (36), 12716-12726 (2020)
   PUBMED   32675284
REFERENCE   4  (bases 1 to 11837)
  AUTHORS   Xia,Y., Shang,Y., Zhang,R. and Zhu,J.
  TITLE     Structure of the PSD-95/MAP1A complex reveals a unique target
            recognition mode of the MAGUK GK domain
  JOURNAL   Biochem J 474 (16), 2817-2828 (2017)
   PUBMED   28701415
  REMARK    GeneRIF: Structure of the PSD-95/MAP1A complex reveals a unique
            target recognition mode of the MAGUK GK domain.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 11837)
  AUTHORS   Zheng,M., Jiao,L., Tang,X., Xiang,X., Wan,X., Yan,Y., Li,X.,
            Zhang,G., Li,Y., Jiang,B., Cai,H. and Lin,X.
  TITLE     Tau haploinsufficiency causes prenatal loss of dopaminergic neurons
            in the ventral tegmental area and reduction of transcription factor
            orthodenticle homeobox 2 expression
  JOURNAL   FASEB J 31 (8), 3349-3358 (2017)
   PUBMED   28424350
REFERENCE   6  (bases 1 to 11837)
  AUTHORS   Edelmann,W., Zervas,M., Costello,P., Roback,L., Fischer,I.,
            Hammarback,J.A., Cowan,N., Davies,P., Wainer,B. and Kucherlapati,R.
  TITLE     Neuronal abnormalities in microtubule-associated protein 1B mutant
            mice
  JOURNAL   Proc Natl Acad Sci U S A 93 (3), 1270-1275 (1996)
   PUBMED   8577753
REFERENCE   7  (bases 1 to 11837)
  AUTHORS   Sullivan,S.L., Adamson,M.C., Ressler,K.J., Kozak,C.A. and Buck,L.B.
  TITLE     The chromosomal distribution of mouse odorant receptor genes
  JOURNAL   Proc Natl Acad Sci U S A 93 (2), 884-888 (1996)
   PUBMED   8570653
REFERENCE   8  (bases 1 to 11837)
  AUTHORS   Kozak,C.A., Adamson,M.C., Buckler,C.E., Segovia,L., Paralkar,V. and
            Wistow,G.
  TITLE     Genomic cloning of mouse MIF (macrophage inhibitory factor) and
            genetic mapping of the human and mouse expressed gene and nine
            mouse pseudogenes
  JOURNAL   Genomics 27 (3), 405-411 (1995)
   PUBMED   7558020
REFERENCE   9  (bases 1 to 11837)
  AUTHORS   Chiannilkulchai,N., Pasturaud,P., Richard,I., Auffray,C. and
            Beckmann,J.S.
  TITLE     A primary expression map of the chromosome 15q15 region containing
            the recessive form of limb-girdle muscular dystrophy (LGMD2A) gene
  JOURNAL   Hum Mol Genet 4 (4), 717-725 (1995)
   PUBMED   7633422
REFERENCE   10 (bases 1 to 11837)
  AUTHORS   Garner,C.C., Garner,A., Huber,G., Kozak,C. and Matus,A.
  TITLE     Molecular cloning of microtubule-associated protein 1 (MAP1A) and
            microtubule-associated protein 5 (MAP1B): identification of
            distinct genes and their differential expression in developing
            brain
  JOURNAL   J Neurochem 55 (1), 146-154 (1990)
   PUBMED   2355215
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF182213.1, AK160546.1, AK147474.1, AL845466.4 and BQ175021.1.
            
            On Mar 13, 2010 this sequence version replaced NM_032393.1.
