LOCUS       NM_010764               4326 bp    mRNA    linear   ROD 20-DEC-2022
DEFINITION  Mus musculus mannosidase 2, alpha B1 (Man2b1), mRNA.
ACCESSION   NM_010764
VERSION     NM_010764.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4326)
  AUTHORS   Stroobants S, Damme M, Van der Jeugd A, Vermaercke B, Andersson C,
            Fogh J, Saftig P, Blanz J and D'Hooge R.
  TITLE     Long-term enzyme replacement therapy improves neurocognitive
            functioning and hippocampal synaptic plasticity in immune-tolerant
            alpha-mannosidosis mice
  JOURNAL   Neurobiol Dis 106, 255-268 (2017)
   PUBMED   28720484
REFERENCE   2  (bases 1 to 4326)
  AUTHORS   Abdallah BM, Ditzel N, Mahmood A, Isa A, Traustadottir GA,
            Schilling AF, Ruiz-Hidalgo MJ, Laborda J, Amling M and Kassem M.
  TITLE     DLK1 is a novel regulator of bone mass that mediates estrogen
            deficiency-induced bone loss in mice
  JOURNAL   J Bone Miner Res 26 (7), 1457-1471 (2011)
   PUBMED   21308776
REFERENCE   3  (bases 1 to 4326)
  AUTHORS   Damme M, Morelle W, Schmidt B, Andersson C, Fogh J, Michalski JC
            and Lubke T.
  TITLE     Impaired lysosomal trimming of N-linked oligosaccharides leads to
            hyperglycosylation of native lysosomal proteins in mice with
            alpha-mannosidosis
  JOURNAL   Mol Cell Biol 30 (1), 273-283 (2010)
   PUBMED   19884343
REFERENCE   4  (bases 1 to 4326)
  AUTHORS   Elvevold K, Simon-Santamaria J, Hasvold H, McCourt P, Smedsrod B
            and Sorensen KK.
  TITLE     Liver sinusoidal endothelial cells depend on mannose
            receptor-mediated recruitment of lysosomal enzymes for normal
            degradation capacity
  JOURNAL   Hepatology 48 (6), 2007-2015 (2008)
   PUBMED   19026003
  REMARK    GeneRIF: Mannose receptor (-/-) liver sinusoidal endothelial cells
            had markedly and significantly reduced enzyme activities for four
            out of five lysosomal enzymes tested, i.e., cathepsin-D,
            alpha-mannosidase, beta-hexosaminidase and arylsulfatase.
REFERENCE   5  (bases 1 to 4326)
  AUTHORS   Ferron M and Vacher J.
  TITLE     Characterization of the murine Inpp4b gene and identification of a
            novel isoform
  JOURNAL   Gene 376 (1), 152-161 (2006)
   PUBMED   16631325
REFERENCE   6  (bases 1 to 4326)
  AUTHORS   Gonzalez DS, Kagawa Y and Moremen KW.
  TITLE     Isolation and characterization of the gene encoding the mouse broad
            specificity lysosomal alpha-mannosidase1
  JOURNAL   Biochim Biophys Acta 1445 (1), 177-183 (1999)
   PUBMED   10209272
REFERENCE   7  (bases 1 to 4326)
  AUTHORS   Stinchi S, Orlacchio A, Costanzi E, Stirling JL, Menghini AR,
            Orlacchio A and Beccari T.
  TITLE     Promoter characterization and structure of the gene encoding mouse
            lysosomal alpha-d-mannosidase
  JOURNAL   Mamm Genome 9 (11), 869-873 (1998)
   PUBMED   9799835
REFERENCE   8  (bases 1 to 4326)
  AUTHORS   Beccari T, Appolloni MG, Costanzi E, Stinchi S, Stirling JL, Della
            Fazia MA, Servillo G, Viola MP and Orlacchio A.
  TITLE     Lysosomal alpha-mannosidases of mouse tissues: characteristics of
            the isoenzymes, and cloning and expression of a full-length cDNA
  JOURNAL   Biochem J 327 (Pt 1) (Pt 1), 45-49 (1997)
   PUBMED   9355733
REFERENCE   9  (bases 1 to 4326)
  AUTHORS   Merkle RK, Zhang Y, Ruest PJ, Lal A, Liao YF and Moremen KW.
  TITLE     Cloning, expression, purification, and characterization of the
            murine lysosomal acid alpha-mannosidase
  JOURNAL   Biochim Biophys Acta 1336 (2), 132-146 (1997)
   PUBMED   9305783
REFERENCE   10 (bases 1 to 4326)
  AUTHORS   Beccari T, Appolloni MG, Stirling JL and Orlacchio A.
  TITLE     Assignment of lysosomal alpha-D-mannosidase to mouse chromosome 8
  JOURNAL   Mamm Genome 7 (9), 707-708 (1996)
   PUBMED   8829553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY289778.1, AC163703.4, AK004817.2 and AI480690.1.
