LOCUS       NM_173740               4161 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus monoamine oxidase A (Maoa), mRNA.
ACCESSION   NM_173740
VERSION     NM_173740.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4161)
  AUTHORS   Li,K.X., Fan,L., Wang,H., Tian,Y., Zhang,S., Hu,Q., Liu,F., Chen,H.
            and Hou,H.
  TITLE     A synonymous mutation of rs1137070 cause the mice Maoa gene
            transcription and translation to decrease
  JOURNAL   Front Mol Neurosci 17, 1406708 (2024)
   PUBMED   39359688
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4161)
  AUTHORS   Shi,Q., Malik,H., Crawford,R.M., Streeter,J., Wang,J., Huo,R.,
            Shih,J.C., Chen,B., Hall,D., Abel,E.D., Song,L.S. and Anderson,E.J.
  TITLE     Cardiac monoamine oxidase-A inhibition protects against
            catecholamine-induced ventricular arrhythmias via enhanced
            diastolic calcium control
  JOURNAL   Cardiovasc Res 120 (6), 596-611 (2024)
   PUBMED   38198753
  REMARK    GeneRIF: Cardiac monoamine oxidase-A inhibition protects against
            catecholamine-induced ventricular arrhythmias via enhanced
            diastolic calcium control.
REFERENCE   3  (bases 1 to 4161)
  AUTHORS   Lapierre,J.A., Geary,L.A., Jang,J.K., Epstein,A.L., Hong,F. and
            Shih,J.C.
  TITLE     Deletion of monoamine oxidase A in a prostate cancer model enhances
            anti-tumor immunity through reduced immune suppression
  JOURNAL   Biochem Biophys Res Commun 634, 100-107 (2022)
   PUBMED   36242915
  REMARK    GeneRIF: Deletion of monoamine oxidase A in a prostate cancer model
            enhances anti-tumor immunity through reduced immune suppression.
REFERENCE   4  (bases 1 to 4161)
  AUTHORS   Wang,Y.B., Song,N.N., Zhang,L., Ma,P., Chen,J.Y., Huang,Y., Hu,L.,
            Mao,B. and Ding,Y.Q.
  TITLE     Rnf220 is Implicated in the Dorsoventral Patterning of the
            Hindbrain Neural Tube in Mice
  JOURNAL   Front Cell Dev Biol 10, 831365 (2022)
   PUBMED   35399523
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4161)
  AUTHORS   Bajaj,J., Dwivedi,J., Sahu,R., Dave,V., Verma,K., Joshi,S.,
            Sati,B., Sharma,S., Seidel,V. and Mishra,A.P.
  TITLE     Antidepressant activity of Spathodea campanulata in mice and
            predictive affinity of spatheosides towards type A monoamine
            oxidase
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 67 (1), 1-8 (2021)
   PUBMED   34817375
  REMARK    GeneRIF: Antidepressant activity of Spathodea campanulata in mice
            and predictive affinity of spatheosides towards type A monoamine
            oxidase.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4161)
  AUTHORS   Cases,O., Seif,I., Grimsby,J., Gaspar,P., Chen,K., Pournin,S.,
            Muller,U., Aguet,M., Babinet,C., Shih,J.C. et al.
  TITLE     Aggressive behavior and altered amounts of brain serotonin and
            norepinephrine in mice lacking MAOA
  JOURNAL   Science 268 (5218), 1763-1766 (1995)
   PUBMED   7792602
REFERENCE   7  (bases 1 to 4161)
  AUTHORS   Charles,C.H., Abler,A.S. and Lau,L.F.
  TITLE     cDNA sequence of a growth factor-inducible immediate early gene and
            characterization of its encoded protein
  JOURNAL   Oncogene 7 (1), 187-190 (1992)
   PUBMED   1741163
REFERENCE   8  (bases 1 to 4161)
  AUTHORS   Herman,G.E., Berry,M., Munro,E., Craig,I.W. and Levy,E.R.
  TITLE     The construction of human somatic cell hybrids containing portions
            of the mouse X chromosome and their use to generate DNA probes via
            interspersed repetitive sequence polymerase chain reaction
  JOURNAL   Genomics 10 (4), 961-970 (1991)
   PUBMED   1916827
REFERENCE   9  (bases 1 to 4161)
  AUTHORS   Laval,S.H., Chen,Z.Y. and Boyd,Y.
