LOCUS       NM_028636               3221 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus mannosidase, alpha, class 2C, member 1 (Man2c1), mRNA.
ACCESSION   NM_028636
VERSION     NM_028636.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3221)
  AUTHORS   Alvarez-Dominguez,J.R., Zhang,X. and Hu,W.
  TITLE     Widespread and dynamic translational control of red blood cell
            development
  JOURNAL   Blood 129 (5), 619-629 (2017)
   PUBMED   27899360
REFERENCE   2  (bases 1 to 3221)
  AUTHORS   Paciotti,S., Persichetti,E., Klein,K., Tasegian,A., Duvet,S.,
            Hartmann,D., Gieselmann,V. and Beccari,T.
  TITLE     Accumulation of free oligosaccharides and tissue damage in
            cytosolic alpha-mannosidase (Man2c1)-deficient mice
  JOURNAL   J Biol Chem 289 (14), 9611-9622 (2014)
   PUBMED   24550399
  REMARK    GeneRIF: These findings confirm the key role played by Man2c1 in
            the catabolism of free oligosaccharides.
REFERENCE   3  (bases 1 to 3221)
  AUTHORS   McDaniel,A.H., Li,X., Tordoff,M.G., Bachmanov,A.A. and Reed,D.R.
  TITLE     A locus on mouse Chromosome 9 (Adip5) affects the relative weight
            of the gonadal but not retroperitoneal adipose depot
  JOURNAL   Mamm Genome 17 (11), 1078-1092 (2006)
   PUBMED   17103052
REFERENCE   4  (bases 1 to 3221)
  AUTHORS   Costanzi,E., Balducci,C., Cacan,R., Duvet,S., Orlacchio,A. and
            Beccari,T.
  TITLE     Cloning and expression of mouse cytosolic alpha-mannosidase
            (Man2c1)
  JOURNAL   Biochim Biophys Acta 1760 (10), 1580-1586 (2006)
   PUBMED   16904268
  REMARK    GeneRIF: Comparison of the mouse genomic sequence with the cDNA
            sequence revealed the presence of 25 introns within the cytosolic
            alpha-mannosidase gene. The gene spans 11.5 kb from the major
            transcription initiation site to the RNA cleavage site.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC132406.4.
            
            On Nov 17, 2006 this sequence version replaced NM_028636.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016253.1, KY499678.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               AC132406.4         36169-36281         c
            114-236             AC132406.4         35777-35899         c
            237-360             AC132406.4         35403-35526         c
            361-431             AC132406.4         33466-33536         c
            432-609             AC132406.4         31791-31968         c
            610-799             AC132406.4         31424-31613         c
            800-906             AC132406.4         30259-30365         c
            907-1017            AC132406.4         29990-30100         c
            1018-1110           AC132406.4         29684-29776         c
            1111-1227           AC132406.4         29473-29589         c
            1228-1323           AC132406.4         29218-29313         c
            1324-1469           AC132406.4         28993-29138         c
            1470-1593           AC132406.4         28538-28661         c
            1594-1715           AC132406.4         28089-28210         c
            1716-1801           AC132406.4         27904-27989         c
            1802-1957           AC132406.4         27657-27812         c
            1958-2055           AC132406.4         27350-27447         c
            2056-2150           AC132406.4         27094-27188         c
            2151-2255           AC132406.4         26755-26859         c
            2256-2412           AC132406.4         26520-26676         c
            2413-2556           AC132406.4         26280-26423         c