            
            Transcript Variant: This variant (1) is the longer transcript and
            encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1420              AF182213.1         1-1420
            1421-1823           AK160546.1         1121-1523
            1824-9792           AK147474.1         36-8004
            9793-11176          AL845466.4         15453-16836
            11177-11837         BQ175021.1         1-661               c
FEATURES             Location/Qualifiers
     source          1..11837
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 60.37 cM"
     gene            1..11837
                     /gene="Map1a"
                     /gene_synonym="6330416M19Rik; moth1; Mtap-1; Mtap1;
                     Mtap1a"
                     /note="microtubule-associated protein 1 A"
                     /db_xref="GeneID:17754"
                     /db_xref="MGI:MGI:1306776"
     exon            1..271
                     /gene="Map1a"
                     /gene_synonym="6330416M19Rik; moth1; Mtap-1; Mtap1;
                     Mtap1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..9078
                     /gene="Map1a"
                     /gene_synonym="6330416M19Rik; moth1; Mtap-1; Mtap1;
                     Mtap1a"
                     /note="isoform 1 is encoded by transcript variant 1;
                     MAP-1A; modifier of tubby hearing 1; short MAP1A; short
                     microtubule-associated protein 1A"
                     /codon_start=1
                     /product="microtubule-associated protein 1A isoform 1"
                     /protein_id="NP_115769.1"
                     /db_xref="CCDS:CCDS38215.1"
                     /db_xref="GeneID:17754"
                     /db_xref="MGI:MGI:1306776"
                     /translation="MATEAGTARPGSVAMETTPELGLQSLGAPPAQNPAEPLCEAGAA
                     VAAARWDLRKYSLLIVIGDIGTESQLRAVRAHLEQGILSWNIDLSSFDLNQQLRLFIT
                     RHLAHFSSEVKGQRTLCHQSETLETIILVNPTADSISSEVHHLLSSPSAHKLLILSGQ
                     TLEPEGDLILQSGTYSYQNFAQVLHKPEIAQLLSNRDPGIQAFLTVSCLGEGDWSHLG
                     LSSSQETLHLRLNPEPVLPTMDGVAEFSEYVSETVDVPSPFDLLEPPTSGGFLKLSKP
                     CCYIFPGGRGDSALFAVNGFNILVDGGSDRKSCFWKLVRHLDRIDSVLLTHIGADNLP
                     GINGLLQRKVAELEEEQSQGSSSYSDWVKNLISPELGVVFFNVPDKLRLPDASRKAKR
                     SIEEACLTLQHLNRLGIQAEPLYRVVSNTIEPLTLFHKMGVGRLDMYVLNPVKDSKEM
                     QFLMQKWAGNSKAKTGIVLANGKEAEISVPYLTSITALVVWLPANPTEKIVRVLFPGN
                     APQNKILEGLEKLRHLDFLRYPVATQKDLAAGAVPANLKPSKIKHRADSKESLKAAPK
                     TAMSKLAKREEVLEEGAKEARSELAKELAKSEKKAKEPSEKPPEKPSKPERVRTESSE
                     ALKAEKRKLIKDKVGKKHLKEKISKLEEKRDKEKKEIKKERKELKKEEGRKEEKKDAK
                     KDEKRKDTKPELKKFSKPDLKPFTPEVRKTLYKAKAPGRLKVDKGRAARGEKELSSEP
                     RTPPAQKGAAPPPAASGHRELALSSPEDLTQDFEELKREERGLLAEPRDTELGEKPLP
                     ADASEQGRPSTAIQVTQPPASVLEQEQVEREKEVVPDFPEDKGSKNRAPDSGAEVERE
                     KETWEERKPREAELTPENIAAAREESEPEVKEDVIEKAELEEMEEVHPSDEEEEETKA
                     ESFYQKHMQEALKVIPKGREALGGRELGFQGKAPEKETASFLSSLATPAGAAEHVSYI
                     QDETIPGYSETEQTISDEEIHDEPDERPAPPRFPTSTYDLSGPEGPGPFEASQSAESA
                     VPASSSKTYGAPETELTYPPNMVAAPLAEEEHVSSATSITECDKLSSFATSVAEDQSV
                     ASLTAPQTEETGKSSLLLDTVTSIPSSRTEATQGLDYVPSAGTISPTSSLEEDKGFKS
