LOCUS       NM_008550               3434 bp    mRNA    linear   ROD 21-DEC-2022
DEFINITION  Mus musculus mannosidase 2, alpha B2 (Man2b2), mRNA.
ACCESSION   NM_008550
VERSION     NM_008550.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3434)
  AUTHORS   Di Lorenzo G, Velho RV, Winter D, Thelen M, Ahmadi S, Schweizer M,
            De Pace R, Cornils K, Yorgan TA, Grub S, Hermans-Borgmeyer I,
            Schinke T, Muller-Loennies S, Braulke T and Pohl S.
  TITLE     Lysosomal Proteome and Secretome Analysis Identifies Missorted
            Enzymes and Their Nondegraded Substrates in Mucolipidosis III Mouse
            Cells
  JOURNAL   Mol Cell Proteomics 17 (8), 1612-1626 (2018)
   PUBMED   29773673
REFERENCE   2  (bases 1 to 3434)
  AUTHORS   Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK,
            Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L,
            Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre
            JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A,
            Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ,
            Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall
            S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA,
            Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR,
            Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana
            S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG,
            Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC,
            Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL,
            de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown
            SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M and Murray
            SA.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   3  (bases 1 to 3434)
  AUTHORS   Abonnenc M, Nabeebaccus AA, Mayr U, Barallobre-Barreiro J, Dong X,
            Cuello F, Sur S, Drozdov I, Langley SR, Lu R, Stathopoulou K,
            Didangelos A, Yin X, Zimmermann WH, Shah AM, Zampetaki A and Mayr
            M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   4  (bases 1 to 3434)
  AUTHORS   Park C, Meng L, Stanton LH, Collins RE, Mast SW, Yi X, Strachan H
            and Moremen KW.
  TITLE     Characterization of a human core-specific lysosomal
            {alpha}1,6-mannosidase involved in N-glycan catabolism
  JOURNAL   J Biol Chem 280 (44), 37204-37216 (2005)
   PUBMED   16115860
REFERENCE   5  (bases 1 to 3434)
  AUTHORS   Okazaki N, F-Kikuno R, Ohara R, Inamoto S, Koseki H, Hiraoka S,
            Saga Y, Seino S, Nishimura M, Kaisho T, Hoshino K, Kitamura H,
            Nagase T, Ohara O and Koga H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   6  (bases 1 to 3434)
  AUTHORS   Tascou S, Nayernia K, Engel W and Burfeind P.
  TITLE     Refinement of the expression pattern of a mouse homologue of the
            porcine 135-kDa alpha-d-mannosidase (MAN2B2)
  JOURNAL   Biochem Biophys Res Commun 272 (3), 951-952 (2000)
   PUBMED   10860856
REFERENCE   7  (bases 1 to 3434)
  AUTHORS   Hiramoto S, Tamba M, Kiuchi S, Jin YZ, Bannai S, Sugita Y, Dacheux
            F, Dacheux JL, Yoshida M and Okamura N.
  TITLE     Stage-specific expression of a mouse homologue of the porcine
            135kDa alpha-D-mannosidase (MAN2B2) in type A spermatogonia
  JOURNAL   Biochem Biophys Res Commun 241 (2), 439-445 (1997)
   PUBMED   9425289
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY315451.1, AK040388.1, AK004900.1 and AW108321.1.
            
            [WARNING] On May 6, 2023 this sequence was replaced by NM_008550.3.