            2557-2666           AC132406.4         25848-25957         c
            2667-2746           AC132406.4         25673-25752         c
            2747-2895           AC132406.4         25346-25494         c
            2896-3005           AC132406.4         25143-25252         c
            3006-3221           AC132406.4         24848-25063         c
FEATURES             Location/Qualifiers
     source          1..3221
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 30.89 cM"
     gene            1..3221
                     /gene="Man2c1"
                     /gene_synonym="1110025H24Rik"
                     /note="mannosidase, alpha, class 2C, member 1"
                     /db_xref="GeneID:73744"
                     /db_xref="MGI:MGI:1920994"
     exon            1..113
                     /gene="Man2c1"
                     /gene_synonym="1110025H24Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..3132
                     /gene="Man2c1"
                     /gene_synonym="1110025H24Rik"
                     /EC_number="3.2.1.24"
                     /note="cytosolic alpha-D-mannosidase; alpha-D-mannoside
                     mannohydrolase; neutral/cytosolic alpha-mannosidase"
                     /codon_start=1
                     /product="alpha-mannosidase 2C1"
                     /protein_id="NP_082912.1"
                     /db_xref="CCDS:CCDS40646.1"
                     /db_xref="GeneID:73744"
                     /db_xref="MGI:MGI:1920994"
                     /translation="MAAAPFLKHWRTTFERVEKFVSPIYFTDCNLRGRLFGDSCSVTL
                     SSFLTPERLPYEKAVQQNFSPAQVGDSFGPTWWTCWFRVELVIPEVWVGQEVHLCWES
                     DGESLVWRDGEPVQGLTKEGEKTSYVLSERLRASDPRSLTLYVEVACNGLLGAGKGSM
                     IAAPDPEKMFQLSQAKLAVFHRDVHSLLVDLELLLGVAKGLGEDSQRSFQALHTANQM
                     VNICDPAQPETYPAAKALASKFFGQHGGESQHTIHAMGHCHIDTAWLWPFKETVRKCA
                     RSWSTAVTLMEQNTDFIFACSQAQQLEWVKSQYPGLHARLQEFACRGQFVPVGGTWVE
                     MDGNLPSGEAMVRQFLQGQNFFLQEFGKMCSEFWLPDTFGYSAQLPQIMQGCGIKRFL
                     TQKLSWNLVNSFPHHTFFWEGLDGSRVLVHFPPGDSYGMQGSVEEVLKTVTNNRDKGR
                     TNHSGFLFGFGDGGGGPTQTMLDRLKRLSNTDGLPRVQLSSPGQLFTALERDSGQLCT
                     WVGELFLELHNGTYTTHAQLKKGNRECEQILHDVEVLSSLALARSAQFLYPAAQLQHL
                     WRLLLLNQFHDVVTGSCIQLVAEDAMNYYEDIRSHGNPLLSAAAAALCAGEPGPKGLL
                     IINTLPWKRTEVLALPKPCGAHSLALVTVPSIGYAPAPTPTSLQPLLPQQPVFVMQET
                     DGSVTLDNGIIRVRLDPTGCLTSLVLVASGREAIAEGALGNQFVLFDDVPLYWDAWDV
                     MDYHLETRKPVLGQAGTLAVGTEGGLRGSAWFLLQISPNSRLSQEVVLDVGCPYVRFH
                     TEVHWHEAHKFLKVEFPARIRSPQATYEIQFGHLQRPTHNNTSWDWARYEVWAHRWID
                     LSECDFGLALLNNCKYGASVRGNVLSLSLLRAPKAPDATADMGRHEFTYALMPHKGSF
                     QEAGVIHAAYNLNFPLLALPAPGPAPDTTWSAFSVSSPAVVLETIKQAERCHQHRTLV
                     LRLYEAHGSHVDCWLHTSLPVQEATLCDLLEQRDPTGHLSLQDNRLKLTFSPFQVRSL
                     LLVLQSPPN"
     exon            114..236
                     /gene="Man2c1"
                     /gene_synonym="1110025H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            237..360
                     /gene="Man2c1"
                     /gene_synonym="1110025H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            361..431
                     /gene="Man2c1"
                     /gene_synonym="1110025H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            432..609
                     /gene="Man2c1"
                     /gene_synonym="1110025H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            610..799
                     /gene="Man2c1"
