LOCUS       NM_172903               6575 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus mannosidase 2, alpha 2 (Man2a2), mRNA.
ACCESSION   NM_172903 XM_981386
VERSION     NM_172903.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6575)
  AUTHORS   Akama,T.O., Nakagawa,H., Wong,N.K., Sutton-Smith,M., Dell,A.,
            Morris,H.R., Nakayama,J., Nishimura,S., Pai,A., Moremen,K.W.,
            Marth,J.D. and Fukuda,M.N.
  TITLE     Essential and mutually compensatory roles of {alpha}-mannosidase II
            and {alpha}-mannosidase IIx in N-glycan processing in vivo in mice
  JOURNAL   Proc Natl Acad Sci U S A 103 (24), 8983-8988 (2006)
   PUBMED   16754854
  REMARK    GeneRIF: Data show that either alpha-Mannosidase II or IIX can
            biochemically compensate for the deficiency of the other in vivo,
            and either of two is required for late embryonic and early
            postnatal development.
REFERENCE   2  (bases 1 to 6575)
  AUTHORS   Akama,T.O. and Fukuda,M.N.
  TITLE     N-Glycan structure analysis using lectins and an alpha-mannosidase
            activity assay
  JOURNAL   Methods Enzymol 416, 304-314 (2006)
   PUBMED   17113875
  REMARK    GeneRIF: MX was produced by transfecting mammalian cells with
            expression vectors and the substrate specificity of MX was
            determined.
REFERENCE   3  (bases 1 to 6575)
  AUTHORS   Lowe,J.B. and Marth,J.D.
  TITLE     A genetic approach to Mammalian glycan function
  JOURNAL   Annu Rev Biochem 72, 643-691 (2003)
   PUBMED   12676797
  REMARK    Review article
REFERENCE   4  (bases 1 to 6575)
  AUTHORS   Fukuda,M.N. and Akama,T.O.
  TITLE     In vivo role of alpha-mannosidase IIx: ineffective spermatogenesis
            resulting from targeted disruption of the Man2a2 in the mouse
  JOURNAL   Biochim Biophys Acta 1573 (3), 382-387 (2002)
   PUBMED   12417422
  REMARK    Review article
            Erratum:[Biochim Biophys Acta. 2003 Jan 20;1619(2)220]
REFERENCE   5  (bases 1 to 6575)
  AUTHORS   Hiramoto,S., Tamba,M., Kiuchi,S., Jin,Y.Z., Bannai,S., Sugita,Y.,
            Dacheux,F., Dacheux,J.L., Yoshida,M. and Okamura,N.
  TITLE     Stage-specific expression of a mouse homologue of the porcine
            135kDa alpha-D-mannosidase (MAN2B2) in type A spermatogonia
  JOURNAL   Biochem Biophys Res Commun 241 (2), 439-445 (1997)
   PUBMED   9425289
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ105476.1, AK029913.1, AC136740.10 and BC055006.1.