                     PPCEDFSVTGESEKKGESVGRGLTGEKAVGKEEKNVTTSEKLSSQYAAVFGAPGHALH
                     PGEPALGEVEERCLSPDDSTVKMASPPPSGPPSAAHTPFHQSPVEEKSEPQDFQEDSW
                     GDTKHAPGVSKEDAEEQTVKPGPEEAMSEEGKVPLSRSPQAQDTLGSLAGGQTGCTIQ
                     LLPEQDKAVVFETGEAGAASGAGSLPGEVRTQEPAEPQKDELLGFTDQSFSPEDAESL
                     SVLSVVSPDTAKQEATPRSPCTPKEQQLHKDLWPMVSPEDTQSLSFSEESPSKETSLD
                     ISSKQLSPESLGTLQFGELSLGKEEKGPLVKAEDNSCHLAPVSIPEPHTATVSPPTDE
                     AAGEAGLTDESPAGNLPGSSFSHSALSGDRKHSPGEITGPGGHFMTSDSSLTKSPESL
                     SSPAMEDLAMEWGGKAPGSEDRATEQKEKELERKSETLQQKDQILSEKAALVQRDSVM
                     HQKDEALDEENKPGGQQDKTSEQKGRDLDKKDTAVELGKGPEPKGKDLYLEDQGLAEK
                     DKALEQRGAALQQTQAPEPRARAQEHRDLEQKDEHLELRDKTPEEKDKVLVLEDRAPE
                     HIIPQPTQTDRAPEHRSKVDKEQKDEASEEKEQVLEQKDWAREKEGAALDQDNRAAGQ
                     KDGTLKEDKTQGQKSSFLEDKSTTPKEMTLDQKSPEKAKGVEQQDGAVPEKTRALGLE
                     ESPEEEGKAREQEEKYWKEQDVVQGWRETSPTRGEPVPAWEGKSPEQEVRYWRDRDIT
                     LQQDAYWKELSCERKVWFPHELDGQGARPRYSEERESTFLDEGPNEQEITPLQHTPRS
                     PWASDFKDFQEPLPQKGLEVERWLAESPVGLPPEEEDKLTRSPFEIISPPASPPEMTG
                     QRVPSAPGQESPVPDTKSTPPTRNEPTTPSWLAEIPPWVPKDRPLPPAPLSPAPAPPT
                     PAPDPHAPAPFSWGIAEYDSVVAAVQEGAAELEGGPYSPLGKDYRKAEGEREGEGGAG
                     APDSSSFSSKVPEVTESHTTRDAEQTEPEQREPTPYPDERSFQYADIYEQMMLTGLGP
                     ACPTREPPLGASGDWPPHLSTKEEAAGRNKSAEKELSSAVSPPNLHSDTPTFSYASLA
                     GPTIPPRQEPEPGPNVEPSFTPPAVPPRAPISLSQDPSPPLNGSTTSCGPDRRTPSPK
                     EAGRSHWDDGTNDSDLEKGAREQPEKETQSPSPHHPMPVGHPSLWPETEAHSSLSSDS
                     HLGPVRPSLDFPASAFGFSSLQPAPPQLPSPAEPRSAPCGSLAFSGDRALALVPGTPT
                     RTRHDEYLEVTKAPSLDSSLPQLPSPSSPGAPLLSNLPRPASPALSEGSSSEATTPVI
                     SSVAERFPPGLEVAEQSSGELGPGNEPAAHSLWDLTPLSPAPLASRDLAPAPAPAPAP
                     SLPGNLGDGTLSCRPECSGELTKKPSPFLSHSGDHEANGPGETSLNPPGFATATAEKE
                     EAEALHAWERGSWPEGAERSSRPDTLLSSEQRPGKSSGGPPCSLSSEVEAGPQGCATD
                     PRPHCGELSPSFLNPPLPPSTDDSDLSTEEARLAGKGGRRRAGRPGATGGPCPMADET
                     PPTSASDSGSSQSDSDVPPETEECPSITAEAALDSDEDGDFLPVDKAGGVSGTHHPRP
                     GHDPPPAPLPDPRPPPPRPDVCMADPEGLSSESGRVERLREKVQGRPGRKAPGRAKPA
                     SPARRLDIRGKRSPTPGKGPVDRTSRALPRPRSTPSQVTSEEKDGHSPMSKGLVNGLK
                     AGSTALGSKGSSGPPVYVDLAYIPNHCSGKTADQDFFRRVRASYYVVSGNDPANGEPS
                     RAVLDALLEGKAQWGENLQVTLIPTHDTEVTREWYQQTHEQQQQLNVLVLASSSTVVM
                     QDESFPACKIEF"
     exon            272..373
                     /gene="Map1a"
                     /gene_synonym="6330416M19Rik; moth1; Mtap-1; Mtap1;
                     Mtap1a"
                     /inference="alignment:Splign:2.1.0"
     exon            374..456
                     /gene="Map1a"
                     /gene_synonym="6330416M19Rik; moth1; Mtap-1; Mtap1;
                     Mtap1a"
                     /inference="alignment:Splign:2.1.0"
     exon            457..597
                     /gene="Map1a"
                     /gene_synonym="6330416M19Rik; moth1; Mtap-1; Mtap1;
                     Mtap1a"
                     /inference="alignment:Splign:2.1.0"
     exon            598..8701
                     /gene="Map1a"
