LOCUS       NM_027288               3688 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus mannosidase, beta A, lysosomal (Manba), mRNA.
ACCESSION   NM_027288
VERSION     NM_027288.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3688)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3688)
  AUTHORS   Gu,X., Yang,H., Sheng,X., Ko,Y.A., Qiu,C., Park,J., Huang,S.,
            Kember,R., Judy,R.L., Park,J., Damrauer,S.M., Nadkarni,G.,
            Loos,R.J.F., My,V.T.H., Chaudhary,K., Bottinger,E.P., Paranjpe,I.,
            Saha,A., Brown,C., Akilesh,S., Hung,A.M., Palmer,M., Baras,A.,
            Overton,J.D., Reid,J., Ritchie,M., Rader,D.J. and Susztak,K.
  TITLE     Kidney disease genetic risk variants alter lysosomal
            beta-mannosidase (MANBA) expression and disease severity
  JOURNAL   Sci Transl Med 13 (576) (2021)
   PUBMED   33441424
REFERENCE   3  (bases 1 to 3688)
  AUTHORS   Gytz,H., Liang,J., Liang,Y., Gorelik,A., Illes,K. and Nagar,B.
  TITLE     The structure of mammalian beta-mannosidase provides insight into
            beta-mannosidosis and nystagmus
  JOURNAL   FEBS J 286 (7), 1319-1331 (2019)
   PUBMED   30552791
REFERENCE   4  (bases 1 to 3688)
  AUTHORS   Di Lorenzo,G., Velho,R.V., Winter,D., Thelen,M., Ahmadi,S.,
            Schweizer,M., De Pace,R., Cornils,K., Yorgan,T.A., Grub,S.,
            Hermans-Borgmeyer,I., Schinke,T., Muller-Loennies,S., Braulke,T.
            and Pohl,S.
  TITLE     Lysosomal Proteome and Secretome Analysis Identifies Missorted
            Enzymes and Their Nondegraded Substrates in Mucolipidosis III Mouse
            Cells
  JOURNAL   Mol Cell Proteomics 17 (8), 1612-1626 (2018)
   PUBMED   29773673
REFERENCE   5  (bases 1 to 3688)
  AUTHORS   Tang,F., Barbacioru,C., Nordman,E., Bao,S., Lee,C., Wang,X.,
            Tuch,B.B., Heard,E., Lao,K. and Surani,M.A.
  TITLE     Deterministic and stochastic allele specific gene expression in
            single mouse blastomeres
  JOURNAL   PLoS One 6 (6), e21208 (2011)
   PUBMED   21731673
REFERENCE   6  (bases 1 to 3688)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 3688)
  AUTHORS   Beccari,T., Bibi,L., Stinchi,S., Stirling,J.L. and Orlacchio,A.
  TITLE     Mouse beta-mannosidase: cDNA cloning, expression, and chromosomal
            localization
  JOURNAL   Biosci Rep 21 (3), 315-323 (2001)
   PUBMED   11892998
REFERENCE   8  (bases 1 to 3688)
  AUTHORS   Alkhayat,A.H., Kraemer,S.A., Leipprandt,J.R., Macek,M.,
            Kleijer,W.J. and Friderici,K.H.
  TITLE     Human beta-mannosidase cDNA characterization and first
            identification of a mutation associated with human
            beta-mannosidosis
  JOURNAL   Hum Mol Genet 7 (1), 75-83 (1998)
   PUBMED   9384606
REFERENCE   9  (bases 1 to 3688)
  AUTHORS   Schmutz,S.M., Moker,J.S., Leipprandt,J.R. and Friderici,K.H.
  TITLE     Beta-mannosidase maps to cattle chromosome 6
  JOURNAL   Mamm Genome 7 (6), 474 (1996)
   PUBMED   8662218
REFERENCE   10 (bases 1 to 3688)
  AUTHORS   Lundin,L.G.
  TITLE     A gene (Bmn) controlling beta-mannosidase activity in the mouse is
            located in the distal part of chromosome 3
  JOURNAL   Biochem Genet 25 (7-8), 603-610 (1987)
   PUBMED   3447593
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF306557.1, BB782198.1 and BU757579.1.