                     /gene_synonym="1110025H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            800..906
                     /gene="Man2c1"
                     /gene_synonym="1110025H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1017
                     /gene="Man2c1"
                     /gene_synonym="1110025H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1110
                     /gene="Man2c1"
                     /gene_synonym="1110025H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1227
                     /gene="Man2c1"
                     /gene_synonym="1110025H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1323
                     /gene="Man2c1"
                     /gene_synonym="1110025H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1469
                     /gene="Man2c1"
                     /gene_synonym="1110025H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1593
                     /gene="Man2c1"
                     /gene_synonym="1110025H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1715
                     /gene="Man2c1"
                     /gene_synonym="1110025H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1801
                     /gene="Man2c1"
                     /gene_synonym="1110025H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..1957
                     /gene="Man2c1"
                     /gene_synonym="1110025H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2055
                     /gene="Man2c1"
                     /gene_synonym="1110025H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2150
                     /gene="Man2c1"
                     /gene_synonym="1110025H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2151..2255
                     /gene="Man2c1"
                     /gene_synonym="1110025H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2256..2412
                     /gene="Man2c1"
                     /gene_synonym="1110025H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2413..2556
                     /gene="Man2c1"
                     /gene_synonym="1110025H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2557..2666
                     /gene="Man2c1"
                     /gene_synonym="1110025H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2667..2746
                     /gene="Man2c1"
                     /gene_synonym="1110025H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2747..2895
                     /gene="Man2c1"
                     /gene_synonym="1110025H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2896..3005
                     /gene="Man2c1"
                     /gene_synonym="1110025H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3006..3221
                     /gene="Man2c1"
                     /gene_synonym="1110025H24Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3196..3201
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Man2c1"
                     /gene_synonym="1110025H24Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3218
                     /gene="Man2c1"
                     /gene_synonym="1110025H24Rik"
                     /note="major polyA site"
ORIGIN      
        1 aggcgcatcg ccatggcggc agcgccgttc ttgaagcact ggcgcaccac tttcgagcgg
       61 gtggagaagt tcgtgtcccc gatctacttc accgactgta accttcgcgg caggctcttc
      121 ggggacagct gctcggtgac actctccagc ttcctgacgc ccgagaggct tccctatgag
      181 aaggcggtgc agcagaactt cagccctgcg caggtcggcg acagcttcgg acccacatgg
      241 tggacctgct ggtttcgggt agaactggtc atccctgaag tttgggtggg ccaggaagtt