  TITLE     The properdin structural locus (Pfc) lies close to the locus for
            tissue inhibitor of metallothionine proteases (Timp) on the mouse X
            chromosome
  JOURNAL   Genomics 10 (4), 1030-1034 (1991)
   PUBMED   1916808
REFERENCE   10 (bases 1 to 4161)
  AUTHORS   Derry,J.M., Lan,N.C., Shih,J.C., Barnard,E.A. and Barnard,P.J.
  TITLE     Localization of monoamine oxidase A and B genes on the mouse X
            chromosome
  JOURNAL   Nucleic Acids Res 17 (20), 8403 (1989)
   PUBMED   2573045
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK146612.1, AK164457.1 and BB694072.1.
            
            On Aug 12, 2009 this sequence version replaced NM_173740.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.5986.1, AK146612.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               AK146612.1         2-165
            165-2648            AK164457.1         2-2485
            2649-4067           AK146612.1         2650-4068
            4068-4161           BB694072.1         454-547
FEATURES             Location/Qualifiers
     source          1..4161
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 11.78 cM"
     gene            1..4161
                     /gene="Maoa"
                     /gene_synonym="1110061B18Rik"
                     /note="monoamine oxidase A"
                     /db_xref="GeneID:17161"
                     /db_xref="MGI:MGI:96915"
     exon            1..216
                     /gene="Maoa"
                     /gene_synonym="1110061B18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..1724
                     /gene="Maoa"
                     /gene_synonym="1110061B18Rik"
                     /EC_number="1.4.3.4"
                     /EC_number="1.4.3.21"
                     /note="MAO-A; monoamine oxidase type A"
                     /codon_start=1
                     /product="amine oxidase [flavin-containing] A"
                     /protein_id="NP_776101.3"
                     /db_xref="CCDS:CCDS30033.1"
                     /db_xref="GeneID:17161"
                     /db_xref="MGI:MGI:96915"
                     /translation="MTDLEKPSITGHMFDVVVIGGGISGLAAAKLLSEYKINVLVLEA
                     RDRVGGRTYTVRNEHVKWVDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVK
                     GKTYPFRGAFPPVWNPLAYLDYNNLWRTMDDMGKEIPVDAPWQARHAEEWDKITMKDL
                     IDKICWTKTAREFAYLFVNINVTSEPHEVSALWFLWYVRQCGGTSRIFSVTNGGQERK
                     FVGGSGQISEQIMVLLGDKVKLSSPVTYIDQTDDNIIIETLNHEHYECKYVISAIPPV
                     LTAKIHFKPELPPERNQLIQRLPMGAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIS
                     ITLDDTKPDGSMPAIMGFILARKAERLAKLHKDIRKRKICELYAKVLGSQEALSPVHY
                     EEKNWCEEQYSGGCYTAYFPPGIMTLYGRVIRQPVGRIYFAGTETATQWSGYMEGAVE
                     AGERAAREVLNALGKVAKKDIWVQEPESKDVPALEITHTFLERNLPSVPGLLKITGFS
                     TSVALLCFVLYKFKQPQS"
     exon            217..311
                     /gene="Maoa"
                     /gene_synonym="1110061B18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            312..449
                     /gene="Maoa"
                     /gene_synonym="1110061B18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            450..554
                     /gene="Maoa"
                     /gene_synonym="1110061B18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            555..646
                     /gene="Maoa"
                     /gene_synonym="1110061B18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            647..788
                     /gene="Maoa"
                     /gene_synonym="1110061B18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            789..938
                     /gene="Maoa"
