LOCUS       NM_172778               2428 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus monoamine oxidase B (Maob), mRNA.
ACCESSION   NM_172778
VERSION     NM_172778.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2428)
  AUTHORS   Liu,L.L., Han,Y., Zhang,Z.J., Wang,Y.Q., Hu,Y.W., Kaznacheyeva,E.,
            Ding,J.Q., Guo,D.K., Wang,G.H., Li,B. and Ren,H.G.
  TITLE     Loss of DJ-1 function contributes to Parkinson's disease
            pathogenesis in mice via RACK1-mediated PKC activation and MAO-B
            upregulation
  JOURNAL   Acta Pharmacol Sin 44 (10), 1948-1961 (2023)
   PUBMED   37225849
  REMARK    GeneRIF: Loss of DJ-1 function contributes to Parkinson's disease
            pathogenesis in mice via RACK1-mediated PKC activation and MAO-B
            upregulation.
REFERENCE   2  (bases 1 to 2428)
  AUTHORS   Heger,J., Szabados,T., Brosinsky,P., Bencsik,P., Ferdinandy,P. and
            Schulz,R.
  TITLE     Sex Difference in Cardioprotection against Acute Myocardial
            Infarction in MAO-B Knockout Mice In Vivo
  JOURNAL   Int J Mol Sci 24 (7), 6443 (2023)
   PUBMED   37047416
  REMARK    GeneRIF: Sex Difference in Cardioprotection against Acute
            Myocardial Infarction in MAO-B Knockout Mice In Vivo.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2428)
  AUTHORS   Wang,S.H., Tsai,F.C., Lin,H.H., Yu,T.Y., Kuo,C.H., Li,H.Y. and
            Lin,M.S.
  TITLE     Inhibition of monoamine oxidase B reduces atherosclerosis and fatty
            liver in mice
  JOURNAL   Clin Sci (Lond) 137 (1), 17-30 (2023)
   PUBMED   36416117
  REMARK    GeneRIF: Inhibition of monoamine oxidase B reduces atherosclerosis
            and fatty liver in mice.
REFERENCE   4  (bases 1 to 2428)
  AUTHORS   Ichise,M., Sakoori,K., Katayama,K.I., Morimura,N., Yamada,K.,
            Ozawa,H., Matsunaga,H., Hatayama,M. and Aruga,J.
  TITLE     Leucine-Rich Repeats and Transmembrane Domain 2 Controls Protein
            Sorting in the Striatal Projection System and Its Deficiency Causes
            Disturbances in Motor Responses and Monoamine Dynamics
  JOURNAL   Front Mol Neurosci 15, 856315 (2022)
   PUBMED   35615067
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2428)
  AUTHORS   Obata,Y., Kubota-Sakashita,M., Kasahara,T., Mizuno,M., Nemoto,T.
            and Kato,T.
  TITLE     Phenethylamine is a substrate of monoamine oxidase B in the
            paraventricular thalamic nucleus
  JOURNAL   Sci Rep 12 (1), 17 (2022)
   PUBMED   34996979
  REMARK    GeneRIF: Phenethylamine is a substrate of monoamine oxidase B in
            the paraventricular thalamic nucleus.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2428)
  AUTHORS   Holschneider,D.P., Scremin,O.U., Huynh,L., Chen,K. and Shih,J.C.
  TITLE     Lack of protection from ischemic injury of monoamine oxidase
            B-deficient mice following middle cerebral artery occlusion
  JOURNAL   Neurosci Lett 259 (3), 161-164 (1999)
   PUBMED   10025583
REFERENCE   7  (bases 1 to 2428)
  AUTHORS   Grimsby,J., Toth,M., Chen,K., Kumazawa,T., Klaidman,L., Adams,J.D.,
            Karoum,F., Gal,J. and Shih,J.C.
  TITLE     Increased stress response and beta-phenylethylamine in
            MAOB-deficient mice
  JOURNAL   Nat Genet 17 (2), 206-210 (1997)
   PUBMED   9326944
REFERENCE   8  (bases 1 to 2428)
  AUTHORS   Saura,J., Richards,J.G. and Mahy,N.
  TITLE     Differential age-related changes of MAO-A and MAO-B in mouse brain
            and peripheral organs
  JOURNAL   Neurobiol Aging 15 (4), 399-408 (1994)
   PUBMED   7969716
REFERENCE   9  (bases 1 to 2428)
  AUTHORS   Rao,V.L., Qureshi,I.A. and Butterworth,R.F.
  TITLE     Activities of monoamine oxidase-A and -B are altered in the brains
            of congenitally hyperammonemic sparse-fur (spf) mice
  JOURNAL   Neurosci Lett 170 (1), 27-30 (1994)
   PUBMED   8041507
REFERENCE   10 (bases 1 to 2428)
  AUTHORS   Derry,J.M., Lan,N.C., Shih,J.C., Barnard,E.A. and Barnard,P.J.