            
            On Mar 26, 2011 this sequence version replaced NM_172903.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029913.1, SRR11927938.3158608.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               CJ105476.1         1-189
            190-781             AK029913.1         1-592
            782-782             AC136740.10        143852-143852       c
            783-5237            AK029913.1         594-5048
            5238-6575           BC055006.1         3294-4631
FEATURES             Location/Qualifiers
     source          1..6575
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 45.65 cM"
     gene            1..6575
                     /gene="Man2a2"
                     /gene_synonym="1700052O22Rik; 4931438M07Rik; Man IIx; MX"
                     /note="mannosidase 2, alpha 2"
                     /db_xref="GeneID:140481"
                     /db_xref="MGI:MGI:2150656"
     exon            1..274
                     /gene="Man2a2"
                     /gene_synonym="1700052O22Rik; 4931438M07Rik; Man IIx; MX"
                     /inference="alignment:Splign:2.1.0"
     exon            275..472
                     /gene="Man2a2"
                     /gene_synonym="1700052O22Rik; 4931438M07Rik; Man IIx; MX"
                     /inference="alignment:Splign:2.1.0"
     exon            473..625
                     /gene="Man2a2"
                     /gene_synonym="1700052O22Rik; 4931438M07Rik; Man IIx; MX"
                     /inference="alignment:Splign:2.1.0"
     CDS             494..3952
                     /gene="Man2a2"
                     /gene_synonym="1700052O22Rik; 4931438M07Rik; Man IIx; MX"
                     /EC_number="3.2.1.114"
                     /note="mannosidase, alpha, class 2A, member 2;
                     alpha-mannosidase IIx; mannosyl-oligosaccharide
                     1,3-1,6-alpha-mannosidase"
                     /codon_start=1
                     /product="alpha-mannosidase 2x"
                     /protein_id="NP_766491.2"
                     /db_xref="CCDS:CCDS57556.1"
                     /db_xref="GeneID:140481"
                     /db_xref="MGI:MGI:2150656"
                     /translation="MKLKKQVTVCGAAIFCVAVFSLYLMLDRVQHDPARHQNGGNFPR
                     SQISVLQNRIEQLEQLLEENHDIISRIKDSVLELTANAEGPPALLPYHTANGSWAVLP
                     EPRPSFFSVSPQDCQFALGGRGQKPELQMLTVSEDLPFDNVEGGVWRQGFDISYSPND
                     WDTEDLQVFVVPHSHNDPGWIKTFDKYYTEQTQHILNSMVSKLQEDPRRRFLWAEVSF
                     FAKWWDNISAQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALVDQLIEGHQWLER
                     NLGATPRSGWAVDPFGHSSTMPYLLRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQ
                     MWDSDSSTDIFCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGGRINCPWKVPPRAIT
                     EANVADRAALLLDQYRKKSRLFRSNVLLVPLGDDFRYDKPQEWDAQFFNYQRLFDFLN
                     SKPEFHVQAQFGTLSEYFDALYKRTGVEPGARPPGFPVLSGDFFSYADREDHYWTGYY
                     TSRPFYKSLDRVLEAHLRGAEILYSLALAHARRSGLAGQYPLSDFALLTEARRTLGLF
                     QHHDAITGTAKEAVVVDYGVRLLRSLVSLKQVIINAAHYLVLGDQETYSFDPGTPFLQ
                     MDDSRVSHDALPERTVIRLDSSPRFVVVFNPLEQERLSVVSLLVNSPRVRVLSEEGQP