            
            [WARNING] On Oct 13, 2023 this sequence was replaced by
            NM_010764.3.
            
            On Aug 24, 2006 this sequence version replaced NM_010764.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK035551.1, BC005430.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                BY289778.1         1-16
            17-49               AC163703.4         77984-78016         c
            50-3169             AK004817.2         7-3126
            3170-4106           AC163703.4         62781-63717         c
            4107-4326           AI480690.1         1-220               c
FEATURES             Location/Qualifiers
     source          1..4326
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 41.55 cM"
     gene            1..4326
                     /gene="Man2b1"
                     /gene_synonym="LAMAN"
                     /note="mannosidase 2, alpha B1"
                     /db_xref="GeneID:17159"
                     /db_xref="MGI:MGI:107286"
     exon            1..220
                     /gene="Man2b1"
                     /gene_synonym="LAMAN"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..3103
                     /gene="Man2b1"
                     /gene_synonym="LAMAN"
                     /EC_number="3.2.1.24"
                     /note="mannosidase alpha-B; lysosomal acid
                     alpha-mannosidase; mannosidase alpha class 2B member 1;
                     lysosomal alpha-mannosidase"
                     /codon_start=1
                     /product="lysosomal alpha-mannosidase precursor"
                     /protein_id="NP_034894.2"
                     /db_xref="CCDS:CCDS22494.1"
                     /db_xref="GeneID:17159"
                     /db_xref="MGI:MGI:107286"
                     /translation="MGTGPLTSGVRAGGGNTGWLWMSSCNLGSPVLPISFLFWLLLAA
                     PGARAAGYKTCPPTKPGMLNVHLLPHTHDDVGWLKTVDQYYYGILSDVQHASVQYILD
                     SVVSSLLEKPTRRFIYVEMAFFSRWWKQQTSATQDAVRNLVRQGRLEFVNGGWVMNDE
                     AATHYGAIVDQMTLGLRFLQDTFGSDGLPRVAWHIDPFGHSREQASLFAQMGFDGFFL
                     GRIDYQDKLNRKKKLRMEELWRASDSLEPPAADLFTGVLPNNYNPPKYLCWDVLCTDP
                     PVVDNPRSPEFNAKTLVNYFLKLASSQKGFYRTNHTVMTMGSDFHYENANMWFKNMDK
                     LIRLVNAQQVNGSLVHVLYSTPTCYLWELNKANLTWTVKEDDFFPYADGPHMFWTGYF
                     SSRPALKRYERLSYNFLQVCNQLEALVGPEANVGPYGSGDSAPLQEAMAVLQHHDAVS
                     GTARQNVVNDYARQLAAGWGPCEVLVSNALARLSHYKQNFSFCRELNISICPVSQTSE
                     RFQVTLYNPLGRKVDQMVRLPVYEGNFIVKDPHDKNISSNVVMVPSYYSETYQWELLF
                     PASVPALGFSTYSVAKMSDLNHQAHNLLSRPRKHKSHHVLVIENKYMRATFDSGTGLL
                     MKIENLEQNLSLPVSQGFFWYNASVGDEESSQASGAYIFRPNVGKPIPVSRWAQISLV
                     KTALVQEVHQNFSAWCSQVIRLYKGQRHLELEWTVGPIPVRDDWGKEVISRFDTPMKT
                     KGQFFTDSNGREILKRRDDYRPTWTLNQTEPVAGNYYPVNTRIYITDGQMQLTVLTDR
                     SQGGSSLQDGSLELMVHRRLLVDDDRGVSEPLLETDTGDKVRGRHLVLLSSVSDAAAR
                     HRLLAEQEVLAPQVVLSLGGSSPYHSRATPKTQFSGLRQELPPQVHLLTLARWGPKML
                     LLRLEHQFALKEDSDRNLSSPVTLNVQNLFQTFTINYLQETTLAANQPLSRASRLKWM
                     TNTGPTSYPEPSKLDPTSVTLKPMEIRTFLASVQWQEHRPA"
     exon            221..323
                     /gene="Man2b1"
                     /gene_synonym="LAMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            324..497
                     /gene="Man2b1"
                     /gene_synonym="LAMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            498..691
                     /gene="Man2b1"
                     /gene_synonym="LAMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            692..824
                     /gene="Man2b1"
                     /gene_synonym="LAMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            825..970
                     /gene="Man2b1"
                     /gene_synonym="LAMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1087
                     /gene="Man2b1"
                     /gene_synonym="LAMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1170