            
            On Oct 23, 2007 this sequence version replaced NM_027288.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031409.1, AK166022.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3553              AF306557.1         5-3557
            3554-3604           BB782198.1         394-444
            3605-3688           BU757579.1         1-84                c
FEATURES             Location/Qualifiers
     source          1..3688
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 62.65 cM"
     gene            1..3688
                     /gene="Manba"
                     /gene_synonym="2410030O07Rik; B930014J03Rik; Bmn"
                     /note="mannosidase, beta A, lysosomal"
                     /db_xref="GeneID:110173"
                     /db_xref="MGI:MGI:88175"
     exon            1..247
                     /gene="Manba"
                     /gene_synonym="2410030O07Rik; B930014J03Rik; Bmn"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..2710
                     /gene="Manba"
                     /gene_synonym="2410030O07Rik; B930014J03Rik; Bmn"
                     /EC_number="3.2.1.25"
                     /note="beta-mannosidase; mannase; mannanase; lysosomal
                     beta A mannosidase"
                     /codon_start=1
                     /product="beta-mannosidase precursor"
                     /protein_id="NP_081564.3"
                     /db_xref="CCDS:CCDS17857.1"
                     /db_xref="GeneID:110173"
                     /db_xref="MGI:MGI:88175"
                     /translation="MHLHLLLILALFRAGCVVAGPSYSLSGSWRVSNGNGSLELPATV
                     PGYVHSALHQHGLIQDPYYRFNDLNYRWISLDNWTYSTEFKIPFNLSEWQKVKLIFDG
                     VDTVAEILFNNVTIGKTDNMFTGYSFDVTNVVKDVNSLKLQFRSAVQYAECQSKAHTS
                     YRVPPECPPVEQKGECHVNFIRKAQCSFSWDWGPSFPSQGIWKDVRIEAYNIAHLDYL
                     TFLPVYDNASQAWNIEIEASFDVASSKSVSGQVTVAIPQLKTQQTNDIELQQEQRIVK
                     LLVKIRKDVAVETWWPRGHGNQTGYNMTILFALDGGLKIEKAAKVYFRTVQLIEEGIK
                     GSPGLSFYFKINGLPIFLKGSNWIPADSFQDKVTSDRLQLLFQSVVDANMNTLRVWGG
                     GIYEQDEFYALCDELGIMVWQDFMFASALYPTEPGFLASVRKEVTYQVRRLKSHPSII
                     IWSGNNENEVALSVNWFHVNPRDMKTYIDDYVTLYVKNIRKIVLSEDKSRPFIASSPT
                     NGMKTMEEGWISYDPYSIQYGDIHFYNYADDCWNWKIFPKARLVSEYGYQSWPSFSTL
                     EKVSSQEDWAYNSRFSLHRQHHEDGNHQMLHQVKMHFKLPQGTDPLRTFKDTIYLTQV
                     MQAQCIKTETEFYLRSRSEIVDGKGHTMGALYWQLNDIWQAPSWASLEYGGKWKMLHY
                     FARRFFAPLLPVGFEDEGVFYVYGVSDLHKDHHTQLTVRLHHWSSPKPLCSLVNSSIV
                     VKAGEAVVLFQMPVSELLKRCRGCTRETCVVSFYFSTDKELFSPTNYHFLSSLKDAKG
                     LLEANITVNISQKGNVFVFDLETSAVAPFVWLDVGSIPGRFSDNGFLMIRKKLSVLFY
                     PWKPTSKSELQQAFSVTSLTDTY"
     exon            248..342
                     /gene="Manba"
                     /gene_synonym="2410030O07Rik; B930014J03Rik; Bmn"
                     /inference="alignment:Splign:2.1.0"
     exon            343..448
                     /gene="Manba"
                     /gene_synonym="2410030O07Rik; B930014J03Rik; Bmn"
                     /inference="alignment:Splign:2.1.0"
     exon            449..619
                     /gene="Manba"
                     /gene_synonym="2410030O07Rik; B930014J03Rik; Bmn"
                     /inference="alignment:Splign:2.1.0"
     exon            620..743
                     /gene="Manba"
                     /gene_synonym="2410030O07Rik; B930014J03Rik; Bmn"
                     /inference="alignment:Splign:2.1.0"
     exon            744..919
                     /gene="Manba"