                     /gene_synonym="6330416M19Rik; moth1; Mtap-1; Mtap1;
                     Mtap1a"
                     /inference="alignment:Splign:2.1.0"
     exon            8702..8922
                     /gene="Map1a"
                     /gene_synonym="6330416M19Rik; moth1; Mtap-1; Mtap1;
                     Mtap1a"
                     /inference="alignment:Splign:2.1.0"
     exon            8923..11823
                     /gene="Map1a"
                     /gene_synonym="6330416M19Rik; moth1; Mtap-1; Mtap1;
                     Mtap1a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10408..10413
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Map1a"
                     /gene_synonym="6330416M19Rik; moth1; Mtap-1; Mtap1;
                     Mtap1a"
                     /note="hexamer: AATAAA"
     polyA_site      10427
                     /gene="Map1a"
                     /gene_synonym="6330416M19Rik; moth1; Mtap-1; Mtap1;
                     Mtap1a"
                     /note="major polyA site"
     regulatory      11112..11117
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Map1a"
                     /gene_synonym="6330416M19Rik; moth1; Mtap-1; Mtap1;
                     Mtap1a"
                     /note="hexamer: AATAAA"
     polyA_site      11137
                     /gene="Map1a"
                     /gene_synonym="6330416M19Rik; moth1; Mtap-1; Mtap1;
                     Mtap1a"
     regulatory      11797..11802
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Map1a"
                     /gene_synonym="6330416M19Rik; moth1; Mtap-1; Mtap1;
                     Mtap1a"
                     /note="hexamer: ATTAAA"
     polyA_site      11820
                     /gene="Map1a"
                     /gene_synonym="6330416M19Rik; moth1; Mtap-1; Mtap1;
                     Mtap1a"
ORIGIN      
        1 acgcagctag cctaacactc cgcgggagtt tccatggcga ccgaagccgg gaccgcgcgg
       61 cctggcagcg ttgccatgga gacaactccg gagctggggc tccagagcct cggtgcaccg
      121 ccagctcaga acccggcgga gcctctttgc gaggccggtg ccgcggtagc ggcagcgcgc
      181 tgggacctgc ggaaatactc cttgctcatc gtgatcggcg atatcggtac agagagtcag
      241 ctgagggccg tgcgggccca ccttgaacaa gggattctct cctggaatat tgacttatca
      301 tcctttgact tgaaccaaca gttgagactc ttcattaccc ggcacctagc tcacttctcc
      361 tcagaggtca aaggccagag gaccctctgc caccagagtg agaccctcga gaccatcatc
      421 ctagtcaacc ccactgcaga cagcatcagc tcagaggttc accatcttct tagtagccca
      481 tcagctcaca aactcctcat cttgagtgga caaactttag aacccgaggg agaccttatc
      541 ctacagagtg gtacttactc atatcaaaac ttcgcccagg tccttcacaa acctgagatt
      601 gcccagttgc ttagcaatag agaccctggg atccaggcct tcctcactgt ttcctgctta
      661 ggggagggtg actggagcca cctgggactg tctagttccc aagagacctt gcacctccgg
      721 ctaaatcctg agcctgtgct gcccaccatg gatggagtgg ccgagttctc cgagtatgtc
      781 tctgagacgg tggatgtgcc gtcccccttt gacctgcttg agccccccac ctcaggaggc
      841 ttcctcaagc tctccaagcc ttgctgttac atcttccctg gtggccgtgg ggactctgct
      901 ctctttgctg tcaatggctt taacatcctg gtggacggcg gttctgaccg caagtcctgc
      961 ttctggaagc tggtgcggca cctggaccgc attgactcgg tgctgctcac gcacattggg
     1021 gctgacaatc tgccaggcat caatgggctc ctgcagcgca aggtggcaga gctagaggag
     1081 gagcagtccc agggctccag cagctacagc gactgggtga agaacctcat ctcccctgag
     1141 ctcggagtcg tgttcttcaa tgtgcctgat aagctccggc tgcccgacgc ctcccgcaag