  TITLE     Localization of monoamine oxidase A and B genes on the mouse X
            chromosome
  JOURNAL   Nucleic Acids Res 17 (20), 8403 (1989)
   PUBMED   2573045
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY257414.1, AK054050.1, AK031833.1 and BE943751.1.
            
            On Sep 3, 2009 this sequence version replaced NM_172778.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK054050.1, AK031833.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 BY257414.1         2-3
            3-1312              AK054050.1         2-1311
            1313-1534           AK031833.1         1297-1518
            1535-2409           AK054050.1         1534-2408
            2410-2428           BE943751.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..2428
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 11.88 cM"
     gene            1..2428
                     /gene="Maob"
                     /gene_synonym="6330414K01Rik; MAO-B"
                     /note="monoamine oxidase B"
                     /db_xref="GeneID:109731"
                     /db_xref="MGI:MGI:96916"
     exon            1..137
                     /gene="Maob"
                     /gene_synonym="6330414K01Rik; MAO-B"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1654
                     /gene="Maob"
                     /gene_synonym="6330414K01Rik; MAO-B"
                     /EC_number="1.4.3.4"
                     /EC_number="1.4.3.21"
                     /note="monoamine oxidase type B"
                     /codon_start=1
                     /product="amine oxidase [flavin-containing] B"
                     /protein_id="NP_766366.2"
                     /db_xref="CCDS:CCDS40882.1"
                     /db_xref="GeneID:109731"
                     /db_xref="MGI:MGI:96916"
                     /translation="MSNKSDVIVVGGGISGMAAAKLLHDCGLSVVVLEARDRVGGRTY
                     TIRNKNVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHFVKGKSYAFRGP
                     FPPVWNPITYLDNNNLWRTMDEMGQEIPSDAPWKAPLAEEWDYMTMKELLDKICWTKS
                     TKQIATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFIGGSGQVS
                     ERIKDILGDRVKLERPVIHIDQTGENVIVKTLNHEIYEAKYVISAIPPALGMKIHYSP
                     PLPMLRNQLISRVPLGSVIKCMVYYKEPFWRKKDFCGTMVIEGEEAPIAYTLDDTKPD
                     GTYAAIMGFILAHKARKLVRLTKEERLRKLCELYAKVLNSQEALQPVHYEEKNWCEEQ
                     YSGGCYTTYFPPGILTQYGRVLRQPVGKIFFAGTETASHWSGYMEGAVEAGERAAREI
                     LHAIGKIPEDEIWQPEPESLDVPARPITSTFLERHLPSVPGLLKLFGLTTILSATALG
                     FLAHKRGLFVHF"
     exon            138..232
                     /gene="Maob"
                     /gene_synonym="6330414K01Rik; MAO-B"
                     /inference="alignment:Splign:2.1.0"
     exon            233..370
                     /gene="Maob"
                     /gene_synonym="6330414K01Rik; MAO-B"
                     /inference="alignment:Splign:2.1.0"
     exon            371..475
                     /gene="Maob"
                     /gene_synonym="6330414K01Rik; MAO-B"
                     /inference="alignment:Splign:2.1.0"
     exon            476..567
                     /gene="Maob"
                     /gene_synonym="6330414K01Rik; MAO-B"
                     /inference="alignment:Splign:2.1.0"
     exon            568..709
                     /gene="Maob"
                     /gene_synonym="6330414K01Rik; MAO-B"
                     /inference="alignment:Splign:2.1.0"
     exon            710..859
                     /gene="Maob"
                     /gene_synonym="6330414K01Rik; MAO-B"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1019
                     /gene="Maob"
                     /gene_synonym="6330414K01Rik; MAO-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1116
                     /gene="Maob"
                     /gene_synonym="6330414K01Rik; MAO-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1170
                     /gene="Maob"
                     /gene_synonym="6330414K01Rik; MAO-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1228
                     /gene="Maob"