                     LSVQISVHWSSATDMVPDVYQVSVPVRLPGLGLGVLQLQPDLDGPYTLQSSVRVYLNG
                     VKLSVSRQSAFPVRVVDSGASDFAISNRYMQVWFSGLTGLLKSIRRVDEEQEQQMELE
                     FLVYGTRTSKDKSGAYLFLPDSEAKPYVPKKPPVLRVTEGPFFSEVAVYYEHFHQVIR
                     LYNLPGVEGLSLDMSFQVDIRDYVNKELALRIHTDIDSQGTFFTDLNGFQIQPRQYLK
                     KLPLQANFYPMPVMAYIQDSQRRLTLHTAQALGVSSLGNGQLEVILDRRLMQDDNRGL
                     GQGLKDNKITCNRFRLLLERRTTMSPEVHQEQERSTSYPSLLSHLTSMYLSTPPLVLP
                     VAKRQGTSPALRSFHPLASPLPCDFHLLNLRMLPAEDTLPATDSALILHRKGFDCGLE
                     AKNLGFNCTTSQGKLALGSLFHGLDVTFLQPTSLTLLYPLASPSNSTDISLEPMEIST
                     FRLRLG"
     exon            626..883
                     /gene="Man2a2"
                     /gene_synonym="1700052O22Rik; 4931438M07Rik; Man IIx; MX"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1028
                     /gene="Man2a2"
                     /gene_synonym="1700052O22Rik; 4931438M07Rik; Man IIx; MX"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1200
                     /gene="Man2a2"
                     /gene_synonym="1700052O22Rik; 4931438M07Rik; Man IIx; MX"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1328
                     /gene="Man2a2"
                     /gene_synonym="1700052O22Rik; 4931438M07Rik; Man IIx; MX"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1502
                     /gene="Man2a2"
                     /gene_synonym="1700052O22Rik; 4931438M07Rik; Man IIx; MX"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1689
                     /gene="Man2a2"
                     /gene_synonym="1700052O22Rik; 4931438M07Rik; Man IIx; MX"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1867
                     /gene="Man2a2"
                     /gene_synonym="1700052O22Rik; 4931438M07Rik; Man IIx; MX"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..2070
                     /gene="Man2a2"
                     /gene_synonym="1700052O22Rik; 4931438M07Rik; Man IIx; MX"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2253
                     /gene="Man2a2"
                     /gene_synonym="1700052O22Rik; 4931438M07Rik; Man IIx; MX"
                     /inference="alignment:Splign:2.1.0"
     exon            2254..2368
                     /gene="Man2a2"
                     /gene_synonym="1700052O22Rik; 4931438M07Rik; Man IIx; MX"
                     /inference="alignment:Splign:2.1.0"
     exon            2369..2436
                     /gene="Man2a2"
                     /gene_synonym="1700052O22Rik; 4931438M07Rik; Man IIx; MX"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2602
                     /gene="Man2a2"
                     /gene_synonym="1700052O22Rik; 4931438M07Rik; Man IIx; MX"
                     /inference="alignment:Splign:2.1.0"
     exon            2603..2839
                     /gene="Man2a2"
                     /gene_synonym="1700052O22Rik; 4931438M07Rik; Man IIx; MX"
                     /inference="alignment:Splign:2.1.0"
     exon            2840..2962
                     /gene="Man2a2"
                     /gene_synonym="1700052O22Rik; 4931438M07Rik; Man IIx; MX"
                     /inference="alignment:Splign:2.1.0"
     exon            2963..3077
