LOCUS       NM_172865               4839 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus mannosidase, endo-alpha (Manea), transcript variant 1,
            mRNA.
ACCESSION   NM_172865
VERSION     NM_172865.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4839)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 4839)
  AUTHORS   Diez-Roux,G., Banfi,S., Sultan,M., Geffers,L., Anand,S., Rozado,D.,
            Magen,A., Canidio,E., Pagani,M., Peluso,I., Lin-Marq,N., Koch,M.,
            Bilio,M., Cantiello,I., Verde,R., De Masi,C., Bianchi,S.A.,
            Cicchini,J., Perroud,E., Mehmeti,S., Dagand,E., Schrinner,S.,
            Nurnberger,A., Schmidt,K., Metz,K., Zwingmann,C., Brieske,N.,
            Springer,C., Hernandez,A.M., Herzog,S., Grabbe,F., Sieverding,C.,
            Fischer,B., Schrader,K., Brockmeyer,M., Dettmer,S., Helbig,C.,
            Alunni,V., Battaini,M.A., Mura,C., Henrichsen,C.N.,
            Garcia-Lopez,R., Echevarria,D., Puelles,E., Garcia-Calero,E.,
            Kruse,S., Uhr,M., Kauck,C., Feng,G., Milyaev,N., Ong,C.K.,
            Kumar,L., Lam,M., Semple,C.A., Gyenesei,A., Mundlos,S., Radelof,U.,
            Lehrach,H., Sarmientos,P., Reymond,A., Davidson,D.R., Dolle,P.,
            Antonarakis,S.E., Yaspo,M.L., Martinez,S., Baldock,R.A., Eichele,G.
            and Ballabio,A.
  TITLE     A high-resolution anatomical atlas of the transcriptome in the
            mouse embryo
  JOURNAL   PLoS Biol 9 (1), e1000582 (2011)
   PUBMED   21267068
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL805949.4.
            
            On Sep 1, 2022 this sequence version replaced NM_172865.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067076.1, AK030141.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-272               AL805949.4         71102-71373         c
            273-854             AL805949.4         64922-65503         c
            855-964             AL805949.4         61126-61235         c
            965-1041            AL805949.4         53591-53667         c
            1042-4839           AL805949.4         49016-52813         c
FEATURES             Location/Qualifiers
     source          1..4839
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 10.92 cM"
     gene            1..4839
                     /gene="Manea"
                     /gene_synonym="4932703L02Rik"
                     /note="mannosidase, endo-alpha"
                     /db_xref="GeneID:242362"
                     /db_xref="MGI:MGI:2444484"
     exon            1..272
                     /gene="Manea"
                     /gene_synonym="4932703L02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            273..854
                     /gene="Manea"
                     /gene_synonym="4932703L02Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             311..1699
                     /gene="Manea"
                     /gene_synonym="4932703L02Rik"
                     /EC_number="3.2.1.130"
                     /note="isoform 1 is encoded by transcript variant 1;
                     glycoprotein endo-alpha-1,2-mannosidase; mEndo;
                     endomannosidase; endo-alpha mannosidase"
                     /codon_start=1
                     /product="glycoprotein endo-alpha-1,2-mannosidase isoform
                     1"
                     /protein_id="NP_766453.2"
                     /db_xref="CCDS:CCDS18012.1"
                     /db_xref="GeneID:242362"
                     /db_xref="MGI:MGI:2444484"
                     /translation="MAKFRRRTCILLSLFILFIFSLMMGLKMLWPNAASFGPPFGLDL
                     LPELHPLNAHSGNKADFQRSDRINMETNTKALKGAGMTVLPAKASEVNLEELPPLNYF