     1201 gccaagcgca gcatcgagga ggcctgtctc acccttcagc acctgaaccg cctcggcatc
     1261 caagccgagc ctctgtaccg agtggtcagc aacaccatcg agccgctgac cctcttccac
     1321 aaaatgggtg tggggaggct ggacatgtat gtcctcaacc ctgtcaagga cagtaaggag
     1381 atgcagttcc tcatgcagaa gtgggcaggc aatagtaaag ccaagacagg catagtgctg
     1441 gccaatggga aggaggcaga gatctccgtc ccctacctga cctccatcac tgccttggtg
     1501 gtatggctcc cagccaaccc tactgagaag attgtgcgag tgcttttccc gggaaatgct
     1561 ccccagaaca agatcttgga gggcctggaa aagctgcggc acctggactt cctgcgctat
     1621 cctgtggcga cacagaagga cctggctgct ggggccgtgc ctgccaactt gaaacccagc
     1681 aaaatcaaac atcgggccga cagcaaggag agcctcaaag ctgcccccaa gacagcaatg
     1741 agcaagctag ccaaacggga ggaggtgtta gaagagggag ccaaggaggc ccgctcagag
     1801 ctggccaagg agttagccaa gtcagaaaag aaagcaaaag agccgtccga gaagccccca
     1861 gaaaaaccct ccaagccaga gagggtgagg acagagtcca gcgaagcact gaaggctgag
     1921 aagcggaagc tgatcaagga taaagtgggc aagaagcacc tgaaggaaaa gatttcaaag
     1981 ctggaggaga agagggacaa ggagaagaag gagatcaaga aggaaaggaa ggaactcaag
     2041 aaggaggagg gaaggaagga ggagaaaaag gacgccaaga aggatgaaaa gaggaaagat
     2101 accaagccgg aactcaagaa attctctaaa ccagacctga agccttttac ccctgaggtc
     2161 cgtaagaccc tctacaaagc caaggcccct ggaaggctca aggtggacaa aggccgagct
     2221 gcccgtgggg aaaaagaatt gtcttctgag ccccggacac ccccagccca gaagggggct
     2281 gcaccgcctc ctgctgccag tgggcacaga gagttggcct tgtcttcacc agaggacctc
     2341 acacaggact ttgaggagtt gaagcgtgag gagagaggtt tgttggctga accaagggac
     2401 acggaactgg gtgagaaacc gctccctgca gatgcctccg agcagggacg cccaagcaca
     2461 gccatccagg tgacccaacc ccctgcttca gtgttggagc aagaacaggt agaaagggag
     2521 aaagaggttg tcccagactt tcccgaggat aaagggagca agaacagagc cccagactca
     2581 ggtgctgagg tagagagaga gaaagaaacc tgggaggaaa ggaagccgag agaagcagag
     2641 ctgaccccag agaacattgc tgcggccagg gaggagagtg aacctgaggt aaaggaggat
     2701 gtgatagaaa aggctgagtt agaggagatg gaggaggtcc atccctcaga tgaggaagag
     2761 gaagagacaa aggctgagag tttttatcaa aaacatatgc aggaagcctt aaaggtaatc
     2821 ccaaaaggca gagaggctct tggcggccgg gaactgggat tccagggcaa ggcgcctgaa
     2881 aaggagacag catccttcct gagcagcttg gccacgcctg caggagccgc tgagcatgtc
     2941 tcctacattc aggatgagac gatccctggc tactcagaga ctgagcagac tatctcagac
     3001 gaggagattc acgacgagcc ggacgaacgc ccagccccac cccgattccc cacgagtacc
     3061 tatgacctct ctgggcctga aggtcctggt ccctttgaag ccagccagtc tgcagagagt
     3121 gctgttccag ccagctcgag caaaacttat ggggcacctg agactgaact cacctaccct
     3181 cccaacatgg tcgctgcccc tctggctgaa gaggaacatg tgtcctcagc cacatcaatc
     3241 acggagtgtg acaaactctc ctcctttgcc acatcggtgg ctgaggacca atctgtggct
     3301 tcactcacag ctccccagac ggaggagaca ggcaagagct ccctgttgct cgacactgtc
     3361 acaagtattc cctcttcccg cactgaagcc actcagggct tggactatgt gccgtcagca
     3421 ggcaccatct cacccacctc ttccctggaa gaagacaagg gcttcaagtc accgccctgt
     3481 gaggatttct ctgtgaccgg ggagtcggag aagaaaggag agtctgtggg gagaggtttg
     3541 accggggaga aggctgtagg aaaggaagaa aagaatgtaa caacgtctga gaaactgtcc
     3601 agtcagtatg ctgccgtgtt tggtgcccct ggacatgccc tacatccggg ggaaccggcc
     3661 ctcggagaag tggaggaacg gtgcctcagc ccagatgata gcaccgtgaa gatggcgtct
     3721 cctccaccat ctggcccacc cagtgctgcc cacacgccct ttcatcagtc ccccgtggaa
     3781 gaaaagtctg agcctcaaga cttccaagaa gattcctggg gagacacaaa gcacgctcct