                     /gene_synonym="2410030O07Rik; B930014J03Rik; Bmn"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1030
                     /gene="Manba"
                     /gene_synonym="2410030O07Rik; B930014J03Rik; Bmn"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1182
                     /gene="Manba"
                     /gene_synonym="2410030O07Rik; B930014J03Rik; Bmn"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1300
                     /gene="Manba"
                     /gene_synonym="2410030O07Rik; B930014J03Rik; Bmn"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1387
                     /gene="Manba"
                     /gene_synonym="2410030O07Rik; B930014J03Rik; Bmn"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1555
                     /gene="Manba"
                     /gene_synonym="2410030O07Rik; B930014J03Rik; Bmn"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1774
                     /gene="Manba"
                     /gene_synonym="2410030O07Rik; B930014J03Rik; Bmn"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1939
                     /gene="Manba"
                     /gene_synonym="2410030O07Rik; B930014J03Rik; Bmn"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2084
                     /gene="Manba"
                     /gene_synonym="2410030O07Rik; B930014J03Rik; Bmn"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2227
                     /gene="Manba"
                     /gene_synonym="2410030O07Rik; B930014J03Rik; Bmn"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2485
                     /gene="Manba"
                     /gene_synonym="2410030O07Rik; B930014J03Rik; Bmn"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..3675
                     /gene="Manba"
                     /gene_synonym="2410030O07Rik; B930014J03Rik; Bmn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3581..3586
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Manba"
                     /gene_synonym="2410030O07Rik; B930014J03Rik; Bmn"
                     /note="hexamer: AATAAA"
     polyA_site      3605
                     /gene="Manba"
                     /gene_synonym="2410030O07Rik; B930014J03Rik; Bmn"
                     /note="major polyA site"
     regulatory      3652..3657
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Manba"
                     /gene_synonym="2410030O07Rik; B930014J03Rik; Bmn"
                     /note="hexamer: AATAAA"
     polyA_site      3675
                     /gene="Manba"
                     /gene_synonym="2410030O07Rik; B930014J03Rik; Bmn"
                     /note="major polyA site"
ORIGIN      
        1 ggggacacag cgtccaggcc ttggcaaggc ttgggcgaca ctgccgggtt cctgcttgcg
       61 agcggtcagc atgcatcttc acctgctctt gatattggcg ctatttcggg ccggctgcgt
      121 ggtggcaggt cctagctaca gcctgagcgg gagctggcgg gtgagcaacg ggaatggctc
      181 cctggagcta ccggcgactg tccccggcta tgtgcacagc gccctgcacc agcacgggct
      241 gatccaggat ccttactaca gatttaatga cctgaactat agatggattt ccttagataa
      301 ctggacctac agcacggaat ttaaaatccc ctttaatctc agtgaatggc agaaggtaaa
      361 gttgatcttt gatggagttg acacggttgc agaaatcctg ttcaacaatg tcaccattgg
      421 gaagacagac aacatgttca ctggatacag ctttgacgtc accaacgtag tcaaagacgt
      481 gaactcctta aagctgcagt tccggtcagc agtgcagtat gcagagtgtc agagcaaggc
      541 tcacactagc taccgggtgc ccccagagtg ccccccggtg gagcagaagg gtgaatgtca
      601 cgtcaacttc atccgaaagg cacagtgttc cttcagctgg gactggggcc cttccttccc
      661 ctctcaggga atctggaaag atgttagaat cgaagcctat aacattgctc atctggatta
      721 cctcacgttt ttgccagtat atgataacgc ttctcaggcc tggaatattg aaatagaggc