                     /gene="Man2b1"
                     /gene_synonym="LAMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1291
                     /gene="Man2b1"
                     /gene_synonym="LAMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1370
                     /gene="Man2b1"
                     /gene_synonym="LAMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1480
                     /gene="Man2b1"
                     /gene_synonym="LAMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1588
                     /gene="Man2b1"
                     /gene_synonym="LAMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1705
                     /gene="Man2b1"
                     /gene_synonym="LAMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1894
                     /gene="Man2b1"
                     /gene_synonym="LAMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..1992
                     /gene="Man2b1"
                     /gene_synonym="LAMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1993..2110
                     /gene="Man2b1"
                     /gene_synonym="LAMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2229
                     /gene="Man2b1"
                     /gene_synonym="LAMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2331
                     /gene="Man2b1"
                     /gene_synonym="LAMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2419
                     /gene="Man2b1"
                     /gene_synonym="LAMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            2420..2500
                     /gene="Man2b1"
                     /gene_synonym="LAMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            2501..2728
                     /gene="Man2b1"
                     /gene_synonym="LAMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            2729..2884
                     /gene="Man2b1"
                     /gene_synonym="LAMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            2885..2987
                     /gene="Man2b1"
                     /gene_synonym="LAMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            2988..4325
                     /gene="Man2b1"
                     /gene_synonym="LAMAN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3152..3157
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Man2b1"
                     /gene_synonym="LAMAN"
                     /note="putative"
     polyA_site      3169
                     /gene="Man2b1"
                     /gene_synonym="LAMAN"
                     /note="putative"
ORIGIN      
        1 ggagcattct cagggattta gctagggtag agaaagccac ggaagcggcg tcgccggaac
       61 catgggcacc ggaccgctca cctctggtgt ccgtgctggt ggcgggaaca ccgggtggct
      121 ctggatgagc tcctgcaacc taggttcgcc agtcctgcct atttcctttc ttttttggct
      181 gttgctggcc gcgcctggcg ctcgggccgc gggttacaag acatgtcccc caacgaagcc
      241 aggcatgctc aatgtgcacc tgctgcctca tacacacgat gatgtaggct ggctgaagac
      301 agtggaccaa tactattacg gcatcctgag tgatgttcag cacgcatctg ttcagtacat
      361 cctagactca gtagtctcct ctctactgga gaaacccacc cgtcgcttca tctatgtgga
      421 aatggctttc ttctcccgtt ggtggaagca gcagaccagt gcaacccagg acgctgtacg
      481 gaacctggtg cgccaggggc gcctggagtt tgtcaatggt ggctgggtga tgaacgacga
      541 agcagccacc cactatggcg cgattgtgga ccagatgaca cttgggctac gcttcctgca
      601 agacacattt ggtagtgatg gacttccccg tgtggcctgg catattgacc ctttcggcca
      661 ctctcgagaa caggcctccc tgtttgccca gatgggtttt gatggcttct tccttgggcg
      721 cattgactat caagataaac ttaatcggaa gaaaaagctg aggatggagg agctgtggag
      781 agctagtgac agcttggagc cccccgctgc tgacctcttt actggtgtgc tccccaataa
      841 ttacaacccc ccgaaatacc tgtgctggga tgtgctatgt acagaccctc ccgtggtgga
      901 taatccccgg agccctgagt tcaatgcaaa aacgttggtc aactacttcc tgaagctcgc
      961 ttcttcccag aaagggtttt accgaaccaa ccacaccgtg atgaccatgg gctcagactt
     1021 ccattatgag aatgccaaca tgtggttcaa aaacatggac aagctgatcc gcctggtcaa