                     LHAFYYSWYGNPQFDGKYIHWNHPVLEHWDPRIAKNYPQGQHSPPDDIGSSFYPELGS
                     YSSRDPSVIETHMKQMRSASIGVLALSWYPPDSRDDNGEATDHLVPTILDKAHKYNLK
                     VTFHIEPYSNRDDQNMHQNIKYIIDKYGNHPAFYRYKTRTGHSLPMFYVYDSYITKPT
                     IWANLLTPSGSQSVRSSPYDGLFIALLVEEKHKNDILQSGFDGIYTYFATNGFTYGSS
                     HQNWNNLKSFCEKNNLMFIPSVGPGYIDTSIRPWNTQNTRNRVNGKYYEVGLSAALQT
                     HPSLISITSFNEWHEGTQIEKAVPKRTANTIYLDYRPHKPSLYLELTRKWSEKFSKER
                     MTYALDQQQPAS"
     exon            855..964
                     /gene="Manea"
                     /gene_synonym="4932703L02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1041
                     /gene="Manea"
                     /gene_synonym="4932703L02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..4839
                     /gene="Manea"
                     /gene_synonym="4932703L02Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4815..4820
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Manea"
                     /gene_synonym="4932703L02Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4839
                     /gene="Manea"
                     /gene_synonym="4932703L02Rik"
                     /note="major polyA site"
ORIGIN      
        1 agcggtgcgg ccgcaagagc tgtcagccct ggtaggattc acggttcttt ctcttatccg
       61 gtgggtccac gcggaggcag ggtcccagac cccggtgagc aattgtgagg ccccggaact
      121 gagacccaca gggactccgc agctaacccc tgcgcgctcg cccgccagcc aatcgtgggc
      181 cgcctgcctg cgacgccctt tgaccccggg cctctaggaa tccagtcgcg ctcagcccag
      241 cagcccggtt ccgcgccggt ccccgccgct agaaaaacat ttactagttt ggagtttaaa
      301 gtatgtcatc atggcaaaat ttcgaagaag gacctgcatc cttttgtcac tttttattct
      361 atttattttt tctctgatga tgggcttaaa gatgctgtgg ccaaacgcag catcctttgg
      421 acctcctttt ggacttgacc tccttccaga acttcatcca ctaaatgcgc attcgggaaa
      481 caaagctgac ttccaaagga gtgatagaat caacatggaa acaaacacca aggctttaaa
      541 aggcgctggc atgactgtgc tgccagccaa agcctctgag gtgaacctgg aagaactacc
      601 tcctctgaat tactttttac atgcatttta ttacagttgg tatggaaatc cacagtttga
      661 tggtaaatat atacactgga atcatccggt cctggaacac tgggaccctc ggatagccaa
      721 gaactatcca caaggacaac atagtcctcc agacgacatt ggctccagtt tttatcctga
      781 gttaggaagt tacagctctc gagacccttc tgtcatagaa actcacatga aacaaatgcg
      841 ctcagcctca attggagttc tggccctgtc ttggtaccca cctgattcaa gggatgacaa
      901 tggcgaagct actgatcact tggtgccaac cattttggat aaagctcata aatataatct
      961 gaaggtcact tttcacatag agccatatag caatcgagat gatcaaaaca tgcatcaaaa
     1021 tatcaagtat attatagaca aatatggaaa ccatccagcc ttttatagat acaagaccag
     1081 gactgggcat tctctgccca tgttttatgt ctatgattct tacatcacaa agcctacaat
     1141 atgggccaat ctgttaacac cctccggatc tcagagtgtt cgcagttctc cttatgatgg
     1201 attgtttatt gcacttctag tagaagaaaa gcataaaaat gatattcttc agagtggttt
     1261 tgatggtatt tacacatatt ttgccacaaa tggctttaca tatggctcat ctcatcagaa
     1321 ttggaataac ctgaaatcct tttgtgaaaa gaacaacttg atgtttatcc caagtgtagg
     1381 cccaggatac atagatacaa gcatccgacc atggaacact cagaacaccc ggaacagagt
     1441 caatgggaag tattatgaag ttggtctaag tgctgcactc cagacccacc ccagtttaat
     1501 ttccatcacc tctttcaatg agtggcatga aggaactcaa attgaaaagg ctgtccccaa
     1561 aagaactgct aacacgatat acctggatta ccggcctcat aagccaagtc tttatctaga
     1621 actaactcga aagtggtctg aaaaattcag taaggaaaga atgacgtatg cattggatca
     1681 acagcagcct gcttcataat gtatccctta cagtttatca cgtctactag cttaagtcaa
     1741 catgctgtgt ttttgttatg gaaagaaaac tcaaaatcaa tctgtgtttg caattataac
     1801 ctttatcagt tatttcattt ttacttttta aaagattcgt tttcctacaa tggataatac
     1861 catacagaga aaacatctga caagaaagat tgtgtctgta acattcctga tgatgtggta