                     /gene_synonym="1110061B18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1098
                     /gene="Maoa"
                     /gene_synonym="1110061B18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1195
                     /gene="Maoa"
                     /gene_synonym="1110061B18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1249
                     /gene="Maoa"
                     /gene_synonym="1110061B18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1307
                     /gene="Maoa"
                     /gene_synonym="1110061B18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1405
                     /gene="Maoa"
                     /gene_synonym="1110061B18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1517
                     /gene="Maoa"
                     /gene_synonym="1110061B18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1580
                     /gene="Maoa"
                     /gene_synonym="1110061B18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..4161
                     /gene="Maoa"
                     /gene_synonym="1110061B18Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1956..1961
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Maoa"
                     /gene_synonym="1110061B18Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1985
                     /gene="Maoa"
                     /gene_synonym="1110061B18Rik"
                     /note="major polyA site"
     polyA_site      2007
                     /gene="Maoa"
                     /gene_synonym="1110061B18Rik"
                     /note="major polyA site"
     regulatory      2069..2074
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Maoa"
                     /gene_synonym="1110061B18Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2093
                     /gene="Maoa"
                     /gene_synonym="1110061B18Rik"
                     /note="major polyA site"
     regulatory      3955..3960
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Maoa"
                     /gene_synonym="1110061B18Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3976
                     /gene="Maoa"
                     /gene_synonym="1110061B18Rik"
ORIGIN      
        1 cttcagggcc gggctcttcc cgggtatgga tagatacatc agctccgccc tcggacttca
       61 gtcaaggggc ggtacaaggg tctgttccac cctgggcggt cccccctttt aaacccaagt
      121 ctcgggagaa ttttacccaa accatgacgg atctggagaa gcccagtatc acaggccaca
      181 tgttcgacgt agtcgtgatt ggaggcggca tctcaggatt ggctgctgcc aaactattgt
      241 cagaatacaa aattaatgtc ttggttctgg aagcccggga tagagttgga ggaagaacat
      301 atactgtgag gaatgagcat gttaaatggg tagatgttgg tggagcttat gtgggaccaa
      361 cccagaacag aatcttacgc ttgtctaagg agctaggcat agagacctat aaagtgaatg
      421 tcaatgagcg tctagttcaa tatgtcaagg ggaaaactta cccattccgt ggtgcatttc
      481 cacctgtgtg gaaccccttg gcatatttgg attacaacaa cctgtggagg acaatggatg
      541 atatgggaaa agagatccct gttgatgcac catggcaagc aagacatgct gaggaatggg
      601 acaagataac catgaaagat ctcattgata aaatctgttg gacaaaaact gctcgagaat
      661 ttgcttatct ttttgtgaac attaatgtga cttctgagcc tcatgaggta tctgccctgt
      721 ggttcttgtg gtatgtgagg cagtgtggag gtacctctcg gatattctca gtcaccaatg
      781 gcggccagga acggaaattt gtaggtggct ctggccaaat aagtgaacag ataatggtcc
      841 tccttgggga taaagtgaag ctgagctctc ctgttactta tattgaccaa acagatgaca
      901 acatcattat agaaacactg aatcatgagc actatgagtg caaatatgta attagtgcca
      961 tcccaccggt tttgactgcc aagatccact ttaaaccaga gcttccacct gagagaaacc
     1021 aattaattca gcgtcttcca atgggggctg tcatcaagtg catggtgtat tacaaggaag
     1081 ccttctggaa gaaaaaggac tattgtggct gcatgataat tgaagatgag gaggctccaa
     1141 tttcaatcac tctggatgac actaaaccag atgggtcaat gcctgccatc atgggcttca