                     /gene="Man2a2"
                     /gene_synonym="1700052O22Rik; 4931438M07Rik; Man IIx; MX"
                     /inference="alignment:Splign:2.1.0"
     exon            3078..3211
                     /gene="Man2a2"
                     /gene_synonym="1700052O22Rik; 4931438M07Rik; Man IIx; MX"
                     /inference="alignment:Splign:2.1.0"
     exon            3212..3353
                     /gene="Man2a2"
                     /gene_synonym="1700052O22Rik; 4931438M07Rik; Man IIx; MX"
                     /inference="alignment:Splign:2.1.0"
     exon            3354..3490
                     /gene="Man2a2"
                     /gene_synonym="1700052O22Rik; 4931438M07Rik; Man IIx; MX"
                     /inference="alignment:Splign:2.1.0"
     exon            3491..3691
                     /gene="Man2a2"
                     /gene_synonym="1700052O22Rik; 4931438M07Rik; Man IIx; MX"
                     /inference="alignment:Splign:2.1.0"
     exon            3692..3799
                     /gene="Man2a2"
                     /gene_synonym="1700052O22Rik; 4931438M07Rik; Man IIx; MX"
                     /inference="alignment:Splign:2.1.0"
     exon            3800..6554
                     /gene="Man2a2"
                     /gene_synonym="1700052O22Rik; 4931438M07Rik; Man IIx; MX"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcggtccc ccgcgcccct cctcctgccg ggcgcaccgc tcggccccgt ggaggcggga
       61 gcgcgggagc acaggcgcgg ggcgagcgca gggagcgcgc agcggccctg gcccccgcgg
      121 gagcgcggct gcggggccga gcaggggcgg tgggtggcca ggcgtccctc ttagcctgcg
      181 caactgcccg cgcgcgggcc gcggtccccc gggatgcgag cagtggcggc tcggccggcc
      241 gggtcccgag cggcgcggag gccggccgcg tacgctccgc cctctttggc ccggacccaa
      301 tctccaggga ctaaaaatat tgcccggagg ctcctgagcg gaatcagatc gcattaagta
      361 ggacgcaggc tgaggtgact gagcttttca gcaccagggc ccgaagagca gactccagag
      421 agcggtcccg cccacgcgcg ttcagcagct agcgtcctcc ctcctccggc aggaacgtgc
      481 ctcctgggtc agtatgaagc tgaaaaagca ggtgacggtg tgtggggctg ctatcttctg
      541 tgtggccgtc ttttctctgt accttatgct ggaccgagtg cagcatgatc ctgccagaca
      601 ccagaatggt gggaacttcc ccaggagcca aatctctgtg ctacagaacc ggatagaaca
      661 gctggaacaa ctgctggagg aaaaccatga catcataagc cgtatcaagg actctgtact
      721 ggaactgaca gccaatgcgg agggcccgcc agccctgctg ccctaccata ccgccaacgg
      781 ttcctgggct gtgctcccgg agccccggcc cagcttcttc tccgtctccc cccaggactg
      841 ccagtttgct ttggggggac ggggtcagaa gccagaacta cagatgttaa ccgtgtctga
      901 ggatttgccg tttgacaatg tggagggtgg cgtgtggagg caaggctttg acatctccta
      961 cagcccaaat gactgggaca ctgaagacct gcaagtgttt gtggtgcctc actcccacaa
     1021 cgatccaggc tggatcaaga cttttgacaa gtactacacg gaacagaccc agcacatcct
     1081 caacagcatg gtgtccaagc tgcaggaaga cccccggcgg cgctttctct gggcagaagt
     1141 ctccttcttc gccaagtggt gggacaacat cagtgcccaa aagagggcag cagttcgaag
     1201 gctggtggga aatgggcagc tggagattgc gacaggcgga tgggtgatgc ccgacgaggc
     1261 caactcccat tactttgcct tggttgacca gctcatcgag gggcaccagt ggctggagag
     1321 aaacctgggt gcaaccccgc gctcgggctg ggcagtggac ccctttggac acagctccac
     1381 catgccttac ctgctgcgcc gtgccaacct gaccagcatg ctgattcaga gggtgcatta
