LOCUS       NP_766366                520 aa            linear   ROD 27-APR-2025
DEFINITION  amine oxidase [flavin-containing] B [Mus musculus].
ACCESSION   NP_766366
VERSION     NP_766366.2
DBSOURCE    REFSEQ: accession NM_172778.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 520)
  AUTHORS   Liu,L.L., Han,Y., Zhang,Z.J., Wang,Y.Q., Hu,Y.W., Kaznacheyeva,E.,
            Ding,J.Q., Guo,D.K., Wang,G.H., Li,B. and Ren,H.G.
  TITLE     Loss of DJ-1 function contributes to Parkinson's disease
            pathogenesis in mice via RACK1-mediated PKC activation and MAO-B
            upregulation
  JOURNAL   Acta Pharmacol Sin 44 (10), 1948-1961 (2023)
   PUBMED   37225849
  REMARK    GeneRIF: Loss of DJ-1 function contributes to Parkinson's disease
            pathogenesis in mice via RACK1-mediated PKC activation and MAO-B
            upregulation.
REFERENCE   2  (residues 1 to 520)
  AUTHORS   Heger,J., Szabados,T., Brosinsky,P., Bencsik,P., Ferdinandy,P. and
            Schulz,R.
  TITLE     Sex Difference in Cardioprotection against Acute Myocardial
            Infarction in MAO-B Knockout Mice In Vivo
  JOURNAL   Int J Mol Sci 24 (7), 6443 (2023)
   PUBMED   37047416
  REMARK    GeneRIF: Sex Difference in Cardioprotection against Acute
            Myocardial Infarction in MAO-B Knockout Mice In Vivo.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 520)
  AUTHORS   Wang,S.H., Tsai,F.C., Lin,H.H., Yu,T.Y., Kuo,C.H., Li,H.Y. and
            Lin,M.S.
  TITLE     Inhibition of monoamine oxidase B reduces atherosclerosis and fatty
            liver in mice
  JOURNAL   Clin Sci (Lond) 137 (1), 17-30 (2023)
   PUBMED   36416117
  REMARK    GeneRIF: Inhibition of monoamine oxidase B reduces atherosclerosis
            and fatty liver in mice.
REFERENCE   4  (residues 1 to 520)
  AUTHORS   Ichise,M., Sakoori,K., Katayama,K.I., Morimura,N., Yamada,K.,
            Ozawa,H., Matsunaga,H., Hatayama,M. and Aruga,J.
  TITLE     Leucine-Rich Repeats and Transmembrane Domain 2 Controls Protein
            Sorting in the Striatal Projection System and Its Deficiency Causes
            Disturbances in Motor Responses and Monoamine Dynamics
  JOURNAL   Front Mol Neurosci 15, 856315 (2022)
   PUBMED   35615067
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 520)
  AUTHORS   Obata,Y., Kubota-Sakashita,M., Kasahara,T., Mizuno,M., Nemoto,T.
            and Kato,T.
  TITLE     Phenethylamine is a substrate of monoamine oxidase B in the
            paraventricular thalamic nucleus
  JOURNAL   Sci Rep 12 (1), 17 (2022)
   PUBMED   34996979
  REMARK    GeneRIF: Phenethylamine is a substrate of monoamine oxidase B in
            the paraventricular thalamic nucleus.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 520)
  AUTHORS   Holschneider,D.P., Scremin,O.U., Huynh,L., Chen,K. and Shih,J.C.
  TITLE     Lack of protection from ischemic injury of monoamine oxidase
            B-deficient mice following middle cerebral artery occlusion
  JOURNAL   Neurosci Lett 259 (3), 161-164 (1999)
   PUBMED   10025583
REFERENCE   7  (residues 1 to 520)
  AUTHORS   Grimsby,J., Toth,M., Chen,K., Kumazawa,T., Klaidman,L., Adams,J.D.,
            Karoum,F., Gal,J. and Shih,J.C.