      301 catctttgct gggaaagcga tggagaaagc cttgtctggc gtgatgggga acctgtccag
      361 ggtttgacca aagaaggcga aaagaccagt tatgtcctga gcgagaggct gcgagcatca
      421 gaccctcgga gcttgactct ctatgtggaa gtagcctgca atgggcttct gggggccggg
      481 aagggaagca tgatcgcagc ccctgaccca gagaagatgt tccagctgag ccaggctaaa
      541 ctggctgtgt tccaccggga tgtccacagt ctcctggtgg acctggagct gttgctgggt
      601 gtggccaagg gcctcgggga ggacagccag cgcagcttcc aggccctgca cacagccaac
      661 cagatggtga acatatgtga ccctgctcag cctgagactt acccagcagc caaagccctg
      721 gcctccaagt tctttggcca acatggaggt gaaagccagc ataccatcca tgccatggga
      781 cactgtcaca ttgatacagc ctggctttgg cccttcaagg agactgtgag gaaatgtgcc
      841 cggagctggt cgacagctgt gacgctcatg gagcagaaca cagacttcat ctttgcctgc
      901 tctcaggcac aacaacttga atgggtcaag agccagtacc ctggtctgca tgcccggctc
      961 caggagtttg cctgccgagg acagtttgtg cctgtggggg gcacctgggt agaaatggat
     1021 gggaaccttc ccagtggaga ggccatggtg aggcagttcc tgcagggcca gaacttcttt
     1081 ctgcaagagt ttgggaagat gtgctctgag ttctggctgc cagacacgtt tggctactca
     1141 gcacagctcc cccagatcat gcaaggctgt ggcatcaagc gcttcctgac ccagaaactg
     1201 agctggaact tggtcaactc ctttccacac catacctttt tctgggaggg gctggatggc
     1261 tcccgagtgc tggtccactt cccacctgga gactcatatg gaatgcaggg cagtgtggag
     1321 gaggtgctga agactgtgac caacaaccgg gacaaggggc ggaccaacca cagtggcttc
     1381 ctcttcggct tcggggatgg gggaggtggc cccacacaga ccatgttgga ccgattgaag
     1441 cggctgagca acactgatgg gctgcccagg gtgcagctat cttctcctgg ccagctcttc
     1501 acggcactgg agagagactc aggacagctg tgcacatggg ttggagaact cttcctggaa
     1561 ctgcacaatg gcacctacac tacgcatgcc cagctcaaga aggggaacag agaatgtgag
     1621 cagattcttc atgacgtgga ggtgctcagc agcctggccc tagcccgaag tgcccagttc
     1681 ctatacccgg cagcccagct gcagcacctc tggaggctcc tgctcctcaa ccagttccat
     1741 gatgtggtga ctggaagctg cattcagctg gtggcagaag atgccatgaa ctactatgaa
     1801 gacatccgtt ctcatggcaa cccactgctc agtgctgcag ccgcagcctt gtgtgccggg
     1861 gagccaggtc ccaagggcct cctcattatc aacacactgc cctggaagcg cactgaagtg
     1921 ttggcactgc ccaagccttg tggggctcac agcctagccc tggtgacagt gccaagtatt
     1981 ggctacgctc ctgctcccac ccctacttca ctgcagcccc tcctccccca gcagcctgtg
     2041 tttgtgatgc aggagactga cggttctgtg actttggaca acggcatcat ccgggtgaga
     2101 ctggatccaa ctggctgtct tacctccctg gtcctggtgg cttctggcag ggaagccatt
     2161 gctgagggag ccctggggaa ccagtttgtg ttgtttgatg atgtgccatt gtactgggat
     2221 gcatgggatg tcatggatta ccatctagag acacggaagc ctgtgctggg ccaggcaggg
     2281 accctggcag tgggcactga aggtggcctc cggggcagtg cctggttcct gctccagatc
     2341 agccccaaca gccggctcag ccaggaggtt gtgctagatg ttggctgccc ctatgtccgc
     2401 ttccacactg aggtgcactg gcacgaggcc cacaagttcc tgaaggtgga gttccctgct
     2461 agaatacgga gcccccaggc tacctatgag atccagtttg ggcacctcca gaggccgacg
     2521 cacaacaaca cctcttggga ctgggctcgc tacgaggtgt gggctcaccg ctggatagat
     2581 ctgtccgagt gtgactttgg gctggccctg ctcaacaact gcaagtatgg agcatcagta
     2641 cgaggcaacg tcctcagcct ctcactgttg cgtgcaccca aggctccaga cgctactgct
     2701 gacatggggc gccatgaatt cacttacgct ttgatgccac acaagggctc cttccaagaa
     2761 gctggtgtca tccatgctgc ctacaacctc aactttcccc tgctggcact gccggctcca
     2821 ggcccggccc ctgacaccac ctggagtgcc ttttctgtgt cttcaccagc agtagtgctg
     2881 gagaccatca agcaggctga gaggtgccat cagcaccgca cactggttct aaggctgtac
     2941 gaggctcatg gcagccatgt ggactgctgg ctgcacacgt cgttgcctgt tcaggaggcc
     3001 accctttgtg acctcctgga gcagcgagac cccactggtc acctttccct ccaggacaac
     3061 cgtctgaagc tcactttttc tcccttccaa gtgagatccc tattgcttgt gcttcagtct
     3121 ccaccaaact gagtcttgac tggatagctt tgggagttcc tcatttccac ctccctagcc
     3181 cgaagcatct tgtgcaataa aagcttagat tagcagcact a
//