     1441 tgccatcaag aagcactttg ctgccactca tagcctggag ttcatgtgga ggcagatgtg
     1501 ggattcagac tccagcacag acatcttttg ccacatgatg cccttctaca gctacgacgt
     1561 tccacacacc tgtggccccg atcccaagat ctgctgccag tttgatttca aacgtctgcc
     1621 gggtgggaga atcaattgcc cttggaaggt gccaccccgg gctattacag aagccaatgt
     1681 ggcagacagg gcagccctgc tcctggacca gtaccggaag aagtcccggc tgttccgaag
     1741 caacgtcctc ctcgtgccac ttggtgatga cttccggtat gacaagcccc aggaatggga
     1801 tgcccagttc ttcaactacc agcggctctt tgacttcctc aacagcaagc ctgagttcca
     1861 tgtgcaggcc cagtttggga ccctctctga gtatttcgat gccctgtata agaggacagg
     1921 agtagagcct ggtgcccggc ctccagggtt tcctgtgctg agtggggact tcttctccta
     1981 cgctgaccgg gaggaccact actggacagg ctattacacc tcccggcctt tctacaagag
     2041 cttggaccgc gtcctagaag cccacctgcg tggggcagag attctataca gcctggcttt
     2101 ggcccatgcc cgccgttctg gactggccgg ccagtacccg ctgtctgatt ttgctcttct
     2161 gacggaagct cggcgtacac tgggcctctt ccagcaccac gatgccatca cgggaaccgc
     2221 caaggaggca gtagtggtag actacggggt caggttgctg cgttccctgg tcagcctcaa
     2281 gcaggttatc atcaatgctg cccactacct ggtgctgggg gaccaggaga cctacagctt
     2341 tgaccctggg acacccttcc tccaaatgga tgacagccgt gtaagccatg atgccctgcc
     2401 cgagcgcacg gtgatccggc tggactcctc acccaggttt gtggtggtat ttaacccgct
     2461 ggaacaggag cggctcagtg tggtgtccct gctggtcaac tcgccccggg tgcgcgtcct
     2521 ttcagaggag ggccagcccc tgtctgtgca gatcagtgtg cactggagct cggctacgga
     2581 catggtccct gatgtctacc aggtgtcagt acccgtccgc ctgccaggcc tgggcctggg
     2641 tgtgctgcag ctgcagccag atctcgatgg gccctacacg ctgcagtctt ccgtgcgggt
     2701 ctacctgaac ggcgtgaaac tgtccgtcag caggcagtca gcattccctg tccgtgttgt
     2761 ggactccggc gccagcgact tcgccatcag caatcgctac atgcaggtct ggttctccgg
     2821 ccttactggg cttctcaaga gcatccgacg ggtggatgag gagcaggagc agcagatgga
     2881 actggagttc ctcgtctacg gcacccgtac ctccaaggac aagagtggcg cctacctctt
     2941 cctgcctgat agcgaggcta agccctacgt ccctaagaaa cctcctgtgc tgcgtgtcac
     3001 cgaaggccct ttcttctcag aggtggctgt gtactatgag cactttcacc aagtgattcg
     3061 actttataac ctgccagggg tagaggggct gtctctggac atgtcattcc aggtagatat
     3121 cagggactat gtgaacaagg aactggccct gcgcatccac acagacattg acagccaggg
     3181 cactttcttc acagacctca atggctttca gatacagccc cggcagtatc tgaagaagct
     3241 gcccctgcag gctaatttct accctatgcc agtcatggcc tatatccaag attcccagag
     3301 gcgcctcacg ctgcacactg cccaggctct gggtgtctcc agcctcggta atggccagct
     3361 ggaggtgatc ttggaccgaa ggctaatgca ggatgacaac cggggactag gccaagggct
     3421 caaagacaac aagatcacct gcaaccgttt ccgcctcctg ttagaacgtc ggaccacaat
     3481 gagcccagag gtgcatcagg agcaggagcg ttctacaagc tacccgtccc tcctcagcca
     3541 cctgacatcc atgtacctca gcacacctcc tcttgtctta cccgtggcca agaggcaggg
     3601 cactagccct gctctgcgct ctttccaccc tctggcttct ccattgccct gtgacttcca
     3661 tttgctcaat ctgcgcatgc tcccagccga ggacaccttg cccgcaactg actctgcgct
     3721 catcttacac cgcaaggggt ttgactgtgg ccttgaagcc aagaacctgg gcttcaactg
     3781 taccacaagc caaggcaagc tagccctggg gagcctcttc catggcctgg atgtgacctt
     3841 cctgcagcca acctccttga ctttgctata ccctctggcc tcaccttcca acagcactga
     3901 catctctctg gagcccatgg agatcagcac cttccgcctg cgcttgggct aggccagggc
     3961 ttcttgtggc ctgaagacag ggttcatcca cagagactgc ctcctaacac caagactaag