     1081 cgcgcagcag gtaaacggga gcctcgtcca cgttctctac tccaccccta cgtgttacct
     1141 ctgggagctg aacaaggcca atctcacctg gacagtgaag gaggacgact tctttcctta
     1201 tgccgatggc ccccacatgt tctggactgg ctatttttcc agcaggccag ccctcaagcg
     1261 ctatgagcgc ctcagttaca acttcctgca ggtgtgtaac cagctggaag cactggtggg
     1321 tcccgaagcc aacgtgggac cctatggctc gggagacagc gcacctcttc aggaggcaat
     1381 ggcggtgctc caacaccacg acgctgtcag tggtactgca aggcagaatg ttgtaaatga
     1441 ctacgcgagg cagctggcag caggctgggg accctgtgag gttctcgtga gcaacgctct
     1501 ggcgcgactc agccattaca aacagaactt ctcattctgt cgtgagctca acattagcat
     1561 ctgcccagtc agccagactt cggagcgttt ccaggtaact ctttacaacc ccctggggcg
     1621 aaaggtggat cagatggttc ggctgcctgt ctatgaaggc aacttcattg tgaaggaccc
     1681 tcatgataag aacatttcca gtaacgtggt gatggttcct agctattaca gtgagactta
     1741 ccaatgggag ctgctgttcc cagcctcagt gcctgccctg ggcttcagca cctactctgt
     1801 ggccaaaatg agtgacctta accaccaagc ccacaacctg ctgtccaggc ccaggaaaca
     1861 caagtcccat catgtcttag tcattgaaaa taagtacatg cgggccacat ttgactctgg
     1921 cacggggtta ttgatgaaga ttgaaaactt ggaacagaac ctctcgctcc ctgtgagcca
     1981 aggcttcttt tggtataatg ccagtgttgg tgatgaggag agttctcagg cctctggggc
     2041 ctacatcttc agacccaatg tcggtaaacc gatacctgtg agccgctggg ctcagatcag
     2101 tttggtgaag acagccttgg tgcaggaggt acaccagaat ttttcagcct ggtgttccca
     2161 agtgattcgc ctgtacaaag gacagcgcca tttggagctg gagtggacgg tgggaccaat
     2221 cccagtgaga gatgactggg ggaaggaagt catcagccgc tttgacaccc caatgaaaac
     2281 caagggacag ttcttcacgg acagcaacgg ccgggaaatc ctgaagagga gggatgatta
     2341 tcgacccacc tggacattga atcagactga gccggtggct ggaaattact atcctgtcaa
     2401 cactcgaatt tatatcacgg atgggcaaat gcagctgacc gtgttgaccg accgctccca
     2461 ggggggcagc agtctgcagg atggctcgtt ggagctcatg gtgcaccgtc ggctgttggt
     2521 agatgatgat cgtggagtgt cggaaccctt gttggagaca gataccgggg ataaggttcg
     2581 aggacgccac cttgtgcttt tgagttctgt cagtgatgcc gctgcaagac accgactgct
     2641 ggcggaacaa gaagtcctgg cccctcaggt ggtgctgtct ctgggtggta gcagtcccta
     2701 tcactcccgg gcgacaccaa aaacgcagtt ttccggactt cgccaggagc tacctcctca
     2761 ggtgcatttg ctcacactgg cccgctgggg gccaaagatg ctgctgctgc gcttggagca
     2821 ccagttcgct ctgaaagaag attcggatcg caacctgagc tcccctgtaa ccttgaacgt
     2881 tcagaacctg ttccagacct tcactatcaa ctacctgcag gagaccacac tggcagccaa
     2941 ccagcccctg tccagggctt ccaggctcaa gtggatgaca aatactggtc ccacctccta
     3001 ccctgagcct tccaagttgg accctacctc agtcacactg aagcctatgg aaatacgtac
     3061 cttcctggcc tctgtacaat ggcaagaaca caggcctgcc tgaaggaggg gcaggcctcc
     3121 ccttctcttg ctgtaaccat tcacaaaaat cattaaaaag ctcctactga gactcaggtc
     3181 acccagtgca ctatcttttc tggaggggac acagactgtg agatgtagga agatcagcat
     3241 atcctagctc agccctgacc ccaggccctg gtgagaggtt acctccccac tggaatcacc
     3301 acatgttctt ccccatctta ctcatccctt ccctctcttc ccacttccat cctttgtcca
     3361 cacaggcctt cacatggctg gccagctctc aggtggccat ctaagaagcg ccgaggatag
     3421 gcctgtgcag gacatggtat cagaaaacct gttgcaccct gggtctttcc taacccagcc
     3481 tttgagtcaa atctaggcta ggaatctgga aggttgagga ggaggtggtg aaagagaggc
     3541 aggtctcagc tttaggcccc tcacaggcag gggaagctcc catccctctt cctgtgagat
     3601 tagcccctgg cttgtacctt ggaggcagtg catcgtgctc tctgggattt tagtgtgttc
     3661 tgatgtctgt ttagatactg agtctggaaa ggaggctctg attagaaaca taaactgtgt
     3721 tcttccagag ggtttgaggt tagcttccag cacctgtggt aggtggctca tcagccgtaa
     3781 caccagccct cgagggatct ctcaccagta gcctttatgg tccatggtca ccttcactca
     3841 cgtgcacaca cccacacata aaatgaccaa aaaaacacac ctaaaaggtt ttttttccaa
     3901 tacattccaa gcacagtttc cctccctcca tccctcccag cctcctccat tccctttccc
     3961 cccaccccaa cagatctatt cctcctctgt ttcccttcag aaaagggaag acctcccagg
     4021 aatatccacc acacacagca taacaagcta tgataaatct aggcacaaac cctcacatca
     4081 aggctgggtg aggcaaccca gaggaagaaa agggtcccaa gagaagatga aagagtcaga
     4141 gacaccccca ctcccacagt caggaatccc acagaaacac caagctaaca accaaaacat
     4201 atgcagaggg ctatggtaga cccatgcagg ggcaatggag ctgttgtgta atccagcact
     4261 cactgtgtag ttagtgagac cttgcttctc tctcaagtaa gtaaataaat aaatgaacaa
     4321 aataaa
//