  TITLE     Increased stress response and beta-phenylethylamine in
            MAOB-deficient mice
  JOURNAL   Nat Genet 17 (2), 206-210 (1997)
   PUBMED   9326944
REFERENCE   8  (residues 1 to 520)
  AUTHORS   Saura,J., Richards,J.G. and Mahy,N.
  TITLE     Differential age-related changes of MAO-A and MAO-B in mouse brain
            and peripheral organs
  JOURNAL   Neurobiol Aging 15 (4), 399-408 (1994)
   PUBMED   7969716
REFERENCE   9  (residues 1 to 520)
  AUTHORS   Rao,V.L., Qureshi,I.A. and Butterworth,R.F.
  TITLE     Activities of monoamine oxidase-A and -B are altered in the brains
            of congenitally hyperammonemic sparse-fur (spf) mice
  JOURNAL   Neurosci Lett 170 (1), 27-30 (1994)
   PUBMED   8041507
REFERENCE   10 (residues 1 to 520)
  AUTHORS   Derry,J.M., Lan,N.C., Shih,J.C., Barnard,E.A. and Barnard,P.J.
  TITLE     Localization of monoamine oxidase A and B genes on the mouse X
            chromosome
  JOURNAL   Nucleic Acids Res 17 (20), 8403 (1989)
   PUBMED   2573045
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY257414.1, AK054050.1, AK031833.1 and BE943751.1.
            
            On Sep 3, 2009 this sequence version replaced NP_766366.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK054050.1, AK031833.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..520
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 11.88 cM"
     Protein         1..520
                     /product="amine oxidase [flavin-containing] B"
                     /EC_number="1.4.3.4"
                     /EC_number="1.4.3.21"
                     /note="monoamine oxidase type B"
                     /calculated_mol_wt=58427
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0000250|UniProtKB:P56560; propagated from
                     UniProtKB/Swiss-Prot (Q8BW75.4)"
     Region          6..455
                     /region_name="YobN"
                     /note="Monoamine oxidase [Amino acid transport and
                     metabolism]; COG1231"
                     /db_xref="CDD:440844"
     Site            52
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (Q8BW75.4)"
     Site            156
                     /site_type="other"
                     /note="Important for catalytic activity.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (Q8BW75.4)"
     Site            248
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (Q8BW75.4)"
     Site            365
                     /site_type="other"
                     /note="Important for catalytic activity.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (Q8BW75.4)"
     Site            382
                     /site_type="other"
                     /note="Important for catalytic activity.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (Q8BW75.4)"
     Site            490..516
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BW75.4)"
     CDS             1..520
                     /gene="Maob"
                     /gene_synonym="6330414K01Rik; MAO-B"
                     /coded_by="NM_172778.2:92..1654"
                     /db_xref="CCDS:CCDS40882.1"
                     /db_xref="GeneID:109731"
                     /db_xref="MGI:MGI:96916"
ORIGIN      
        1 msnksdvivv gggisgmaaa kllhdcglsv vvleardrvg grtytirnkn vkyvdlggsy
       61 vgptqnrilr lakelglety kvneverlih fvkgksyafr gpfppvwnpi tyldnnnlwr
      121 tmdemgqeip sdapwkapla eewdymtmke lldkicwtks tkqiatlfvn lcvtaethev
      181 salwflwyvk qcggttriis ttnggqerkf iggsgqvser ikdilgdrvk lerpvihidq
      241 tgenvivktl nheiyeakyv isaippalgm kihyspplpm lrnqlisrvp lgsvikcmvy
      301 ykepfwrkkd fcgtmviege eapiaytldd tkpdgtyaai mgfilahkar klvrltkeer
      361 lrklcelyak vlnsqealqp vhyeeknwce eqysggcytt yfppgiltqy grvlrqpvgk
      421 iffagtetas hwsgymegav eageraarei lhaigkiped eiwqpepesl dvparpitst
      481 flerhlpsvp gllklfgltt ilsatalgfl ahkrglfvhf
//