     1921 ttctgaattt ctagctacat tgaaatctta atgggatagc cttttagttt tttgtttcac
     1981 agtagaaaaa aaaatgatta tattatcatc acaaaaagta gctaacgtcc aagtaagtca
     2041 tacttatata ctgggtccaa agacatagaa gtatgtacat gctaagtaca tctggcaaca
     2101 aaagttcagg ctaacgaaca gtaaccagat gtgcttcatt tctggtctct tcagtgaagt
     2161 ttgttaataa tattcagatt ccggctggct tcccctggtg atcaaactca cttctcaagt
     2221 ttcttgtgaa cacaaacttg tttaagtaac aagctatttt attacatttc tctatttctg
     2281 ttagccatgg tctgttctcg aatggctttg tgcagagcat ccatcagtgt catcatttga
     2341 agacttgggt gcctgtggct ctaagtgctt ttctatgttt aatgccctgc ctggtgtgtc
     2401 ctgctgaatt aaagactaga aacaatatat agtttattaa gtgttaatga ctggtacacg
     2461 cctttaatcc cagcacttgg gaggcagagg caggtgggtt tctgagtacg aggccaactt
     2521 agtctacaaa gtgagttcca ggacagccag agctatacag agaaactctg tctcgaaaac
     2581 ccagaaaaat acatacatat atacatacat acatacatac atacatacat acatacatac
     2641 atgttaatga ctgctcttat ctatgaggaa aaccattgtt tctcagtggt taaaataaat
     2701 gttcaccaga aactactgaa ctgactgaaa aaggataaca ttaatcctca agagtgtttt
     2761 ccttttaata ttttcattta attttactgt aagacagaaa aaaattgctt atcacttcaa
     2821 aactagagat aaatagtttt aaagtaacat atttttcagt tatgtcctca tatttggatg
     2881 tcttacactt ttggtttaaa aagaaactgt tagtgatata gttacaaatt gaaaagttct
     2941 atgctaaaaa taaatttttg taaaagtgaa aataggagaa attgactgaa ttcaatattt
     3001 ataattaaaa tagaaaaacc acctagtcta tataatttta cacaactgtt atttcttagt
     3061 actacagaga ggaccagttg agtaacacta acaaatattg catgccagcc ttcatagcat
     3121 aaagacattt agaaaccagt aagttctggg atgtatttta aaatacacag cagagaggaa
     3181 gcagttttag ggtaagagtg actgctctgt ggggaaagtt cttgctgtgc aagcctgaag
     3241 acctgagtct gaacacctag aactcaaaca gatacgagct cacgagcatg catgttctag
     3301 tccacggctt ctccagtgag cgagagaaag tggacacagt acagagccca gaagtgcatg
     3361 agccagttag cctgccgtac acaacagcac taagacatat gtctcaaaca tggtgggcag
     3421 cagaggtcgg caggcaaggt tgctctgaca ttcagaccca tgtcatgtca tagtcagtct
     3481 ccctcttact ctggaatgtt tgaacatact tacacacaga gcttttttaa aacgcatgtt
     3541 taaaataatt cttttagcat aaaatctttt tcaagagata tactaacctt attaaattaa
     3601 aattttctat ttatcagaat attattgggc cattaaaaat tatgaaaata atagtctgat
     3661 ttttccagat aaattgtaag aataatttaa tatagtagta ttttaatatt acacatctcc
     3721 attgggataa ggagaaatat aacctataga tctttttttt ttgctttgct actagattaa
     3781 agctgaattt taatacatag acttttacag catatgctgt tttcttcata ccttatgtta
     3841 cattttctat ttgagtccac catgacaaaa agtgaatgtt atgaaacaat tctgagacag
     3901 aataagtcta cgcaaataag gtctagcaac tgtccataag agttcaactt tctcagtgga
     3961 cagctcactc tagctcttgc tgttcccagt acatctaccc gatcaatagt cagtcagaac
     4021 ttaaaattag acagacgtta tctttatttt tttaaagaat tgctgtctaa ggaatgactg
     4081 aaatatcttt tcataagact tattagttga taattatata aaggaccata gccacccctc
     4141 tggtttccac aaccaaatat tcagccaact aaggctcaaa atacttggga acaaaactcc
     4201 acttgtatat atcaagcatg tttagtgtgt ctccatccct taagccatac agtataacca
     4261 ccacttagat ttttctaggt attacaaata agttgagagg gtttaaagtg tacctgaaga
     4321 tcattgtgga attatattca aatcctgttc cacgttttaa aacgacctaa gcatattcag
     4381 ccatttttac ctttgggtcc tgaagccagt tctacacaga tatcaaggga tggctatatt
     4441 cacaatattg ctagtgattg ttagaggagc ctctttttcc aggtgtctct gctgtctgac
     4501 tggaaacaca gctggaattg caatgatcac aagtcaatct aatcaaatga tcctgttctt
     4561 atttttataa atctgaatat taggattcag taaacttaaa gaggtacagt atgaattaaa
     4621 tcagtttttt aataagcctt ttgttttgtg gattaaccca tctaattgtt tagagaacta
     4681 gatccttatt tcttctttca agatgtaatt gtaaaagact gcccttatta gtgtttgaat
     4741 tgtatattaa cttgcttatt tatgtgtgta aagtggaaaa tgttttattt tattatatgg
     4801 tgttaatttt gtctaataaa agcataaatg aatactgtt
//