      781 ttcttttgat gtcgccagct cgaagtccgt tagtggtcag gtgacagtag ccatccctca
      841 actgaaaaca cagcagacaa acgacattga acttcaacaa gagcaaagga ttgttaaact
      901 actggtcaaa attaggaagg acgttgctgt ggagacctgg tggcctcgtg gacatgggaa
      961 ccagactggg tacaacatga caattctctt tgctctggat ggaggcttaa aaattgagaa
     1021 agcagccaag gtttatttca ggacagtgca actgatagaa gagggcataa aagggtctcc
     1081 tggtctgagt ttctacttca aaattaatgg gcttcctata tttctgaaag gctcaaattg
     1141 gattccagcc gactccttcc aagacaaagt cacttccgat cggctgcagc tccttttcca
     1201 gtccgtcgtg gatgcgaaca tgaacactct gcgcgtgtgg gggggtggca tctacgagca
     1261 ggatgagttc tatgcgctct gtgatgaact tgggataatg gtgtggcagg actttatgtt
     1321 tgccagtgcc ctttatccaa ctgagcctgg cttcttagcc tccgtgagga aagaagtcac
     1381 ctaccaggtc aggagactga aatctcaccc ctccatcatc atatggagtg gtaataatga
     1441 gaatgaagtg gctctcagcg tgaactggtt ccacgtaaat cccagggaca tgaaaacgta
     1501 cattgacgac tacgtgaccc tctatgtgaa gaacatcagg aagattgtct tatcagaaga
     1561 caagagccgt cctttcattg catccagccc aaccaacggg atgaaaacca tggaggaagg
     1621 ctggatctct tacgaccctt atagcatcca gtatggtgat attcattttt ataactatgc
     1681 cgatgactgc tggaattgga agatcttccc aaaagctcga ttagtgtctg aatatggcta
     1741 ccagtcctgg ccttctttta gcacactaga aaaggtctca tctcaggagg actgggctta
     1801 caacagccgc ttctcccttc atcggcagca tcatgaagat ggcaaccatc agatgctgca
     1861 ccaggtcaag atgcatttca aactccccca ggggacagac ccattgcgca catttaaaga
     1921 cactatctac cttactcagg tgatgcaagc ccagtgcatc aaaacagaaa ccgagttcta
     1981 cctgcgcagc cgcagcgaga tagtggacgg aaaaggccac accatggggg cactgtactg
     2041 gcagctgaac gatatctggc aggctccttc ctgggcctct cttgagtacg gagggaaatg
     2101 gaaaatgctg cattacttcg ctcggcgttt cttcgctcca ctgttgccag tgggatttga
     2161 agatgaaggt gttttttacg tctatggcgt ctcagatctt cacaaagacc accacacgca
     2221 gctcaccgtg aggctccatc actggagctc cccgaagcct ttgtgctccc tcgtgaattc
     2281 aagtattgtg gttaaggccg gagaggcagt ggttctgttc cagatgccgg tgtctgagct
     2341 gctgaagaga tgcaggggat gcacgaggga gacatgcgtg gtctcctttt acttttcaac
     2401 tgacaaagaa ctcttcagcc caaccaacta ccacttcctg tcctccctga aggacgctaa
     2461 agggctgctc gaggccaaca tcactgtcaa catctctcag aagggcaatg tttttgtttt
     2521 tgatctggaa acgtctgcgg tcgctccctt tgtttggttg gatgtaggaa gtatccccgg
     2581 gagatttagt gataacggct tcctcatgat tcggaagaaa ctctcggtac tgttttaccc
     2641 ttggaagccc accagcaaga gtgagctgca gcaggccttc agcgtcacct ccctgacgga
     2701 tacctactga agggacatgg cttgtaattc agtggacact ggggacaaag gctttctaaa
     2761 gcatggctgg agaagaaggc agcctgagat aaaaccgtca agaagtatct gctgcctggg
     2821 gtgctatgac ttcccagtga atactgttca tcctggtgat gtctttagac aaggtcatgc
     2881 ccggggattc ttgaatctcc caggattgtg gttttgtccc acagctaaag cacggccaga
     2941 agactcatac cacccaatga cctttttggg agaccactag actgtgacat gattgtgtgg
     3001 aaccaaatgt ggaggttctg aagtaatgta ggcctttcat agcaccagga attctaccca
     3061 ctgtaggtga agtgtgtggc taggattgcc agaggaaatg ggaactcaga tcctacaata
     3121 gagattgctt gatggcagcc atattgattg ttggtagaca gctgaggggc ctgaatgttg
     3181 tatctgatta ctatctttag gtaggattcc ctttttcata tagtttggca ataactctct
     3241 ttctgaaaag accaagagat ctttgcagcc taggctgatt gtgctgtcac ctgtgtagtc
     3301 tcagactctg gaggcagagg caggaggacc acaaattcaa agttggcccc gactatactg
     3361 ttgaattttt cacttctcct cgtcctgagt gttcttgtga gctttaggct taccactgat
     3421 tctgatggac tctcgaatcc aaagttagga gctacattta aactcattgg ctctgctgtg
     3481 gaagtggcaa aaaatgttaa taagtagcta ttttgggcac tggtttgtgg gctttttggt
     3541 atgactttta tactttttct atatactata tatatatata aataaaaacc cacagattat
     3601 ataaattgca ctgacaactt gaaagtttat ttgcgctctg tttaaccatg taataaacat
     3661 ttcattgcat acaaaaaaaa aaaaaaaa
//