     1201 tacttgcccg gaaagctgaa cgacttgcta aactacataa agacataagg aagaggaaaa
     1261 tctgtgagct gtatgccaaa gttctgggat ctcaagaagc tttatctccc gtccattatg
     1321 aagagaagaa ctggtgtgag gagcagtact ccgggggctg ctacacagcc tacttccctc
     1381 ctggtatcat gactctgtat ggaagggtga ttcggcagcc agtaggcagg atttactttg
     1441 caggcacaga gacagcaaca cagtggagtg gctacatgga aggtgcagtt gaagctggag
     1501 aacgagcagc tagagaggtc ttgaatgctc taggaaaagt tgccaagaag gatatatggg
     1561 ttcaagagcc tgagtccaag gatgttccag ctcttgaaat tacccacacc ttcttagaga
     1621 ggaacctgcc ttccgtgcct ggtctgctca agatcactgg tttttccact tctgtggctc
     1681 ttctctgctt tgtattgtac aagtttaaac agccccagtc ctgaagtttt cacccacagg
     1741 cctcctgctt gatcatcctt agcacaatga gcatgtaaag gaaagtgagg atgaattaca
     1801 gcctgtggtt tgggcaattt aagtgcactt gatttaaccc tgctcagttt aatttcagtc
     1861 tttgtaaagt ggtaacagtc caaagaatca cctagctaat ttccataaga atgagtttca
     1921 tcttgtttgt tagactaatt tgtgttggtt gatagaataa aatgttgagt gcttaatttc
     1981 aaaaagttaa gtgcttatga ggaataattt ctggattctg tttttttttt tcttttgcct
     2041 ttaatgcaaa acagctaatg gtttcagaaa taaaataact tgacttactg tgacttttgt
     2101 gtagcatcca atgtgtacag aggaaaatag tggctgaaat gttccctagg tatcctcact
     2161 gattactagt tccatgtgac gcacactaca ataggcactt ccttttctgg actgtatcta
     2221 gacaagcatt gctccttgtc agtaacattc tgtgctgatt taaggaaagt agcattattt
     2281 taatgtgttc tatggctgtc tgatcataga attagatttc taagcctacc tgtgtcttca
     2341 aaatggttaa atatttgtct tggttgatag tataccattt tctctcaagt gccaaaggac
     2401 atatgaaatt ttctctgttg ttacagtcaa acacagaatg aaattagggc tctgtgtgat
     2461 aacatgacct cttttaatta ttaggtttta taacagacat taaattgaat gattttatat
     2521 atctgtactg ggttctatat cttagtagag ttgtgggtcc agaatggtgc ctgtattttt
     2581 ttctttccca tctgaaatcc tgtcaattaa aaaaaaaaat tccaaaggtt tcaaccacaa
     2641 agcactttaa aaaaaaatgt aagtatagtt tttatttaag gagaattatg tcagcatatg
     2701 ctggccaacc caagtttatt atactagctt tatccaaaat gtaaatttaa gcctctagat
     2761 gctgatgtgt ggacttacag cctttaaagt tttgcccagt ctaagagcaa agatctagat
     2821 ttcttacctt actctatctt ataattcaaa agcattttaa ctaacttaaa agattcagtg
     2881 atgtcttaga tgttctccag tccataaggt gttgcctcaa ttcatatcaa actgtagtga
     2941 gagctctcag cactaatctg ctccagttgt gtgtattaac ttagtcgtga ctcatcttga
     3001 aatgatttaa aggagtggat aggcaagagg tctaaaagta ttcagattgt taacactaaa
     3061 ctgttgaata ttgaaaacct cctgagtttg cagtttactc tctgcttttt agaaaaccag
     3121 ttgatctatc ctaatgatat caaccctatt aagctacagt ctgggtatta aaatgatttc
     3181 cagtacagcc catgtgttta gacatgtaac gggaattaag aagcactata tgtttccaat
     3241 tctaagaagg ggcaaagtgt ccacactttg gtctatgttc ttcttcagtt tcatgtgttt
     3301 tacaaattgt ctcttatatc tcgggtatac taagtttctg ggctaatatc cacttatcag
     3361 tgagtacata tcatttgagt tcttttgtga ttgtgttacc tcactcagga tgatgccctc
     3421 caggtataac catttgccta ggaatttcat aaattcattc tttttaatag ctgagtagta
     3481 ctctaggtgc aacaacatta tgaactaacc agtaccccag agctcttgac tctagctgca
     3541 tatgtatcaa aagatggcct agtaggccat cactggaaag agaggcccat tggacactca
     3601 aactttatat gcccgagtac aggggaacgc cagggccaaa aagtgggagt gggtgggtag
     3661 gggagtgggg gaagggtatg ggggactttt gggatagcat tggaaatgta attgaggaaa
     3721 atacgtaata aaaaaattaa aaaaaaaagt agcactatat gtgaggctgt ctaccacaaa
     3781 gttaacattg ccctttactt tgcaacagag aaacaaaaat catttcaaga gattgataat
     3841 ccccttcata gatctgatgg ccagttggcc tttctccata gttaggatga gaattggttt
     3901 tttaaaagta catctttttg tcatagctgt taaatatgat ctcatattac actgaataaa
     3961 tttaaacttt actgaaggac tgtgaactat gttttgcttg atggttgtaa acttggtacc
     4021 taatgttcca cgtaaaaata aagttggcca cagagctaca tatgggcata tgcatatgta
     4081 tttgatttgc cactgaagta agatattgtc tgtgtggtac tgagttttgt tgttgttctt
     4141 aataaaatgt gatgccatcc t
//