            
            On Apr 22, 2009 this sequence version replaced NM_008550.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004900.1, AB006458.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                BY315451.1         6-44
            40-3194             AK040388.1         1-3155
            3195-3362           AK004900.1         3149-3316
            3363-3434           AW108321.1         1-72                c
FEATURES             Location/Qualifiers
     source          1..3434
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5"
     gene            1..3434
                     /gene="Man2b2"
                     /gene_synonym="mKIAA0935"
                     /note="mannosidase 2, alpha B2"
                     /db_xref="GeneID:17160"
                     /db_xref="MGI:MGI:1195262"
     exon            1..212
                     /gene="Man2b2"
                     /gene_synonym="mKIAA0935"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..3131
                     /gene="Man2b2"
                     /gene_synonym="mKIAA0935"
                     /EC_number="3.2.1.24"
                     /note="epididymis-specific alpha-mannosidase; mannosidase
                     alpha class 2B member 2; 135 kDa alpha-D-mannosidase; 135
                     kD alpha-D-mannosidase"
                     /codon_start=1
                     /product="epididymis-specific alpha-mannosidase precursor"
                     /protein_id="NP_032576.2"
                     /db_xref="CCDS:CCDS19243.1"
                     /db_xref="GeneID:17160"
                     /db_xref="MGI:MGI:1195262"
                     /translation="MGPLRWLPLLGQLLLLWPRAAQPAGPIRAFVVPHSHMDVGWVFT
                     VQESMRAYAANVYTTVVAELVRGGQRRFIAVEQEFFRLWWDGVASEQQKQQVRQLLHE
                     GRLEFVLGGQVMHDEAVTHLDDQILQLTEGHGFLYETFGIRPQFSWHVDPFGASATTP
                     TLFALAGFNAHLISRIDYDLKDAMQEAQMLQFVWHGSPSLSGQQEIFTHVMDHYSYCT
                     PSHIPFSNRSGFYWNGVAVFPEPPPDGVYPNMSEPVTGANIHLYAEALVANVKQRAAW
                     FRTPHVLWPWGCDKQFFNASVQFDNMDPLLDYINQRTAQFGISVQYATLNDYFQALHA
                     TNMTWGIRDHQDFLPYSSEPLQAWTGFYTSRSTLKGLARQASALLYAGESMFTRYMWP
                     DPSGTLDPTWALQQLQQLRWAVSEVQHHDAITGTESPKVKNMYTEHLRMGMLGVRKLM
                     VSIALGGPPGSGTGAPKDIMGPQVTPVLSVDTRPVGYSASVYNPLAWKITTIITLTVA
                     FPNVSVTDELGHPVSTQIQNSTKDPSAYDLLILTTIPGLNYRHYQVMHARGDQAGTRE
                     LVAPRANTLKFSLKLRNQPSQEGKRLVPVMNDCYILLFDQDTNMLHSIQDRQSNRTVR
                     MTQEFLEYQANWDVKQGPISDNYLFAPNNTAEPSWEAVGMEMVAGTLVTDIRQYFYRY
                     ITDQEYIYSIHTRLAHPSLAGELLCQRIEQQYRVGPLDLNREAILRTSSDLNSQQVLY
                     SDNNGYQMQRRPYKAFKSNPIPRNYYPMVQSAFIEDDKSRLVLLAERPHGVSSQGNGQ
                     VEVMLHRRLWNNLAWDLKYNLTLNDTSIVHPVLWLMLGPKSTMTALHPRSGVALQHGP
                     VVLLKELADEETPVHGPHNPWPVTLPPNLHLQILSVPGWTYSRSHAQHLRNLQRGHPE
                     KPQANLQRVLLRLRHLYEAGEDPVLSRPATVDLKVVLRGLGSVVAVEERSLTGTWDVQ
                     MLQRWHWSTKTDHLKGHPTSPPRPPGGSIITVYPKEIRTFFIKFQQ"
     exon            213..359
                     /gene="Man2b2"
                     /gene_synonym="mKIAA0935"
                     /inference="alignment:Splign:2.1.0"
     exon            360..465
                     /gene="Man2b2"
                     /gene_synonym="mKIAA0935"
                     /inference="alignment:Splign:2.1.0"