     3841 ggtgtgagca aggaagatgc tgaagagcag acagttaagc cagggcctga ggaggccatg
     3901 tcagaagagg gcaaagtacc tctttccagg agcccccaag cccaggacac acttgggagc
     3961 cttgctgggg gtcagactgg ctgtactatt caactgttgc cagaacaaga caaagcagta
     4021 gtgtttgaga ctggagaggc aggcgcagct tcaggagcag gcagccttcc tggagaagtg
     4081 aggactcagg agcccgctga gcctcagaaa gatgagctgc ttgggtttac tgatcaaagc
     4141 ttttcccctg aagatgcaga gtccctgtct gtcctcagtg tggtctcccc agacactgcc
     4201 aaacaagagg ccacccccag gtctccctgt accccgaaag agcagcagct acacaaagac
     4261 ctttggccaa tggtgtcccc agaagacacc cagtcacttt ctttctcgga agagagtcct
     4321 agcaaggaga cctctctgga tatctcttct aagcagctct ctccagaaag ccttggcacc
     4381 ctccagtttg gagaactaag cctaggaaag gaagaaaagg ggcctctggt gaaggcagaa
     4441 gacaactctt gccacctagc tcctgtgtct attccagagc cccacacagc cacagtgtca
     4501 cctcccacag atgaggctgc tggagaggca ggtctcacag atgagagccc tgctggaaat
     4561 ttacctggca gctctttctc tcactctgca ctgtcaggtg acaggaaaca ctcacctgga
     4621 gagatcacgg gccctggtgg acactttatg acatcggata gctccctcac caagagtccc
     4681 gagtctttgt caagtcccgc catggaggac ctggccatgg agtggggggg taaagctccg
     4741 gggtcggaag acagagccac tgaacagaag gagaaggaac tcgagcgaaa gagtgaaacc
     4801 ctacagcaga aggaccagat tctgtcggag aaggctgctc ttgtccagcg ggactcagtc
     4861 atgcatcaga aggacgaggc tctagatgaa gagaacaagc ctggaggaca gcaggataag
     4921 acttcagaac agaaaggcag agacttggac aaaaaagaca cggctgtgga gctgggcaaa
     4981 ggcccagaac ccaaaggcaa agacttatat ctggaggacc agggcctggc agagaaggac
     5041 aaggccttag aacaaagggg tgcagccctg caacagaccc aggcccctga accaagagcc
     5101 agagcacaag agcacagaga tttagaacaa aaggacgagc atttagagct gagagataag
     5161 actcctgaag agaaagataa agtgttagta ctggaagaca gggctccaga gcacatcatc
     5221 ccccaaccaa cacagacaga cagagctcca gaacacagaa gcaaggttga taaagaacag
     5281 aaggatgagg cctcggaaga gaaagaacag gttttagaac aaaaagactg ggcccgagaa
     5341 aaagagggtg ctgccttgga ccaagacaac agggctgctg gacagaaaga tgggacccta
     5401 aaagaagaca aaactcaggg gcagaagagc tctttcctgg aagataaaag tacaacacca
     5461 aaagagatga cccttgacca aaagtctcca gaaaaggcca aaggtgtgga gcagcaggat
     5521 ggagctgtcc cggagaagac cagagctttg gggctggaag agagcccaga agaggagggc
     5581 aaggctcgag agcaggaaga gaaatactgg aaggagcagg atgtggtcca gggatggcga
     5641 gaaacatctc caaccagagg agagcctgtt ccagcctggg agggcaagtc tcctgagcag
     5701 gaagtcaggt attggagaga cagagacata accctacagc aggatgcata ctggaaggag
     5761 ctaagctgtg agaggaaggt ctggttcccc catgagctag atggacaagg agcccgtcca
     5821 cggtactctg aggaacgtga aagtacgttt cttgatgagg ggccaaatga acaagaaata
     5881 accccactgc agcacactcc ccggagtccc tgggcctcgg atttcaagga tttccaggag
     5941 cccctgccac agaaggggct ggaagtagag cgctggcttg ctgagtcgcc agttggcttg
     6001 ccaccagagg aggaggacaa actgactcgc tctccctttg agatcatctc ccctccagca
     6061 tccccacctg agatgactgg acagagggtt ccctcagctc caggacagga aagccctgtt
     6121 ccagacacta agtccacacc acccacgagg aatgaaccta ccaccccatc atggctagct
     6181 gagatcccac catgggtacc taaggacagg cccctgcctc ctgcacccct ctctccagct
     6241 ccagctcccc cgaccccggc cccagaccca catgctcctg cgcccttctc ctggggcatc
     6301 gctgaatatg acagtgtggt ggctgcggtg caggaggggg cagctgagtt ggaaggtggt
     6361 ccatactccc ccctagggaa ggactatcgc aaagctgaag gggaaaggga aggagagggt
     6421 ggggctggag ctcctgacag cagctccttc agttcaaagg tcccagaggt tacggagagt
     6481 cacaccacca gggatgctga gcagactgag ccagagcaga gggagcccac accctatccc