     4021 ctggacaagc cacaccaagt ctcccctccg ctctgcctca gaagtgacag actgtgctgt
     4081 gcccttccgt tgtctattgc tgctcctgcg tttggaacag tccttacatc agcaggcggc
     4141 gggggcagag agacagggga gaggaggccc ttgccctagg ctgtgagtag gtacccagct
     4201 gggcacaact caggcttcat ccttttccca aaatgggatg taggaagagt ggggacaagc
     4261 agaagaggtc agggaggctg ggggacaacc tcacgctagg agactgcagg tatgagcttg
     4321 ctctgcgggg tcatatggac cccacagtgc tggtatgagg gtacaggagc agggtgattc
     4381 tgggaggaga ggggtaggcg cccattatta gtggagtaaa ggcgtggaag gagtccctgg
     4441 ttctcctaag agcctaaagg ctttgctgct ttctgctctg gctctgttct gagtgccact
     4501 gggcctgctc tgagtgccac tgggcctgca tgccctggct aggggctgct gggtgcagga
     4561 agggcttgct tcagactcca ggccagaggc cacggaacac ttcaggcact agcactagtt
     4621 ctcagctgat catttggtgt tgatctgtga caggggtagg gagtgtctcc ccctgatctg
     4681 ctttcttatc tcacacacca ggctccccac gagttcccat tgtggggatc ctggcaggat
     4741 tcctttctct aaaatggaaa cagagtttcc aagagggctg tgcttgggtg tcttgggaag
     4801 gcatcctgtg ctggggcccc tggtgggctg aggaggttca ctcgtatccc acctgcagaa
     4861 gtattacctg cccgctgtgt ggacgaggaa ggcagagaca aaattaggag gtcatgtgct
     4921 tggatgaacc ttcgtttttg cttcaatcaa tagagaatct gtctataaat gataagagtt
     4981 ggtaaaagca aagttccatc cttacgaaaa cttagtaagc caagactaga aagaagcccg
     5041 taatctggat aaagatctcg tcaccagtaa gcgaaggcgc ccaaagcatc ggacagagca
     5101 ggctctgatc ccctcagtca gaaactgccc ggcggcacag tgtgttggtg tcactaaccc
     5161 acacttcaga tggaaacaag aattacaatt gccactgttt taaaaccata agctacctaa
     5221 gaaacctgtg tgtcaactag caaggcattc tgtgagttgc cctgtaacga ctggttctcc
     5281 ccaaatcaac ccataaacat cagtgtaatt cccacgaggt tggacacttt ctggaactct
     5341 tcaggtcctg gcattcatct ggaaggtgac aggctgagga tgtgaagtag ttctgaatgg
     5401 ccgaggtgat gaacggctgc tgacactaag gcgggcaaca ggcagtagct gtcttaacag
     5461 agttctcaaa cgacttggac tcttctgcca gcgtgaattc agctgccatg ataggtcagg
     5521 tcagacagac ctaggcacgt agaaattcag tatatgattt caggtgcagg ggaggggagg
     5581 tggatatttt catagtgctt tgagacagct acctacctat gagacttctg tttcaaaaac
     5641 aaaacaaaac aacctagggc tagagggaaa aaagcaaaag caaacaacaa aattgttatt
     5701 attattatta ttattaatta ttattttagt ctcactatgt acctctggct gtgctggaac
     5761 tcattatgta aaccaagctg gcctggaaat cacagagatt ccccacctgc ctctgcctcc
     5821 tgagttctgg gactaaaggc atgcgccatc atcacacctg ggaggaaaaa aatttttttg
     5881 tttttttgag acagggtttc tctgtgtagc tctggctgtc ctggaactca ctctgtagac
     5941 caggctggcc ttgaactcag aaatccacct gcctctgcct tcctagtgct gggattaaag
     6001 gcgtgcacca ccactgccca gcagaaaaaa atatttttat acctgattta ggaaaccctt
     6061 ttctagacat aacatgaaac ctaatatata atgggggaac attaaaaaat aggttttgac
     6121 acacacacac acacacacac acacacacac acacacacac acacacacac acacacaaag
     6181 cttgaaagca tgctatagga aacaggttaa atcaatacag ctgtgtgggt ggaaacgagt
     6241 ctgcagtgag ttctgtcact gctggagaaa agtgtgtttt gacttctcag agaacgtcac
     6301 tagggtctgt ccagcagcac ccaaagactc agtagtgaca aggctgagtt cttgcagggt
     6361 ctccatggtt tatgttgcca ggctcaggcc acacggcttc ctattcatgt cttggtgaca
     6421 ggaatgagat gaagagtggg gagcgcttag cacagagcag gggttgcgcc tacagcaaga
     6481 cttatttgct accatatggt ttgtaatcaa atgataggga actgtgcaga ataaagaata
     6541 ttctttggag gtcaaaaaaa aaaaaaaaaa aaaaa
//