                     /gene_synonym="6330414K01Rik; MAO-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1326
                     /gene="Maob"
                     /gene_synonym="6330414K01Rik; MAO-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1438
                     /gene="Maob"
                     /gene_synonym="6330414K01Rik; MAO-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1501
                     /gene="Maob"
                     /gene_synonym="6330414K01Rik; MAO-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..2412
                     /gene="Maob"
                     /gene_synonym="6330414K01Rik; MAO-B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2393..2398
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Maob"
                     /gene_synonym="6330414K01Rik; MAO-B"
                     /note="hexamer: AATAAA"
     polyA_site      2412
                     /gene="Maob"
                     /gene_synonym="6330414K01Rik; MAO-B"
                     /note="major polyA site"
ORIGIN      
        1 tagtgtgagg ggacagtaag cagcgcggtc gcaggcagag gtccagacgc agtagcagcg
       61 gacgcaagag acctggaacc tagcaagcag catgagcaac aaaagcgatg tgatcgtggt
      121 ggggggcggc atctcaggta tggcggcagc caaacttctg catgattgtg gcctcagtgt
      181 ggtggttctg gaagcacggg accgtgtagg aggcaggact tacacaatta ggaataaaaa
      241 cgttaaatat gtggaccttg gaggatctta tgttgggcca acccagaatc gtatcttacg
      301 attggccaaa gagctaggat tggagaccta taaagttaat gaagttgagc ggctgataca
      361 ctttgtaaag ggaaaatcat atgccttcag gggcccattt ccaccagtat ggaatcctat
      421 cacctaccta gataataaca acctctggag gacaatggat gagatgggcc aagagattcc
      481 cagtgatgct ccatggaaag caccccttgc tgaagagtgg gactacatga caatgaaaga
      541 attgctagat aagatctgct ggaccaaatc tacaaagcag attgccacgc tctttgtgaa
      601 cctgtgtgta actgcagaga cccatgaggt ctctgcacta tggttcctgt ggtatgtgaa
      661 gcagtgtgga ggtacaacca gaatcatctc aacaaccaat ggaggacagg agaggaaatt
      721 tattggtgga tctggtcaag tgagtgaacg gataaaggat atacttgggg accgagtgaa
      781 gctggagagg cctgtgatcc acattgacca gacaggggaa aatgttattg tgaaaaccct
      841 aaaccatgaa atatatgagg ctaaatatgt gattagtgcc attccacctg ctttgggcat
      901 gaagattcac tatagtcctc ctctgcccat gctaagaaac cagctgatct ctcgtgtgcc
      961 tttgggttca gttattaaat gcatggttta ttacaaagag cccttctgga ggaaaaagga
     1021 tttctgtgga accatggtta tcgaaggaga ggaagctcca attgcataca cattggatga
     1081 taccaaacca gatggcacct atgctgctat aatgggattt atccttgctc acaaagctag
     1141 aaaactggta cgtctcacca aagaagaaag actgaggaaa ctttgtgagc tatatgcaaa
     1201 agtgctgaac tcccaagaag ctctgcagcc cgtccattat gaagagaaga actggtgtga
     1261 ggaacagtat tctgggggct gctacacaac ctacttccct cccggcatct tgacccagta
     1321 tggaagggtt ctacgtcagc cagtgggcaa gattttcttt gcaggcactg aaacagcctc
     1381 acactggagc ggctacatgg agggggctgt ggaggctggg gagagagcag ccagagagat
     1441 tcttcatgcc attgggaaga ttccagaaga tgaaatttgg cagccagaac cagaatcttt
     1501 ggatgtccct gcacgaccca ttaccagtac cttcctggag agacacctgc cttctgtacc
     1561 aggcctgcta aagctgtttg gattgaccac catcttgtca gcaacagctc ttggtttcct
     1621 ggcccacaaa aggggcctgt ttgtacattt ttaaagatgg gctttagagc cacatccaca
     1681 agcttctcat tcagtgtgtc tcaaaggctt gacaaaggag ttgagataaa aaagaaaaaa
     1741 tcttacaaag agaaaataga gtgagaaagc ccagtaattt gttctccatt ttggctcatt
     1801 tccaactttc ctgccctctg agtgtttcga acagacacac aggctttccc ttgctatctc
     1861 acaacctacc tgccccatgt acacagggtt tttcaaaacc ctacgacttt gtgcttgtct
     1921 ttcttctggt gtgttatgtc ctcacctatg tcaagttatt tgccattgta cctagaatcc
     1981 tgtcttgtta gaactggtag ccattagata ctatacttca ttgtctactt taaagttaaa
     2041 taaaccaaat gcaacaaagg taaaccctaa tcacacaagc cctacactaa gctcctggta
     2101 tttgagtgac tagaacacaa gctgatgctt ttctcacctc ccaaggttca ttcccctata
     2161 tcctcctcca ccttatgcca tagtcactga tggttgttct tgtgggttta ctctgtatta
     2221 actggtattg tgttactcag tagatatctt ctactctggc tgttttgtgc agcattgcca
     2281 gctgattcta aattttctta agagtgggag tcttgttttt ggcatttttt ttcttgcatc
     2341 ttctagttag tctgcttcca ttcaaagatt aagacatgct taggtaatta acaataaagc
     2401 tgtttgacca taaaaaaaaa aaaaaaaa
//