     6541 gacgagagga gctttcagta tgcagacatc tacgaacaga tgatgcttac tgggttgggc
     6601 cctgcttgcc ccaccaggga gcctccactg ggggcatctg gggattggcc cccacacctc
     6661 tcaaccaagg aggaggctgc tggccgcaat aagtctgcag agaaggagct ttcatccgct
     6721 gtgtcgcccc caaacctcca ctctgacact ccaacgttta gctatgcatc tctggcagga
     6781 cccactatac ctcccaggca agaacctgag ccagggccca atgtggagcc cagcttcacc
     6841 cctcctgcag tgccccctcg tgcccctatc tccctgagcc aagacccaag tccccctctt
     6901 aatggaagca ctacgagctg tggcccagac aggaggaccc catccccaaa ggaagcaggc
     6961 cgaagtcact gggatgatgg tactaatgac tcagacctgg agaagggggc tcgggaacag
     7021 ccggagaaag agacccagtc cccaagtccc catcacccca tgcctgtggg ccacccttca
     7081 ctgtggcctg aaactgaggc gcatagcagc ctttcctcag actctcacct aggacctgtc
     7141 cgaccaagtt tggacttccc tgcttcagcc tttggcttct cctccttgca gcctgctccc
     7201 cctcagctgc cctctccggc tgaaccccgc tccgcaccct gtggctctct tgccttctct
     7261 ggggaccgag ctctggccct ggttccagga actccaacca gaacccgaca tgatgagtac
     7321 ttggaagtga ccaaggcacc cagcctggat tcctcactgc cccaactccc atcacccagc
     7381 tcgccagggg cccctcttct ctccaatcta ccccgacctg cctcgccagc cttgtctgaa
     7441 gggtcctctt ctgaggctac cacgcctgtg atttcaagtg tggctgaacg cttccctcca
     7501 ggtctagagg tggctgaaca gagttcagga gaattgggcc cagggaacga gccagctgcc
     7561 cacagcctct gggacctcac tcctctgagc ccagcccctt tagcttcccg ggacttggct
     7621 ccagctccag ctccagctcc agctccaagc ctgcctggaa acttgggtga cggtaccctg
     7681 tcctgccgcc cggagtgctc aggggaactc accaagaagc caagcccctt tctgagccac
     7741 tctggagatc atgaagctaa tggcccagga gaaaccagcc ttaatccccc agggtttgcc
     7801 acagccacag cagaaaaaga agaggctgaa gcccttcatg cttgggaacg agggtcctgg
     7861 cccgagggag cggagaggag ctcccggccg gatacacttc tctcatctga gcagcgtcct
     7921 gggaagagct ccgggggtcc accctgcagt ctttcttctg aagtcgaggc tggacctcag
     7981 ggatgtgcta cagacccccg cccccactgc ggggagcttt ccccttcatt cctgaaccct
     8041 cctttgcccc catccacaga tgacagtgac ctttcaacgg aagaggctcg gctggcagga
     8101 aaaggagggc ggcgccgggc agggaggcca ggggccacag gaggtccatg ccctatggct
     8161 gatgagacac cccccacatc agccagcgac tcaggctcct cacaatcaga ttctgatgtc
     8221 ccaccagaaa ctgaggagtg tccatccatc acagctgagg cagcccttga ctcagatgaa
     8281 gatggggact tcttgcctgt ggacaaagct gggggagtta gtggaactca ccaccccaga
     8341 cctggccatg acccaccccc agccccccta ccggaccccc gcccaccccc tccccgaccg
     8401 gatgtttgca tggctgaccc cgaggggctc agctcagagt ctgggagagt tgagagacta
     8461 cgggaaaagg tgcagggacg acctggccgt aaggcccctg gacgggccaa gcctgcatct
     8521 cctgctcggc gtctggatat tcggggaaaa cggtcaccta ctcctggcaa agggcctgta
     8581 gatcgaacat cccgggccct accccgacca cggagcaccc caagccaggt cacctcagaa
     8641 gaaaaggatg gtcacagccc catgtctaaa ggcttagtca atggcctcaa ggcaggatcc
     8701 acagccttgg ggtccaaggg tagctctggc cctcctgtgt atgtggatct tgcctatatc
     8761 ccaaatcact gcagcggcaa gactgctgat caggacttct tccgccgagt gcgtgcatcc
     8821 tactatgtgg tcagtggaaa tgaccctgcc aatggcgagc caagccgggc tgtgctggat
     8881 gccctgctgg aaggcaaggc ccaatggggg gagaaccttc aggtgactct gattcccact
     8941 catgatacgg aggtgactcg tgagtggtat cagcagacac acgagcaaca gcagcaactg
     9001 aacgtcctgg tcctggctag cagcagcact gtggtgatgc aggacgagtc ctttccagcc
     9061 tgcaagattg agttctgaat gacctgcgct cccttcccta aggatccact cctacagttc
     9121 atttagagaa tggctactgc tgagtcctct ggggttgagg gaaggcgagc cgggcagggg