     exon            466..638
                     /gene="Man2b2"
                     /gene_synonym="mKIAA0935"
                     /inference="alignment:Splign:2.1.0"
     exon            639..754
                     /gene="Man2b2"
                     /gene_synonym="mKIAA0935"
                     /inference="alignment:Splign:2.1.0"
     exon            755..932
                     /gene="Man2b2"
                     /gene_synonym="mKIAA0935"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1131
                     /gene="Man2b2"
                     /gene_synonym="mKIAA0935"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1322
                     /gene="Man2b2"
                     /gene_synonym="mKIAA0935"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1464
                     /gene="Man2b2"
                     /gene_synonym="mKIAA0935"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1649
                     /gene="Man2b2"
                     /gene_synonym="mKIAA0935"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1924
                     /gene="Man2b2"
                     /gene_synonym="mKIAA0935"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..2116
                     /gene="Man2b2"
                     /gene_synonym="mKIAA0935"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2363
                     /gene="Man2b2"
                     /gene_synonym="mKIAA0935"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2474
                     /gene="Man2b2"
                     /gene_synonym="mKIAA0935"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..2688
                     /gene="Man2b2"
                     /gene_synonym="mKIAA0935"
                     /inference="alignment:Splign:2.1.0"
     exon            2689..2805
                     /gene="Man2b2"
                     /gene_synonym="mKIAA0935"
                     /inference="alignment:Splign:2.1.0"
     exon            2806..2918
                     /gene="Man2b2"
                     /gene_synonym="mKIAA0935"
                     /inference="alignment:Splign:2.1.0"
     exon            2919..3036
                     /gene="Man2b2"
                     /gene_synonym="mKIAA0935"
                     /inference="alignment:Splign:2.1.0"
     exon            3037..3434
                     /gene="Man2b2"
                     /gene_synonym="mKIAA0935"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcgggtcc cggacccgga agtggaccgc tctacccagg acccgctgcc ctggcagcgt
       61 cccactgccc agcaatgggg ccgctgcgct ggctgccgct actcggccag ctgttgctgt
      121 tgtggccgcg ggcagctcag cccgccggcc cgatccgggc cttcgtggtg ccccacagtc
      181 acatggacgt gggctgggtc ttcacggtcc aggaaagcat gagagcctat gcagccaatg
      241 tctacactac cgtggtggcg gaactggtcc gcggagggca gcggcgcttc atcgccgtgg
      301 agcaggagtt cttccggctg tggtgggacg gtgtggcctc tgagcagcag aaacagcagg
      361 tccgccagct cctgcatgaa ggacgcctgg agtttgttct cggaggccaa gtcatgcatg
      421 atgaggctgt gacccacctg gatgaccaga tcttacagct cacagaagga catggctttc
      481 tctatgaaac gtttggaatc cggccacagt tctcctggca cgtggaccct ttcggtgcat
      541 cagcaacgac ccctaccctg tttgccctgg caggcttcaa tgcccatctc atctctcgta
      601 ttgactacga cctcaaggat gccatgcagg aagctcagat gctgcagttc gtgtggcatg
      661 ggtccccatc cctgtcaggg cagcaggaaa tcttcactca cgtcatggac cattatagct
      721 actgcacccc ctcacacatc cccttttcta acaggtctgg attttactgg aatggtgtgg
      781 ccgtcttccc agagccaccc ccagacggcg tgtatcctaa catgagcgag cctgtcaccg
      841 gagccaacat ccacctctac gctgaggctc tggtggccaa cgttaaacag agggctgcgt
      901 ggttccggac gccccacgtc ctctggccct ggggatgtga caagcagttc ttcaatgcct
      961 cggtgcagtt tgacaacatg gatcccctgc tggactacat caaccagcgc acggcccagt
     1021 ttggcatctc ggtgcagtac gccacactga acgactactt ccaagccctg cacgccacca
     1081 acatgacctg gggcatccgt gaccaccagg acttccttcc ctattcttca gaaccacttc
     1141 aggcctggac cggcttctac acatcccgga gcaccctcaa gggtctagcg agacaagcca
     1201 gtgccttgct ctatgctggg gagtccatgt tcacacgcta catgtggcca gaccccagtg
     1261 ggactctgga ccctacctgg gccctgcagc agctccaaca gcttcgctgg gctgtgtctg
     1321 aggtccagca ccacgatgcc atcacaggca ctgagtcccc caaggtgaag aacatgtaca
     1381 cggaacatct caggatgggg atgctgggcg tgcgcaagct gatggtctcc attgccctgg
     1441 gcgggccccc agggtctggc acaggagccc ccaaagacat catggggcct caagtgacac
     1501 ctgtcctctc ggtagacaca aggcctgtag gatactccgc ctctgtgtac aacccgctgg
     1561 cctggaagat caccaccatt atcaccctga ctgtcgcttt ccccaatgtc agcgtcaccg
     1621 atgagttggg ccacccggtg tcaacacaga ttcagaactc tacaaaggac ccttctgcat
     1681 acgacctgct catcctgacc accatccccg gcctcaacta tcggcactat caagtcatgc
     1741 acgcccgcgg ggaccaggca ggcaccaggg agctggtcgc ccccagggcc aacaccctca
     1801 agtttagtct caaactgagg aaccagccca gccaggaagg caagcgcctg gtgcccgtga
     1861 tgaatgactg ctatattctg ctgttcgacc aggacaccaa catgttacat agcattcagg
     1921 atagacagag caaccgcacg gtgcgcatga cccaagagtt cctggagtac caggccaact
     1981 gggacgtgaa gcagggcccc atttctgaca actacctctt tgcacccaac aacaccgctg
     2041 agccttcctg ggaagcggtg gggatggaaa tggtggcagg cacactggta acggacataa
     2101 ggcagtattt ctacaggtac ataacagacc aggagtacat ctattccatc cacacccgtc
     2161 tggcccaccc gagcctcgct ggagaactgc tctgccaacg gatagagcag cagtaccgag
     2221 tgggccccct ggacctaaac cgtgaggcca tcctgaggac cagcagcgac ctaaacagcc
     2281 agcaagtcct ctactctgac aacaacggct accagatgca gcggaggccc tacaaggctt
     2341 tcaagagcaa tcccatcccc cggaattact accccatggt acagtcagcc ttcatcgagg
     2401 atgacaagag caggctggtg ctgctggcag agcgaccgca cggtgtctcc agccaaggga
     2461 atgggcaggt ggaggtgatg ctccatcgac ggctgtggaa caacctggcc tgggacctga
     2521 agtacaacct cacgctgaac gacacctcca ttgtccaccc ggtgctctgg ctcatgctgg
     2581 ggcccaagtc caccatgacg gccctgcacc caaggagtgg ggtggctctg cagcacgggc
     2641 ccgttgtgtt gttaaaagaa ctggctgacg aagaaacgcc cgttcacgga ccccacaatc
     2701 cctggcctgt gacactgccc ccaaacctgc atctgcagat cctcagcgta cctggctgga
     2761 cgtacagcag gagccatgcc cagcacctga ggaaccttca gagaggccac ccggagaagc
     2821 cacaggccaa cctgcaaagg gtgctgctgc gcctgcgcca cctgtatgaa gcaggggagg
     2881 acccagtact gtctcggcct gcgacagtgg atctcaaggt tgtacttcga ggactagggt
     2941 ctgtagtggc tgtggaggaa cgctcactca cagggacctg ggatgtgcag atgctgcagc
     3001 gctggcactg gagcacaaag actgaccacc tgaaaggcca ccccacctct ccaccaaggc
     3061 caccaggagg ctccatcatc accgtgtacc ctaaggaaat ccggaccttc ttcattaaat
     3121 tccagcagtg acatcaatgc attggcccca gggacatgga actggaaacc ccacccaccc
     3181 cacccccaaa aaaacaacga cttcagaccc agagggagga acaagctgcg catcagacag
     3241 ctgtgtggca gaaagtggcc atgggggaga gggatagctc ttattatttt tttttttttt
     3301 aataaaaatt aaggtctggg ctctttcttc ccatgttcaa gccagacctc tcttttcacc
     3361 tgagtaaccc ctccctccct cccctccctc ctacccactc tcaattgtta aaaagagcct
     3421 ttatttttca aaag
//