     9181 ccatgtcatg ttattgggac ttggggctaa gtgggaggtc ctgtccttcc cctcatctct
     9241 tcctggggtt tcaagaccaa aggcaatgag gagatacacg attctgaaag gtcatctgaa
     9301 gcctgaaacc cctagagcaa ccccctctcc tagcattgcc aaatgctggt cttggtgagg
     9361 atgggtttca aacagcacac tcctcccggt ggaggaagat taacaacagt ctctccccca
     9421 gaacctcatt atttatttat ttggcattcc agaaaggatt gctgataatt tagatgatgc
     9481 agggaaggcc actgttagta aggtgccaga gctgcgccct ttcctccatc tgccatgccc
     9541 tagccactag agtctgggtt ccagcagcta cctggggaca tgtggctgct ctattgtctt
     9601 actgcgtccc acaatatctg aatgtctcaa tccaaaactt gaagctcttt agaccaagaa
     9661 ctagggagag gaaaaaggag ctcatctctc agccccttct tcatagcatt tacagccccg
     9721 ggctgtaccc agaccaggct acctgggcag cacaaagggc aaggagagcc ccaaccccag
     9781 ttgctccaag ctccccaatc acttagtctt cacctacccc attccaataa gcctcatttc
     9841 ttctcatccc ctgcttggct tctctgcatg tggtcatctg ctatggcctg gtgtgtaatg
     9901 ggttaaacaa taagccactg cctgacaccc acatccactt tagccatgtg tgactcccta
     9961 acattccaat cctctaccat cctgcagctg aaatgggaac actggctgcc tctctaaacc
    10021 taaactcttg gatagagttt ctgggaggtg gaggctggac tagagaactg ggggagggga
    10081 gatgggaggg agggaggagg ggaaagaaga gaggaaggtg agctatagct taactcctcc
    10141 agagtgagga gaggctgagc attctactac aggacaggac ctcgccccaa gcaagccagt
    10201 gagcagcccg gccagaccct gctggactga gagacccagc cgctgacagt ccctggggct
    10261 tgccttcttt gccaagccaa tgggaaacca aaaggagctc acttcctgtt cttcctagct
    10321 cccctccctg ccgctgtgct ccgctcctcc ccacacttcc ttgctacagt tcccagctgc
    10381 tgtaacagag ccacctccac ctctaacaat aaaccaagtt cattgcagat ggtgtggtgc
    10441 tgcctaggct ttccaaggct cctccagaca gtaagctatc ctggtttcca tccctctggt
    10501 tcagttatca tttatcttgg aagactctcc attattcaaa cccatcccag gactcgggag
    10561 agccagcctg tgtgaaagga ggatgagatg agagaaccat catcatttct gaaaagaagc
    10621 agggtgtgat ggtgcatgcc tgtgatctta acactcaggg tagaggtgga agaattagga
    10681 gtttgagggc agcctgggct atagaaagtt ttgggccagc ctgagctaca cagtgagtga
    10741 gtccttgtct caaaaaaaaa aaaaaaaaaa aaaaaaaaac aagggctgga gatagcttag
    10801 tggttaagaa cactggctgc tcttccagaa ctcacatagc agtttacaac tctatatctc
    10861 cacttcctgt ggcttcaaca cccttttctg gtccctgtgg gcaccaggca tacatgcagt
    10921 atatagactt atattcaggc aaaacgccca tacacataaa gtaaaaattt aagcaagaaa
    10981 caaacaaaaa aaatataaaa atagtctaaa atgtgggagc ctgtagcagg aacataaaca
    11041 tctggtttag agagtgcaat ctgcattcta tggggtcaaa agtagtccct gtattttccc
    11101 agaaaactct taataaatct tttcatttac tgcccaatgg atgaaagcta cattaagtcc
    11161 ccatagtaaa accctttgta gtcttaggca tgtcatgagt ggtcaggtta taaatgtgta
    11221 tatgagaagg gaaccttgta gtcatcccag tgtctggagc tttcctgatg tacatatgtc
    11281 aacagagcag aggccaggca gtgcctcttc ctgtcagctc ccgactcaca ccccaaggca
    11341 ccagagagga aggcatcaga ggctgctgct cagaaactac ccagcattct gctcagtaaa
    11401 aacacttggg atggtagact gaccactaca gggactcttt aaagccaatc cccgctcatc
    11461 tccagtatgt gattggttca gtcatggaca caatgggatt acatattcat tcttgagttc
    11521 acaaaggtca caaaggagtc acaccccctc gttctcatta ttttgtgttt attgagcact
    11581 tgtcatgttc cggccccaga ctccaatgac aacattaccc acacccactc ccatccctag
    11641 atctttggga aaagctttgt aatcacatat ggtcataaag acacatgata taaggacaaa
    11701 cctcttgggg accctggagt gtttgatctt tggccagtct gtccctggca aactacagaa
    11761 atatatatgt ttatatatat atatatatat atatatatta aatctttgct catatctgta
    11821 caaaaaaaaa aaaaaaa
//
